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The purpose was to determine the possible effects of exercise and/or caffeine on hypoglycemia and liver gluconeogenesis in diabetic rats. These were divided into four subgroups: (a) intraperitoneal insulin only, (b) exercise bout before insulin, (c) caffeine after insulin, and (d) exercise bout before and caffeine after insulin. The marked glycemic drop 45 min after insulin (0 min = 229.00, 45 min = 75.75) was considerably reduced (p < 0.05) by caffeine or exercise (45 min: exercise = 127.00, caffeine = 104.78). However, this systemic effect was lost (p > 0.05) when they were combined (45 min: exercise + caffeine = 65.44) (Mean, in mg·dL−1). Caffeine alone strongly inhibited liver glucose production from 2 mM lactate 45 min after insulin (without caffeine = 3.05, with caffeine = 0.27; p < 0.05), while exercise + caffeine partially re-established the liver gluconeogenic capacity (exercise + caffeine = 1.61; p < 0.05 relative to the other groups) (Mean, in μmol·g−1). The improved hypoglycemia with caffeine or exercise cannot be explained by their actions on liver gluconeogenesis. As their beneficial effect disappeared when they were combined, such association in diabetic patients should be avoided during the period of hyperinsulinemia due to the risk of severe hypoglycemia.
-
1.
Afonso M , de Souza CN , Zagatto AM , Luciano E : Respostas metabólicas agudas ao exercício moderado em ratos wistar (Metabolic response to acute physical exercise in Wistar rats). Motriz 9, 87–92 (2003)
-
2.
Albuquerque GG , Gazola VAFG , Garcia RF , Souza KLA , Barrena HC , Curi R , Bazotte RB : Gluconeogenesis and ketogenesis in perfused liver of rats submitted to short-term insulin-induced hypoglycaemia. Cell Biochem. Funct. 26, 228–232 (2008)
-
3.
Altimari LR , de Moraes AC , Tirapegui J , Moreau RLM : Cafeína e performance em exercícios anaeróbios (Caffeine and performance in anaerobic exercise). Rev. Bras. Ciênc. Farm. 42, 17–27 (2006)
-
4.
Babata LKB , Malta A , Godoi VAF , Pedrosa MMD : Acute exercise and caffeine improve insulin-induced hypoglycemia in normal and malnourished rats. Acta Sci. Biol. Sci. 37, 123–130 (2015)
-
5.
Berglund ED , Lee-Young RS , Lustig DG , Lynes SE , Donahue EP , Camacho RC , Meredith ME , Magnuson MA , Charron MJ , Wasserman DH : Hepatic energy state is regulated by glucagon receptor signaling in mice. J. Clin. Invest. 119, 2412–2422 (2009)
-
6.
Bergmeyer HU , Bernt E (1974): Determination of glucose with glucose-oxidase and peroxidase. In: Methods of Enzymatic Analysis, ed Bergmeyer HU, Verlag Chemie, Academic Press, Weinheim, New York and London, pp. 1205–1215
-
7.
Crist GH , Xu B , Lanoue KF , Lang CH : Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats. FASEB J. 12, 1301–1308 (1998)
-
8.
Czok R , Lamprecht W (1974): Pyruvate, phosphoenolpyruvate and glycerate-2-phosphate. In: Methods of Enzymatic Analysis, ed Bermeyer HU, 3rd ed., Academic Press, New York and London, pp. 1446–1448
-
9.
Davis JK , Green JM : Caffeine and anaerobic performance: ergogenic value and mechanisms of action. Sports Med. 39, 813–832 (2009)
-
10.
Davis JM , Zhao Z , Stock HS , Mehl KA , Buggy J , Hand GA : Central nervous system effects of caffeine and adenosine on fatigue. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284, 399–404 (2003)
-
11.
DeFronzo RA : Pathogenesis of type 2 diabetes mellitus. Med. Clin. North Am. 88, 787–835 (2004)
-
12.
Eltzschig HK , Abdulla P , Hoffman E , Hamilton KE , Daniels D , Schönfeld C , Löffler M , Reyes G , Duszenko M , Karhausen J , Robinson A , Westerman KA , Coe IR , Colgan SP : HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J. Exp. Physiol. 202, 1493–1505 (2005)
-
13.
