Nephrology Section, Memphis VA Medical Center, Memphis, TN, USA
Search for other papers by CP Kovesdy in
Current site
Google Scholar
PubMed
Search for other papers by S Furth in
Current site
Google Scholar
PubMed
Search for other papers by C Zoccali in
Current site
Google Scholar
PubMed
Search for other papers by World Kidney Day Steering Committee in
Current site
Google Scholar
PubMed
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term. The incidence of obesity-related glomerulopathy has increased tenfold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle, and health policy measures that makes preventive behaviors an affordable option.
-
1.
Ahmadi SF , Zahmatkesh G , Ahmadi E , Streja E , Rhee CM , Gillen DL , De Nicola L , Minutolo R , Ricardo AC , Kovesdy CP , Kalantar-Zadeh K : Association of body mass index with clinical outcomes in non-dialysis-dependent chronic kidney disease: a systematic review and meta-analysis. Cardiorenal. Med. 6, 37–49 (2015)
-
2.
Arnold M , Pandeya N , Byrnes G , Renehan AG , Stevens GA , Ezzati M , Ferlay J , Miranda JJ , Romieu I , Dikshit R , Forman D , Soerjomataram I : Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol. 16, 36–46 (2015)
-
3.
Bastard JP , Maachi M , Lagathu C , Kim MJ , Caron M , Vidal H , Capeau J , Feve B : Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine Netw. 17, 4–12 (2006)
-
4.
Beddhu S , Pappas LM , Ramkumar N , Samore M : Effects of body size and body composition on survival in hemodialysis patients. J. Am. Soc. Nephrol. 14, 2366–2372 (2003)
-
5.
Bhaskaran K , Douglas I , Forbes H , dos-Santos-Silva I , Leon DA , Smeeth L : Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet 384, 755–765 (2014)
-
6.
Bluher M : The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals. Curr. Opin. Lipidol. 21, 38–43 (2010)
-
7.
Bolignano D , Zoccali C : Effects of weight loss on renal function in obese CKD patients: a systematic review. Nephrol. Dial Transplant. 28(Suppl. 4), iv82–iv98 (2013)
-
8.
Calle EE , Kaaks R : Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 4, 579–591 (2004)
-
9.
Cattaneo A , Monasta L , Stamatakis E , Lioret S , Castetbon K , Frenken F , Manios Y , Moschonis G , Savva S , Zaborskis A , Rito AI , Nanu M , Vignerova J , Caroli M , Ludvigsson J , Koch FS , Serra-Majem L , Szponar L , van Lenthe F , Brug J : Overweight and obesity in infants and pre-school children in the European Union: a review of existing data. Obes. Rev. 11, 389–398 (2010)
-
10.
Chang A , Van Horn L , Jacobs DR Jr , Liu K , Muntner P , Newsome B , Shoham DA , Durazo-Arvizu R , Bibbins-Domingo K , Reis J , Kramer H : Lifestyle-related factors, obesity, and incident microalbuminuria: the CARDIA (Coronary Artery Risk Development in Young Adults) study. Am. J. Kidney Dis. 62, 267–275 (2013)
-
11.
Chang AR , Chen Y , Still C , Wood GC , Kirchner HL , Lewis M , Kramer H , Hartle JE , Carey D , Appel LJ , Grams ME : Bariatric surgery is associated with improvement in kidney outcomes. Kidney Int. 90, 164–171 (2016)
-
12.
Chang Y , Ryu S , Choi Y , Zhang Y , Cho J , Kwon MJ , Hyun YY , Lee KB , Kim H , Jung HS , Yun KE , Ahn J , Rampal S , Zhao D , Suh BS , Chung EC , Shin H , Pastor-Barriuso R , Guallar E : Metabolically healthy obesity and development of chronic kidney disease: a cohort study. Ann. Intern. Med. 164, 305–312 (2016)
-
13.
Chobanian MC , Hammerman MR : Insulin stimulates ammoniagenesis in canine renal proximal tubular segments. Am. J. Physiol. 253, F1171–F1177 (1987)
-
14.
