View More View Less
  • 1 Necmettin Erbakan University, Turkey
  • 2 Medline Hospital, Turkey
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $752.00

The effects of moderate hypothermia (28 °C) on the response of human varicose spermatic vein to α1-adrenoceptor agonist phenylephrine and the role of endothelial nitric oxide (NO) in these effects were studied. Concentration–response curves for phenylephrine (10−9 to 3 × 10−4 M) were recorded in rings with and without endothelium at 37 and 28 °C. To further analyze the role of NO, in the response to phenylephrine during hypothermia, the effects of this agonist in the presence of NG-nitro-L-arginine methyl ester (10−4 M) were also determined. Under every condition tested, phenylephrine produced a marked, concentration-dependent contraction. Sensitivity of intact veins to the agonist was consistently lower at 28 °C than at 37 °C. There was no significant difference in phenylephrine response at 28 and 37 °C in vessels without endothelium but at 28 °C veins without endothelium showed a higher sensitivity than intact veins to phenylephrine. The sensitivity of veins with and without endothelium to nitroprusside (10−9 to 3 × 10−3 M) was significantly decreased during hypothermia, and endothelium removal did not affect the relaxation to this nitrovasodilator. These results suggest that moderate hypothermia decreases the sensitivity of human varicose spermatic vein to phenylephrine probably by increasing the availability of endothelial NO.

  • 1.

    Atalik KE , Şahin AS , Kiliç M , Doğan N : Role of the endothelium on the response to adrenoceptor agonists of rabbit aorta during cooling. Fundam. Clin. Pharmacol. 14, 2530 (2000)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2.

    Atalik KE , Kiliç M , Doğan N : Role of the nitric oxide on diazoxide-induced relaxation of the calf cardiac vein and coronary artery during cooling. Fundam. Clin. Pharmacol. 23, 271277 (2009)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Fernández N , Monge L , García-Villalón AL , García JL , Gómez B , Diéguez G : Cooling effects on nitric oxide production by rabbit ear and femoral arteries during cholinergic stimulation. Br. J. Pharmacol. 113, 550554 (1994)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Ignarro LJ , Kadowitz PJ : The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Annu. Rev. Pharmacol. Toxicol. 25, 171191 (1985)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Jantschak F , Popp AM , Hofmann RA , Villalón CM , Centurión D , Pertz HH : Postjunctional α2 c-adrenoceptors mediate vasoconstriction in rat tail artery: influence of precontraction and temperature on vasoreactivity. Naunyn Schmiedebergs Arch. Pharmacol. 382, 487497 (2010)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6.

    Karaki H , Nagase H : Low temperature augments the endothelium dependent relaxation in isolated rat aorta. Eur. J. Pharmacol. 142, 129132 (1987)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Lubbe AS : Heat shock attenuates endothelium-dependent vasodilation in skeletal muscle microcirculation. Shock 2, 179184 (1994)

  • 8.

    Moncada S , Rees DD , Schulz R , Palmer RM : Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc. Natl. Acad. Sci. U S A 88, 21662170 (1991)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 9.

    Monge L , García-Villalón AL , Montoya JJ , García JL , Fernández N , Gómez B , Diéguez G : Role of the endothelium in the response to cholinoceptor stimulation of rabbit ear and femoral arteries during cooling. Br. J. Pharmacol. 109, 6167 (1993)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10.

    Monge L , García-Villalón AL , Montoya JJ , García JL , Gómez B , Diéguez G : Response of rabbit ear artery to endothelin-1 during cooling. Br. J. Pharmacol. 104, 609612 (1991)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Nurullahoğlu Atalik KE : Role of calcium on contractile response of calf cardiac vein during cooling. J. Smooth Muscle Res. 47, 135142 (2011)

  • 12.

    Palmer RM , Ferrige AG , Moncada S : Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327(6122), 524526 (1987)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13.

    Romeo C , Ientile R , Santoro G , Impellizzeri P , Turiaco N , Impalà P , Cifalà S , Cutroneo G , Trimarchi F , Gentile F : Nitric oxide production is increased in the spermatic veins of adolescents with left idiopathic varicocele. J. Pediatr. Surg. 36, 389393 (2001)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14.

