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  • 1 Department of Psychiatry, Chung Ang University, College of Medicine, Seoul, Korea
  • 2 Department of Brain and Cognitive Sciences, Graduate School, Ewha Womans University, Seoul, Korea
  • 3 The Brain Institute, University of Utah, Salt Lake City, UT, USA
  • 4 Department of Psychiatry, Chung Ang University Hospital, HeukSeok dong, Dong Jack Gu, Seoul, Korea
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Abstract

Background and aims: Several studies have suggested that addictive disorders including substance abuse and pathologic gambling might be associated with dysfunction on working memory and prefrontal activity. We hypothesized that excessive online game playing is associated with deficits in prefrontal cortex function and that recovery from excessive online game playing might improve prefrontal cortical activation in response to working memory stimulation. Methods: Thirteen adolescents with excessive online game playing (AEOP) and ten healthy adolescents (HC) agreed to participate in this study. The severity of online game play and playing time were evaluated for a baseline measurement and again following four weeks of treatment. Brain activation in response to working memory tasks (simple and complex calculations) at baseline and subsequent measurements was assessed using BOLD functional magnetic resonance imaging (fMRI). Results: Compared to the HC subjects, the AEOP participants exhibited significantly greater activity in the right middle occipital gyrus, left cerebellum posterior lobe, left premotor cortex and left middle temporal gyrus in response to working memory tasks during baseline measurements. After four weeks of treatment, the AEOP subjects showed increased activity within the right dorsolateral prefrontal cortex and left occipital fusiform gyrus. After four weeks of treatment, changes in the severity of online game playing were negatively correlated with changes in the mean β value of the right dorsolateral prefrontal cortex in response to complex stimulation. Conclusions: We suggest that the effects of online game addiction on working memory may be similar to those observed in patients with substance dependence.

  • M. Abe T. Hanakawa Y. Takayama C. Kuroki S. Ogawa H. Fukuyama 2007 Functional coupling of human prefrontal and premotor areas during cognitive manipulation The Journal of Neuroscience 27 13 3429 3438.

    • Search Google Scholar
    • Export Citation
  • K. W. Beard E. M. Wolf 2001 Modification in the proposed diagnostic criteria for Internet addiction Cyberpsychology and Behavior 4 3 377 383.

    • Search Google Scholar
    • Export Citation
  • A. T. Beck C. H. Ward M. Mendelson J. Mock J. Erbaugh 1961 An inventory for measuring depression Archives of General Psychiatry 4 561 571.

    • Search Google Scholar
    • Export Citation
  • S. A. Brown S. F. Tapert E. Granholm D. C. Delis 2000 Neurocognitive functioning of adolescents: Effects of protracted alcohol use Alcoholism, Clinical and Experimental Research 24 2 164 171.

    • Search Google Scholar
    • Export Citation
  • P. W. Burgess E. Veitch A. de Lacy Costello T. Shallice 2000 The cognitive and neuroanatomical correlates of multitasking Neuropsychologia 38 6 848 863.

    • Search Google Scholar
    • Export Citation
  • D. N. Crockford B. Goodyear J. Edwards J. Quickfall N. el-Guebaly 2005 Cue-induced brain activity in pathological gamblers Biological Psychiatry 58 10 787 795.

    • Search Google Scholar
    • Export Citation
  • G. di Pellegrino S. P. Wise 1993 Visuospatial versus visuomotor activity in the premotor and prefrontal cortex of a primate The Journal of Neuroscience 13 3 1227 1243.

    • Search Google Scholar
    • Export Citation
  • J. D. Feigenbaum C. E. Polkey R. G. Morris 1996 Deficits in spatial working memory after unilateral temporal lobectomy in man Neuropsychologia 34 3 163 176.

    • Search Google Scholar
    • Export Citation
  • J. J. Fitzpatrick 2008 Internet addiction: Recognition and interventions Archives of Psychiatric Nursing 22 2 59 60.

  • I. H. Franken 2003 Drug craving and addiction: Integrating psychological and neuropsychopharmacological approaches Progress in Neuro-psychopharmacology & Biological Psychiatry 27 4 563 579.

