Search for other papers by B Borda in
Current site
Google Scholar
PubMed
Search for other papers by T Németh in
Current site
Google Scholar
PubMed
Search for other papers by A Ottlakan in
Current site
Google Scholar
PubMed
Search for other papers by C Keresztes in
Current site
Google Scholar
PubMed
Search for other papers by É Kemény in
Current site
Google Scholar
PubMed
Search for other papers by G Lázár in
Current site
Google Scholar
PubMed
Introduction
Despite an increase in the number of cadaver donors and overall organ transplantations, the dramatic increase in the waiting list makes it necessary to reconsider donor criteria. The authors wanted to examine whether differences could exist in the function and/or morphology of transplanted kidneys originated from expanded criteria donors (ECDs) and ideal donors 1 and 5 years after transplantation.
Methods
Kidney function and histopathologic findings were analyzed and compared 1 and 5 years after transplantation in 97 patients having ECD kidneys and in 178 patients who received ideal donor kidneys (IDK).
Results
Serum creatinine level was significantly higher (p = 0.001) and estimated glomerular filtration rate was significantly lower (p = 0.003) in patients having ECD kidneys as compared with those with IDK 5 years after transplantation. Morphological changes in the transplanted kidneys, such as tubulitis (p = 0.025) and interstitial inflammation (p = 0.002), were significantly more frequently present in patients with ECD kidneys than in those with IDK 1 year after transplantation.
Conclusion
Despite an absence of differences in kidney function 1 year after kidney transplantation between patients having ECD and IDK, morphological differences in the transplanted kidneys can be detected between the two groups of patients.
-
1.
Baskin-Bey ES , Kremers W , Nyberg SL : Improving utilization of deceased donor kidneys by matching recipient and graft survival. Transplantation 82, 10–14 (2006)
-
2.
Borda B , Szederkényi E , Szenohradszky P , Kemény É , Marofka F , Keresztes C , Lázár G : Functional and morphological changes in kidneys from marginal donors. Transplant. Proc. 44, 2139–2142 (2012)
-
3.
Fehrman-Ekholm I , Dunér F , Brink B , Tydén G , Elinder CG : No evidence of accelerated loss of kidney function in living kidney donors: results from a cross-sectional follow-up. Transplantation 72, 444–449 (2001)
-
4.
Gopalakrishnan G , Gourabathini SP : Expanded criteria donors kidney donor. Indian J. Urol. 23, 286–293 (2007)
-
5.
Loupy A , Haas M , Solez K , Racusen L , Glotz D , Seron D , Nankivell BJ , Colvin RB , Afrouzian M , Akalin E , Alachkar N , Bagnasco S , Becker JU , Cornell L , Drachenberg C , Dragun D , de Kort H , Gibson IW , Kraus ES , Lefaucheur C , Legendre C , Liapis H , Muthukumar T , Nickeleit V , Orandi B , Park W , Rabant M , Randhawa P , Reed EF , Roufosse C , Seshan SV , Sis B , Singh HK , Schinstock C , Tambur A , Zeevi A , Mengel M : The Banff 2015 kidney meeting report: current challenges in rejection classification and prospects for adopting molecular pathology. Am. J. Transplant. 17, 28–41 (2017)
-
6.
Mengel M , Gwinner W , Schwarz A , Bajeski R , Franz I , Bröcker V , Becker T , Neipp M , Klempnauer J , Haller H , Kreipe H : Infiltrates in protocol biopsies from renal allografts. Am. J. Transplant. 7, 356–365 (2007)
-
7.
Mor E , Michowiz R , Ashkenazi T , Shabtai E , Nakache R , Eid A , Hoffman A , Mizrahi S , Shabtai M , Shapira Z : Extension of the organ pool in kidney transplantation: first year experience of the Israel Transplant Center. Isr. Med. Assoc. J. 2, 302–305 (2000)
-
8.
Ojo AO , Hanson JA , Meier-Kriesche HU , Okechukwu CN , Wolfe RA , Leichtman AB , Agodoa LY , Kaplan B , Port FK : Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J. Am. Soc. Nephrol. 12, 589–597 (2001)
-
9.
