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  • 1 Université de Lomé Centre Hospitalier Universitaire Lomé Togo
  • 2 Centre Hospitalier Régional (CHR) Sokodé Togo
  • 3 Onchocerciasis Reference Laboratory Institut National d’Hygiène Sokodé Togo
  • 4 University Clinics of Tübingen Institute of Tropical Medicine Tübingen Germany
Open access

Chemokine a nd antibody response profiles were investigated in children and adults with severe or uncomplicated Plasmodium falciparum malaria; the aim was to reveal which profiles are associated with severe disease, as often seen in nonimmune children, or with mild and uncomplicated disease, as seen in semi-immune adults. Blood samples were obtained from children under 5 years of age as well as adults with falciparum malaria. Classification of malaria was performed according to parasite densities and hemoglobin concentrations. Plasma levels of chemokines (IL-8, IP-10, MCP-4, TARC, PARC, MIP-1δ, eotaxins) were quantified, and antibody responses (IgE, IgG1, and IgG4) to P. falciparum, Entamoeba histolytica-specific antigen, and mite allergen extracts were determined. In children with severe malaria proinflammatory, IL-8, IP10, MIP-1δ, and LARC were at highly elevated levels, suggesting an association with severe disease. In contrast, the Th2-type chemokines TARC, PARC, and eotaxin-2 attained in children the same levels as in adults suggesting the evolution of immune regulatory components. In children with severe malaria, an elevated IgG1 and IgE reactivity to mite allergens and intestinal protozoan parasites was observed. In conclusion, exacerbated proinflammatory chemokines together with IgE responses to mite allergens or E. histolytica-specific antigen extract were observed in children with severe falciparum malaria.

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  • Gallagher M, Malhotra I, Mungai PL, Wamachi AN, Kioko JM, Ouma JH, Muchiri E, King CL: The effects of maternal helminth and malaria infections on mother-to-child HIV transmission. AIDS 19, 1849–1855 (2005)

    King CL , 'The effects of maternal helminth and malaria infections on mother-to-child HIV transmission ' (2005 ) 19 AIDS : 1849 -1855.

    • Search Google Scholar
  • Kirch AK, Agossou A, Banla M, Hoffmann WH, Schulz-Key H, Soboslay PT: Parasite-specific antibody and cytokine profiles in newborns from Plasmodium falciparum and Entamoeba histolytica/dispar-infected mothers. Pediatr Allergy Immunol 15, 133–1341 (2004)

    Soboslay PT , 'Parasite-specific antibody and cytokine profiles in newborns from Plasmodium falciparum and Entamoeba histolytica/dispar-infected mothers ' (2004 ) 15 Pediatr Allergy Immunol : 133 -1341.

    • Search Google Scholar
  • Kocherscheidt L, Agossou A, Gantin RG, Hamm DM, Banla M, Soboslay PT: Cytokine and chemokine responses in adults, newborns and children exposed to Entamoeba histolytica/dispar, Onchocerca volvulus and Plasmodium falciparum. Pediatr Allergy Immunol 21, e756–763 (2010)

    Soboslay PT , 'Cytokine and chemokine responses in adults, newborns and children exposed to Entamoeba histolytica/dispar, Onchocerca volvulus and Plasmodium falciparum ' (2010 ) 21 Pediatr Allergy Immunol : e756 -763.

    • Search Google Scholar
  • Deloron P, Dubois B, Le Hesran JY, Riche D, Fievet N, Cornet M, Ringwald P, Cot M: Isotypic analysis of maternally transmitted Plasmodium falciparum-specific antibodies in Cameroon, and relationship with risk of P. falciparum infection. Clin Exp Immunol 110, 212–218 (1997)

    Cot M , 'Isotypic analysis of maternally transmitted Plasmodium falciparum-specific antibodies in Cameroon, and relationship with risk of P. falciparum infection ' (1997 ) 110 Clin Exp Immunol : 212 -218.

    • Search Google Scholar
  • Riley EM, Wagner GE, Ofori MF: Lack of association between maternal antibody and protection of African children from malaria infection. Infect Immun 68, 5856–5563 (2000)

    Ofori MF , 'Lack of association between maternal antibody and protection of African children from malaria infection ' (2000 ) 68 Infect Immun : 5856 -5563.

    • Search Google Scholar
  • Druilhe P, Pérignon JL: Mechanisms of defense against P. falciparum asexual blood stages in humans. Immunol Lett 41, 115–120 (1994)

    Pérignon JL , 'Mechanisms of defense against P. falciparum asexual blood stages in humans ' (1994 ) 41 Immunol Lett : 115 -120.

