Authors:
F Strube Department of Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke-University, Magdeburg, Germany

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M Infanger Department of Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke-University, Magdeburg, Germany

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C Dietz Department of Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke-University, Magdeburg, Germany

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A Romswinkel Department of Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke-University, Magdeburg, Germany

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A Kraus Department of Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke-University, Magdeburg, Germany

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Introduction

Microgravity has been shown to impose various effects on breast cancer cells. We exposed human breast cancer cells to simulated microgravity and studied morphology and alterations in gene expression.

Materials and methods

Human breast cancer cells were exposed to simulated microgravity in a random positioning machine (RPM) for 24 h. Morphology was observed under light microscopy, and gene alteration was studied by qPCR.

Results

After 24 h, formation of three-dimensional structures (spheroids) occurred. BRCA1 expression was significantly increased (1.9×, p < 0.05) in the adherent cells under simulated microgravity compared to the control. Expression of KRAS was significantly decreased (0.6×, p < 0.05) in the adherent cells compared to the control. VCAM1 was significantly upregulated (6.6×, 2.0×, p < 0.05 each) in the adherent cells under simulated microgravity and in the spheroids. VIM expression was significantly downregulated (0.45×, 0.44×, p < 0.05 each) in the adherent cells under simulated microgravity and in the spheroids. There was no significant alteration in the expression of MAPK1, MMP13, PTEN, and TP53.

Conclusions

Simulated microgravity induces spheroid formation in human breast cancer cells within 24 h and alters gene expression toward modified adhesion properties, enhanced cell repair, and phenotype preservation. Further insights into the underlying mechanisms could open up the way toward new therapies.

  • 1.

    Aleshcheva G , Sahana J , Ma X , Hauslage J , Hemmersbach R , Egli M , Infanger M , Bauer J , Grimm D : Changes in morphology, gene expression and protein content in chondrocytes cultured on a random positioning machine. PLoS One 8, e79057 (2013)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2.

    Aleshcheva G , Wehland M , Sahana J , Bauer J , Corydon TJ , Hemmersbach R , Frett T , Egli M , Infanger M , Grosse J , Grimm D : Moderate alterations of the cytoskeleton in human chondrocytes after short-term microgravity produced by parabolic flight maneuvers could be prevented by up-regulation of BMP-2 and SOX-9. FASEB J. 29, 23032314 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Arizti P , Fang L , Park I , Yin Y , Solomon E , Ouchi T , Aaronson SA , Lee SW : Tumor suppressor p53 is required to modulate BRCA1 expression. Mol. Cell. Biol. 20, 74507459 (2000)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Blaber EA , Finkelstein H , Dvorochkin N , Sato KY , Yousuf R , Burns BP , Globus RK , Almeida EA : Microgravity reduces the differentiation and regenerative potential of embryonic stem cells. Stem Cells Dev. 24, 26052621 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Boulton SJ : Cellular functions of the BRCA tumour-suppressor proteins. Biochem. Soc. Trans. 34, 633645 (2006)

  • 6.

    Chen ZY , Guo S , Li BB , Jiang N , Li A , Yan HF , Yang HM , Zhou JL , Li CL , Cui Y : Effect of weightlessness on the 3D structure formation and physiologic function of human cancer cells. Biomed. Res. Int. 2019, 4894083 (2019)

    • Search Google Scholar
    • Export Citation
  • 7.

    Easton D , Ford D , Peto J : Inherited susceptibility to breast cancer. Cancer Surv. 18, 95113 (1993)

  • 8.

    Feger BJ , Thompson JW , Dubois LG , Kommaddi RP , Foster MW , Mishra R , Shenoy SK , Shibata Y , Kidane YH , Moseley MA , Carnell LS , Bowles DE : Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection. Sci. Rep. 6, 34091 (2016)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 9.

    Froehlich K , Haeger JD , Heger J , Pastuschek J , Photini SM , Yan Y , Lupp A , Pfarrer C , Mrowka R , Schleussner E , Markert UR , Schmidt A : Generation of multicellular breast cancer tumor spheroids: comparison of different protocols. J. Mammary Gland Biol. Neoplasia. 21, 8998 (2016)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10.