Curhan GC , Willett WC , Rimm EB , Speizer FE , Stampfer MJ : Body size and risk of kidney stones. J. Am. Soc. Nephrol. 9, 1645–1652 (1998)
-
15.
Curtis JP , Selter JG , Wang Y , Rathore SS , Jovin IS , Jadbabaie F , Kosiborod M , Portnay EL , Sokol SI , Bader F , Krumholz HM : The obesity paradox: body mass index and outcomes in patients with heart failure. Arch. Intern. Med. 165, 55–61 (2005)
-
16.
Dalamaga M , Diakopoulos KN , Mantzoros CS : The role of adiponectin in cancer: a review of current evidence. Endocr. Rev. 33, 547–594 (2012)
-
17.
Daudon M , Lacour B , Jungers P : Influence of body size on urinary stone composition in men and women. Urol. Res. 34, 193–199 (2006)
-
18.
Dekker FW , de Mutsert R , van Dijk PC , Zoccali C , Jager KJ : Survival analysis: time-dependent effects and time-varying risk factors. Kidney Int. 74, 994–997 (2008)
-
19.
de Vries AP , Ruggenenti P , Ruan XZ , Praga M , Cruzado JM , Bajema IM , D’Agati VD , Lamb HJ , Pongrac BD , Hojs R , Abbate M , Rodriquez R , Mogensen CE , Porrini E : Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease. Lancet Diabetes Endocrinol. 2, 417–426 (2014)
-
20.
Ejerblad E , Fored CM , Lindblad P , Fryzek J , McLaughlin JK , Nyren O : Obesity and risk for chronic renal failure. J. Am. Soc. Nephrol. 17, 1695–1702 (2006)
-
21.
Ellington AA , Malik AR , Klee GG , Turner ST , Rule AD , Mosley TH Jr , Kullo IJ : Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults. Hypertension 50, 708–714 (2007)
-
22.
Elsayed EF , Sarnak MJ , Tighiouart H , Griffith JL , Kurth T , Salem DN , Levey AS , Weiner DE : Waist-to-hip ratio, body mass index, and subsequent kidney disease and death. Am. J. Kidney Dis. 52, 29–38 (2008)
-
23.
Escalante A , Haas RW , del Rincón I : Paradoxical effect of body mass index on survival in rheumatoid arthritis: role of comorbidity and systemic inflammation. Arch. Intern. Med. 165, 1624–1629 (2005)
-
24.
Flegal KM , Kruszon-Moran D , Carroll MD , Fryar CD , Ogden CL : Trends in obesity among adults in the United States, 2005 to 2014. JAMA 315, 2284–2291 (2016)
-
25.
Forouzanfar MH , Alexander L , Anderson HR , Bachman VF , Biryukov S , Brauer M , Burnett R , Casey D , Coates MM , Cohen A , Delwiche K , Estep K , Frostad JJ , Astha KC , Kyu HH , Moradi-Lakeh M , Ng M , Slepak EL , Thomas BA , Wagner J , Aasvang GM , Abbafati C , Abbasoglu OA , Abd-Allah F , Abera SF , Aboyans V , Abraham B , Abraham JP , Abubakar I , Abu-Rmeileh NM , Aburto TC , Achoki T , Adelekan A , Adofo K , Adou AK , Adsuar JC , Afshin A , Agardh EE , Al Khabouri MJ , Al Lami FH , Alam SS , Alasfoor D , Albittar MI , Alegretti MA , Aleman AV , Alemu ZA , Alfonso-Cristancho R , Alhabib S , Ali R , Ali MK , Alla F , Allebeck P , Allen PJ , Alsharif U , Alvarez E , Alvis-Guzman N , Amankwaa AA , Amare AT , Ameh EA , Ameli O , Amini H , Ammar W , Anderson BO , Antonio CA , Anwari P , Argeseanu CS , Arnlov J , Arsenijevic VS , Artaman A , Asghar RJ , Assadi R , Atkins LS , Atkinson C , Avila MA , Awuah B , Badawi A , Bahit MC , Bakfalouni T , Balakrishnan K , Balalla S , Balu RK , Banerjee A , Barber RM , Barker-Collo SL , Barquera S , Barregard L , Barrero LH , Barrientos-Gutierrez T , Basto-Abreu AC , Basu A , Basu S , Basulaiman MO , Batis RC , Beardsley J , Bedi N , Bekele T , Bell ML , Benjet C , Bennett DA , Benzian H , Bernabe E , Beyene TJ , Bhala N , Bhalla A , Bhutta ZA , Bikbov B , Bin Abdulhak AA , Blore JD , Blyth FM , Bohensky MA , Bora BB , Borges G , Bornstein NM , Bose D , Boufous S , Bourne RR , Brainin M , Brazinova A , Breitborde NJ , Brenner H , Briggs AD , Broday DM , Brooks PM , Bruce NG , Brugha TS , Brunekreef B , Buchbinder R , Bui LN , Bukhman G , Bulloch AG , Burch M , Burney PG , Campos-Nonato IR , Campuzano JC , Cantoral AJ , Caravanos J , Cardenas R , Cardis E , Carpenter DO , Caso V , Castaneda-Orjuela CA , Castro RE , Catala-Lopez F , Cavalleri F , Cavlin A , Chadha VK , Chang JC , Charlson FJ , Chen H , Chen W , Chen Z , Chiang PP , Chimed-Ochir O , Chowdhury R , Christophi CA , Chuang TW , Chugh SS , Cirillo M , Classen TK , Colistro V , Colomar M , Colquhoun SM , Contreras AG , Cooper C , Cooperrider K , Cooper LT , Coresh J , Courville KJ , Criqui MH , Cuevas-Nasu L , Damsere-Derry J , Danawi H , Dandona L , Dandona R , Dargan PI , Davis A , Davitoiu DV , Dayama A , de Castro EF , De la Cruz-Góngora V , De Leo D , de Lima G , Degenhardt L , del Pozo-Cruz B , Dellavalle RP , Deribe K , Derrett S , Des Jarlais DC , Dessalegn M , deVeber GA , Devries KM , Dharmaratne SD , Dherani MK , Dicker D , Ding EL , Dokova K , Dorsey ER , Driscoll TR , Duan L , Durrani AM , Ebel BE , Ellenbogen RG , Elshrek YM , Endres M , Ermakov SP , Erskine HE , Eshrati B , Esteghamati A , Fahimi S , Faraon EJ , Farzadfar F , Fay DF , Feigin VL , Feigl AB , Fereshtehnejad SM , Ferrari AJ , Ferri CP , Flaxman AD , Fleming TD , Foigt N , Foreman KJ , Paleo UF , Franklin RC , Gabbe B , Gaffikin L , Gakidou E , Gamkrelidze A , Gankpe FG , Gansevoort RT , Garcia-Guerra FA , Gasana E , Geleijnse JM , Gessner BD , Gething P , Gibney KB , Gillum RF , Ginawi IA , Giroud M , Giussani G , Goenka S , Goginashvili K , Gomez DH , Gona P , Gonzalez de CT , Gonzalez-Castell D , Gotay CC , Goto A , Gouda HN , Guerrant RL , Gugnani HC , Guillemin F , Gunnell D , Gupta R , Gupta R , Gutierrez RA : Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 386, 2287–2323 (2015)
-
26.
Foster MC , Hwang SJ , Larson MG , Lichtman JH , Parikh NI , Vasan RS , Levy D , Fox CS : Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study. Am. J. Kidney Dis. 52, 39–48 (2008)
-
27.
Foster MC , Hwang SJ , Massaro JM , Hoffmann U , DeBoer IH , Robins SJ , Vasan RS , Fox CS : Association of subcutaneous and visceral adiposity with albuminuria: the Framingham Heart Study. Obesity (Silver Spring) 19, 1284–1289 (2011)
-
28.
Foster MC , Hwang SJ , Porter SA , Massaro JM , Hoffmann U , Fox CS : Fatty kidney, hypertension, and chronic kidney disease: the Framingham Heart Study. Hypertension 58, 784–790 (2011)
-
29.