    • Search Google Scholar
    • Export Citation
  • V. Goel R. J. Dolan 2000 Anatomical segregation of component processes in an inductive inference task Journal of Cognitive Neuroscience 12 1 110 119.

    • Search Google Scholar
    • Export Citation
  • V. Goel J. Grafman 1995 Are the frontal lobes implicated in “planning” functions? Interpreting data from the Tower of Hanoi Neuropsychologia 33 5 623 642.

    • Search Google Scholar
    • Export Citation
  • E. Goldberg K. Podell R. Harner S. Riggio M. Lovell 1994 Cognitive bias, functional cortical geometry, and the frontal lobes: Laterality, sex, and handedness Journal of Cognitive Neuroscience 6 276 296.

    • Search Google Scholar
    • Export Citation
  • A. E. Goudriaan M. B. de Ruiter W. van den Brink J. Oosterlaan D. J. Veltman 2010 Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: An fMRI study Addiction Biology 15 4 491 503.

    • Search Google Scholar
    • Export Citation
  • A. E. Goudriaan J. Oosterlaan E. de Beurs W. van den Brink 2006 Neurocognitive functions in pathological gambling: A comparison with alcohol dependence, Tourette syndrome and normal controls Addiction 101 4 534 547.

    • Search Google Scholar
    • Export Citation
  • J. H. Ha H. J. Yoo I. H. Cho B. Chin D. Shin J. H. Kim 2006 Psychiatric comorbidity assessed in Korean children and adolescents who screen positive for Internet addiction The Journal of Clinical Psychiatry 67 5 821 826.

    • Search Google Scholar
    • Export Citation
  • D. H. Han N. Bolo M. A. Daniels L. Arenella I. K. Lyoo P. F. Renshaw 2011 Brain activity and desire for Internet video game play Comprehensive Psychiatry 52 1 88 95.

    • Search Google Scholar
    • Export Citation
  • Han, D. H., Daniels, M. A., Bolo, N., Arenella, L. S. & Lyoo, I. K. (2008). The correlation between cue-induced craving for internet video game play and brain activation. Paper presented at The College on Problems of Drug Dependence, San Juan, Puerto Rico.

    • Search Google Scholar
    • Export Citation
  • D. H. Han J. W. Hwang P. F. Renshaw 2010 Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with Internet video game addiction Experimental and Clinical Psychopharmacology 18 4 297 304.

    • Search Google Scholar
    • Export Citation
  • D. H. Han Y. S. Lee K. C. Yang E. Y. Kim I. K. Lyoo P. F. Renshaw 2007 Dopamine genes and reward dependence in adolescents with excessive internet video game play Journal of Addiction Medicine 1 3 133 138.

    • Search Google Scholar
    • Export Citation
  • L. K. Jacobsen K. R. Pugh R. T. Constable M. Westerveld W. E. Mencl 2007 Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users Biological Psychiatry 61 1 31 40.

    • Search Google Scholar
    • Export Citation
  • M. J. Kane R. W. Engle 2002 The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective Psychonomic Bulletin & Review 9 4 637 671.

    • Search Google Scholar
    • Export Citation
  • Y. Khazaal A. Chatton K. Atwi D. Zullino R. Khan J. Billieux 2011 Arabic validation of the Compulsive Internet Use Scale (CIUS) Substance Abuse Treatment, Prevention, and Policy 6 32.

    • Search Google Scholar
    • Export Citation
  • C. H. Ko G. C. Liu S. Hsiao J. Y. Yen M. J. Yang W. C. Lin 2009 Brain activities associated with gaming urge of online gaming addiction Journal of Psychiatric Research 43 7 739 747.

    • Search Google Scholar
    • Export Citation
  • Korea Agency for Digital Opportunity & Promotion [KADO] (2009). National Survey of Internet Use in Korea. Retrieved December 1, 2010 from http://www.kado.or.kr.

    • Search Google Scholar
    • Export Citation
  • Korean Statistical Information Service [KOSIS] (2009). High Speed Internet Market Penetration. Retrieved December 1, 2010 from http://kostat.go.kr.

