Studies on the continuous-flow synthesis of nonpeptidal bis-tetrahydrofuran moiety of Darunavir

Raquel A. C. Leão; Raquel de O. Lopes; Marco A. de M. Bezerra; Mauro N. Muniz; Bruna B. Casanova; Simone C. B. Gnoatto; Grace Gosmann; Laszlo Kocsis; Rodrigo O.M.A. de Souza; Leandro S. de M. Miranda

doi:10.1556/1846.2015.00031

Journal of Flow Chemistry

Volume/Issue:: Volume 5: Issue 4

Studies on the continuous-flow synthesis of nonpeptidal bis-tetrahydrofuran moiety of Darunavir

Authors: Raquel A. C. Leão¹, Raquel de O. Lopes¹, Marco A. de M. Bezerra¹, Mauro N. Muniz², Bruna B. Casanova², Simone C. B. Gnoatto², Grace Gosmann², Laszlo Kocsis³, Rodrigo O.M.A. de Souza¹, and Leandro S. de M. Miranda¹

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¹ Universidade Federal do Rio de Janeiro, Rio de Janeiro, Bloco A 622, RJ 21941—909, Brazil
² Universidade Federal do Rio Grande do Sul, Faculty of Pharmacy,, Av. Ipiranga, 2752, Porto Alegre-RS, 90610—000, Brazil
³ Faculty of Pharmacy, Budapest 1031, Brazil

DOI:: https://doi.org/10.1556/1846.2015.00031

Page Count:: 216–219

Publication Date:: 01 Dec 2015

Online Publication Date:: Dec 2015

Article Category:: Research Article

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The use of continuous-flow chemistry has shown to be an important tool in improving API manufacture. In the present paper, we report the use of continuous-flow reactors in the synthesis of the bicyclic side chain of antiretroviral Darunavir.