Friedman AN , Wolfe B : Is bariatric surgery an effective treatment for type II diabetic kidney disease? Clin. J. Am. Soc. Nephrol. 11, 528–535 (2016)
-
30.
Furukawa S , Fujita T , Shimabukuro M , Iwaki M , Yamada Y , Nakajima Y , Nakayama O , Makishima M , Matsuda M , Shimomura I : Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114, 1752–1761 (2004)
-
31.
Gelber RP , Kurth T , Kausz AT , Manson JE , Buring JE , Levey AS , Gaziano JM : Association between body mass index and CKD in apparently healthy men. Am. J. Kidney Dis. 46, 871–880 (2005)
-
32.
Grivennikov SI , Greten FR , Karin M : Immunity, inflammation, and cancer. Cell 140, 883–899 (2010)
-
33.
Henegar JR , Bigler SA , Henegar LK , Tyagi SC , Hall JE : Functional and structural changes in the kidney in the early stages of obesity. J. Am. Soc. Nephrol. 12, 1211–1217 (2001)
-
34.
Horwich TB , Fonarow GC , Hamilton MA , MacLellan WR , Woo MA , Tillisch JH : The relationship between obesity and mortality in patients with heart failure. J. Am. Coll. Cardiol. 38, 789–795 (2001)
-
35.
Hsu C , McCulloch C , Iribarren C , Darbinian J , Go A : Body mass index and risk for end-stage renal disease. Ann. Intern. Med. 144, 21–28 (2006)
-
36.
Iseki K , Ikemiya Y , Kinjo K , Inoue T , Iseki C , Takishita S : Body mass index and the risk of development of end-stage renal disease in a screened cohort. Kidney Int. 65, 1870–1876 (2004)
-
37.
Jamal MH , Corcelles R , Daigle CR , Rogula T , Kroh M , Schauer PR , Brethauer SA : Safety and effectiveness of bariatric surgery in dialysis patients and kidney transplantation candidates. Surg. Obes. Relat. Dis. 11, 419–423 (2015)
-
38.
Jandacek RJ , Anderson N , Liu M , Zheng S , Yang Q , Tso P : Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G292–G299 (2005)
-
39.
Kalantar-Zadeh K , Kilpatrick RD , Kuwae N , Wu DY : Reverse epidemiology: a spurious hypothesis or a hardcore reality? Blood Purif. 23, 57–63 (2005)
-
40.
Kalantar-Zadeh K , Kuwae N , Wu DY , Shantouf RS , Fouque D , Anker SD , Block G , Kopple JD : Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients. Am. J. Clin. Nutr. 83, 202–210 (2006)
-
41.
Kambham N , Markowitz GS , Valeri AM , Lin J , D’Agati VD : Obesity-related glomerulopathy: an emerging epidemic. Kidney Int. 59, 1498–1509 (2001)
-
42.
Klisic J , Hu MC , Nief V , Reyes L , Fuster D , Moe OW , Ambuhl PM : Insulin activates Na+/H+ exchanger 3: biphasic response and glucocorticoid dependence. Am. J. Physiol. Renal. Physiol. 283, F532–F539 (2002)
-
43.
Knight SF , Quigley JE , Yuan J , Roy SS , Elmarakby A , Imig JD : Endothelial dysfunction and the development of renal injury in spontaneously hypertensive rats fed a high-fat diet. Hypertension 51, 352–359 (2008)
-
44.
Kovesdy CP , Anderson JE , Kalantar-Zadeh K : Paradoxical association between body mass index and mortality in men with CKD not yet on dialysis. Am. J. Kidney Dis. 49, 581–591 (2007)
-
45.
Kovesdy CP , Czira ME , Rudas A , Ujszaszi A , Rosivall L , Novak M , Kalantar-Zadeh K , Molnar MZ , Mucsi I : Body mass index, waist circumference and mortality in kidney transplant recipients. Am. J. Transplant. 10, 2644–2651 (2010)
-
46.