    • Search Google Scholar
    • Export Citation
  • R. H. Lazeron S. A. Rombouts W. C. Machielsen P. Scheltens M. P. Witter H. B. Uylings 2000 Visualizing brain activation during planning: The Tower of London test adapted for functional MR imaging American Journal of Neuroradiology 21 8 1407 1414.

    • Search Google Scholar
    • Export Citation
  • Y. S. Lee D. H. Han K. C. Yang M. A. Daniels C. Na B. S. Kee 2008 Depression like characteristics of 5HTTLPR polymorphism and temperament in excessive internet users Journal of Affective Disorders 109 1–2 165 169.

    • Search Google Scholar
    • Export Citation
  • V. Leiserson R. O. Pihl 2007 Reward-sensitivity, inhibition of reward-seeking, and dorsolateral prefrontal working memory function in problem gamblers not in treatment Journal of Gambling Studies 23 4 435 455.

    • Search Google Scholar
    • Export Citation
  • L. C. Maas S. E. Lukas M. J. Kaufman R. D. Weiss S. L. Daniels V. W. Rogers 1998 Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving The American Journal of Psychiatry 155 1 124 126.

    • Search Google Scholar
    • Export Citation
  • E. C. Miotto P. Bullock C. E. Polkey R. G. Morris 1996 Spatial working memory and strategy formation in patients with frontal lobe excisions Cortex 32 4 613 630.

    • Search Google Scholar
    • Export Citation
  • R. G. Morris E. C. Miotto J. D. Feigenbaum P. Bullock C. E. Polkey 1997 The effect of goal-subgoal conflict on planning ability after frontal- and temporal-lobe lesions in humans Neuropsychologia 35 8 1147 1157.

    • Search Google Scholar
    • Export Citation
  • H. B. Moss L. Kirisci H. W. Gordon R. E. Tarter 1994 A neuropsychologic profile of adolescent alcoholics Alcoholism, Clinical and Experimental Research 18 1 159 163.

    • Search Google Scholar
    • Export Citation
  • S. D. Newman P. A. Carpenter S. Varma M. A. Just 2003 Frontal and parietal participation in problem solving in the Tower of London: fMRI and computational modeling of planning and high-level perception Neuropsychologia 41 12 1668 1682.

    • Search Google Scholar
    • Export Citation
  • H. S. Park S. H. Kim S. A. Bang E. J. Yoon S. S. Cho S. E. Kim 2010 Altered regional cerebral glucose metabolism in internet game overusers: A 18F-fluorodeoxyglucose positron emission tomography study CNS Spectrums 15 3 159 166.

    • Search Google Scholar
    • Export Citation
  • M. H. Park E. J. Park J. Choi S. Chai J. H. Lee C. Lee 2011 Preliminary study of Internet addiction and cognitive function in adolescents based on IQ tests Psychiatry Research 190 2–3 275 281.

    • Search Google Scholar
    • Export Citation
  • S. K. Park J. Y. Kim C. B. Cho 2008 Prevalence of Internet addiction and correlations with family factors among South Korean adolescents Adolescence 43 172 895 909.

    • Search Google Scholar
    • Export Citation
  • H. G. Pope Jr. A. J. Gruber J. I. Hudson M. A. Huestis D. Yurgelun-Todd 2001 Neuropsychological performance in long-term cannabis users Archives of General Psychiatry 58 10 909 915.

    • Search Google Scholar
    • Export Citation
  • M. N. Potenza M. A. Steinberg P. Skudlarski R. K. Fulbright C. M. Lacadie M. K. Wilber 2003 Gambling urges in pathological gambling: A functional magnetic resonance imaging study Archives of General Psychiatry 60 8 828 836.

    • Search Google Scholar
    • Export Citation
  • R. H. Schwartz P. J. Gruenewald M. Klitzner P. Fedio 1989 Short-term memory impairment in cannabis-dependent adolescents American Journal of Diseases of Children 143 10 1214 1219.