    Stahl P , Schlegel PN : Standardization and documentation of varicocele evaluation. Curr. Opin. Urol. 21, 500505 (2011)

  • 15.

    Yamazaki F , Sone R , Zhao K , Alvarez GE , Kosiba WA , Johnson JM : Rate dependency and role of nitric oxide in the vascular response to direct cooling in human skin. J. Appl. Physiol. 100, 4250 (2006)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16.

    Yildiz O , Gul H , Ozgok Y , Onguru O , Kilciler M , Aydin A , Isimer A , Harmankaya AC : Increased vasoconstrictor reactivity and decreased endothelial function in high grade varicocele; functional and morphological study. Urol. Res. 31, 323328 (2003)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17.

    Zerpa H , Berhane Y , Elliott J , Bailey SR : The effect of cooling on the contractility of equine digital small lamellar arteries: modulating role of the endothelium. Exp. Physiol. 95, 10331042 (2010)

    • Crossref
    • Search Google Scholar
    • Export Citation

The author instruction is available in PDF.

Please, download the file from HERE

  • Impact Factor (2019): 1.410
  • Scimago Journal Rank (2019): 0.267
  • SJR Hirsch-Index (2019): 27
  • SJR Quartile Score (2019): Q4 Physiology (medical)
  • Impact Factor (2018): 1.113
  • Scimago Journal Rank (2018): 0.262
  • SJR Hirsch-Index (2018): 26
  • SJR Quartile Score (2018): Q4 Physiology (medical)

Language: English

Founded in 1950
Publication: One volume of four issues annually
Publication Programme: 2020. Vol. 107
Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • EMBASE/Excerpta Medica
  • Global Health
  • Index Copernicus
  • Index Medicus
  • Medline
  • Referativnyi Zhurnal
  • SCOPUS
  • Social Science Citation Index

 

Subscribers can access the electronic version of every printed article.

Senior editors

Editor(s)-in-Chief: Rosivall, László

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor; Radák, Zsolt

Assistant Editor(s): G. Dörnyei (Budapest), Zs. Miklós (Budapest), Gy. Nádasy (Budapest)

Hungarian Editorial Board

      Benedek, György (Szeged)
      Benyó, Zoltán (Budapest)
      Boros, Mihály (Szeged)
      Chernoch, László (Debrecen)
      Détári, László (Budapest)
      Hamar, János (Budapest)
      Hantos, Zoltán (Szeged)
      Hunyady, László (Budapest)
      Jancsó, Gábor (Szeged)
      Karádi, Zoltán (Pécs)
      Kovács, László (Debrecen)
      Palkovits, Miklós (Budapest)
      Papp, Gyula (Szeged)
      Pavlik, Gábor (Budapest)
      Spät, András (Budapest)
      Szabó, Gyula (Szeged)
      Szelényi, Zoltán (Pécs)
      Szollár, Lajos (Budapest)
      Szücs, Géza (Debrecen)
      Telegdy, Gyula (Szeged)
      Toldi, József (Szeged)
      Tósaki, Árpád (Debrecen)

 

International Editorial Board

      R. Bauer (Jena)
      W. Benjelloun (Rabat)
      A. W. Cowley Jr. (Milwaukee)
      D. Djuric (Belgrade)
      C. Fry (London)
      S. Greenwald (London)
      O. Hänninen (Kuopio)
      H. G. Hinghofer-Szalkay (Graz)
      Gy. Kunos (Richmond)
      M. Mahmoudian (Tehran)
      T. Mano (Seki, Gifu)
      G. Navar (New Orleans)
      H. Nishino (Nagoya)
      O. Petersen (Liverpool)
      U. Pohl (Münich)
      R. S. Reneman (Maastricht)
      A. Romanovsky (Phoenix)
      G. M. Rubanyi (Richmond)
      T. Sakata (Oita)
      A. Siddiqui (Karachi)
      Cs. Szabo (Beverly)
      E. Vicaut (Paris)
      N. Westerhof (Amsterdam)
      L. F. Zhang (Xi'an)

Editorial Office:
Akadémiai Kiadó Zrt.
Prielle Kornélia u. 21–35, H-1117 Budapest, Hungary

Editorial Correspondence:
Physiology International
Semmelweis University, Faculty of Medicine Institute of Pathophysiology
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: pi@semmelweis-univ.hu