    • Search Google Scholar
  • Stanisic DI, Richards JS, McCallum FJ, Michon P, King CL, Schoepflin S, Gilson PR, Murphy VJ, Anders RF, Mueller I, Beeson JG: Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness. Infect Immun 77, 1165–1174 (2009)

    Beeson JG , 'Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness ' (2009 ) 77 Infect Immun : 1165 -1174.

    • Search Google Scholar
  • Roussilhon C, Oeuvray C, Müller-Graf C, Tall A, Rogier C, Trape JF, Theisen M, Balde A, Pérignon JL, Druilhe P: Long-term clinical protection from falciparum malaria is strongly associated with IgG3 antibodies to merozoite surface protein. PLoS Med 4, e320 (2007)

    Druilhe P , 'Long-term clinical protection from falciparum malaria is strongly associated with IgG3 antibodies to merozoite surface protein ' (2007 ) 4 PLoS Med : 320 -.

    • Search Google Scholar
  • Luster AD: The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol 14, 129–135 (2002)

    Luster AD , 'The role of chemokines in linking innate and adaptive immunity ' (2002 ) 14 Curr Opin Immunol : 129 -135.

    • Search Google Scholar
  • Iriemenam NC, Khirelsied AH, Nasr A, ElGhazali G, Giha HA, Elhassan A-Elgadir TM, Agab-Aldour AA, Montgomery SM, Anders RF, Theisen M, Troye-Blomberg M, Elbashir MI, Berzins K: Antibody responses to a panel of Plasmodium falciparum malaria blood-stage antigens in relation to clinical disease outcome in Sudan. Vaccine 27, 62–71

  • Good MF: Identification of early cellular immune factors regulating growth of malaria parasites in humans. Immunity 23, 241–244 (2007)

    Good MF , 'Identification of early cellular immune factors regulating growth of malaria parasites in humans ' (2007 ) 23 Immunity : 241 -244.

    • Search Google Scholar
  • Schofield L: Intravascular infiltrates and organ-specific inflammation in malaria pathogenesis. Immunol Cell Biol 85, 130–137 (2007)

    Schofield L , 'Intravascular infiltrates and organ-specific inflammation in malaria pathogenesis ' (2007 ) 85 Immunol Cell Biol : 130 -137.

    • Search Google Scholar
  • Torre D, Giola M, Speranza F, Matteelli A, Basilico C, Biondi G: Serum levels of interleukin-18 in patients with uncomplicated Plasmodium falciparum malaria. Eur Cytokine Netw 12, 361–364 (2001)

    Biondi G , 'Serum levels of interleukin-18 in patients with uncomplicated Plasmodium falciparum malaria ' (2001 ) 12 Eur Cytokine Netw : 361 -364.

    • Search Google Scholar
  • Freitas do Rosario AP, Langhorne J: T cell-derived IL-10 and its impact on the regulation of host responses during malaria. Int J Parasitol 42, 549–555 (2012)

    Langhorne J , 'T cell-derived IL-10 and its impact on the regulation of host responses during malaria ' (2012 ) 42 Int J Parasitol : 549 -555.

    • Search Google Scholar
  • Freitas do Rosário AP, Lamb T, Spence P, Stephens R, Lang A, Roers A, Muller W, O’Garra A, Langhorne J: IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol 188, 1178–1190 (2012)

    Langhorne J , 'IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection ' (2012 ) 188 J Immunol : 1178 -1190.

    • Search Google Scholar
  • Lechner CJ, Komander K, Hegewald J, Huang X, Gantin RG, Soboslay PT, Agossou A, Banla M, Köhler C: Cytokine and chemokine responses to helminth and protozoan parasites and to fungus and mite allergens in neonates, children, adults, and the elderly. Immun Ageing 10, 29 (2013)

    Köhler C , 'Cytokine and chemokine responses to helminth and protozoan parasites and to fungus and mite allergens in neonates, children, adults, and the elderly ' (2013 ) 10 Immun Ageing : 29 -.

    • Search Google Scholar
  • Ochiel DO, Awandare GA, Keller CC, Hittner JB, Kremsner PG, Weinberg JB, Perkins DJ: Differential regulation of beta-chemokines in children with Plasmodium falciparum malaria. Infect Immun 73, 4190–4197 (2005)

    Perkins DJ , 'Differential regulation of beta-chemokines in children with Plasmodium falciparum malaria ' (2005 ) 73 Infect Immun : 4190 -4197.