    • Search Google Scholar
    • Export Citation
  • A. D. Schweinsburg B. J. Nagel B. C. Schweinsburg A. Park R. J. Theilmann S. F. Tapert 2008 Abstinent adolescent marijuana users show altered fMRI response during spatial working memory Psychiatry Research 163 1 40 51.

    • Search Google Scholar
    • Export Citation
  • T. Shallice 1982 Specific impairments of planning Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 298 1089 199 209.

    • Search Google Scholar
    • Export Citation
  • J. Talairach P. Tournoux 1988 Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system: An approach to cerebral imaging Thieme Medical Publishers New York.

    • Search Google Scholar
    • Export Citation
  • S. F. Tapert E. Granholm N. G. Leedy S. A. Brown 2002 Substance use and withdrawal: Neuropsychological functioning over 8 years in youth Journal of the International Neuropsychological Society 8 7 873 883.

    • Search Google Scholar
    • Export Citation
  • S. F. Tapert A. D. Schweinsburg V. C. Barlett S. A. Brown L. R. Frank G. G. Brown 2004 Blood oxygen level dependent response and spatial working memory in adolescents with alcohol use disorders Alcoholism, Clinical and Experimental Research 28 10 1577 1586.

    • Search Google Scholar
    • Export Citation
  • O. A. Van den Heuvel H. J. Groenewegen F. Barkhof R. H. Lazeron R. van Dyck D. J. Veltman 2003 Frontostriatal system in planning complexity: A parametric functional magnetic resonance version of Tower of London task Neuroimage 18 2 367 374.

    • Search Google Scholar
    • Export Citation
  • R. J. van Holst W. van den Brink D. J. Veltman A. E. Goudriaan 2010 Brain imaging studies in pathological gambling Current Psychiatry Reports 12 5 418 425.

    • Search Google Scholar
    • Export Citation
  • M. B. Walker 1989 Some problems with the concept of “gambling addiction”: Should theories of addiction be generalized to include excessive gambling? Journal of Gambling Studies 5 3 179 200.

    • Search Google Scholar
    • Export Citation
  • J. D. Wallis E. K. Miller 2003 Neuronal activity in primate dorsolateral and orbital prefrontal cortex during performance of a reward preference task The European Journal of Neuroscience 18 7 2069 2081.

    • Search Google Scholar
    • Export Citation
  • M. Watanabe H. C. Cromwell L. Tremblay J. R. Hollerman K. Hikosaka W. Schultz 2001 Behavioral reactions reflecting differential reward expectations in monkeys Experimental Brain Research 140 4 511 518.

    • Search Google Scholar
    • Export Citation
  • S. J. Wilson M. A. Sayette J. A. Fiez 2004 Prefrontal responses to drug cues: A neurocognitive analysis Nature Neuroscience 7 3 211 214.

    • Search Google Scholar
    • Export Citation
  • K. S. Young 1996 Psychology of computer use: XL. Addictive use of the Internet: A case that breaks the stereotype Psychological Reports 79 3Pt1 899 902.

    • Search Google Scholar
    • Export Citation
  • K. S. Young 1998 Caught in the Net: How to recognize the signs of Internet addiction and a winning strategy for recovery John Wiley & Sons New York, NY.

    • Search Google Scholar
    • Export Citation
  • K. Yuan W. Qin Y. Liu J. Tian 2011 Internet addiction: Neuroimaging findings Communicative and Integrative Biology 4 6 637 639.

  • Yurgelun-Todd, D. A., Gruber, S. A., Hanson, R. A., Baird, A. A., Renshaw, P. F. & Pope, H. G., Jr. (1998). Residual effects of marijuana use: An fMRI study. In Problems of drug dependence. Paper presented at the 60th Annual Scientific Meeting, the College on Problems of Drug Dependence, Bethesda.

    • Search Google Scholar
    • Export Citation
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Including gaming disorder in the ICD-11: The need to do so from a clinical and public health perspective

Commentary on: A weak scientific basis for gaming disorder: Let us err on the side of caution (van Rooij et al., 2018)