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Alzheimer’s disease (AD) has been reported to be linked with diabetes mellitus and insulin resistance. Adiponectin (ADN), an adipocytokine secreted from adipose tissue, is involved in the regulation of insulin sensitivity, energy homeostasis, and mitochondrial dysfunction. In this study, we examined the effect of ADN on passive avoidance memory in animal model of sporadic AD (sAD). On days 1 and 3 after cannulation, rats received intracerebroventricular (icv) injection of streptozotocin (STZ) (3 mg/kg). Thirty minutes before the learning process, animals received saline or ADN in different doses (6, 60, and 600 µg). The step-through latency (STL) and total time spent in the dark compartment (TDC) were recorded and analyzed. In STZ-treated rats, STL was significantly decreased, whereas TDC showed a dramatic increase. In ADN-treated rats, STL was significantly increased (P < 0.01) in all treatment doses. The number of entries was decreased in all applied doses; however, TDC was reduced only by the application of 6 ng of ADN (P < 0.05). It can be concluded that ADN is useful to improve the STZ-induced memory impairment. This study showed, for the first time, that icv administration of ADN could improve the memory acquisition in animal model of sAD.
-
1.
Awazawa M , Ueki K , Inabe K , Yamauchi T , Kubota N , Kaneko K , Kobayashi M , Iwane A , Sasako T , Okazaki Y , Ohsugi M , Takamoto I , Yamashita S , Asahara H , Akira S , Kasuga M , Kadowaki T : Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metab. 13, 401–412 (2011)
-
2.
Benomar Y , Amine H , Crépin D , Al Rifai S , Riffault L , Gertler A , Taouis M : Central Resistin/TLR4 impairs adiponectin signaling contributing to insulin and FGF21 resistance. Diabetes 65, 913–926 (2016)
-
3.
Coope A , Milanski M , Araújo EP , Tambascia M , Saad MJ , Geloneze B , Velloso LA : AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS Lett. 582, 1471–1476 (2008)
-
4.
Craft S : Alzheimer disease: insulin resistance and AD – extending the translational path. Nat. Rev. Neurol. 8, 360–362 (2012)
-
5.
Deepa SS , Dong LQ : APPL1: role in adiponectin signaling and beyond. Am. J. Physiol. Endocrinol. Metab. 296, E22–E36 (2009)
-
6.
De Felice FG , Benedict C : A key role of insulin receptors in memory. Diabetes 64, 3653–3655 (2015)
-
7.
García-Casares N , García-Arnés JA , Rioja J , Ariza MJ , Gutiérrez A , Alfaro F , Nabrozidis A , González-Alegre P , González-Santos P : Alzheimer’s like brain changes correlate with low adiponectin plasma levels in type 2 diabetic patients. J. Diabetes Complications 30, 281–286 (2016)
-
8.
González-Reyes RE , Aliev G , Ávila-Rodrigues M , Barreto GE : Alterations in glucose metabolism on cognition: a possible link between diabetes and dementia. Curr. Pharm. Des. 22, 812–818 (2016)
-
9.
Harvey J , Solovyova N , Irving A : Leptin and its role in hippocampal synaptic plasticity. Prog. Lipid Res. 45, 369–378 (2006)
-
10.
Hotta K , Funahashi T , Arita Y , Takahashi M , Matsuda M , Okamoto Y , Iwahashi H , Kuriyama H , Ouchi N , Maeda K , Nishida M , Kihara S , Sakai N , Nakajima T , Hasegawa K , Muraguchi M , Ohmoto Y , Nakamura T , Yamashita S , Hanafusa T , Matsuzawa Y : Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler. Thromb. Vasc. Biol. 20, 1595–1599 (2000)
-
11.
Hu E , Liang P , Spiegelman BM : AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271, 10697–10703 (1996)
-
12.
