University of Pécs, Hungary
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It has been reported that some of the food additives may cause sensitization, inflammation of tissues, and potentially risk factors in the development of several chronic diseases. Thus, we hypothesized that expressions of common inflammatory molecules – known to be involved in the development of various inflammatory conditions and cancers – are affected by these food additives. We investigated the effects of commonly used food preservatives and artificial food colorants based on the expressions of NFκB, GADD45α, and MAPK8 (JNK1) from the tissues of liver. RNA was isolated based on Trizol protocol and the activation levels were compared between the treated and the control groups. Tartrazine alone could elicit effects on the expressions of NFκB (p = 0.013) and MAPK8 (p = 0.022). Azorubine also resulted in apoptosis according to MAPK8 expression (p = 0.009). Preservatives were anti-apoptotic in high dose. Sodium benzoate (from low to high doses) dose-dependently silenced MAPK8 expression (p = 0.004 to p = 0.002). Addition of the two preservatives together elicited significantly greater expression of MAPK8 at half-fold dose (p = 0.002) and at fivefold dose (p = 0.008). This study suggests that some of the food preservatives and colorants can contribute to the activation of inflammatory pathways.
-
1.
Amin KA , Abdel Hameid IIH , Abd Elsttar AH : Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats. Food Chem. Toxicol. 48, 2994–2999 (2010)
-
2.
Banning A , Regenbrecht CRA , Tikkanen R : Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model. Cell Signal. 26, 198–207 (2014)
-
3.
Bateman B , Warner JO , Hutchinson E , Dean T , Rowlandson P , Gant C , Grundy J , Fitzgerald C , Stevenson J : The effects of a double blind, placebo-controlled, artificial food colourings and benzoate preservative challenge on hyperactivity in a general population sample of preschool children. Arch. Dis. Child. 89, 506–551 (2004)
-
4.
Brahmachari S , Pahan K : Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T-cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis. J. Immunol. 179, 275–283 (2007)
-
5.
Brasier AR : The NF-κB regulatory network. Cardiovasc. Toxicol. 6, 111–130 (2006)
-
6.
Chequer FM , Venâncio VP , Bianchi ML , Antunes LM : Genotoxic and mutagenic effects of erythrosine B, a xanthene food dye, on HepG2 cells. Food Chem. Toxicol. 50, 3447–3451 (2012)
-
7.
Chomczynski P , Sacchi N : Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156–159 (1987)
-
8.
European Parliament and of the Council [EC]: Regulation No. 1333/2008: establishing a common authorisation procedure for food additives, food enzymes and food flavourings. OJ. L. 354, 1–33 (2008)
-
9.
European Food Safety Agency [EFSA]: Assessment of the results of the study by McCann et al. (2007) on the effects of some colours and sodium benzoate on children’s behaviour. EFSA J. 660, 1–53 (2008)
-
10.
Gao Y , Li C , Yin H , An X , Jin H : Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved. J. Food Sci. 76, 125–129 (2011)
-
11.
Gilmore TD : Introduction to NF-κB: players, pathways, perspectives. Oncogene 25, 6680–6684 (2006)
-
12.
Görena AC , Bilsela G , Şimşeka A , Bilsela M , Akçadağa F , Topala K , Ozgenb H : HPLC and LC-MS/MS methods for determination of sodium benzoate and potassium sorbate in food and beverages: performances of local accredited laboratories via proficiency tests in Turkey. Food Chem. 175, 273–279 (2015)
-
13.
Jarskog LF : Apoptosis in schizophrenia: pathophysiologic and therapeutic considerations. Curr. Opin. Psychiatry 19, 307–312 (2006)
-
14.
Kitano K , Fukukawa T , Ohtsuji Y , Masuda T , Yamaguchi H : Mutagenicity and DNA-damaging activity caused by decomposed products of potassium sorbate reacting with ascorbic acid in the presence of Fe salt. Food Chem. Toxicol. 40, 1589–1594 (2002)
-
15.
Klock A , Herrmann BG : Cloning and expression of the mouse dual-specificity mitogen-activated protein (MAP) kinase phosphatase Mkp3 during mouse embryogenesis. Mech. Develop. 116, 243–247 (2002)
-
16.
Leathwood PD , Richardson DP , Sträter P , Todd PM , van Trijp HC : Consumer understanding of nutrition and health claims: sources of evidence. Br. J. Nutr. 98, 474–484 (2007)
-
17.
Mamur S , Yüzbaşıoğlu D , Ünal F , Yılmaz S : Does potassium sorbate induce genotoxic or mutagenic effects in lymphocytes? Toxicol. In Vitro 24, 790–794 (2010)
-
18.
Mielke K , Brecht S , Dorst A , Herdegen T : Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures. Neuroscience 91, 471–483 (1999)
-
19.
Miotto B , Struhl K : JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol. Cell 7, 62–71 (2011)
-
20.
Peretz G , Bakhrat A , Abdu U : Expression of the Drosophila melanogaster GADD45 homolog (CG11086) affects egg asymmetric development that is mediated by the c-Jun N-terminal kinase pathway. Genetics 177, 1691–1702 (2007)
-
21.
