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Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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Endoscopic & Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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Recent studies suggest that proinsulin-connecting peptide (C-peptide) may exhibit characteristics of a hormone and show physiological functions in various tissues. This study was aimed to determine whether C-peptide could be involved in the regulation of lipolysis, adiponectin release, and function of mesenchymal stem cells (MSCs) in adipose tissue. Human subcutaneous adipose tissue was cultured in the presence of C-peptide. The level of lipolysis was determined by glycerol measurement in the conditioned media. Effect of C-peptide on adiponectin secretion was evaluated in differentiated adipocytes. The adipogenic and osteogenic abilities of adipose MSCs were evaluated using oil red and alizarin red staining, respectively. The tetrazolium bromide test was conducted for evaluating the effect of C-peptide on MSCs proliferation. C-peptide induced a significant decrease in basal lipolysis at concentrations of 8 and 16 nM (p < 0.05). It had no significant effects on isoproterenol-stimulated lipolysis, adiponectin secretion, and adipogenic or osteogenic differentiation of MSCs. At a concentration of 4 nM, this peptide significantly increased the proliferative capability of MSCs (p < 0.05). These results suggest that C-peptide has some physiological effects in human subcutaneous adipose tissue and contributes to the regulation of basal lipolysis and pool of MSCs.
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Editor-in-Chief
László ROSIVALL (Semmelweis University, Budapest, Hungary)
Managing Editor
Anna BERHIDI (Semmelweis University, Budapest, Hungary)
Co-Editors
- Gábor SZÉNÁSI (Semmelweis University, Budapest, Hungary)
- Ákos KOLLER (Semmelweis University, Budapest, Hungary)
- Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
- László LÉNÁRD (University of Pécs, Hungary)
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Assistant Editors
- Gabriella DÖRNYEI (Semmelweis University, Budapest, Hungary)
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Hungarian Editorial Board
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- Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
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- Magdolna DANK (Semmelweis University, Budapest, Hungary)
- László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
- Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
- Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
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- László HUNYADI (Semmelweis University, Budapest, Hungary)
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- Gyula PAPP (University of Szeged, Hungary)
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- WoS - Science Citation Index Expanded
| 2022 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
335 |
| Journal Impact Factor | 1.4 |
| Rank by Impact Factor |
Physiology (Q4) |
| Impact Factor without Journal Self Cites |
1.4 |
| 5 Year Impact Factor |
1.6 |
| Journal Citation Indicator | 0.42 |
| Rank by Journal Citation Indicator |
Physiology (Q4) |
| Scimago | |
| Scimago H-index |
33 |
| Scimago Journal Rank |
0.362 |
| Scimago Quartile Score |
Physiology (medical) (Q3) |
| Scopus | |
| Scopus Cite Score |
2.8 |
| Scopus CIte Score Rank |
Physiology 68/102 (33rd PCTL) |
| Scopus SNIP |
0.508 |
| 2021 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
330 |
| Journal Impact Factor | 1,697 |
| Rank by Impact Factor |
Physiology 73/81 |
| Impact Factor without Journal Self Cites |
1,697 |
| 5 Year Impact Factor |
1,806 |
| Journal Citation Indicator | 0,47 |
| Rank by Journal Citation Indicator |
Physiology 69/86 |
| Scimago | |
| Scimago H-index |
31 |
| Scimago Journal Rank |
0,32 |
| Scimago Quartile Score | Medicine (miscellaneous) (Q3) Physiology (medical) (Q3) |
| Scopus | |
| Scopus Cite Score |
2,7 |
| Scopus CIte Score Rank |
Physiology (medical) 69/101 (Q3) |
| Scopus SNIP |
0,591 |
| 2020 | |
| Total Cites | 245 |
| WoS | |
| Journal Impact Factor |
2,090 |
| Rank by | Physiology 62/81 (Q4) |
| Impact Factor | |
| Impact Factor | 1,866 |
| without | |
| Journal Self Cites | |
| 5 Year | 1,703 |
| Impact Factor | |
| Journal | 0,51 |
| Citation Indicator | |
| Rank by Journal | Physiology 67/84 (Q4) |
| Citation Indicator | |
| Citable | 42 |
| Items | |
| Total | 42 |
| Articles | |
| Total | 0 |
| Reviews | |
| Scimago | 29 |
| H-index | |
| Scimago | 0,417 |
| Journal Rank | |
| Scimago | Physiology (medical) Q3 |
| Quartile Score | |
| Scopus | 270/1140=1,9 |
| Scite Score | |
| Scopus | Physiology (medical) 71/98 (Q3) |
| Scite Score Rank | |
| Scopus | 0,528 |
| SNIP | |
| Days from | 172 |
| submission | |
| to acceptance | |
| Days from | 106 |
| acceptance | |
| to publication |
| 2019 | |
|---|---|
| Total Cites WoS |
137 |
| Impact Factor | 1,410 |
| Impact Factor without Journal Self Cites |
1,361 |
| 5 Year Impact Factor |
1,221 |
| Immediacy Index |
0,294 |
| Citable Items |
34 |
| Total Articles |
33 |
| Total Reviews |
1 |
| Cited Half-Life |
2,1 |
| Citing Half-Life |
9,3 |
| Eigenfactor Score |
0,00028 |
| Article Influence Score |
0,215 |
| % Articles in Citable Items |
97,06 |
| Normalized Eigenfactor |
0,03445 |
| Average IF Percentile |
12,963 |
| Scimago H-index |
27 |
| Scimago Journal Rank |
0,267 |
| Scopus Scite Score |
235/157=1,5 |
| Scopus Scite Score Rank |
Physiology (medical) 73/99 (Q3) |
| Scopus SNIP |
0,38 |
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| Physiology International | |
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| Language | English |
| Size | B5 |
| Year of Foundation |
2006 (1950) |
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1 |
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4 |
| Founder | Magyar Tudományos Akadémia |
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