    Grimm D , Infanger M , Westphal K , Ulbrich C , Pietsch J , Kossmehl P , Vadrucci S , Baatout S , Flick B , Paul M , Bauer J : A delayed type of three-dimensional growth of human endothelial cells under simulated weightlessness. Tissue Eng. Part A 15, 22672275 (2009)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Hada M , Ikeda H , Rhone JR , Beitman AJ , Plante I , Souda H , Yoshida Y , Held KD , Fujiwara K , Saganti PB , Takahashi A : Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation. Int. J. Mol. Sci. 20, 43 (2018)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12.

    Hendrix A , Hume AN : Exosome signaling in mammary gland development and cancer. Int. J. Dev. Biol. 55, 879887 (2011)

  • 13.

    Huang B , Liu N , Rong X , Ruan J , Huang Y : Effects of simulated microgravity and spaceflight on morphological differentiation and secondary metabolism of Streptomyces coelicolor A3(2). Appl. Microbiol. Biotechnol. 99, 44094422 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14.

    Jancik S , Drabek J , Radzioch D , Hajduch M : Clinical relevance of KRAS in human cancers. J. Biomed. Biotechnol. 2010, 150960 (2010)

  • 15.

    Kokkinos MI , Wafai R , Wong MK , Newgreen DF , Thompson EW , Waltham M : Vimentin and epithelial-mesenchymal transition in human breast cancer – observations in vitro and in vivo. Cells Tissues Organs. 185, 191203 (2007)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16.

    Kopp S , Slumstrup L , Corydon TJ , Sahana J , Aleshcheva G , Islam T , Magnusson NE , Wehland M , Bauer J , Infanger M , Grimm D : Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the random positioning machine. Sci. Rep. 6, 26887 (2016)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17.

    Kraus A , Luetzenberg R , Abuagela N , Hollenberg S , Infanger M : Spheroid formation and modulation of tenocyte-specific gene expression under simulated microgravity. Muscles Ligaments Tendons J. 7, 411417 (2018)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 18.

    Kruger M , Melnik D , Kopp S , Buken C , Sahana J , Bauer J , Wehland M , Hemmersbach R , Corydon TJ , Infanger M , Grimm D : Fighting thyroid cancer with microgravity research. Int. J. Mol. Sci. 20, 2553 (2019)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 19.

    Lane DP : Cancer. p53, guardian of the genome. Nature 358, 1516 (1992)

  • 20.

    Li J , Yen C , Liaw D , Podsypanina K , Bose S , Wang SI , Puc J , Miliaresis C , Rodgers L , McCombie R , Bigner SH , Giovanella BC , Ittmann M , Tycko B , Hibshoosh H , Wigler MH , Parsons R : PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275, 19431947 (1997)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21.

    Li J , Zhang S , Chen J , Du T , Wang Y , Wang Z : Modeled microgravity causes changes in the cytoskeleton and focal adhesions, and decreases in migration in malignant human MCF-7 cells. Protoplasma 238, 2333 (2009)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 22.

    Li N , An L , Hang H : Increased sensitivity of DNA damage response-deficient cells to stimulated microgravity-induced DNA lesions. PLoS One 10, e0125236 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 23.

    Louis F , Deroanne C , Nusgens B , Vico L , Guignandon A : RhoGTPases as key players in mammalian cell adaptation to microgravity. Biomed. Res. Int. 2015, 747693 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 24.

    Martinez EM , Yoshida MC , Candelario TL , Hughes-Fulford M : Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 308, R480R488 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 25.

    McCaffrey LM , Macara IG : Epithelial organization, cell polarity and tumorigenesis. Trends Cell Biol. 21, 727735 (2011)

  • 26.

    McCormick F : KRAS as a therapeutic target. Clin. Cancer Res. 21, 17971801 (2015)

  • 27.

    Nan X , Tamguney TM , Collisson EA , Lin LJ , Pitt C , Galeas J , Lewis S , Gray JW , McCormick F , Chu S : Ras-GTP dimers activate the mitogen-activated protein kinase (MAPK) pathway. Proc. Natl. Acad. Sci. U. S. A. 112, 79968001 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 28.

    Qian A , Zhang W , Li X , Weng Y , Tian Z , Di S , Yang P , Yin D , Hu L , Xu Z , Shang P : Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF. Acta Astronaut. 63, 947958 (2008)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 29.