    • Search Google Scholar
  • Ayimba E, Hegewald J, Ségbéna AY, Gantin RG, Lechner CJ, Agosssou A, Banla M, Soboslay PT: Proinflammatory and regulatory cytokines and chemokines in children with uncomplicated and severe Plasmodium falciparum malaria. Clin Exp Immunol 166, 218–26 (2011)

    Soboslay PT , 'Proinflammatory and regulatory cytokines and chemokines in children with uncomplicated and severe Plasmodium falciparum malaria ' (2011 ) 166 Clin Exp Immunol : 218 -26.

    • Search Google Scholar
  • Armah HB, Wilson NO, Sarfo BY, Powell MD, Bond VC, Anderson W, Adjei AA, Gyasi RK, Tettey Y, Wiredu EK, Tongren JE, Udhayakumar V, Stiles JK: Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. Malar J. 6, 147 (2007)

    Stiles JK , 'Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children ' (2007 ) 6 Malar J. : 147 -.

    • Search Google Scholar
  • Köhler C, Tebo AE, Dubois B, Deloron P, Kremsner PG, Luty AJ: Temporal variations in immune responses to conserved regions of Plasmodium falciparum merozoite surface proteins related to the severity of a prior malaria episode in Gabonese children. Trans R Soc Trop Med Hyg 97, 455–461 (2003)

    Luty AJ , 'Temporal variations in immune responses to conserved regions of Plasmodium falciparum merozoite surface proteins related to the severity of a prior malaria episode in Gabonese children ' (2003 ) 97 Trans R Soc Trop Med Hyg : 455 -461.

    • Search Google Scholar
  • Courtin D, Oesterholt M, Huismans H, Kusi K, Milet J, Badaut C, Gaye O, Roeffen W, Remarque EJ, Sauerwein R, Garcia A, Luty AJ: The quantity and quality of African children’s IgG responses to merozoite surface antigens reflect protection against Plasmodium falciparum malaria. PLoS One 4, e7590 (2009)

    Luty AJ , 'The quantity and quality of African children’s IgG responses to merozoite surface antigens reflect protection against Plasmodium falciparum malaria ' (2009 ) 4 PLoS One : 7590 -.

    • Search Google Scholar
  • Perlmann H, Helmby H, Hagstedt M, Carlson J, Larsson PH, Troye-Blomberg M, Perlmann P: IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. Clin Exp Immunol 97, 284–292 (1994)

    Perlmann P , 'IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria ' (1994 ) 97 Clin Exp Immunol : 284 -292.

    • Search Google Scholar
  • John CC, Moormann AM, Pregibon DC, Sumba PO, McHugh MM, Narum DL, Lanar DE, Schluchter MD, Kazura JW: Correlation of high levels of antibodies to multiple pre-erythrocytic Plasmodium falciparum antigens and protection from infection. Am J Trop Med Hyg 73, 222–228 (2005)

    Kazura JW , 'Correlation of high levels of antibodies to multiple pre-erythrocytic Plasmodium falciparum antigens and protection from infection ' (2005 ) 73 Am J Trop Med Hyg : 222 -228.

    • Search Google Scholar
  • Perlmann P, Perlmann H, Flyg BW, Hagstedt M, Elghazali G, Worku S, Fernandez V, Rutta AS, Troye-Blomberg M: Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria. Infect Immun 65, 116–121 (1997)

    Troye-Blomberg M , 'Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria ' (1997 ) 65 Infect Immun : 116 -121.

    • Search Google Scholar
  • Blank U, Mécheri S: Duality and complexity of allergictype inflammatory mechanisms in determining the outcome of malaria disease. Front Immunol 2, 78 (2011)

    Mécheri S , 'Duality and complexity of allergictype inflammatory mechanisms in determining the outcome of malaria disease ' (2011 ) 2 Front Immunol : 78 -.

    • Search Google Scholar
  • Duarte J, Deshpande P, Guiyedi V, Mécheri S, Fesel C, Cazenave PA, Mishra GC, Kombila M, Pied S: Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status. Malar J 4, 6 (2007)

    Pied S , 'Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status ' (2007 ) 4 Malar J : 6 -.

    • Search Google Scholar
  • Mulu A, Kassu A, Legesse M, Erko B, Nigussie D, Shimelis T, Belyhun Y, Moges B, Ota F, Elias D: Helminths and malaria co-infections are associated with elevated serum IgE. Parasit Vectors 23, 7 (2014)

    Elias D , 'Helminths and malaria co-infections are associated with elevated serum IgE ' (2014 ) 23 Parasit Vectors : 7 -.

