Authors:
Jiangang YuQuzhou University, Quzhou 324000, P. R. China

Search for other papers by Jiangang Yu in
Current site
Google Scholar
PubMed
Close
,
Jianguo XuQuzhou University, Quzhou 324000, P. R. China

Search for other papers by Jianguo Xu in
Current site
Google Scholar
PubMed
Close
,
Zhiqun YuZhejiang University of Technology, Hangzhou 310014, P. R. China

Search for other papers by Zhiqun Yu in
Current site
Google Scholar
PubMed
Close
,
Yi JinQuzhou University, Quzhou 324000, P. R. China

Search for other papers by Yi Jin in
Current site
Google Scholar
PubMed
Close
,
Jie LiQuzhou University, Quzhou 324000, P. R. China

Search for other papers by Jie Li in
Current site
Google Scholar
PubMed
Close
, and
Yanwen LvQuzhou University, Quzhou 324000, P. R. China

Search for other papers by Yanwen Lv in
Current site
Google Scholar
PubMed
Close
Restricted access

A continuous-flow reactor (Corning G1 reactor) was hereby introduced for Fischer indole synthesis of 3-methylindole by reaction of phenyl hydrazines and propylaldehyde. Stoichiometric Lewis acid, ZnCl2, was supplied as catalyst as well as remover of NH3 which generated during the indole ring formation. Ionic liquid ([EMIM][BF4]) was employed as solvent according to its high-temperature tolerance and good product distribution. After a straightforward extraction process, 3-methylindole could be obtained in a 95.3% yield (96.0% purity) under optimized conditions. Ionic liquid (IL) was then recovered by another extraction process, and the recovered IL acted nearly as efficiently as new IL for this Fischer indole reaction.

Supplementary Materials

    • Supplementary Material
  • Collapse
  • Expand
  • Top

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation
2011
Volumes
per Year
1
Issues
per Year
4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address
H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2022 12 0 0
May 2022 14 0 0
Jun 2022 12 0 0
Jul 2022 8 0 0
Aug 2022 6 0 0
Sep 2022 6 0 0
Oct 2022 3 0 0