Journal of Flow Chemistry
Volume/Issue:
Volume 5: Issue 2
The Use of Flow Chemistry for Two-Phase Dibromocyclopropanation of Alkenes
Authors:
Runa B. Østby Norwegian University of Life Sciences, P.O. Box 5003, NO-1432 Ås, Norway

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Yngve H. Stenstrøm Norwegian University of Life Sciences, P.O. Box 5003, NO-1432 Ås, Norway

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Terje Didriksen SINTEF Materials and Chemistry, P.O. Box 124 Blindern, NO-0314 Oslo, Norway

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Pages:
69–73
Online Publication Date:
Jun 2015
Publication Date:
01 Jun 2015
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jfc-d-14-00041
Keywords:
dibromocyclopropanation; CHBr3; Makosza reaction; phase-transfer catalysis; microreactor; flow chemistry
Restricted access

Conventional batch dibromocyclopropanations by reaction of bromoform and alkenes under phase-transfer conditions require strong base (50% NaOH (aq)), vigorous stirring, and often long reaction times. Using flow chemistry in a microreactor, the reactions were found to be smooth, rapid, and high-yielding under ambient conditions when 40% (w/w) NaOH was used as the base. The reaction has been tested with a representative selection of alkenes, displaying a variety of structural features.

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Cover Journal of Flow Chemistry
Journal of Flow Chemistry A Journal of the Flow Chemistry Society
Print ISSN:
2062-249X
Online ISSN:
2063-0212

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation		 2011
Volumes
per Year		 1
Issues
per Year		 4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address		 H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

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