    Riboh J , Chong AK , Pham H , Longaker M , Jacobs C , Chang J : Optimization of flexor tendon tissue engineering with a cyclic strain bioreactor. J. Hand Surg. Am. 33, 13881396 (2008)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 30.

    Sanchez-Vega F , Mina M , Armenia J , Chatila WK , Luna A , La KC , Dimitriadoy S , Liu DL , Kantheti HS , Saghafinia S , Chakravarty D , Daian F , Gao Q , Bailey MH , Liang WW , Foltz SM , Shmulevich I , Ding L , Heins Z , Ochoa A , Gross B , Gao J , Zhang H , Kundra R , Kandoth C , Bahceci I , Dervishi L , Dogrusoz U , Zhou W , Shen H , Laird PW , Way GP , Greene CS , Liang H , Xiao Y , Wang C , Iavarone A , Berger AH , Bivona TG , Lazar AJ , Hammer GD , Giordano T , Kwong LN , McArthur G , Huang C , Tward AD , Frederick MJ , McCormick F , Meyerson M , Cancer Genome Atlas Research N , Van Allen EM , Cherniack AD , Ciriello G , Sander C , Schultz N : Oncogenic signaling pathways in the cancer genome atlas. Cell 173, 32137.e10 (2018)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 31.

    Satelli A , Li S : Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell. Mol. Life Sci. 68, 30333046 (2011)

  • 32.

    Schmit K , Michiels C : TMEM proteins in cancer: a review. Front. Pharmacol. 9, 1345 (2018)

  • 33.

    Shah M , Huang D , Blick T , Connor A , Reiter LA , Hardink JR , Lynch CC , Waltham M , Thompson EW : An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer. PLoS One 7, e29615 (2012)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 34.

    Sharma R , Sharma R , Khaket TP , Dutta C , Chakraborty B , Mukherjee TK : Breast cancer metastasis: putative therapeutic role of vascular cell adhesion molecule-1. Cell. Oncol. (Dordr.). 40, 199208 (2017)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 35.

    Shi ZX , Rao W , Wang H , Wang ND , Si JW , Zhao J , Li JC , Wang ZR : Modeled microgravity suppressed invasion and migration of human glioblastoma U87 cells through downregulating store-operated calcium entry. Biochem. Biophys. Res. Commun. 457, 378384 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 36.

    Takeda M , Magaki T , Okazaki T , Kawahara Y , Manabe T , Yuge L , Kurisu K : Effects of simulated microgravity on proliferation and chemosensitivity in malignant glioma cells. Neurosci. Lett. 463, 5459 (2009)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 37.

    Tan X , Xu A , Zhao T , Zhao Q , Zhang J , Fan C , Deng Y , Freywald A , Genth H , Xiang J : Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways. Sci. Rep. 8, 3769 (2018)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 38.

    Taneja P , Maglic D , Kai F , Zhu S , Kendig RD , Fry EA , Inoue K : Classical and novel prognostic markers for breast cancer and their clinical significance. Clin. Med. Insights Oncol. 4, 1534 (2010)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 39.

    Venkitaraman AR : Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108, 171182 (2002)

  • 40.

    Vorselen D , Roos WH , MacKintosh FC , Wuite GJ , van Loon JJ : The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells. FASEB J. 28, 536547 (2014)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 41.

    Warnke E , Pietsch J , Wehland M , Bauer J , Infanger M , Gorog M , Hemmersbach R , Braun M , Ma X , Sahana J , Grimm D : Spheroid formation of human thyroid cancer cells under simulated microgravity: a possible role of CTGF and CAV1. Cell Commun. Signal. 12, 32 (2014)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 42.

    Weigelt B , Ghajar CM , Bissell MJ : The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer. Adv. Drug Deliv. Rev. 69–70, 4251 (2014)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 43.

    Wuest SL , Richard S , Kopp S , Grimm D , Egli M : Simulated microgravity: critical review on the use of random positioning machines for mammalian cell culture. Biomed. Res. Int. 2015, 971474 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 44.

    Yin Y , Shen WH : PTEN: a new guardian of the genome. Oncogene 27, 54435453 (2008)

  • 45.

