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Aim

This study investigated whether kisspeptin-10 (KP-10) prevents diabetic rhesus monkeys from insulin-induced hypoglycemic shock.

Materials and methods

Thirty-six adult male rhesus monkeys were used, six in each group. Diabetes was induced with streptozotocin (45 mg/kg b.w.; single dose i.v.). Groups were as: saline control, insulin alone, pre-insulin (treated with KP-10, 30 min before insulin), post-insulin (treated with KP-10, 30 min after insulin), treated with premix dose of KP-10 (50 μg) and insulin, and the group treated with the kisspeptin antagonist P234 (50 μg). Following an overnight fast, each animal was subjected to respective treatment, and blood glucose concentrations were recorded every 30-min interval for 3 h.

Results

Intergroup comparisons demonstrated that treatment with KP-10 prior to insulin administration and kisspeptin–insulin premix treatment allowed blood glucose levels to rise to significantly higher levels (p < 0.001) by 180 min in diabetic and healthy animals compared to treatment with insulin alone. However, intragroup comparisons revealed a significant decrease in blood glucose level in diabetic animals only. Treatment with P234 antagonist followed by insulin administration abolished the preventive action of kisspeptin, whereby blood glucose decreased significantly (p < 0.001) in both diabetic and healthy animals. KP-10 post-insulin treatment, however, remained ineffective and led, instead, to significantly decreased glucose concentrations by 180 min in both diabetic and healthy animals when compared to animals treated with insulin alone.

Conclusions

KP-10 bears therapeutic potential to prevent hypoglycemic shock that may sometimes occur during intensive insulin therapy. Several pharmacological aspects of its interaction with insulin and other drugs, however, remain to be investigated.

  • 1.

    Andreozzi F , Mannino GC , Mancuso E , Spiga R , Perticone F , Sesti G : Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals. PLoS One 12, 19 (2017)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2.

    Anjum S , Krishna A : Kisspeptin acts as a common messenger in the pathways controlling nutrition and reproduction in male mouse. Eur. J. Biomed. Pharm. Sci. 4, 317329 (2017)

    • Search Google Scholar
    • Export Citation
  • 3.

    Bowe JE , King AJ , Kinsey-Jones JS , Foot VL , Li XF , O’Byrne KT , Persaud SJ , Jones PM : Kisspeptin stimulation of insulin secretion: mechanisms of action in mouse islets and rats. Diabetologia 52, 855862 (2009)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Budnitz DS , Lovegrove MC , Shehab N , Richards CL : Emergency hospitalizations for adverse drug events in older Americans. N. Engl. J. Med. 365, 20022012 (2011)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Chen Y , Li L , Xia H : Diabetes alters the blood glucose response to ketamine in streptozotocin-diabetic rats. Int. J. Clin. Exp. Med. 8, 1134711351 (2015)

    • Search Google Scholar
    • Export Citation
  • 6.

    Ciaramella V , Corte CMD , Ciardiello F , Morgillo F : Kisspeptin and cancer: molecular interaction, biological functions, and future perspectives. Front. Endocrinol. 9, 115 (2018)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Cryer PE (1993): Glucose counterregulation: the physiological mechanisms that prevent or correct hypoglycaemia. In: Hypoglycaemia and Diabetes: Clinical and Physiological Aspects, eds Frier BM, Fisher BM, Edward Arnold, London, pp. 3455

    • Search Google Scholar
    • Export Citation
  • 8.

    de Tassigny XA , Jayasena CN , Murphy KG , Dhillo WS , Colledge WH : Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo. PLoS One 12, e0176821 (2017)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 9.

    Harwood H , Listrani P , Wagner J : Nonhuman primates and other animal models in diabetes research. J. Diabetes Sci. Technol. 6, 503514 (2012)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10.