Persson MO , Persson NH , Källén R , Ekberg H , Hermerén G : Kidneys from marginal donors: Views of patients on informed consent. Nephrol. Dial. Transplant. 17, 1497–1502 (2002)
-
10.
Pokorná E , Vítko S , Chadimová M , Schück O , Ekberg H : Proportion of glomerulosclerosis in procurement wedge renal biopsy cannot alone discriminate for acceptance of marginal donors. Transplantation 69, 36–43 (2000)
-
11.
Racusen LC , Halloran PF , Solez K : Banff 2003 meeting report: new diagnostic insights and standards. Am. J. Transplant. 4, 1562–1566 (2004)
-
12.
Remuzzi G , Cravedi P , Perna A , Dimitrov BD , Turturro M , Locatelli G , Rigotti P , Baldan N , Beatini M , Valente U , Scalamogna M , Ruggenenti P , Dual Kidney Transplant Group: Long-term outcome of renal transplantation from older donors. N. Engl. J. Med. 354, 343–352 (2006)
-
13.
Sanchez-Fructuoso AI , Prats D , Torrente J , Pérez-Contín MJ , Fernández C , Alvarez J , Barrientos A: Renal transplantation from non-heart beating donors: a promising alternative to enlarge the donor pool. J. Am. Soc. Nephrol. 11, 350–358 (2000)
-
14.
Satayathum S , Pisoni RL , McCullough KP , Merion RM , Wikström B , Levin N , Chen K , Wolfe RA , Goodkin DA , Piera L , Asano Y , Kurokawa K , Fukuhara S , Held PJ , Port FK : Kidney transplantation and wait-listing rates from the international Dialysis Outcomes and Practice Patterns Study (DOPPS). Kidney Int. 68, 330–337 (2005)
-
15.
Textor SC , Taler SJ , Driscoll N , Larson TS , Gloor J , Griffin M , Cosio F , Schwab T , Prieto M , Nyberg S , Ishitani M , Stegall M : Blood pressure and renal function after kidney donation from hypertensive living donors. Transplantation 78, 276–282 (2004)
-
16.
Toma H , Tanabe K , Tokumoto T , Shimizu T , Shimmura H : Time-dependent risk factors influencing the long-term outcome in living renal allografts: donor age is a crucial risk factor for long-term graft survival more than 5 years after transplantation. Transplantation 72, 940–947 (2001)
-
17.
Whiting JF , Zavala EY , Alexander JW , First MR : The cost-effectiveness of transplantation with expanded donor kidneys. Transplant. Proc. 31, 1320–1321 (1999)
-
18.
Wolfe RA , Ashby VB , Milford EL , Ojo AO , Ettenger RE , Agodoa LY , Held PJ , Port FK : Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N. Engl. J. Med. 341, 1725–1730 (1999)
Editor-in-Chief
László ROSIVALL (Semmelweis University, Budapest, Hungary)
Managing Editor
Anna BERHIDI (Semmelweis University, Budapest, Hungary)
Co-Editors
- Gábor SZÉNÁSI (Semmelweis University, Budapest, Hungary)
- Ákos KOLLER (Semmelweis University, Budapest, Hungary)
- Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
- László LÉNÁRD (University of Pécs, Hungary)
- Zoltán UNGVÁRI (Semmelweis University, Budapest, Hungary)
Assistant Editors
- Gabriella DÖRNYEI (Semmelweis University, Budapest, Hungary)
- Zsuzsanna MIKLÓS (Semmelweis University, Budapest, Hungary)
- György NÁDASY (Semmelweis University, Budapest, Hungary)
Hungarian Editorial Board
- György BENEDEK (University of Szeged, Hungary)
- Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
- Mihály BOROS (University of Szeged, Hungary)
- László CSERNOCH (University of Debrecen, Hungary)
- Magdolna DANK (Semmelweis University, Budapest, Hungary)
- László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
- Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
- Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
- Zoltán HEROLD (Semmelweis University, Budapest, Hungary)
- László HUNYADI (Semmelweis University, Budapest, Hungary)
- Gábor JANCSÓ (University of Pécs, Hungary)