Kramer H , Gutierrez OM , Judd SE , Muntner P , Warnock DG , Tanner RM , Panwar B , Shoham DA , McClellan W : Waist circumference, body mass index, and ESRD in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study. Am. J. Kidney Dis. 67, 62–69 (2016)
-
47.
Kramer H , Luke A , Bidani A , Cao G , Cooper R , McGee D : Obesity and prevalent and incident CKD: the hypertension detection and follow-up program. Am. J. Kidney Dis. 46, 587–594 (2005)
-
48.
Kramer HJ , Saranathan A , Luke A , Durazo-Arvizu RA , Guichan C , Hou S , Cooper R : Increasing body mass index and obesity in the incident ESRD population. J. Am. Soc. Nephrol. 17, 1453–1459 (2006)
-
49.
Lamas O , Marti A , Martinez JA : Obesity and immunocompetence. Eur. J. Clin. Nutr. 56(Suppl. 3), S42–S45 (2002)
-
50.
Lee PS , Sampath K , Karumanchi SA , Tamez H , Bhan I , Isakova T , Gutierrez OM , Wolf M , Chang Y , Stossel TP , Thadhani R : Plasma gelsolin and circulating actin correlate with hemodialysis mortality. J. Am. Soc. Nephrol. 20, 1140–1148 (2009)
-
51.
Lemann J Jr , Pleuss JA , Worcester EM , Hornick L , Schrab D , Hoffmann RG : Urinary oxalate excretion increases with body size and decreases with increasing dietary calcium intake among healthy adults. Kidney Int. 49, 200–208 (1996)
-
52.
Lim C , Savan R : The role of the IL-22/IL-22R1 axis in cancer. Cytokine Growth Factor Rev. 25, 257–271 (2014)
-
53.
Lu JL , Kalantar-Zadeh K , Ma JZ , Quarles LD , Kovesdy CP : Association of body mass index with outcomes in patients with CKD. J. Am. Soc. Nephrol. 25, 2088–2096 (2014)
-
54.
Lu JL , Molnar MZ , Naseer A , Mikkelsen MK , Kalantar-Zadeh K , Kovesdy CP : Association of age and BMI with kidney function and mortality: a cohort study. Lancet Diabetes Endocrinol. 3, 704–714 (2015)
-
55.
Maalouf NM , Sakhaee K , Parks JH , Coe FL , Adams-Huet B , Pak CY : Association of urinary pH with body weight in nephrolithiasis. Kidney Int. 65, 1422–1425 (2004)
-
56.
Mallamaci F , Ruggenenti P , Perna A , Leonardis D , Tripepi R , Tripepi G , Remuzzi G , Zoccali C : ACE inhibition is renoprotective among obese patients with proteinuria. J. Am. Soc. Nephrol. 22, 1122–1128 (2011)
-
57.
Mohamed-Ali V , Goodrick S , Bulmer K , Holly JM , Yudkin JS , Coppack SW : Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo. Am. J. Physiol. 277, E971–E975 (1999)
-
58.
Munkhaugen J , Lydersen S , Wideroe TE , Hallan S : Prehypertension, obesity, and risk of kidney disease: 20-year follow-up of the HUNT I study in Norway. Am. J. Kidney Dis. 54, 638–646 (2009)
-
59.
Noori N , Kopple JD , Kovesdy CP , Feroze U , Sim JJ , Murali SB , Luna A , Gomez M , Luna C , Bross R , Nissenson AR , Kalantar-Zadeh K : Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients. Clin. J. Am. Soc. Nephrol. 5, 2258–2268 (2010)
-
60.
O’Donoghue DJ , Stevens PE : A decade after the KDOQI CKD/guidelines: a perspective from the United Kingdom. Am. J. Kidney Dis. 60, 740–742 (2012)
-
61.
Olaya B , Moneta MV , Pez O , Bitfoi A , Carta MG , Eke C , Goelitz D , Keyes KM , Kuijpers R , Lesinskiene S , Mihova Z , Otten R , Fermanian C , Haro JM , Kovess V : Country-level and individual correlates of overweight and obesity among primary school children: a cross-sectional study in seven European countries. BMC Public Health 15, 475 (2015)
-
62.
