Authors:
A SzabóKaposvár University, Hungary
Hungarian Academy of Sciences, Kaposvár University, Hungary

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J Szabó-FodorHungarian Academy of Sciences, Kaposvár University, Hungary

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H FébelNational Agricultural Research Center, Hungary

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M MézesSzent István University, Hungary

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G BajzikKaposvár University, Hungary

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M KovácsHungarian Academy of Sciences, Kaposvár University, Hungary

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Weaned rabbits were fed diets contaminated with 2 mg/kg diet T-2 toxin alone, or 10 mg/kg diet fumonisin B1 (FB1) alone, and both toxins in combination (2 + 10 mg/kg, respectively) compared to a toxin-free control diet. Samplings were performed after 4 weeks (blood and liver). Bodyweight of T-2-fed group was lower after 4 weeks; the liver weight was increased dramatically (threefold of control). Liver total phospholipids (PLs) provided slight alterations in the fatty acid (FA) composition; all three toxin-treated groups showed a decrease in palmitoleic acid (C16:1 n7) proportion. In the liver mitochondrial PL FA composition, margaric acid (C17:0) proportion decreased in the separated toxin treatments compared to the combined setting. Oleic acid (C18:1 n9) proportion was increased and arachidonic acid (C20:4 n6) was decreased in the FB1-treated group, while docosapentaenoic acid (C22:5 n3) was decreased in the separated treatments. The total monounsaturation was significantly higher in the FB1 group’s mitochondrial PL FA profile. After 4 weeks, all toxin treatments decreased the blood plasma reduced glutathione and glutathione peroxidase activity, and FB1 increased the plasma sphinganine/sphingosine ratio. Both mycotoxins seem to cross the hepatocellular and the hepatic mitochondrial membrane, without drastic membrane disruption, as assessed from the PL FA composition, but inducing detectable lipid peroxidation.

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Editor-in-Chief

László ROSIVALL (Semmelweis University, Budapest, Hungary)

Managing Editor

Anna BERHIDI (Semmelweis University, Budapest, Hungary)

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  • Ákos KOLLER (Semmelweis University, Budapest, Hungary)
  • Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
  • László LÉNÁRD (University of Pécs, Hungary)
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  • Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
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  • László CSERNOCH (University of Debrecen, Hungary)
  • Magdolna DANK (Semmelweis University, Budapest, Hungary)
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  • László HUNYADI (Semmelweis University, Budapest, Hungary)
  • Gábor JANCSÓ (University of Pécs, Hungary)
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  • Gyula PAPP (University of Szeged, Hungary)
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  • Gyula SZABÓ (University of Szeged, Hungary)
  • Zoltán SZELÉNYI (University of Pécs, Hungary)
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  • József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
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  • Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
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  • Eric VICAUT (Université de Paris, UMRS 942 INSERM, France)
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2021  
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Total Cites
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330
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Physiology 73/81

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Scopus 0,528
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2019  
Total Cites
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137
Impact Factor 1,410
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5 Year
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Scimago
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27
Scimago
Journal Rank
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Scopus
Scite Score
235/157=1,5
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Physiology (medical) 73/99 (Q3)
Scopus
SNIP
0,38

 

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