    Yu XQ , De Angelis R , Luo Q , Kahn C , Houssami N , O’Connell DL : A population-based study of breast cancer prevalence in Australia: predicting the future health care needs of women living with breast cancer. BMC Cancer 14, 936 (2014)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 46.

    Zhang Z , Jiang G , Yang F , Wang J : Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells. Cancer Biol. Ther. 5, 14811486 (2006)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 47.

    Zheng H , Tian W , Yan H , Jiang H , Liu S , Yue L , Han F , Wei L , Chen X , Li Y : Expression of estrogen receptor α in human breast cancer cells regulates mitochondrial oxidative stress under simulated microgravity. Adv. Space Res. 49, 14321440 (2012)

    • Crossref
    • Search Google Scholar
    • Export Citation
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Editor-in-Chief

László ROSIVALL (Semmelweis University, Budapest, Hungary)

Managing Editor

Anna BERHIDI (Semmelweis University, Budapest, Hungary)

Co-Editors

  • Gábor SZÉNÁSI (Semmelweis University, Budapest, Hungary)
  • Ákos KOLLER (Semmelweis University, Budapest, Hungary)
  • Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
  • László LÉNÁRD (University of Pécs, Hungary)
  • Zoltán UNGVÁRI (Semmelweis University, Budapest, Hungary)

Assistant Editors

  • Gabriella DÖRNYEI (Semmelweis University, Budapest, Hungary)
  • Zsuzsanna MIKLÓS (Semmelweis University, Budapest, Hungary)
  • György NÁDASY (Semmelweis University, Budapest, Hungary)

Hungarian Editorial Board

  • György BENEDEK (University of Szeged, Hungary)
  • Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
  • Mihály BOROS (University of Szeged, Hungary)
  • László CSERNOCH (University of Debrecen, Hungary)
  • Magdolna DANK (Semmelweis University, Budapest, Hungary)
  • László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
  • Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
  • Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
  • László HUNYADI (Semmelweis University, Budapest, Hungary)
  • Gábor JANCSÓ (University of Pécs, Hungary)
  • Zoltán KARÁDI (University of Pecs, Hungary)
  • Miklós PALKOVITS (Semmelweis University, Budapest, Hungary)
  • Gyula PAPP (University of Szeged, Hungary)
  • Gábor PAVLIK (University of Physical Education, Budapest, Hungary)
  • András SPÄT (Semmelweis University, Budapest, Hungary)
  • Gyula SZABÓ (University of Szeged, Hungary)
  • Zoltán SZELÉNYI (University of Pécs, Hungary)
  • Lajos SZOLLÁR (Semmelweis University, Budapest, Hungary)
  • Gyula TELEGDY (MTA-SZTE, Neuroscience Research Group and University of Szeged, Hungary)
  • József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
  • Árpád TÓSAKI (University of Debrecen, Hungary)

International Editorial Board

  • Dragan DJURIC (University of Belgrade, Serbia)
  • Christopher H.  FRY (University of Bristol, UK)
  • Stephen E. GREENWALD (Blizard Institute, Barts and Queen Mary University of London, UK)
  • Osmo Otto Päiviö HÄNNINEN (Finnish Institute for Health and Welfare, Kuopio, Finland)
  • Helmut G. HINGHOFER-SZALKAY (Medical University of Graz, Austria)
  • Tibor HORTOBÁGYI (University of Groningen, Netherlands)
  • George KUNOS (National Institutes of Health, Bethesda, USA)
  • Massoud MAHMOUDIAN (Iran University of Medical Sciences, Tehran, Iran)
  • Tadaaki MANO (Gifu University of Medical Science, Japan)
  • Luis Gabriel NAVAR (Tulane University School of Medicine, New Orleans, USA)
  • Hitoo NISHINO (Nagoya City University, Japan)
  • Ole H. PETERSEN (Cardiff University, UK)
  • Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
  • Andrej A. ROMANOVSKY (University of Arizona, USA)
  • Anwar Ali SIDDIQUI (Aga Khan University, Karachi, Pakistan)
  • Csaba SZABÓ (University of Fribourg, Switzerland)
  • Eric VICAUT (Université de Paris, UMRS 942 INSERM, France)
  • Nico WESTERHOF (Vrije Universiteit Amsterdam, The Netherlands)

 

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Physiology (medical) 73/99 (Q3)
Scopus
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Physiology International
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