Authors:
SB Zanjani Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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L Chodari Department of Physiology, Urmia University of Medical Sciences, Urmia, Iran
Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran

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FM Bavil Laboratory of Physiology, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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P Sadeghzadeh Laboratory of Physiology, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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P Shahabi Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Laboratory of Physiology, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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Objectives

Impaired angiogenesis in sciatic nerve is a major complication of diabetic neuropathy. Protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling pathways play critical roles during capillary-like network formation in the angiogenesis process.

Methods

Twenty-four adult male Wistar rats (weight: 250–300 g) were used in the research. The rats were randomly divided into four groups (n = 6): (1) diabetic (Dia), (2) diabetic + castration (Dia-Cas), (3) diabetic + exercise (Dia-E), and (4) diabetic + castration + exercise (Dia-Cas-E). Type 1 diabetes (T1D) was induced with streptozotocin (50 mg/kg). After 6 weeks, sciatic nerve was separated and used for histological evaluation and determination of phosphorylated AKT (P-AKT) and phosphorylated ERK (P-ERK) levels by ELISA method.

Results

Glucose levels decreased in the Dia-E group compared to the Dia-Cas group (p < 0.01). In addition, our finding shows that exercise in the Dia-Cas group diminished blood glucose levels compared to the Dia-Cas group but this effect of exercise was not significant. Voluntary exercise in the diabetic castrated group decreased P-AKT protein and increased P-ERK 1/2 protein levels in the sciatic tissue compared to the diabetes group significantly (p < 0.05). Histopathological findings showed that Dia-Cas group with 6-week exercise training significantly raised the number of microvascular density in the sciatic tissue of diabetic rats compared to the diabetic group (p < 0.05).

Conclusions

Voluntary exercise in diabetic rats increases angiogenesis in the sciatic nerve. The possible mechanism is the increase of P-ERK 1/2 but not P-AKT levels in the sciatic nerve of T1D rats.

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Editor-in-Chief

László ROSIVALL (Semmelweis University, Budapest, Hungary)

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Anna BERHIDI (Semmelweis University, Budapest, Hungary)

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  • Ákos KOLLER (Semmelweis University, Budapest, Hungary)
  • Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
  • László LÉNÁRD (University of Pécs, Hungary)
  • Zoltán UNGVÁRI (Semmelweis University, Budapest, Hungary)

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  • Zsuzsanna MIKLÓS (Semmelweis University, Budapest, Hungary)
  • György NÁDASY (Semmelweis University, Budapest, Hungary)

Hungarian Editorial Board

  • György BENEDEK (University of Szeged, Hungary)
  • Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
  • Mihály BOROS (University of Szeged, Hungary)
  • László CSERNOCH (University of Debrecen, Hungary)
  • Magdolna DANK (Semmelweis University, Budapest, Hungary)
  • László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
  • Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
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  • Gyula PAPP (University of Szeged, Hungary)
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  • Gyula SZABÓ (University of Szeged, Hungary)
  • Zoltán SZELÉNYI (University of Pécs, Hungary)
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  • Gyula TELEGDY (MTA-SZTE, Neuroscience Research Group and University of Szeged, Hungary)
  • József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
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  • Tadaaki MANO (Gifu University of Medical Science, Japan)
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  • Hitoo NISHINO (Nagoya City University, Japan)
  • Ole H. PETERSEN (Cardiff University, UK)
  • Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
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  • Anwar Ali SIDDIQUI (Aga Khan University, Karachi, Pakistan)
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2022  
Web of Science  
Total Cites
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335
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Physiology (Q4)

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2021  
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Total Cites
WoS
330
Journal Impact Factor 1,697
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Physiology 73/81

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5 Year
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1,806
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0,591

 

2020  
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Scimago 29
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Scopus 270/1140=1,9
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Scopus Physiology (medical) 71/98 (Q3)
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Scopus 0,528
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2019  
Total Cites
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137
Impact Factor 1,410
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1,361
5 Year
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1,221
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0,294
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34
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33
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1
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9,3
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0,00028
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0,215
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97,06
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0,03445
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12,963
Scimago
H-index
27
Scimago
Journal Rank
0,267
Scopus
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235/157=1,5
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Physiology (medical) 73/99 (Q3)
Scopus
SNIP
0,38

 

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Physiology International
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