Physiology International
Volume/Issue:
Volume 104: Issue 2
Alteration of sarcoplasmic reticulum Ca2+ ATPase expression in lower limb ischemia caused by atherosclerosis obliterans
Authors:
J Fodor Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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A Gomba-Tóth Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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T Oláh Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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E Zádor Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, Hungary

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Zs Cs Tóth Limb Surgery Ward, Kenézy Hospital and Outpatient Clinic, Debrecen, Hungary

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I Ioannis Limb Surgery Ward, Kenézy Hospital and Outpatient Clinic, Debrecen, Hungary

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B Molnár Limb Surgery Ward, Kenézy Hospital and Outpatient Clinic, Debrecen, Hungary

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I Kovács Pathology Department, Kenézy Hospital and Outpatient Clinic, Debrecen, Hungary

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L Csernoch Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Pages:
183–192
Online Publication Date:
21 Jun 2017
Publication Date:
01 Jun 2017
Article Category:
Research Article
DOI:
https://doi.org/10.1556/2060.104.2017.2.1
Keywords:
atherosclerosis; amputation; Ca2+; skeletal muscle; SERCA1
Restricted access

Atherosclerosis is a disease caused by a build-up of fatty plaques and cholesterol in the arteries. The lumen of the vessels is obliterated resulting in restricted blood supply to tissues. In ischemic conditions, the cytosolic Ca2+ level of skeletal muscle may increase, indicating the alteration of Ca2+ removal mechanisms. Ca2+ is transported from cytosol into the sarcoplasmic reticulum by Ca2+ ATPase (SERCA), with its 1a isoform expressed in adult, while its 1b isoform in neonatal and regenerating fast-twitch skeletal muscle. To investigate the role of these isoforms in ischemic skeletal muscle, biopsies from musculus biceps femoris of patients who underwent amputation due to atherosclerosis were examined. Samples were removed from the visibly healthy and hypoxia-affected tissue. Significantly increased SERCA1a expression was detected under the ischemic conditions (246 ± 69%; p < 0.05) compared with the healthy tissue. Furthermore, the ratio of SERCA1a-positive fibers was slightly increased (46 ± 4% in healthy tissue and 60 ± 5% in ischemic tissue; p > 0.05), whereas SERCA2a did not change. In addition, in primary cultures derived from hypoxia-affected tissue, the diameter and fusion index of myotubes were significantly increased (30 ± 1.6 µm vs. 41 ± 2.4 µm and 31 ± 4% vs. 45 ± 3%; p < 0.05). We propose that the increased SERCA1a expression indicates the existence and location of compensating mechanisms in ischemic muscle.

  • 1.

    Blaisdell F : The pathophysiology of skeletal muscle ischaemia and the reperfusion syndrome: a review. Cardiovasc. Surg. 10, 620–630 (2002)

  • 2.

    Chaillou T , Koulmann N , Meunier A , Chapot R , Serrurier B , Beaudry M , Bigard X : Effect of hypoxia exposure on the recovery of skeletal muscle phenotype during regeneration. Mol. Cell. Biochem. 390(1 – 2), 31–40 (2014)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Cseri K , Vincze J , Cseri J , Fodor J , Csernatony Z , Csernoch L , Danko K : HMGB1 expression and muscle regeneration in idiopathic inflammatory myopathies and degenerative joint diseases. J. Muscle Res. Cell Motil. 36(3), 255–262 (2015)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Mounier R , Chretien F , Chazaud B : Blood vessels and the satellite cell niche. Curr. Top. Dev. Biol. 96, 121–138 (2011)

  • 5.

    Oláh T , Fodor J , Ruzsnavszky O , Vincze J , Berbey C , Allard B , Csernoch L : Overexpression of transient receptor potential canonical type 1 (TRPC1) alters both store operated calcium entry and depolarization-evoked calcium signals in C2C12 cells. Cell Calcium 49(6), 415–425 (2011)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Periasamy M , Kalyanasundaram A : SERCA pump isoforms: their role in calcium transport and disease. Muscle Nerve 35(4), 430–442 (2007)

  • 7.