Poul M , Jarry G , Elhkim MO , Poul JM : Lack of genotoxic effect of food dyes amaranth, sunset yellow and tartrazine and their metabolites in the gut micronucleus assay in mice. Food Chem. Toxicol. 47, 443–448 (2009)
-
22.
Reagan-Shaw S , Nihal M , Ahmad N : Dose translation from animal to human studies revisited. FASEB J. 22, 659–661 (2007)
-
23.
Sasaki YF , Kawaguchi S , Kamaya A , Ohshita M , Kabasawa K , Iwama K , Taniguchi K , Tsuda S : The comet assay with 8 mouse organs results with 39 currently used food additives. Mutat. Res. 519, 103–119 (2002)
-
24.
Sheikh MS , Hollander MC , Fornace AJ : Role of Gadd45 in apoptosis. Biochem. Pharmacol. 59, 43–45 (2000)
-
25.
Soares BM , Araújo TM , Ramos JA , Pinto LC , Khayat BM , De Oliveira Bahia M , Montenegro RC , Burbano RM , Khayat AS : Effects on DNA repair in human lymphocytes exposed to the food dye tartrazine yellow. Anticancer Res. 35, 1465–1474 (2015)
-
26.
Solinas G , Vilcu C , Neels JG , Bandyopadhyay GK , Luo JL , Naugler W , Grivennikov S , Wynshaw-Boris A , Scadeng M , Olefsky JM , Karin M : JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 6, 386–397 (2007)
-
27.
Takekawa M , Saito H : A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95, 521–530 (1998)
-
28.
Tsuda S , Murakami M , Matsusaka N , Kano K , Taniguchi K , Sasaki YF : DNA damage induced by red food dyes orally administered to pregnant and male mice. Toxicol. Sci. 61, 92–99 (2001)
-
29.
Türkoğlu S : Genotoxicity of five food preservatives tested on root tips of Allium cepa L. Mutat. Res. 626, 4–14 (2007)
-
30.
Zheng X , Zhang Y , Chen Y , Castranova V , Shi X , Chen F : Inhibition of NF-κB stabilizes gadd45α mRNA. Biochem. Biophys. Res. Commun. 329, 95–99 (2005)
Editor-in-Chief
László ROSIVALL (Semmelweis University, Budapest, Hungary)
Managing Editor
Anna BERHIDI (Semmelweis University, Budapest, Hungary)
Co-Editors
- Gábor SZÉNÁSI (Semmelweis University, Budapest, Hungary)
- Ákos KOLLER (Semmelweis University, Budapest, Hungary)
- Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
- László LÉNÁRD (University of Pécs, Hungary)
- Zoltán UNGVÁRI (Semmelweis University, Budapest, Hungary)
Assistant Editors
- Gabriella DÖRNYEI (Semmelweis University, Budapest, Hungary)
- Zsuzsanna MIKLÓS (Semmelweis University, Budapest, Hungary)
- György NÁDASY (Semmelweis University, Budapest, Hungary)
Hungarian Editorial Board
- György BENEDEK (University of Szeged, Hungary)
- Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
- Mihály BOROS (University of Szeged, Hungary)
- László CSERNOCH (University of Debrecen, Hungary)
- Magdolna DANK (Semmelweis University, Budapest, Hungary)
- László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
- Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
- Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
- Zoltán HEROLD (Semmelweis University, Budapest, Hungary)
- László HUNYADI (Semmelweis University, Budapest, Hungary)
- Gábor JANCSÓ (University of Pécs, Hungary)
- Zoltán KARÁDI (University of Pecs, Hungary)
- Miklós PALKOVITS (Semmelweis University, Budapest, Hungary)
- Gyula PAPP (University of Szeged, Hungary)
- Gábor PAVLIK (University of Physical Education, Budapest, Hungary)
- András SPÄT (Semmelweis University, Budapest, Hungary)
- Gyula SZABÓ (University of Szeged, Hungary)
- Zoltán SZELÉNYI (University of Pécs, Hungary)
- Lajos SZOLLÁR (Semmelweis University, Budapest, Hungary)
- Gyula TELEGDY (MTA-SZTE, Neuroscience Research Group and University of Szeged, Hungary)
- József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
- Árpád TÓSAKI (University of Debrecen, Hungary)
International Editorial Board
- Dragan DJURIC (University of Belgrade, Serbia)
- Christopher H. FRY (University of Bristol, UK)
- Stephen E. GREENWALD (Blizard Institute, Barts and Queen Mary University of London, UK)
- Osmo Otto Päiviö HÄNNINEN (Finnish Institute for Health and Welfare, Kuopio, Finland)
- Helmut G. HINGHOFER-SZALKAY (Medical University of Graz, Austria)
- Tibor HORTOBÁGYI (University of Groningen, Netherlands)
- George KUNOS (National Institutes of Health, Bethesda, USA)
- Massoud MAHMOUDIAN (Iran University of Medical Sciences, Tehran, Iran)
- Tadaaki MANO (Gifu University of Medical Science, Japan)