    • Search Google Scholar
  • Riley EM, Allen SJ, Troye-Blomberg M, Bennett S, Perlmann H, Andersson G, Smedman L, Perlmann P, Greenwood BM: Association between immune recognition of the malaria vaccine candidate antigen Pf155/RESA and resistance to clinical disease: a prospective study in a malariaendemic region of west Africa. Trans R. Soc Trop Med Hyg 85, 436–443 (1991)

    Greenwood BM , 'Association between immune recognition of the malaria vaccine candidate antigen Pf155/RESA and resistance to clinical disease: a prospective study in a malariaendemic region of west Africa ' (1991 ) 85 Trans R. Soc Trop Med Hyg : 436 -443.

    • Search Google Scholar
  • Patarroyo ME, Romero P, Torres ML, Clavijo P, Moreno A, Martínez A, Rodríguez R, Guzman F, Cabezas E: Induction of protective immunity against experimental infection with malaria using synthetic peptides. Nature 328, 629–632 (1987)

    Cabezas E , 'Induction of protective immunity against experimental infection with malaria using synthetic peptides ' (1987 ) 328 Nature : 629 -632.

    • Search Google Scholar
  • Riley EM, Allen SJ, Wheeler JG, Blackman MJ, Bennett S, Takacs B, Schönfeld HJ, Holder AA, Greenwood BM: Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen (PfMSP1) of Plasmodium falciparum are associated with reduced malaria morbidity. Parasite Immunol 14, 321–337 (1992)

    Greenwood BM , 'Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen (PfMSP1) of Plasmodium falciparum are associated with reduced malaria morbidity ' (1992 ) 14 Parasite Immunol : 321 -337.

    • Search Google Scholar
  • Jones GL, Edmundson HM, Lord R, Spencer L, Mollard R, Saul AJ: Immunological fine structure of the variable and constant regions of a polymorphic malarial surface antigen from Plasmodium falciparum. Mol Biochem Parasitol 48, 1–9 (1991)

    Saul AJ , 'Immunological fine structure of the variable and constant regions of a polymorphic malarial surface antigen from Plasmodium falciparum ' (1991 ) 48 Mol Biochem Parasitol : 1 -9.

    • Search Google Scholar
  • Clark IA, Alleva LM, Mills AC, Cowden WB: Pathogenesis of malaria and clinically similar conditions. Clin Microbiol Rev 17, 509–539 (2004)

    Cowden WB , 'Pathogenesis of malaria and clinically similar conditions ' (2004 ) 17 Clin Microbiol Rev : 509 -539.

    • Search Google Scholar
  • Clark IA, Budd AC, Alleva LM, Cowden WB: Human malarial disease: a consequence of inflammatory cytokine release. Malar J 5, 85–117 (2006)

    Cowden WB , 'Human malarial disease: a consequence of inflammatory cytokine release ' (2006 ) 5 Malar J : 85 -117.

    • Search Google Scholar
  • Mécheri S: Contribution of allergic inflammatory response to the pathogenesis of malaria disease. Biochim Biophys Acta 1822, 49–56 (2012)

    Mécheri S , 'Contribution of allergic inflammatory response to the pathogenesis of malaria disease ' (2012 ) 1822 Biochim Biophys Acta : 49 -56.

    • Search Google Scholar
  • Pelleau S, Diop S, Dia Badiane M, Vitte J, Beguin P, Nato F, Diop BM, Bongrand P, Parzy D, Jambou R: Enhanced basophil reactivities during severe malaria and their relationship with the Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein. Infect Immun 80, 2963–2970 (2012)

    Jambou R , 'Enhanced basophil reactivities during severe malaria and their relationship with the Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein ' (2012 ) 80 Infect Immun : 2963 -2970.

    • Search Google Scholar
  • Luty AJ, Perkins DJ, Lell B, Schmidt-Ott R, Lehman LG, Luckner D, Greve B, Matousek P, Herbich K, Schmid D, Weinberg JB, Kremsner PG: Low interleukin-12 activity in severe Plasmodium falciparum malaria. Infect Immun 68, 3909–3915 (2000)

    Kremsner PG , 'Low interleukin-12 activity in severe Plasmodium falciparum malaria ' (2000 ) 68 Infect Immun : 3909 -3915.