Enjyoji K , Kotani K , Thukral C , Blumel B , Sun X , Wu Y , Imai M , Friedman D , Csizmadia E , Bleibel W , Kahn BB , Robson SC : Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes 57, 2311–2320 (2008)
-
14.
González-Benítez E , Guinzberg R , Díaz-Cruz A , Piña E : Regulation of glycogen metabolism in hepatocytes through adenosine receptors. Role of Ca2+ and cAMP. Eur. J. Pharmacol. 437, 105–111 (2002)
-
15.
Grden M , Podgorska M , Szutowicz A , Pawelczyk T : Diabetes-induced alterations of adenosine receptors expression level in rat liver. Exp. Mol. Pathol. 83, 392–398 (2007)
-
16.
Greenberg JA , Boozer CN , Geliebter A : Coffee, diabetes, and weight control. Am. J. Clin. Nutr. 84, 682–693 (2006)
-
17.
Greer F , Hudson R , Ross R , Graham T : Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes 50, 2349–2354 (2001)
-
18.
Guinzberg R , Cortés D , Díaz-Cruz A , Riveros-Rosas H , Villalobos-Molina R , Piña E : Inosine released after hypoxia activates hepatic glucose liberation through A3 adenosine receptors. Am. J. Physiol. Endocrinol. Metab. 290, 940–951 (2006)
-
19.
Hadjicharalambous MP , Kilduff LP , Pitsiladis YP : Brain serotonergic and dopaminergic modulators, perceptual responses and endurance exercise performance following caffeine co-ingested with a high fat meal in trained humans. J. Int. Soc. Sports Nutr. 7, 1–10 (2010)
-
20.
Halliwill JR , Buck TM , Lacewell AN , Romero SA : Postexercise hypotension and sustained postexercise vasodilatation: what happens after we exercise? Exp. Physiol. 98, 7–18 (2013)
-
21.
Harada H , Asano O , Hoshino Y , Yoshikawa S , Matsukura M , Kabasawa Y , Niijima J , Kotake Y , Watanabe N , Kawata T , Inoue T , Horizoe T , Yasuda N , Minami H , Nagata K , Murakami M , Nagaoka J , Kobayashi S , Tanaka I , Abe S : 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A2B receptor. J. Med. Chem. 44, 170–179 (2001)
-
22.
Haskó G , Linden J , Cronstein B , Pacher P : Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat. Rev. Drug Discov. 7, 759–770 (2008)
-
23.
Johnston-Cox H , Koupenova M , Yang D , Corkey B , Gokce N , Farb MG , LeBrasseur N , Ravid K : The A2b adenosine receptor modulates glucose homeostasis and obesity. PLoS One 7, e40584 (2012)
-
24.
Johnston KL , Clifford MN , Morgan LM : Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am. J. Clin. Nutr. 78, 728–733 (2003)
-
25.
Keijzers GB , De Galan BE , Tack CJ , Smits P : Caffeine can decrease insulin sensitivity in humans. Diabetes Care 25, 364–369 (2002)
-
26.
Kjaer M , Kiens B , Hargreaves M , Richter EA : Influence of active muscle mass on glucose homeostasis during exercise in humans. J. Appl. Physiol. 71, 552–557 (1991)
-
27.
Koupenova M , Ravid K : Adenosine, adenosine receptors and their role in glucose homeostasis and lipid metabolism. J. Cell. Physiol. 1–22 (2014)
-
28.
Lane JD , Feinglos MN , Surwit RS : Caffeine increases ambulatory glucose and postprandial responses in coffee drinkers with type 2 diabetes. Diabetes Care 31, 221–222 (2008)
-
29.
Liu IM , Tzeng TF , Tsai CC , Lai TY , Chang CT , Cheng JT : Increase in adenosine A1 receptor gene expression in the liver of streptozotocin-induced diabetic rats. Diabetes Metab. Res. Rev. 19, 209–215 (2003)
-
30.
Mitrakou A , Ryan C , Veneman T , Mokan M , Jenssen T , Kiss I , Durrant J , Cryer P , Gerich J : Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am. J. Physiol. 260, 67–74 (1991)
-
31.
