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Uroš Novak University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia

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Daniela Lavric Corning S.A.S. Corning European Technology Center, 7 bis Avenue de Valvins, CS 70156 Samois sur Seine, 77215 Avon Cedex, France

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Polona Žnidaršič-Plazl University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia

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The performance of the Corning AFR™ Low Flow (LF) fluidic module for Candida antarctica lipase B-catalyzed isoamyl acetate synthesis in an n-heptane–buffer two-liquid phase system was evaluated. Obtained flow regime of dispersed n-heptane droplets in a continuous buffer phase, which enables in situ extraction of the produced isoamyl acetate to the n-heptane phase, provides a very large interfacial area for the esterification catalyzed by an amphiphilic lipase B, which positions itself on the n-heptane–buffer interface. Productivities obtained were the highest reported so far for this reaction and indicate that Corning Advanced-Flow Reactor™ (AFR™) modules are also very efficient for carrying out biotransformations in two-phase systems. Additionally, for the separation of the n-heptane from the aqueous phase, a membrane separator consisting of a hydrophobic PTFE membrane was integrated, which enabled the reuse of biocatalyst in several consecutive biotransformations.

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation
2011
Volumes
per Year
1
Issues
per Year
4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address
H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)