    • Search Google Scholar
  • Gbédandé K, Varani S, Ibitokou S, Houngbegnon P, Borgella S, Nouatin O, Ezinmegnon S, Adeothy AL, Cottrell G, Massougbodji A, Moutairou K, Troye-Blomberg M, Deloron P, Fievet N, Luty AJ: Malaria modifies neonatal and early-life toll-like receptor cytokine responses. Infect Immun 81, 2686–2696 (2013)

    Luty AJ , 'Malaria modifies neonatal and early-life toll-like receptor cytokine responses ' (2013 ) 81 Infect Immun : 2686 -2696.

    • Search Google Scholar
  • Lyke KE, Burges R, Cissoko Y, Sangare L, Dao M, Diarra I, Kone A, Harley R, Plowe CV, Doumbo OK, Sztein MB: Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. Infect Immun 72, 5630–5637 (2004)

    Sztein MB , 'Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls ' (2004 ) 72 Infect Immun : 5630 -5637.

    • Search Google Scholar
  • Ong’echa JM, Davenport GC, Vulule JM, Hittner JB, Perkins DJ: Identification of inflammatory biomarkers for pediatric malarial anemia severity using novel statistical methods. Infect Immun 79, 4674–4680 (2011)

    Perkins DJ , 'Identification of inflammatory biomarkers for pediatric malarial anemia severity using novel statistical methods ' (2011 ) 79 Infect Immun : 4674 -4680.

    • Search Google Scholar
  • Friedland JS, Ho M, Remick DG, Bunnag D, White NJ, Griffin GE: Interleukin-8 and Plasmodium falciparum malaria in Thailand. Trans R Soc Trop Med Hyg 87, 54–55 (1993)

    Griffin GE , 'Interleukin-8 and Plasmodium falciparum malaria in Thailand ' (1993 ) 87 Trans R Soc Trop Med Hyg : 54 -55.

    • Search Google Scholar
  • Graça-Souza AV, Arruda MA, de Freitas MS, Barja-Fidalgo C, Oliveira PL: Neutrophil activation by heme: implications for inflammatory processes. Blood 99, 4160–4165 (2002)

    Oliveira PL , 'Neutrophil activation by heme: implications for inflammatory processes ' (2002 ) 99 Blood : 4160 -4165.

    • Search Google Scholar
  • Deroost K, Tyberghein A, Lays N, Noppen S, Schwarzer E, Vanstreels E, Komuta M, Prato M, Lin JW, Pamplona A, Janse CJ, Arese P, Roskams T, Daelemans D, Opdenakker G, Van den Steen PE: Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome. Am J Respir Cell Mol Biol 48, 589–600 (2013)

    Steen PE , 'Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome ' (2013 ) 48 Am J Respir Cell Mol Biol : 589 -600.

    • Search Google Scholar
  • Schutyser E, Richmond A, Van Damme J: Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. J Leukoc Biol 78, 14–26 (2005)

    Damme J , 'Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes ' (2005 ) 78 J Leukoc Biol : 14 -26.

    • Search Google Scholar
  • Bruna-Romero O, Schmieg J, Del Val M, Buschle M, Tsuji M: The dendritic cell-specific chemokine, dendritic cellderived CC chemokine 1, enhances protective cell-mediated immunity to murine malaria. J Immunol 170, 3195–203 (2003)

    Tsuji M , 'The dendritic cell-specific chemokine, dendritic cellderived CC chemokine 1, enhances protective cell-mediated immunity to murine malaria ' (2003 ) 170 J Immunol : 3195 -203.

    • Search Google Scholar
  • Porcherie A, Mathieu C, Peronet R, Schneider E, Claver J, Commere PH, Kiefer-Biasizzo H, Karasuyama H, Milon G, Dy M, Kinet JP, Louis J, Blank U, Mécheri S: Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria. J Exp Med 208, 2225–2236 (2011)

    Mécheri S , 'Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria ' (2011 ) 208 J Exp Med : 2225 -2236.

    • Search Google Scholar
  • Ying S, Robinson DS, Meng Q, Barata LT, McEuen AR, Buckley MG, Walls AF, Askenase PW, Kay AB: C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). J Immunol 163, 3976–3984 (1999)

    Kay AB , 'C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES) ' (1999 ) 163 J Immunol : 3976 -3984.

    • Search Google Scholar
  • Ravensberg AJ, Ricciardolo FL, van Schadewijk A, Rabe KF, Sterk PJ, Hiemstra PS, Mauad T: Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge. J Allergy Clin Immunol 115, 779–785 (2005)

    Mauad T , 'Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge ' (2005 ) 115 J Allergy Clin Immunol : 779 -785.