Oterdoom LH , de Vries AP , Gansevoort RT , de Jong PE , Gans RO , Bakker SJ : Fasting insulin modifies the relation between age and renal function. Nephrol. Dial. Transplant. 22, 1587–1592 (2007)
-
63.
Pinto-Sietsma SJ , Navis G , Janssen WM , de Zeeuw D , Gans RO , de Jong PE : A central body fat distribution is related to renal function impairment, even in lean subjects. Am. J. Kidney Dis. 41, 733–741 (2003)
-
64.
Postorino M , Mancini E , D’Arrigo G , Marino C , Vilasi A , Tripepi G , Gallus S , Lugo A , Santoro A , Zoccali C : Body mass index trend in haemodialysis patients: the shift of nutritional disorders in two Italian regions. Nephrol. Dial. Transplant. 31, 1699–1705 (2016)
-
65.
Postorino M , Marino C , Tripepi G , Zoccali C : Abdominal obesity and all-cause and cardiovascular mortality in end-stage renal disease. J. Am. Coll. Cardiol. 53, 1265–1272 (2009)
-
66.
Rauchhaus M , Coats AJ , Anker SD : The endotoxin-lipoprotein hypothesis. Lancet 356, 930–933 (2000)
-
67.
Reaven GM : Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37, 1595–1607 (1988)
-
68.
Renehan AG , Tyson M , Egger M , Heller RF , Zwahlen M : Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371, 569–578 (2008)
-
69.
Ribstein J , du Cailar G , Mimran A : Combined renal effects of overweight and hypertension. Hypertension 26, 610–615 (1995)
-
70.
Ruan XZ , Varghese Z , Moorhead JF : An update on the lipid nephrotoxicity hypothesis. Nat. Rev. Nephrol. 5, 713–721 (2009)
-
71.
Ruster C , Wolf G : The role of the renin-angiotensin-aldosterone system in obesity-related renal diseases. Semin. Nephrol. 33, 44–53 (2013)
-
72.
Scales CD Jr , Smith AC , Hanley JM , Saigal CS : Prevalence of kidney stones in the United States. Eur. Urol. 62, 160–165 (2012)
-
73.
Sharma K : The link between obesity and albuminuria: adiponectin and podocyte dysfunction. Kidney Int. 76, 145–148 (2009)
-
74.
Siener R , Glatz S , Nicolay C , Hesse A : The role of overweight and obesity in calcium oxalate stone formation. Obes. Res. 12, 106–113 (2004)
-
75.
Sinha MK , Collazo-Clavell ML , Rule A , Milliner DS , Nelson W , Sarr MG , Kumar R , Lieske JC : Hyperoxaluric nephrolithiasis is a complication of Roux-en-Y gastric bypass surgery. Kidney Int. 72, 100–107 (2007)
-
76.
Snyder JJ , Foley RN , Gilbertson DT , Vonesh EF , Collins AJ : Body size and outcomes on peritoneal dialysis in the United States. Kidney Int. 64, 1838–1844 (2003)
-
77.
Stenvinkel P , Marchlewska A , Pecoits-Filho R , Heimburger O , Zhang Z , Hoff C , Holmes C , Axelsson J , Arvidsson S , Schalling M , Barany P , Lindholm B , Nordfors L : Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin. Kidney Int. 65, 274–281 (2004)
-
78.
Subramanian SV , Perkins JM , Ozaltin E , Davey SG : Weight of nations: a socioeconomic analysis of women in low- to middle-income countries. Am. J. Clin. Nutr. 93, 413–421 (2011)
-
79.
Taylor EN , Stampfer MJ , Curhan GC : Diabetes mellitus and the risk of nephrolithiasis. Kidney Int. 68, 1230–1235 (2005)
-
80.
Taylor EN , Stampfer MJ , Curhan GC : Obesity, weight gain, and the risk of kidney stones. JAMA 293, 455–462 (2005)
-
81.
