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Department of Orthopedics, Jubilee Mission Medical College, Thrissur, Kerala, India
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Background
Type 2 diabetes mellitus (T2DM)-induced neuropathy and ischemia-reperfusion post-surgery prolong carpal tunnel syndrome (CTS) pathology, but the effect of T2DM on the prognostic outcome of carpal tunnel (CT) release surgery needs to be investigated.
Materials and methods
A total of 64 individuals with CTS underwent CT release surgery. HbA1c levels identified their diabetic status. The individual prognostic outcomes were measured by nerve conduction velocity (NCV), amplitude, and latency. Measurement of [Ca2+]c and reactive oxygen species (ROS) from isolated endothelial cells (ECs) revealed the oxidative burden of the normal and diabetic CTS phenotypes.
Results
CTS individuals with HbA1c > 7 showed decreased NCV (≈22 m/s) and amplitude (≈4.2 mV) with increased latency (≈6 ms), compared to groups with HbA1c ≤ 7. Further to CT release surgery, the reversal of the nerve conduction to normalcy was greatly influenced by the diabetic profile of the individuals. Our results showed elevated basal [Ca2+]c and corresponding high cytosolic ROS in the ECs isolated from individuals with HbA1c > 7 compared to the diabetic and healthy control groups.
Conclusion
The individuals with diabetic index showed suboptimal neuronal performance pre- and post-CT release surgery. Oxidative stress mediated by high [Ca2+]c and ROS of ECs dissipates to adjoining cells worsening the pathology of the untreated CTS.
-
1.
Basiri K , Katirji B : Practical approach to electrodiagnosis of the carpal tunnel syndrome: a review. Adv. Biomed. Res. 4, 50 (2015)
-
2.
Bin-Jaliah IM , Shariff ME , Chandramoorthy HC : Elevated basal cytosolic calcium influences the postsurgical outcome in diabetic patients with carpal tunnel syndrome. Proceedings of the 38th Annual meeting of the Japan Neuroscience Society, Kobe, Japan, 26–31 July 2015
-
3.
Borradaile NM , Han X , Harp JD , Gale SE , Ory DS , Schaffer JE : Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J. Lipid Res. 47, 2726–2737 (2006)
-
4.
Chammas M , Boretto J , Burmann LM , Ramos RM , Dos Santos Neto FC , Silva JB : Carpal tunnel syndrome – part I (anatomy, physiology, etiology and diagnosis). Rev. Bras. Ortop. 49, 429–436 (2014)
-
5.
Deger AN , Deger H , Taser F : The role of neoangiogenesis and vascular endothelial growth factor in the development of carpal tunnel syndrome in patients with diabetes. Niger. J. Clin. Pract. 19, 189–195 (2016)
-
6.
Diabetic Neuropathies: The nerve damage of diabetes. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: http://www.niddk.nih.gov/health-information/health-topics/Diabetes/diabetic-neuropathies-nerve-damage-diabetes/Pages/diabetic-neuropathies-nerve-damage.aspx. Updated 26 Nov 2013.
-
7.
Hagberg M (1987): Shoulder pain pathogenesis. In: Clinical Concepts in Regional Musculoskeletal Illness, ed Hadler NM, Grune and Stratton, Orlando, FL, USA, pp. 191–200
-
8.
Haidara MA , Assiri AS , Youssef MA , Mahmoud MM , Eajaz A , Al-Hakami A , Chandramoorthy HC : Differentiated mesenchymal stem cells ameliorate cardiovascular complications in diabetic rats. Cell Tissue Res. 359, 565–575 (2015)
-
9.
Hirata H , Nagakura T , Tsujii M , Morita A , Fujisawa K , Uchida A : The relationship of VEGF and PGE2 expression to extracellular matrix remodelling of the tenosynovium in the carpal tunnel syndrome. J. Pathol. 204, 605–612 (2004)
-
10.
Ibrahim I , Khan W , Goddard N , Smitham P : Carpal tunnel syndrome: a review of the recent literature. Open Orthop. J. 6, 69–76 (2012)
-
11.
Imbriglia JE , Boland DM : An exercise-induced compartment syndrome of the dorsal forearm – a case report. J. Hand Surg. Am. 9, 142–143 (1984)
-
12.
Jablecki CK , Andary MT , Floeter MK , Miller RG , Quartly CA , Vennix MJ , Wilson JR : Electrodiagnostic studies in carpal tunnel syndrome. Neurology 58, 1589–1592 (2002)
-
13.
Jeppsson JO , Kobold U , Barr J , Finke A , Hoelzel W , Hoshino T , Miedema K , Mosca A , Mauri P , Paroni R , Thienpont L , Umemoto M , Weykamp C : Approved IFCC reference method for the measurement of HbA1c in human blood. Clin. Chem. Lab. Med. 40, 78–89 (2002)
-
14.