    • Search Google Scholar
  • Osier FH, Fegan G, Polley SD, Murungi L, Verra F, Tetteh KK, Lowe B, Mwangi T, Bull PC, Thomas AW, Cavanagh DR, McBride JS, Lanar DE, Mackinnon MJ, Conway DJ, Marsh K: Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria. Infect Immun 76, 2240–2248 (2008)

    Marsh K , 'Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria ' (2008 ) 76 Infect Immun : 2240 -2248.

    • Search Google Scholar
  • Remoue F, Diallo TO, Angeli V, Hervé M, de Clercq D, Schacht AM, Charrier N, Capron M, Vercruysse J, Ly A, Capron A, Riveau G: Malaria co-infection in children influences antibody response to schistosome antigens and inflammatory markers associated with morbidity. Trans R Soc Trop Med Hyg 97, 361–364 (2003)

    Riveau G , 'Malaria co-infection in children influences antibody response to schistosome antigens and inflammatory markers associated with morbidity ' (2003 ) 97 Trans R Soc Trop Med Hyg : 361 -364.

    • Search Google Scholar
  • Roussilhon C, Brasseur P, Agnamey P, Pérignon JL, Druilhe P: Understanding human-Plasmodium falciparum immune interactions uncovers the immunological role of worms. PLoS One 5, e9309 (2010)

    Druilhe P , 'Understanding human-Plasmodium falciparum immune interactions uncovers the immunological role of worms ' (2010 ) 5 PLoS One : 9309 -.

    • Search Google Scholar
  • Esen M, Mordmüller B, de Salazar PM, Adegnika AA, Agnandji ST, Schaumburg F, Hounkpatin AB, Brückner S, Theisen M, Bélard S, Ngoa UA, Issifou S, Yazdanbakhsh M, Kremsner PG: Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura. Vaccine 30, 7621–7624 (2012)

    Kremsner PG , 'Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura ' (2012 ) 30 Vaccine : 7621 -7624.

    • Search Google Scholar
  • Sokhna C, Le Hesran JY, Mbaye PA, Akiana J, Camara P, Diop M, Ly A, Druilhe P: Increase of malaria attacks among children presenting concomitant infection by Schistosoma mansoni in Senegal. Malar J 3, 43 (2004)

    Druilhe P , 'Increase of malaria attacks among children presenting concomitant infection by Schistosoma mansoni in Senegal ' (2004 ) 3 Malar J : 43 -.

    • Search Google Scholar
  • Courtin D, Djilali-Saïah A, Milet J, Soulard V, Gaye O, Migot-Nabias F, Sauerwein R, Garcia A, Luty AJ: Schistosoma haematobium infection affects Plasmodium falciparum-specific IgG responses associated with protection against malaria. Parasite Immunol 33, 124–131 (2011)

    Luty AJ , 'Schistosoma haematobium infection affects Plasmodium falciparum-specific IgG responses associated with protection against malaria ' (2011 ) 33 Parasite Immunol : 124 -131.

    • Search Google Scholar

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Jeffrey S. Buguliskis (Thomas Jefferson University, USA)

  • Jörn Albring (University of Münster, Germany)
  • Stefan Bereswill (Charité - University Medicine Berlin, Germany)
  • Dunja Bruder (University of Megdeburg, Germany)
  • Jan Buer (University of Duisburg, Germany)
  • Jeff Buguliskis (Thomas Jefferson University, USA)
  • Edit Buzas (Semmelweis University, Hungary)
  • Charles Collyer (University of Sydney, Australia)
  • Renato Damatta (UENF, Brazil)
  • Ivelina Damjanova (Semmelweis University, Hungary)
  • Maria Deli (Biological Research Center, HAS, Hungary)
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  • Nancy Guillen (Institute Pasteur, France)
  • Georgina L. Hold (University of Aberdeen, United Kingdom)
  • Ralf Ignatius (Charité - University Medicine Berlin, Germany)
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  • Shreemanta Parida (Vaccine Grand Challenge Program, India)
  • Matyas Sandor (University of Wisconsin, USA)
  • Ulrich Steinhoff (University of Marburg, Germany)
  • Michal Toborek (University of Miami, USA)
  • Mary Jo Wick (University of Gothenburg, Sweden)
  • Susanne A. Wolf (MDC-Berlin, Germany)

 

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