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  • 1 Kaposvár University, Hungary
  • | 2 Hungarian Academy of Sciences, Kaposvár University, Hungary
  • | 3 National Agricultural Research Center, Hungary
  • | 4 Szent István University, Hungary
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Weaned rabbits were fed diets contaminated with 2 mg/kg diet T-2 toxin alone, or 10 mg/kg diet fumonisin B1 (FB1) alone, and both toxins in combination (2 + 10 mg/kg, respectively) compared to a toxin-free control diet. Samplings were performed after 4 weeks (blood and liver). Bodyweight of T-2-fed group was lower after 4 weeks; the liver weight was increased dramatically (threefold of control). Liver total phospholipids (PLs) provided slight alterations in the fatty acid (FA) composition; all three toxin-treated groups showed a decrease in palmitoleic acid (C16:1 n7) proportion. In the liver mitochondrial PL FA composition, margaric acid (C17:0) proportion decreased in the separated toxin treatments compared to the combined setting. Oleic acid (C18:1 n9) proportion was increased and arachidonic acid (C20:4 n6) was decreased in the FB1-treated group, while docosapentaenoic acid (C22:5 n3) was decreased in the separated treatments. The total monounsaturation was significantly higher in the FB1 group’s mitochondrial PL FA profile. After 4 weeks, all toxin treatments decreased the blood plasma reduced glutathione and glutathione peroxidase activity, and FB1 increased the plasma sphinganine/sphingosine ratio. Both mycotoxins seem to cross the hepatocellular and the hepatic mitochondrial membrane, without drastic membrane disruption, as assessed from the PL FA composition, but inducing detectable lipid peroxidation.

  • 1.

    Abel S , Smuts CM , de Villiers C , Gelderblom W : Changes in essential fatty acid patterns associated with normal liver regeneration and the progression of hepatocyte nodules in rat hepatocarcinogenesis. Carcinogenesis 22, 795804 (2001)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2.

    Bagga D , Wang L , Farias-Eisner R , Glaspy JA , Reddy ST : Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proc. Natl. Acad. Sci. U. S. A. 100, 17511756 (2003)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Black JA , Foarde KK , Menetrez MY : Solvent comparison in the isolation, solubilization, and toxicity of Stachybotrys chartarum spore trichothecene mycotoxins in an established in vitro luminescence protein translation inhibition assay. J. Microbiol. Methods 66, 354361 (2006)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Bócsai A , Pelyhe C , Zándoki E , Ancsin Z , Szabó-Fodor J , Erdélyi M , Mézes M , Balogh K : Short-term effects of T-2 toxin exposure on some lipid peroxide and glutathione redox parameters of broiler chickens. J. Anim. Physiol. Anim. Nutr. (Berl) 100, 520525 (2016)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Brand MD , Turner N , Ocloo A , Else PL , Hulbert AJ : Proton conductance and fatty acyl composition of liver mitochondria correlates with body mass in birds. Biochem. J. 376, 741748 (2003)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6.

    Burger HM , Abel S , Snijman PW , Swanevelder S , Gelderblom WCA : Altered lipid parameters in hepatic subcellular membrane fractions induced by fumonisin B1. Lipids 42, 249261 (2007)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Buttemer WA , Battam H , Hulbert AJ : Fowl play and the price of petrel: long-living Procellariiformes have peroxidation-resistant membrane composition compared with short-living Galliformes. Biol. Lett. 4, 351354 (2006)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8.

    Cevc G (1993): Phospholipids Handbook. Marcel Dekker, New York, USA

  • 9.

    Christie WW : A simple procedure for rapid transmethylation of glycerolipids and cholesteryl esters. J. Lipid Res. 23, 10721075 (1982)

    • Search Google Scholar
    • Export Citation
  • 10.

    Clarke R , Connolly L , Frizzell C , Elliott CT : Cytotoxic assessment of the regulated, co-existing mycotoxins aflatoxin B1, fumonisin B1 and ochratoxin, in single, binary, and tertiary mixtures. Toxicon 90, 7081 (2014)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Dutton MF : Fumonisins, mycotoxins of increasing importance: their nature and their effects. Pharmacol. Ther. 70, 137161 (1996)

  • 12.

    EFSA (European Food Safety Authority): Scientific opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed. EFSA J 9, 24812668 (2011)

    • Search Google Scholar
    • Export Citation
  • 13.

    Escrivá L , Font G , Manyes L : In vivo toxicity studies of fusarium mycotoxins in the last decade: a review. Food Chem. Toxicol. 78, 185206 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14.

    Fang H , Wu Y , Guo J , Rong J , Ma L , Zhao Z , Zuo D , Peng S : T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway. Apoptosis 17, 895907 (2012)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 15.