Moore MC , Connolly CC , Cherrington AD : Autoregulation of hepatic glucose production. Eur. J. Endocrinol. 138, 240–248 (1998)
-
32.
Notkins AL : The causes of diabetes. Sci. Am. 241, 62–73 (1979)
-
33.
Ropelle ER , Pauli JR , Carvalheira JBC : Efeitos moleculares do exercício físico sobre as vias de sinalização insulínica (Molecular effects of physical exercise on the insulin-signaling pathways). Motriz 11, 49–55 (2005)
-
34.
Rose AJ , Richter EA : Skeletal muscle glucose uptake during exercise: how is it regulated? Physiology 20, 260–270 (2005)
-
35.
Rücker B , Abreu-Vieira G , Bischoff LB , Harthmann AD , Sarkis JJF , Wink MR , Casali EA : The nucleotide hydrolysis is altered in blood serum of streptozotocin-induced diabetic rats. Arch. Physiol. Biochem. 116, 79–87 (2010)
-
36.
Rüsing D , Müller CE , Verspohl EJ : The impact of adenosine and A2B receptors on glucose homoeostasis. J. Pharm. Pharmacol. 58, 1639–1645 (2006)
-
37.
Salvatore CA , Jacobson MA , Taylor HE , Linden J , Johnson RG : Molecular cloning and characterization of the human A3 adenosine receptor. Proc. Natl. Acad. Sci. U. S. A. 90, 10365–10369 (1993)
-
38.
Silveira LR , Alves AA , Denadai BS : Efeito da lipólise induzida pela cafeína na performance e no metabolismo de glicose durante o exercício intermitente (Effect of increased caffeine-induced lipolysis on performance and glucose metabolism during intermittent exercise). Rev. Bras. Ciência e Mov. 12, 21–26 (2004)
-
39.
Skyler JS : Diabetes mellitus: pathogenesis and treatment strategies. J. Med. Chem. 47, 4113–4117 (2004)
-
40.
Spyridopoulos I , Fichtlscherer S , Popp R , Toennes SW , Fisslthaler B , Trepels T , Zernecke A , Liehn EA , Weber C , Zeiher AM , Dimmeler S , Haendeler J : Caffeine enhances endothelial repair by an AMPK-dependent mechanism. Arterioscler. Thromb. Vasc. Biol. 28, 1967–1974 (2008)
-
41.
Suh S-H , Paik I-Y , Jacobs K : Regulation of blood glucose homeostasis during prolonged exercise. Mol. Cells 23, 272–279 (2007)
-
42.
Thong FSL , Derave W , Kiens B , Graham TE , Ursø B , Wojtaszewski JFP , Hansen BF , Richter EA : Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise. Diabetes 51, 583–590 (2002)
-
43.
Tucker AL , Linden J : Cloned receptors and cardiovascular responses to adenosine. Cardiovasc. Res. 27, 62–67 (1993)
-
44.
Van Soeren MH , Graham TE : Effect of caffeine on metabolism, exercise endurance, and catecholamine responses after withdrawal. J. Appl. Physiol. 85, 1493–1501 (1998)
-
45.
Vendramini LC , Nishiura JL , Baxmann AC , Heilberg IP : Caffeine intake by patients with autosomal dominant polycystic kidney disease. Braz. J. Med. Biol. Res. 45, 834–840 (2012)
-
46.
Wahren J , Ekberg K : Splanchnic regulation of glucose production. Annu. Rev. Nutr. 27, 329–345 (2007)
-
47.
Watson JM , Jenkins EJ , Hamilton P , Lunt MJ , Kerr D : Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 23, 455–459 (2000)
-
48.
Yang D , Koupenova M , McCrann DJ , Kopeikina KJ , Kagan HM , Schreiber BM , Ravid K : The A2b adenosine receptor protects against vascular injury. Proc. Natl. Acad. Sci. U. S. A. 105, 792–796 (2008)
-
49.
Yegutkin GG : Nucleotide- and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade. Biochim. Biophys. Acta 1783, 673–694 (2008)
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László ROSIVALL (Semmelweis University, Budapest, Hungary)
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