Thoenes M , Reil JC , Khan BV , Bramlage P , Volpe M , Kirch W , Bohm M : Abdominal obesity is associated with microalbuminuria and an elevated cardiovascular risk profile in patients with hypertension. Vasc. Health Risk Manag. 5, 577–585 (2009)
-
82.
Tsuboi N , Utsunomiya Y , Kanzaki G , Koike K , Ikegami M , Kawamura T , Hosoya T : Low glomerular density with glomerulomegaly in obesity-related glomerulopathy. Clin. J. Am. Soc. Nephrol. 7, 735–741 (2012)
-
83.
Tsujimoto T , Sairenchi T , Iso H , Irie F , Yamagishi K , Watanabe H , Tanaka K , Muto T , Ota H : The dose-response relationship between body mass index and the risk of incident stage ≥3 chronic kidney disease in a general Japanese population: the Ibaraki Prefectural Health Study (IPHS). J. Epidemiol. 24, 444–451 (2014)
-
84.
Vivante A , Golan E , Tzur D , Leiba A , Tirosh A , Skorecki K , Calderon-Margalit R : Body mass index in 1.2 million adolescents and risk for end-stage renal disease. Arch. Intern. Med. 172, 1644–1650 (2012)
-
85.
Wilson DO , Rogers RM , Wright EC , Anthonisen NR : Body weight in chronic obstructive pulmonary disease. The National Institutes of Health Intermittent Positive-Pressure Breathing Trial. Am. Rev. Respir. Dis. 139, 1435–1438 (1989)
-
86.
Wing RR , Bolin P , Brancati FL , Bray GA , Clark JM , Coday M , Crow RS , Curtis JM , Egan CM , Espeland MA , Evans M , Foreyt JP , Ghazarian S , Gregg EW , Harrison B , Hazuda HP , Hill JO , Horton ES , Hubbard VS , Jakicic JM , Jeffery RW , Johnson KC , Kahn SE , Kitabchi AE , Knowler WC , Lewis CE , Maschak-Carey BJ , Montez MG , Murillo A , Nathan DM , Patricio J , Peters A , Pi-Sunyer X , Pownall H , Reboussin D , Regensteiner JG , Rickman AD , Ryan DH , Safford M , Wadden TA , Wagenknecht LE , West DS , Williamson DF , Yanovski SZ : Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N. Engl. J. Med. 369, 145–154 (2013)
-
87.
Wolf G , Ziyadeh FN : Leptin and renal fibrosis. Contrib. Nephrol. 151, 175–183 (2006)
-
88.
World Health Organization (2009): 2008–2013 Action Plan for the Global Strategy for the Prevention and Control of Noncommunicable Diseases. World Health Organization, Geneva.
Editor-in-Chief
László ROSIVALL (Semmelweis University, Budapest, Hungary)
Managing Editor
Anna BERHIDI (Semmelweis University, Budapest, Hungary)
Co-Editors
- Gábor SZÉNÁSI (Semmelweis University, Budapest, Hungary)
- Ákos KOLLER (Semmelweis University, Budapest, Hungary)
- Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
- László LÉNÁRD (University of Pécs, Hungary)
- Zoltán UNGVÁRI (Semmelweis University, Budapest, Hungary)
Assistant Editors
- Gabriella DÖRNYEI (Semmelweis University, Budapest, Hungary)
- Zsuzsanna MIKLÓS (Semmelweis University, Budapest, Hungary)
- György NÁDASY (Semmelweis University, Budapest, Hungary)
Hungarian Editorial Board
- György BENEDEK (University of Szeged, Hungary)
- Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
- Mihály BOROS (University of Szeged, Hungary)
- László CSERNOCH (University of Debrecen, Hungary)
- Magdolna DANK (Semmelweis University, Budapest, Hungary)
- László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
- Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
- Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
- Zoltán HEROLD (Semmelweis University, Budapest, Hungary)
- László HUNYADI (Semmelweis University, Budapest, Hungary)
- Gábor JANCSÓ (University of Pécs, Hungary)
- Zoltán KARÁDI (University of Pecs, Hungary)
- Miklós PALKOVITS (Semmelweis University, Budapest, Hungary)