Jeon BT , Shin HJ , Kim JB , Kim YK , Lee DH , Kim KH , Kim HJ , Kang SS , Cho GJ , Choi WS , Roh GS : Adiponectin protects hippocampal neurons against kainic acid-induced excitotoxicity. Brain Res. Rev. 61, 81–88 (2009)
-
13.
Liu C , Feng X , Li Q , Wang Y , Li Q , Hua M : Adiponectin, TNF-α and inflammatory cytokines and risk of type 2 diabetes: a systematic review and meta-analysis. Cytokine 86, 100–109 (2016)
-
14.
Matsuzawa Y : Adipocytokines and metabolic syndrome. Semin. Vasc. Med. 5, 34–39 (2005)
-
15.
Merlo S , Spampinato S , Canonico PL , Copani A , Sortino MA : Alzheimer’s disease: brain expression of a metabolic disorder? Trends Endocrinol. Metab. 21, 537–544 (2010)
-
16.
Midaoui AE , Talbot S , Lahjouji K , Dias JP , Fantus IG , Couture R : Effects of alpha-lipoic acid on oxidative stress and kinin receptor expression in obese zucker diabetic fatty rats. J. Diabetes Metab. 6, 1–7 (2015)
-
17.
Pákáski M , Fehér A , Juhász A , Drótos G , Fazekas OC , Kovács J , Janka Z , Kálmán J : Serum adipokine levels modified by donepezil treatment in Alzheimer’s disease. J. Alzheimers Dis. 38, 371–377 (2014)
-
18.
Paxinos G , Watson C (1986): The Rat Brain in Stereotaxic Coordinates. Academic Press, New York
-
19.
Qiu G , Wan R , Hu J , Mattson MP , Spangler E , Liu S , Yau SY , Lee TM , Gleichmann M , Ingram DK , So KF , Zou S : Adiponectin protects rat hippocampal neurons against excitotoxicity. Age (Dordr.) 33, 155–165 (2011)
-
20.
Samy DM , Ismail CA , Nassra RA , Zeitoun TM , Nomair AM : Downstream modulation of extrinsic apoptotic pathway in streptozotocin-induced Alzheimer’s dementia in rats: erythropoietin versus curcumin. Eur. J. Pharmacol. 770, 52–60 (2016)
-
21.
Selkoe DJ : Alzheimer’s disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J. Alzheimers Dis. 3, 75–80 (2001)
-
22.
Smith MA : Alzheimer disease. Int. Rev. Neurobiol. 42, 1–54 (1998)
-
23.
Solano DC , Sironi M , Bonfini C , Solerte SB , Govoni S , Racchi M : Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway. FASEB J. 14, 1015–1022 (2000)
-
24.
Tao C , Sifuentes A , Holland WL : Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes. Best Pract. Res. Clin. Endocrinol. Metab. 28, 43–58 (2014)
-
25.
Teixeira AL , Diniz BS , Campos AC , Miranda AS , Rocha NP , Talib LL , Gattaz WF , Forlenza OV : Decreased levels of circulating adiponectin in mild cognitive impairment and Alzheimer’s disease. Neuromolecular Med. 15, 115–121 (2013)
-
26.
Wolf AM , Wolf D , Rumpold H , Enrich B , Tilg H : Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem. Biophys. Res. Commun. 323, 630–635 (2004)
-
27.
Yamauchi T , Kamon J , Waki H , Terauchi Y , Kubota N , Hara K , Mori Y , Ide T , Murakami K , Tsuboyama-Kasaoka N , Ezaki O , Akanuma Y , Gavrilova O , Vinson C , Reitman ML , Kagechika H , Shudo K , Yoda M , Nakano Y , Tobe K , Nagai R , Kimura S , Tomita M , Froguel P , Kadowaki T : The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7, 941–946 (2001)
-
28.
Zamani M , Rohampour K , Zeraati M , Hosseinmardi N , Kazemian MM : Pre-training catechin gavage prevents memory impairment induced by intracerebroventricular streptozotocin in rats. Neurosciences (Riyadh) 20, 225–229 (2015)
-
29.