- Luis Gabriel NAVAR (Tulane University School of Medicine, New Orleans, USA)
- Hitoo NISHINO (Nagoya City University, Japan)
- Ole H. PETERSEN (Cardiff University, UK)
- Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
- Andrej A. ROMANOVSKY (University of Arizona, USA)
- Anwar Ali SIDDIQUI (Aga Khan University, Karachi, Pakistan)
- Csaba SZABÓ (University of Fribourg, Switzerland)
- Eric VICAUT (Université de Paris, UMRS 942 INSERM, France)
- Nico WESTERHOF (Vrije Universiteit Amsterdam, The Netherlands)
Editorial Correspondence:
Physiology International
Semmelweis University
Faculty of Medicine, Institute of Translational Medicine
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: pi@semmelweis-univ.hu
Indexing and Abstracting Services:
- Biological Abstracts
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- EMBASE/Excerpta Medica
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- Index Copernicus
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- Referativnyi Zhurnal
- SCOPUS
- WoS - Science Citation Index Expanded
| 2022 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
335 |
| Journal Impact Factor | 1.4 |
| Rank by Impact Factor |
Physiology (Q4) |
| Impact Factor without Journal Self Cites |
1.4 |
| 5 Year Impact Factor |
1.6 |
| Journal Citation Indicator | 0.42 |
| Rank by Journal Citation Indicator |
Physiology (Q4) |
| Scimago | |
| Scimago H-index |
33 |
| Scimago Journal Rank |
0.362 |
| Scimago Quartile Score |
Physiology (medical) (Q3) |
| Scopus | |
| Scopus Cite Score |
2.8 |
| Scopus CIte Score Rank |
Physiology 68/102 (33rd PCTL) |
| Scopus SNIP |
0.508 |
| 2021 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
330 |
| Journal Impact Factor | 1,697 |
| Rank by Impact Factor |
Physiology 73/81 |
| Impact Factor without Journal Self Cites |
1,697 |
| 5 Year Impact Factor |
1,806 |
| Journal Citation Indicator | 0,47 |
| Rank by Journal Citation Indicator |
Physiology 69/86 |
| Scimago | |
| Scimago H-index |
31 |
| Scimago Journal Rank |
0,32 |
| Scimago Quartile Score | Medicine (miscellaneous) (Q3) Physiology (medical) (Q3) |
| Scopus | |
| Scopus Cite Score |
2,7 |
| Scopus CIte Score Rank |
Physiology (medical) 69/101 (Q3) |
| Scopus SNIP |
0,591 |
| 2020 | |
| Total Cites | 245 |
| WoS | |
| Journal Impact Factor |
2,090 |
| Rank by | Physiology 62/81 (Q4) |
| Impact Factor | |
| Impact Factor | 1,866 |
| without | |
| Journal Self Cites | |
| 5 Year | 1,703 |
| Impact Factor | |
| Journal | 0,51 |
| Citation Indicator | |
| Rank by Journal | Physiology 67/84 (Q4) |
| Citation Indicator | |
| Citable | 42 |
| Items | |
| Total | 42 |
| Articles | |
| Total | 0 |
| Reviews | |
| Scimago | 29 |
| H-index | |
| Scimago | 0,417 |
| Journal Rank | |
| Scimago | Physiology (medical) Q3 |
| Quartile Score | |
| Scopus | 270/1140=1,9 |
| Scite Score | |
| Scopus | Physiology (medical) 71/98 (Q3) |
| Scite Score Rank | |
| Scopus | 0,528 |
| SNIP | |
| Days from | 172 |
| submission | |
| to acceptance | |
| Days from | 106 |
| acceptance | |
| to publication |
| 2019 | |
|---|---|
| Total Cites WoS |
137 |
| Impact Factor | 1,410 |
| Impact Factor without Journal Self Cites |
1,361 |
| 5 Year Impact Factor |
1,221 |
| Immediacy Index |
0,294 |
| Citable Items |
34 |
| Total Articles |
33 |
| Total Reviews |
1 |
| Cited Half-Life |
2,1 |
| Citing Half-Life |
9,3 |
| Eigenfactor Score |
0,00028 |
| Article Influence Score |
0,215 |
| % Articles in Citable Items |
97,06 |
| Normalized Eigenfactor |
0,03445 |
| Average IF Percentile |
12,963 |
| Scimago H-index |
27 |
| Scimago Journal Rank |
0,267 |
| Scopus Scite Score |
235/157=1,5 |
| Scopus Scite Score Rank |
Physiology (medical) 73/99 (Q3) |
| Scopus SNIP |
0,38 |
| Physiology International | |
|---|---|
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| Physiology International | |
|---|---|
| Language | English |
| Size | B5 |
| Year of Foundation |
2006 (1950) |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Magyar Tudományos Akadémia |
| Founder's Address |
H-1051 Budapest, Hungary, Széchenyi István tér 9. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 2498-602X (Print) |
| ISSN | 2677-0164 (Online) |
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