Jinrok O , Zhao C , Amadio PC , An KN , Zobitz ME , Wold LE : Vascular pathologic changes in the flexor tenosynovium (subsynovial connective tissue) in idiopathic carpal tunnel syndrome. J. Orthop. Res. 22, 1310–1315 (2004)
-
15.
Kayali H , Kahraman S , Sirin S , Bedük A , Timurkaynak E : Bilateral carpal tunnel syndrome with type 1 diabetes mellitus in childhood. Pediatr. Neurosurg. 38, 262–264 (2003)
-
16.
Kim JK , Koh YD , Kim JS , Hann HJ , Kim MJ : Oxidative stress in subsynovial connective tissue of idiopathic carpal tunnel syndrome. J. Orthop. Res. 28, 1463–1468 (2010)
-
17.
Li L , Tan H , Gu Z : Heat stress induces apoptosis through a Ca2+-mediated mitochondrial apoptotic pathway in human umbilical vein endothelial cells. PLoS One 9, 1–16 (2014)
-
18.
Mallilankaraman K , Cárdenas C , Doonan PJ , Chandramoorthy HC , Irrinki KM , Golenár T , Csordás G , Madireddi P , Yang J , Müller M , Miller R , Kolesar JE , Molgó J , Kaufman B , Hajnóczky G , Foskett JK , Madesh M : MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Nat. Cell Biol. 14, 1336–1343 (2012)
-
19.
Mallilankaraman K , Doonan P , Cárdenas C , Chandramoorthy HC , Müller M , Miller R , Hoffman NE , Gandhirajan RK , Molgó J , Birnbaum MJ , Rothberg BS , Mak DO , Foskett JK , Madesh M : MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca2+ uptake that regulates cell survival. Cell 151, 630–644 (2012)
-
20.
Moghtaderi A , Dabiri S , Dahmardeh M : Asymptomatic carpal tunnel syndrome in obese and overweight patients with metabolic syndrome. Neurosciences (Riyadh) 18, 87–90 (2013)
-
21.
Mojaddidi MA , Ahmed MS , Ali R , Jeziorska M , Al-Sunni A , Thomsen NO , Dahlin LB , Malik RA : Molecular and pathological studies in the posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome. Diabetologia 57, 1711–1719 (2014)
-
22.
Neha HP , Kinnar SD , Amita KM , Toral MG , Mitesh NS , Vaishali NP : Electrophysiological changes in sensorimotor nerves in diabetes mellitus & usefulness of nerve conduction studies for early diagnosis of diabetic neuropathy. Int. J. Biomed. Adv. Res. 4, 187–191 (2013)
-
23.
Nourbakhsh MR , Bell TJ , Martin JB , Arab AM : The effects of oscillatory biofield therapy on pain and functional limitations associated with carpal tunnel syndrome: randomized, placebo-controlled, double-blind study. J. Altern. Complement. Med. 22, 911–920 (2016)
-
24.
Paryavi E , Zimmerman RM , Means KR Jr : Endoscopic compared with open operative treatment of carpal tunnel syndrome. JBJS Rev. 4, e2 (2016)
-
25.
Pourmemari MH , Shiri R : Diabetes as a risk factor for carpal tunnel syndrome: systematic review and meta-analysis. Diabet. Med. 33, 10–16 (2016)
-
26.
Reale F , Ginanneschi F , Sicurelli F , Mondelli M : Protocol of outcome evaluation for surgical release of carpal tunnel syndrome. Neurosurgery 53, 343–350 (2003)
-
27.
Saint-Lary O , Rébois A , Mediouni Z , Descatha A : Carpal tunnel syndrome: primary care and occupational factors. Front. Med. (Lausanne) 2, 28 (2015)
-
28.
Singh VP , Bali A , Singh N , Jaggi AS : Advanced glycation end products and diabetic complications. Korean J. Physiol. Pharmacol. 18, 1–14 (2014)
-
29.
Sjøgaard G : Exercise-induced muscle fatigue: the significance of potassium. Acta Physiol. Scand. Suppl. 593, 1–63 (1990)
-
30.
Sud V , Freeland AE : Biochemistry of carpal tunnel syndrome. Microsurgery 25, 44–46 (2005)
-
31.
Vinik A , Mehrabyan A , Colen L , Boulton A : Focal entrapment neuropathies in diabetes. Diabetes Care 27, 1783–1788 (2004)
-
32.
Weber RA , Rude MJ : Clinical outcomes of carpal tunnel release in patients 65 and older. J. Hand Surg. Am. 30, 75–80 (2005)
-
33.
Zhang W , Johnston JA , Ross MA , Smith AA , Coakley BJ , Gleason EA , Dueck AC , Santello M : Effects of carpal tunnel syndrome on adaptation of multi-digit forces to object weight for whole-hand manipulation. PLoS One 6, e27715 (2011)
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