    Fodor J , Balogh K , Weber M , Miklós M , Kametler L , Pósa R , Mamet R , Bauer J , Horn P , Kovács F , Kovács M : Absorption, distribution and elimination of fumonisin B(1) metabolites in weaned piglets. Food Addit. Contam. Part A 25, 8896 (2008)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16.

    Folch JM , Lees M , Sloane-Stanley GH : A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 495509 (1957)

    • Search Google Scholar
    • Export Citation
  • 17.

    Gelderblom WCA , Moritz W , Swanevelder S , Smuts CM , Abel S : Lipids and delta6-desaturase activity alterations in rat liver microsomal membranes induced by fumonisin B1. Lipids 37, 869877 (2002)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 18.

    Gunstone FD , Harwood JL , Padley FB (1994): The Lipid Handbook. Chapman and Hall, London, UK

  • 19.

    IBM (2012). IBM SPSS 20 for Windows. SPSS Inc., Chicago, IL, USA

  • 20.

    Klarić MS , Pepeljnjak S , Domijan AM , Petrik J : Lipid peroxidation and glutathione levels in porcine kidney PK15 cells after individual and combined treatment with fumonisin B(1), beauvericin and ochratoxin A. Basic Clin. Pharmacol. Toxicol. 100, 157164 (2007)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21.

    Lands WE : Metabolism of glycerolipids. 2. The enzymatic acylation of lysolecithin. J. Biol. Chem. 235, 22332237 (1960)

  • 22.

    Lawrence RA , Burk RF : Species, tissue and subcellular distribution of non Se-dependent glutathione peroxidase activity. J. Nutr. 108, 211215 (1978)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 23.

    Leray C , Andriamampandry M , Gutbier G , Cavadenti J , Klein-Soyer C , Gachet C , Cazenave JP : Quantitative analysis of vitamin E, cholesterol and phospholipid fatty acids in a single aliquot of human platelets and cultured endothelial cells. J. Chromatogr. B. Biomed. Sci. Appl. 696, 3342 (1997)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 24.

    Mead JF , Alfin-Slater RB , Howton DR , Popják G (1986): Lipids: Chemistry, Biochemistry and Nutrition. Plenum Press, NY, USA

  • 25.

    Moon WS , Kim JH , Kang MJ , Lee DG : Early ultrastructural changes of apoptosis induced by fumonisin B1 in rat liver. Yonsei Med. J. 41, 195204 (2000)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 26.

    Ngampongsa S , Hanafusa M , Ando K , Ito K , Kuwahara M , Yamamoto Y , Yamashita M , Tsuru Y , Tsubone H : Toxic effects of T-2 toxin and deoxynivalenol on the mitochondrial electron transport system of cardiomyocytes in rats. J. Toxicol. Sci. 38, 495502 (2013)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 27.

    Pace JG : Effect of T-2 mycotoxin on rat liver mitochondria electron transport system. Toxicon 21, 675680 (1983)

  • 28.

    Pace JG , Watts MR : Hepatic subcellular distribution of [3H ]T-2 toxin. Toxicon 27, 13071311 (1989)

  • 29.

    Pamplona R , Portero-Otı́n M , Ruiz C , Gredilla R , Herrero A , Barja G : Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals. Mech. Ageing Dev. 112, 169183 (2000)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 30.

    Placer ZA , Cushman LL , Johnson BC : Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal. Biochem. 16, 359364 (1966)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 31.

    Sedlak J , Lindsay RH : Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal. Biochem. 25, 192205 (1968)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 32.

    Sharma D , Asrani RK , Ledoux DR , Rottinghaus GE , Gupta VK : Toxic interaction between fumonisin B1 and moniliformin for cardiac lesions in Japanese quail. Avian Dis. 56, 545554 (2012)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 33.

    Szabó A , Szabó-Fodor J , Fébel H , Romvári R , Kovács M : Individual and combined haematotoxic effects of fumonisin B(1) and T-2 mycotoxins in rabbits. Food Chem. Toxicol. 72, 257264 (2014)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 34.

    Szabó-Fodor J , Dall’Asta C , Falavigna C , Kachlek M , Szécsi Á , Szabó A , Kovács M : Determination of the amount of bioaccessible fumonisin B1 in different matrices after in vitro digestion. World Mycotoxin J. 8, 261267 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation

 

 

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  • Détári, László (Budapest)
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  • Spät, András (Budapest)
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  • Szelényi, Zoltán (Pécs)
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2020  
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WoS
Journal
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without
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Citable 42
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Articles
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Scimago 29
H-index
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Scimago Physiology (medical) Q3
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2019  
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WoS
137
Impact Factor 1,410
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without
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1,361
5 Year
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Immediacy
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Cited
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Scimago
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Scopus
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Scopus
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Physiology (medical) 73/99 (Q3)
Scopus
SNIP
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Physiology International
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