- Gyula PAPP (University of Szeged, Hungary)
- Gábor PAVLIK (University of Physical Education, Budapest, Hungary)
- András SPÄT (Semmelweis University, Budapest, Hungary)
- Gyula SZABÓ (University of Szeged, Hungary)
- Zoltán SZELÉNYI (University of Pécs, Hungary)
- Lajos SZOLLÁR (Semmelweis University, Budapest, Hungary)
- József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
- Árpád TÓSAKI (University of Debrecen, Hungary)
International Editorial Board
- Dragan DJURIC (University of Belgrade, Serbia)
- Christopher H. FRY (University of Bristol, UK)
- Stephen E. GREENWALD (Blizard Institute, Barts and Queen Mary University of London, UK)
- Tibor HORTOBÁGYI (University of Groningen, Netherlands)
- George KUNOS (National Institutes of Health, Bethesda, USA)
- Massoud MAHMOUDIAN (Iran University of Medical Sciences, Tehran, Iran)
- Tadaaki MANO (Gifu University of Medical Science, Japan)
- Luis Gabriel NAVAR (Tulane University School of Medicine, New Orleans, USA)
- Hitoo NISHINO (Nagoya City University, Japan)
- Ole H. PETERSEN (Cardiff University, UK)
- Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
- Andrej A. ROMANOVSKY (University of Arizona, USA)
- Anwar Ali SIDDIQUI (Aga Khan University, Karachi, Pakistan)
- Csaba SZABÓ (University of Fribourg, Switzerland)
- Eric VICAUT (Université de Paris, UMRS 942 INSERM, France)
Editorial Correspondence:
Physiology International
Semmelweis University
Faculty of Medicine, Institute of Translational Medicine
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: pi@semmelweis.hu
Indexing and Abstracting Services:
- Biological Abstracts
- BIOSIS Previews
- CAB Abstracts
- CABELLS Journalytics
- EMBASE/Excerpta Medica
- Global Health
- Index Copernicus
- Index Medicus
- Medline
- Referativnyi Zhurnal
- SCOPUS
- WoS - Science Citation Index Expanded
| 2023 | |
|---|---|
| Web of Science | |
| Journal Impact Factor | 2.2 |
| Rank by Impact Factor | Q3 (Physiology) |
| Journal Citation Indicator | 0.58 |
| Scopus | |
| CiteScore | 3.4 |
| CiteScore rank | Q2 (Physical Therapy, Sports Therapy and Rehabilitation) |
| SNIP | 0.508 |
| Scimago | |
| SJR index | 0.407 |
| SJR Q rank | Q2 |
| Physiology International | |
|---|---|
| Publication Model | Hybrid |
| Submission Fee | none |
| Article Processing Charge | 1100 EUR/article |
| Printed Color Illustrations | 40 EUR (or 10 000 HUF) + VAT / piece |
| Regional discounts on country of the funding agency | World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100% |
| Further Discounts | Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100% |
| Subscription fee 2025 | Online subsscription: 752 EUR / 828 USD Print + online subscription: 880 EUR / 968 USD |
| Subscription Information | Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content. |
| Purchase per Title | Individual articles are sold on the displayed price. |
| Physiology International | |
|---|---|
| Language | English |
| Size | B5 |
| Year of Foundation |
2006 (1950) |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Magyar Tudományos Akadémia |
| Founder's Address |
H-1051 Budapest, Hungary, Széchenyi István tér 9. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 2498-602X (Print) |
| ISSN | 2677-0164 (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Aug 2024 | 166 | 0 | 0 |
| Sep 2024 | 169 | 0 | 0 |
| Oct 2024 | 304 | 0 | 0 |
| Nov 2024 | 283 | 0 | 0 |
| Dec 2024 | 195 | 0 | 0 |
| Jan 2025 | 137 | 0 | 0 |
| Feb 2025 | 0 | 0 | 0 |
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.