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Using a simple flow reactor, the safe use of nitromethane at elevated reaction temperatures was demonstrated in a nitroaldol reaction of different aldehydes. The reaction products were isolated in good yields after a short reaction time.

  • 1.

    Utkin, A. V.; Mochalova, V.M. Combust. Explos. Shock Waves 2015, 51, 6371.

  • 2.

    McCoy, H. D. Railroad Accident Investigation No. 213. Retrieved 08 June 2016 from http://www.blet602.org/Historic_accidents/Mt.%20Pulaski_ 6.1.1958.pdf.

  • 3.

    Sullivan, J.; Sunderland, W. Liquid Explosive in Pipes, 1994, 810.

  • 4.

    Ballini, R.; Bosica, G.; Fiorini, D.; Palmieri, A.; Petrini, M. Chem. Rev. 2005, 105, 933972.

  • 5.

    Luzzio, F. A. Tetrahedron 2001, 57, 915945.

  • 6.

    Boruwa, J.; Gogoi, N.; Saikia, P. P.; Barua, N. C. Tetrahedron: Asymmetry 2006, 17, 33153326.

  • 7.

    Biradar, A. V.; Sharma, K. K.; Asefa, T. Appl. Catal. A Gen. 2010, 389, 1926.

  • 8.

    Kawai, K.; Ebata, T.; Kitazume, T. J. Fluor. Chem. 2005, 126, 956961.

  • 9.

    Hashimoto, K.; Kumagai, N.; Shibasaki, M. Org. Lett. 2014, 16, 34963499.

  • 10.

    Tsubogo, T.; Oyamada, H.; Kobayashi, S. Nature 2016, 520, 329332.

  • 11.

    Roberge, D. M.; Noti, C.; Irle, E.; Eyholzer, M.; Rittiner, B.; Penn, G.; Sedelmeier, G.; Schenkel, B. J. Flow. Chem. 2014, 4, 2634.

    • Search Google Scholar
    • Export Citation
  • 12.

    Deadman, B. J.; Battilocchio, C.; Sliwinski, E.; Ley, S. V. Green Chem. 2013, 15, 20502055.

  • 13.

    Ishitani, H.; Saito, Y.; Tsubogo, T.; Kobayashi, S. Org. Lett. 2016, 18, 13461349.

  • 14.

    Soldi, L.; Ferstl, W.; Loebbecke, S.; Maggi, R.; Malmassari, C.; Sartori, G.; Yada, S. J. Cat. 2008, 258, 289295.

  • 15.

    The micromixing device ‘Comet X-01’, available from Techno Applications Co., Ltd., 34-16-204, Hon, Denenchofu, Oota, Tokyo 145-0072, Japan, was used.

  • 16.

    Evans, D. A.; Seidel, D.; Rueping. M.; Lam, H. W.; Shaw, J. T.; Downey, C. W. J. Am. Chem. Soc. 2003, 125, 1269212693.

  • 17.

    Odedra, A.; Seeberger, P. H. Angew. Chem. Int. Ed. 2009, 48, 26992702.

  • 18.

    Alvarez-Casao, Y.; Marques-Lopez, E.; Herrera, R. P. Symmetry 2011, 3, 220245.

  • 19.

    Hutchings, M.; Wirth, T. Synlett 2016, 27, in press. DOI: 10.1055/s-0035-1561624.

  • 20.

    Blay, G.; Domingo, L. R.; Hernández-Olmos, Pedro, J. R. Chem. Eur. J. 2008, 14, 47254730.