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  • 1 Institute of Medical Microbiology, University Hospital, University of Duisburg-Essen, Essen, Germany
  • 2 Department of Dermatology and Interdisciplinary Center of Clinical Research (IZKF), University of Münster, Münster, Germany
  • 3 Department of Dermatology, Venerology and Allergology, University Hospital, University Duisburg-Essen, Essen, Germany
  • 4 Mucosal Immunity Group, Institute of Medical Microbiology, University Hospital Essen, Hufelandstr. 55, D-45122, Essen, Germany
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Abstract

CD8+ regulatory T cells appear impaired in number and/or function in some autoimmune diseases. However, the role of CD8+ regulatory T cells in the pathogenesis of skin inflammation and psoriasis remains unknown. In this study, we set out to analyze the capability of CD8+ regulatory T cells to inhibit skin inflammation in a murine model and to determine the frequency of CD8+ regulatory T cells in patients with psoriasis. We demonstrate that murine fully competent CD8+ regulatory T cells can be induced by stimulating naïve CD8+ T cells in the presence of TGF-β and retinoic acid (RA). Importantly, in vitro induced CD8+ regulatory T cells significantly suppressed skin inflammation in vivo. Furthermore, we found that the frequency of regulatory CD8+CD25+Foxp3+ T cells is decreased in peripheral blood but increased in lesional psoriatic skin of patients with psoriasis. Thus, our study suggests a previously unappreciated role of CD8+CD25+ Foxp3+ T cells in skin disorders, and induction of these cells in vitro may be an effective immunotherapy for skin inflammation.

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