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  • 1 Semmelweis University, Hungary
  • | 2 Semmelweis University, Hungary
  • | 3 Semmelweis University, Hungary
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Aims

Labyrinthectomized rats are suitable models to test consequences of vestibular lesion and are widely used to study neural plasticity. We describe a combined microsurgical–chemical technique that can be routinely performed with minimum damage.

Methods

Caudal leaflet of the parotis is elevated. The tendinous fascia covering the bulla is opened frontally from the sternomastoid muscle’s tendon while sparing facial nerve branches. A 4 mm diameter hole is drilled into the bulla’s hind lower lateral wall to open the common (in rodents) mastoid-tympanic cavity. The cochlear crista (promontory) at the lower posterior part of its medial wall is identified as a bony prominence. A 1 mm diameter hole is drilled into its lower part. The perilymphatic/endolymphatic fluids with tissue debris of the Corti organ are suctioned. Ethanol is injected into the hole. Finally, 10 µL of sodium arsenite solution (50 µM/mL) is pumped into the labyrinth and left in place for 15 min. Simple closure in two layers (fascia and skin) is sufficient.

Results and conclusion

All rats had neurological symptoms specific for labyrinthectomy (muscle tone, body position, rotatory movements, nystagmus, central deafness). Otherwise, their behavior was unaffected, drinking and eating normally. After a few days, they learned to balance relying on visual and somatic stimuli (neuroplasticity).

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Senior editors

Editor(s)-in-Chief: Rosivall, László

Managing Editor: Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor; Radák, Zsolt

Assistant Editor(s): G. Dörnyei (Budapest), Zs. Miklós (Budapest), Gy. Nádasy (Budapest)

Hungarian Editorial Board

  • Benedek, György (Szeged)
  • Benyó, Zoltán (Budapest)
  • Boros, Mihály (Szeged)
  • Chernoch, László (Debrecen)
  • Détári, László (Budapest)
  • Giricz, Zoltán (Budapest)
  • Hamar, János (Budapest)
  • Hantos, Zoltán (Szeged)
  • Hunyady, László (Budapest)
  • Jancsó, Gábor (Szeged)
  • Karádi, Zoltán (Pécs)
  • Palkovits, Miklós (Budapest)
  • Papp, Gyula (Szeged)
  • Pavlik, Gábor (Budapest)
  • Spät, András (Budapest)
  • Szabó, Gyula (Szeged)
  • Szelényi, Zoltán (Pécs)
  • Szollár, Lajos (Budapest)
  • Szücs, Géza (Debrecen)
  • Telegdy, Gyula (Szeged)
  • Toldi, József (Szeged)
  • Tósaki, Árpád (Debrecen)

 

International Editorial Board

  • R. Bauer (Jena)
  • W. Benjelloun (Rabat)
  • A. W. Cowley Jr. (Milwaukee)
  • D. Djuric (Belgrade)
  • C. Fry (London)
  • S. Greenwald (London)
  • O. Hänninen (Kuopio)
  • H. G. Hinghofer-Szalkay (Graz)
  • T. Hortobágyi (Groningen)
  • Gy. Kunos (Richmond)
  • M. Mahmoudian (Tehran)
  • T. Mano (Seki, Gifu)
  • G. Navar (New Orleans)
  • H. Nishino (Nagoya)
  • O. Petersen (Liverpool)
  • U. Pohl (Münich)
  • R. S. Reneman (Maastricht)
  • A. Romanovsky (Phoenix)
  • G. M. Rubanyi (Richmond)
  • T. Sakata (Oita)
  • A. Siddiqui (Karachi)
  • Cs. Szabo (Beverly)
  • E. Vicaut (Paris)
  • N. Westerhof (Amsterdam)
  • L. F. Zhang (Xi'an)

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2020  
Total Cites 245
WoS
Journal
Impact Factor
2,090
Rank by Physiology 62/81 (Q4)
Impact Factor  
Impact Factor 1,866
without
Journal Self Cites
5 Year 1,703
Impact Factor
Journal  0,51
Citation Indicator  
Rank by Journal  Physiology 67/84 (Q4)
Citation Indicator   
Citable 42
Items
Total 42
Articles
Total 0
Reviews
Scimago 29
H-index
Scimago 0,417
Journal Rank
Scimago Physiology (medical) Q3
Quartile Score  
Scopus 270/1140=1,9
Scite Score  
Scopus Physiology (medical) 71/98 (Q3)
Scite Score Rank  
Scopus 0,528
SNIP  
Days from  172
sumbission  
to acceptance  
Days from  106
acceptance  
to publication  

2019  
Total Cites
WoS
137
Impact Factor 1,410
Impact Factor
without
Journal Self Cites
1,361
5 Year
Impact Factor
1,221
Immediacy
Index
0,294
Citable
Items
34
Total
Articles
33
Total
Reviews
1
Cited
Half-Life
2,1
Citing
Half-Life
9,3
Eigenfactor
Score
0,00028
Article Influence
Score
0,215
% Articles
in
Citable Items
97,06
Normalized
Eigenfactor
0,03445
Average
IF
Percentile
12,963
Scimago
H-index
27
Scimago
Journal Rank
0,267
Scopus
Scite Score
235/157=1,5
Scopus
Scite Score Rank
Physiology (medical) 73/99 (Q3)
Scopus
SNIP
0,38

 

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Physiology International
Language English
Size B5
Year of
Foundation
2006 (1950)
Publication
Programme
2021 Volume 108
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2498-602X (Print)
ISSN 2677-0164 (Online)

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