Zhao WQ , Alkon DL : Role of insulin and insulin receptor in learning and memory. Mol. Cell. Endocrinol. 177, 125–134 (2001)
Editor-in-Chief
László ROSIVALL (Semmelweis University, Budapest, Hungary)
Managing Editor
Anna BERHIDI (Semmelweis University, Budapest, Hungary)
Co-Editors
- Gábor SZÉNÁSI (Semmelweis University, Budapest, Hungary)
- Ákos KOLLER (Semmelweis University, Budapest, Hungary)
- Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
- László LÉNÁRD (University of Pécs, Hungary)
- Zoltán UNGVÁRI (Semmelweis University, Budapest, Hungary)
Assistant Editors
- Gabriella DÖRNYEI (Semmelweis University, Budapest, Hungary)
- Zsuzsanna MIKLÓS (Semmelweis University, Budapest, Hungary)
- György NÁDASY (Semmelweis University, Budapest, Hungary)
Hungarian Editorial Board
- György BENEDEK (University of Szeged, Hungary)
- Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
- Mihály BOROS (University of Szeged, Hungary)
- László CSERNOCH (University of Debrecen, Hungary)
- Magdolna DANK (Semmelweis University, Budapest, Hungary)
- László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
- Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
- Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
- Zoltán HEROLD (Semmelweis University, Budapest, Hungary)
- László HUNYADI (Semmelweis University, Budapest, Hungary)
- Gábor JANCSÓ (University of Pécs, Hungary)
- Zoltán KARÁDI (University of Pecs, Hungary)
- Miklós PALKOVITS (Semmelweis University, Budapest, Hungary)
- Gyula PAPP (University of Szeged, Hungary)
- Gábor PAVLIK (University of Physical Education, Budapest, Hungary)
- András SPÄT (Semmelweis University, Budapest, Hungary)
- Gyula SZABÓ (University of Szeged, Hungary)
- Zoltán SZELÉNYI (University of Pécs, Hungary)
- Lajos SZOLLÁR (Semmelweis University, Budapest, Hungary)
- Gyula TELEGDY (MTA-SZTE, Neuroscience Research Group and University of Szeged, Hungary)
- József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
- Árpád TÓSAKI (University of Debrecen, Hungary)
International Editorial Board
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- Christopher H. FRY (University of Bristol, UK)
- Stephen E. GREENWALD (Blizard Institute, Barts and Queen Mary University of London, UK)
- Osmo Otto Päiviö HÄNNINEN (Finnish Institute for Health and Welfare, Kuopio, Finland)
- Helmut G. HINGHOFER-SZALKAY (Medical University of Graz, Austria)
- Tibor HORTOBÁGYI (University of Groningen, Netherlands)
- George KUNOS (National Institutes of Health, Bethesda, USA)
- Massoud MAHMOUDIAN (Iran University of Medical Sciences, Tehran, Iran)
- Tadaaki MANO (Gifu University of Medical Science, Japan)
- Luis Gabriel NAVAR (Tulane University School of Medicine, New Orleans, USA)
- Hitoo NISHINO (Nagoya City University, Japan)
- Ole H. PETERSEN (Cardiff University, UK)
- Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
- Andrej A. ROMANOVSKY (University of Arizona, USA)
- Anwar Ali SIDDIQUI (Aga Khan University, Karachi, Pakistan)
- Csaba SZABÓ (University of Fribourg, Switzerland)
- Eric VICAUT (Université de Paris, UMRS 942 INSERM, France)
- Nico WESTERHOF (Vrije Universiteit Amsterdam, The Netherlands)
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Physiology International
Semmelweis University
Faculty of Medicine, Institute of Translational Medicine
