Atherosclerosis is a disease caused by a build-up of fatty plaques and cholesterol in the arteries. The lumen of the vessels is obliterated resulting in restricted blood supply to tissues. In ischemic conditions, the cytosolic Ca2+ level of skeletal muscle may increase, indicating the alteration of Ca2+ removal mechanisms. Ca2+ is transported from cytosol into the sarcoplasmic reticulum by Ca2+ ATPase (SERCA), with its 1a isoform expressed in adult, while its 1b isoform in neonatal and regenerating fast-twitch skeletal muscle. To investigate the role of these isoforms in ischemic skeletal muscle, biopsies from musculus biceps femoris of patients who underwent amputation due to atherosclerosis were examined. Samples were removed from the visibly healthy and hypoxia-affected tissue. Significantly increased SERCA1a expression was detected under the ischemic conditions (246 ± 69%; p < 0.05) compared with the healthy tissue. Furthermore, the ratio of SERCA1a-positive fibers was slightly increased (46 ± 4% in healthy tissue and 60 ± 5% in ischemic tissue; p > 0.05), whereas SERCA2a did not change. In addition, in primary cultures derived from hypoxia-affected tissue, the diameter and fusion index of myotubes were significantly increased (30 ± 1.6 µm vs. 41 ± 2.4 µm and 31 ± 4% vs. 45 ± 3%; p < 0.05). We propose that the increased SERCA1a expression indicates the existence and location of compensating mechanisms in ischemic muscle.
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Reference Manager
BibTeX
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EndNote
-
1.
Blaisdell F : The pathophysiology of skeletal muscle ischaemia and the reperfusion syndrome: a review. Cardiovasc. Surg. 10, 620–630 (2002)
-
2.
Chaillou T , Koulmann N , Meunier A , Chapot R , Serrurier B , Beaudry M , Bigard X : Effect of hypoxia exposure on the recovery of skeletal muscle phenotype during regeneration. Mol. Cell. Biochem. 390(1 – 2), 31–40 (2014)
-
3.
Cseri K , Vincze J , Cseri J , Fodor J , Csernatony Z , Csernoch L , Danko K : HMGB1 expression and muscle regeneration in idiopathic inflammatory myopathies and degenerative joint diseases. J. Muscle Res. Cell Motil. 36(3), 255–262 (2015)
-
4.
Mounier R , Chretien F , Chazaud B : Blood vessels and the satellite cell niche. Curr. Top. Dev. Biol. 96, 121–138 (2011)
-
5.
Oláh T , Fodor J , Ruzsnavszky O , Vincze J , Berbey C , Allard B , Csernoch L : Overexpression of transient receptor potential canonical type 1 (TRPC1) alters both store operated calcium entry and depolarization-evoked calcium signals in C2C12 cells. Cell Calcium 49(6), 415–425 (2011)
-
6.
Periasamy M , Kalyanasundaram A : SERCA pump isoforms: their role in calcium transport and disease. Muscle Nerve 35(4), 430–442 (2007)
-
7.
Roos S , Fyhr IM , Sunnerhagen KS , Moslemi AR , Oldfors A , Ullman M : Histopathological changes in skeletal muscle associated with chronic ischaemia. APMIS 124(11), 935–941 (2016)
-
8.
Ruzsnavszky O , Telek A , Gönczi M , Balogh A , Remenyik E , Csernoch L : UV-B induced alteration in purinergic receptors and signaling on HaCaT keratinocytes. J. Photochem. Photobiol. B 105, 113–118 (2011)
-
9.
Shortt C , Fredsted A , Bradford A , O’Halloran K : Diaphragm muscle remodeling in a rat model of chronic intermittent hypoxia. J. Histochem. Cytochem. 61, 487–499 (2013)
-
10.
Szijártó A , Turóczi Z , Arányi P , Nagy Z , Gyurkovics E : Acute and critical ischaemia of the lower limb. Orv. Hetil. 151(50), 2057–2066 (2010)
-
11.
Szostak J , Laurant P : The forgotten face of regular physical exercise: a ‘natural’ anti atherogenic activity. Clin. Sci. (Lond.) 121, 91–106 (2011)
-
12.
Talukder M , Kalyanasundaram A , Zhao X , Zuo L , Bhupathy P , Babu G , Cardounel A , Periasamy M , Zweier J : Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 293, 2418–2428 (2007)
-
13.
Watanabe Y , Cohen RA , Matsui R : Redox regulation of ischemic angiogenesis – another aspect of reactive oxygen species. Circ. J. 80(6), 1278–1284 (2016)
-
14.
Zádor E , Kósa M : The neonatal sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA1b): a neglected pump in scope. Pflugers Arch. 467(7), 1395–1401 (2015)
-
15.
Zádor E , Vangheluwe P , Wuytack F : The expression of the neonatal sarcoplasmic reticulum Ca2+ pump (SERCA1b) hints to a role in muscle growth and development. Cell Calcium 41, 379–388 (2007)
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| 2021 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
330 |
| Journal Impact Factor | 1,697 |
| Rank by Impact Factor |
Physiology 73/81 |
| Impact Factor without Journal Self Cites |
1,697 |
| 5 Year Impact Factor |
1,806 |
| Journal Citation Indicator | 0,47 |
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Physiology 69/86 |
| Scimago | |
| Scimago H-index |
31 |
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0,32 |
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| Scopus | |
| Scopus Cite Score |
2,7 |
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Physiology (medical) 69/101 (Q3) |
| Scopus SNIP |
0,591 |
| 2020 | |
| Total Cites | 245 |
| WoS | |
| Journal Impact Factor |
2,090 |
| Rank by | Physiology 62/81 (Q4) |
| Impact Factor | |
| Impact Factor | 1,866 |
| without | |
| Journal Self Cites | |
| 5 Year | 1,703 |
| Impact Factor | |
| Journal | 0,51 |
| Citation Indicator | |
| Rank by Journal | Physiology 67/84 (Q4) |
| Citation Indicator | |
| Citable | 42 |
| Items | |
| Total | 42 |
| Articles | |
| Total | 0 |
| Reviews | |
| Scimago | 29 |
| H-index | |
| Scimago | 0,417 |
| Journal Rank | |
| Scimago | Physiology (medical) Q3 |
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| Scopus | 270/1140=1,9 |
| Scite Score | |
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| Scopus | 0,528 |
| SNIP | |
| Days from | 172 |
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| 2019 | |
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137 |
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1,361 |
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1,221 |
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0,294 |
| Citable Items |
34 |
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33 |
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1 |
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2,1 |
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9,3 |
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0,00028 |
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0,215 |
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97,06 |
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0,03445 |
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12,963 |
| Scimago H-index |
27 |
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0,267 |
| Scopus Scite Score |
235/157=1,5 |
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Physiology (medical) 73/99 (Q3) |
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0,38 |
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