    Hauge-Evans AC , Richardson CC , Milne HM , Christie MR , Persaud SJ , Jones PM : A role for kisspeptin in islet function. Diabetologia 49, 21312135 (2006)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Huma T , Ulla F , Hanif F , Rizak JD , Shahab M : Peripheral administration of kisspeptin antagonist does not alter basal plasma testosterone but decreases plasma adiponectin levels in adult male rhesus macaques. Turk. J. Biol. 38, 450456 (2014)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12.

    Hussain MA , Akalestou E , Song WJ : Inter-organ communication and regulation of beta cell function. Diabetoloogia 59, 659667 (2016)

  • 13.

    Hussain MA , Song WJ , Wolfe A : There is kisspeptin – and then there is kisspeptin. Trends Endocrinol. Metab. 26, 564572 (2015)

  • 14.

    Irwin N , Flatt PR : New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders. World J. Diabetes 6, 12851295 (2015)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 15.

    Ortiz MR : Hypoglycemia in diabetes. Nurs. Clin. North Am. 52, 565574 (2017)

  • 16.

    Schwetz TA , Reissaus CA , Piston DW : Differential stimulation of insulin secretion by GLP-1 and kisspeptin-10. PLoS One 9, e113020 (2014)

  • 17.

    Seminara SB , Dipietro MJ , Ramaswamy S , Crowley WF Jr , Plant TM : Continuous human metastin 45–54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male rhesus monkey (Macaca mulatta): A finding with therapeutic implications. Endocrinology 147, 21222126 (2006)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 18.

    Service FJ : Hypoglycemic disorders. N. Engl. J. Med. 332, 11441152 (1995)

  • 19.

    Silvestre RA , Egido EM , Hernandez R , Marco J : Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas. J. Endocrinol. 196, 283290 (2008)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 20.

    Song WJ , Mondal P , Wolfe A , Alonso LC , Stamateris R , Ong BWT , Lim OC , Yang KS , Radovick S , Novaria HJ , Farber EA , Farber CR , Turner SD , Hussain MA : Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 19, 667681 (2014)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21.

    Tesfaye N , Seaquist ER : Neuroendocrine responses to hypoglycemia. Ann. N. Y. Acad. Sci. 1212, 1228 (2010)

  • 22.

    Tritschler S , Theis FJ , Lickert H , Böttcher A : Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas. Mol. Metab. 6, 974990 (2017)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 23.

    Vikman J , Ahren B : Inhibitory effect of kisspeptins on insulin secretion from isolated mouse islets. Diabetes Obes. Metab. 11, 197201 (2009)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 24.

    Wahab F , Riaz T , Shahab M : Study on the effect of peripheral kisspeptin administration on basal and glucose-induced insulin secretion under fed and fasting conditions in the adult male rhesus monkey (Macaca mulatta). Horm. Metab. Res. 43, 3742 (2011)

    • Crossref
    • Search Google Scholar
    • Export Citation

 

 

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László ROSIVALL (Semmelweis University, Budapest, Hungary)

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  • Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
  • Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
  • László HUNYADI (Semmelweis University, Budapest, Hungary)
  • Gábor JANCSÓ  (University of Pécs, Hungary)
  • Zoltán KARÁDI  (University of Pecs, Hungary)
  • Miklós PALKOVITS (Semmelweis University, Budapest, Hungary)
  • Gyula PAPP (University of Szeged, Hungary)
  • Gábor PAVLIK    (University of Physical Education, Budapest, Hungary)
  • András SPÄT (Semmelweis University, Budapest, Hungary)
  • Gyula SZABÓ (University of Szeged, Hungary)
  • Zoltán SZELÉNYI (University of Pécs, Hungary)
  • Lajos SZOLLÁR (Semmelweis University, Budapest, Hungary)
  • Gyula TELEGDY (MTA-SZTE, Neuroscience Research Group and University of Szeged, Hungary)
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2020  
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Journal
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2019  
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Physiology International
Language English
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2021 Volume 108
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