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Indexing and Abstracting Services:
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- SCOPUS
- WoS - Science Citation Index Expanded
| 2022 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
335 |
| Journal Impact Factor | 1.4 |
| Rank by Impact Factor |
Physiology (Q4) |
| Impact Factor without Journal Self Cites |
1.4 |
| 5 Year Impact Factor |
1.6 |
| Journal Citation Indicator | 0.42 |
| Rank by Journal Citation Indicator |
Physiology (Q4) |
| Scimago | |
| Scimago H-index |
33 |
| Scimago Journal Rank |
0.362 |
| Scimago Quartile Score |
Physiology (medical) (Q3) |
| Scopus | |
| Scopus Cite Score |
2.8 |
| Scopus CIte Score Rank |
Physiology 68/102 (33rd PCTL) |
| Scopus SNIP |
0.508 |
| 2021 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
330 |
| Journal Impact Factor | 1,697 |
| Rank by Impact Factor |
Physiology 73/81 |
| Impact Factor without Journal Self Cites |
1,697 |
| 5 Year Impact Factor |
1,806 |
| Journal Citation Indicator | 0,47 |
| Rank by Journal Citation Indicator |
Physiology 69/86 |
| Scimago | |
| Scimago H-index |
31 |
| Scimago Journal Rank |
0,32 |
| Scimago Quartile Score | Medicine (miscellaneous) (Q3) Physiology (medical) (Q3) |
| Scopus | |
| Scopus Cite Score |
2,7 |
| Scopus CIte Score Rank |
Physiology (medical) 69/101 (Q3) |
| Scopus SNIP |
0,591 |
| 2020 | |
| Total Cites | 245 |
| WoS | |
| Journal Impact Factor |
2,090 |
| Rank by | Physiology 62/81 (Q4) |
| Impact Factor | |
| Impact Factor | 1,866 |
| without | |
| Journal Self Cites | |
| 5 Year | 1,703 |
| Impact Factor | |
| Journal | 0,51 |
| Citation Indicator | |
| Rank by Journal | Physiology 67/84 (Q4) |
| Citation Indicator | |
| Citable | 42 |
| Items | |
| Total | 42 |
| Articles | |
| Total | 0 |
| Reviews | |
| Scimago | 29 |
| H-index | |
| Scimago | 0,417 |
| Journal Rank | |
| Scimago | Physiology (medical) Q3 |
| Quartile Score | |
| Scopus | 270/1140=1,9 |
| Scite Score | |
| Scopus | Physiology (medical) 71/98 (Q3) |
| Scite Score Rank | |
| Scopus | 0,528 |
| SNIP | |
| Days from | 172 |
| submission | |
| to acceptance | |
| Days from | 106 |
| acceptance | |
| to publication |
| 2019 | |
|---|---|
| Total Cites WoS |
137 |
| Impact Factor | 1,410 |
| Impact Factor without Journal Self Cites |
1,361 |
| 5 Year Impact Factor |
1,221 |
| Immediacy Index |
0,294 |
| Citable Items |
34 |
| Total Articles |
33 |
| Total Reviews |
1 |
| Cited Half-Life |
2,1 |
| Citing Half-Life |
9,3 |
| Eigenfactor Score |
0,00028 |
| Article Influence Score |
0,215 |
| % Articles in Citable Items |
97,06 |
| Normalized Eigenfactor |
0,03445 |
| Average IF Percentile |
12,963 |
| Scimago H-index |
27 |
| Scimago Journal Rank |
0,267 |
| Scopus Scite Score |
235/157=1,5 |
| Scopus Scite Score Rank |
Physiology (medical) 73/99 (Q3) |
| Scopus SNIP |
0,38 |
| Physiology International | |
|---|---|
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| Physiology International | |
|---|---|
| Language | English |
| Size | B5 |
| Year of Foundation |
2006 (1950) |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Magyar Tudományos Akadémia |
| Founder's Address |
H-1051 Budapest, Hungary, Széchenyi István tér 9. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 2498-602X (Print) |
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