- Zoltán KARÁDI (University of Pecs, Hungary)
- Miklós PALKOVITS (Semmelweis University, Budapest, Hungary)
- Gyula PAPP (University of Szeged, Hungary)
- Gábor PAVLIK (University of Physical Education, Budapest, Hungary)
- András SPÄT (Semmelweis University, Budapest, Hungary)
- Gyula SZABÓ (University of Szeged, Hungary)
- Zoltán SZELÉNYI (University of Pécs, Hungary)
- Lajos SZOLLÁR (Semmelweis University, Budapest, Hungary)
- József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
- Árpád TÓSAKI (University of Debrecen, Hungary)
International Editorial Board
- Dragan DJURIC (University of Belgrade, Serbia)
- Christopher H. FRY (University of Bristol, UK)
- Stephen E. GREENWALD (Blizard Institute, Barts and Queen Mary University of London, UK)
- Tibor HORTOBÁGYI (University of Groningen, Netherlands)
- George KUNOS (National Institutes of Health, Bethesda, USA)
- Massoud MAHMOUDIAN (Iran University of Medical Sciences, Tehran, Iran)
- Tadaaki MANO (Gifu University of Medical Science, Japan)
- Luis Gabriel NAVAR (Tulane University School of Medicine, New Orleans, USA)
- Hitoo NISHINO (Nagoya City University, Japan)
- Ole H. PETERSEN (Cardiff University, UK)
- Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
- Andrej A. ROMANOVSKY (University of Arizona, USA)
- Anwar Ali SIDDIQUI (Aga Khan University, Karachi, Pakistan)
- Csaba SZABÓ (University of Fribourg, Switzerland)
- Eric VICAUT (Université de Paris, UMRS 942 INSERM, France)
Editorial Correspondence:
Physiology International
Semmelweis University
Faculty of Medicine, Institute of Translational Medicine
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: pi@semmelweis.hu
Indexing and Abstracting Services:
- Biological Abstracts
- BIOSIS Previews
- CAB Abstracts
- CABELLS Journalytics
- EMBASE/Excerpta Medica
- Global Health
- Index Copernicus
- Index Medicus
- Medline
- Referativnyi Zhurnal
- SCOPUS
- WoS - Science Citation Index Expanded
| 2023 | |
|---|---|
| Web of Science | |
| Journal Impact Factor | 2.2 |
| Rank by Impact Factor | Q3 (Physiology) |
| Journal Citation Indicator | 0.58 |
| Scopus | |
| CiteScore | 3.4 |
| CiteScore rank | Q2 (Physical Therapy, Sports Therapy and Rehabilitation) |
| SNIP | 0.508 |
| Scimago | |
| SJR index | 0.407 |
| SJR Q rank | Q2 |
| Physiology International | |
|---|---|
| Publication Model | Hybrid |
| Submission Fee | none |
| Article Processing Charge | 1100 EUR/article |
| Printed Color Illustrations | 40 EUR (or 10 000 HUF) + VAT / piece |
| Regional discounts on country of the funding agency | World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100% |
| Further Discounts | Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100% |
| Subscription fee 2025 | Online subsscription: 752 EUR / 828 USD Print + online subscription: 880 EUR / 968 USD |
| Subscription Information | Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content. |
| Purchase per Title | Individual articles are sold on the displayed price. |
| Physiology International | |
|---|---|
| Language | English |
| Size | B5 |
| Year of Foundation |
2006 (1950) |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Magyar Tudományos Akadémia |
| Founder's Address |
H-1051 Budapest, Hungary, Széchenyi István tér 9. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 2498-602X (Print) |
| ISSN | 2677-0164 (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Sep 2024 | 24 | 0 | 0 |
| Oct 2024 | 63 | 0 | 0 |
| Nov 2024 | 51 | 0 | 0 |
| Dec 2024 | 32 | 0 | 0 |
| Jan 2025 | 44 | 0 | 0 |
| Feb 2025 | 43 | 0 | 0 |
| Mar 2025 | 20 | 0 | 0 |
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.