    Roos S , Fyhr IM , Sunnerhagen KS , Moslemi AR , Oldfors A , Ullman M : Histopathological changes in skeletal muscle associated with chronic ischaemia. APMIS 124(11), 935–941 (2016)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Ruzsnavszky O , Telek A , Gönczi M , Balogh A , Remenyik E , Csernoch L : UV-B induced alteration in purinergic receptors and signaling on HaCaT keratinocytes. J. Photochem. Photobiol. B 105, 113–118 (2011)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Shortt C , Fredsted A , Bradford A , O’Halloran K : Diaphragm muscle remodeling in a rat model of chronic intermittent hypoxia. J. Histochem. Cytochem. 61, 487–499 (2013)

    • Search Google Scholar
    • Export Citation
  • 10.

    Szijártó A , Turóczi Z , Arányi P , Nagy Z , Gyurkovics E : Acute and critical ischaemia of the lower limb. Orv. Hetil. 151(50), 2057–2066 (2010)

  • 11.

    Szostak J , Laurant P : The forgotten face of regular physical exercise: a ‘natural’ anti atherogenic activity. Clin. Sci. (Lond.) 121, 91–106 (2011)

    • Search Google Scholar
    • Export Citation
  • 12.

    Talukder M , Kalyanasundaram A , Zhao X , Zuo L , Bhupathy P , Babu G , Cardounel A , Periasamy M , Zweier J : Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 293, 2418–2428 (2007)

    • Search Google Scholar
    • Export Citation
  • 13.

    Watanabe Y , Cohen RA , Matsui R : Redox regulation of ischemic angiogenesis – another aspect of reactive oxygen species. Circ. J. 80(6), 1278–1284 (2016)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Zádor E , Kósa M : The neonatal sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA1b): a neglected pump in scope. Pflugers Arch. 467(7), 1395–1401 (2015)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Zádor E , Vangheluwe P , Wuytack F : The expression of the neonatal sarcoplasmic reticulum Ca2+ pump (SERCA1b) hints to a role in muscle growth and development. Cell Calcium 41, 379–388 (2007)

    • PubMed
    • Search Google Scholar
    • Export Citation
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Physiology International
Print ISSN:
2498-602X

Editor-in-Chief

László ROSIVALL (Semmelweis University, Budapest, Hungary)

Managing Editor

Anna BERHIDI (Semmelweis University, Budapest, Hungary)

Co-Editors

  • Gábor SZÉNÁSI (Semmelweis University, Budapest, Hungary)
  • Ákos KOLLER (Semmelweis University, Budapest, Hungary)
  • Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
  • László LÉNÁRD (University of Pécs, Hungary)
  • Zoltán UNGVÁRI (Semmelweis University, Budapest, Hungary)

Assistant Editors

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  • György NÁDASY (Semmelweis University, Budapest, Hungary)

Hungarian Editorial Board

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  • Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
  • Mihály BOROS (University of Szeged, Hungary)
  • László CSERNOCH (University of Debrecen, Hungary)
  • Magdolna DANK (Semmelweis University, Budapest, Hungary)
  • László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
  • Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
  • Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
  • Zoltán HEROLD (Semmelweis University, Budapest, Hungary) 
  • László HUNYADI (Semmelweis University, Budapest, Hungary)
  • Gábor JANCSÓ (University of Pécs, Hungary)
  • Zoltán KARÁDI (University of Pecs, Hungary)
  • Miklós PALKOVITS (Semmelweis University, Budapest, Hungary)
  • Gyula PAPP (University of Szeged, Hungary)
  • Gábor PAVLIK (University of Physical Education, Budapest, Hungary)
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  • Zoltán SZELÉNYI (University of Pécs, Hungary)
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  • József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
  • Árpád TÓSAKI (University of Debrecen, Hungary)

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  • Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
  • Andrej A. ROMANOVSKY (University of Arizona, USA)
  • Anwar Ali SIDDIQUI (Aga Khan University, Karachi, Pakistan)
  • Csaba SZABÓ (University of Fribourg, Switzerland)
  • Eric VICAUT (Université de Paris, UMRS 942 INSERM, France)

 

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Physiology International
Language English
Size B5
Year of
Foundation		 2006 (1950)
Volumes
per Year		 1
Issues
per Year		 4
Founder Magyar Tudományos Akadémia
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Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
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ISSN 2498-602X (Print)
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