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  • 1 University of North Carolina, USA
  • 2 Jacksonville University, USA
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Purpose

Our intent was to (a) characterize weekly changes in resting testosterone (T), cortisol (C), and the T:C ratio in males during an intensive endurance training program, and (b) determine if clinical androgen deficiency (AD) based upon T-level criteria developed.

Methods

An 18-week training program in which individual training volume (km/week) increased at 25% increments over baseline (BL) levels observed prior to the study beginning at 4-week intervals throughout the first 12 weeks. After 12 weeks, the volume was reduced to that of the first 4 weeks until the study end (week 18). Competitive performance running tests were assessed at BL and every 4 weeks, while blood T and C were assessed weekly.

Results

Performance improved from BL at weeks 4–16 (p < 0.01). T was reduced (p < 0.01) from BL at weeks 3, and 5–18. The greatest reduction from BL was at week 13, subsequently T returned toward BL at week 18. C was highly variable, and no significant changes from BL were noted. The T:C ratio at weeks 5, 6, and 8–16 was significantly less than at BL (p < 0.01), the greatest reduction at week 13. The T:C ratio values also returned toward BL by week 18. Finally, ∼50% of the subjects reached T levels to be classified as AD.

Conclusions

Sports scientists should recognize decreases in T or T:C ratio is not always indicative of compromised competitive performance potential. Clinicians should be aware increased training loads can lead to AD in men.

  • 1.

    Adlercreutz H , Härkönen M , Kuoppasalmi K , Näveri H , Huhtaniemi I , Tikkanen H , Remes K , Dessypris A , Karvonen J : Effect of training on plasma anabolic and catabolic steroid hormones and their response during physical exercise. Int. J. Sports Med. 7, 2728 (1986)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2.

    Aversa A , Morgentaler A : The practical management of testosterone deficiency in men. Nat. Rev. Urol. 12, 641650 (2015)

  • 3.

    Borg GA : Psychophysical bases of perceived exertion. Med. Sci. Sports Exerc. 14, 377381 (1982)

  • 4.

    Bouchard C , An P , Rice T , Skinner J , Wilmore JH , Gagnon J , Pérusse L , Leon AS , Rao DC : Familial aggregation of VO2max response to exercise training: results from the HERITAGE family study. J. Appl. Physiol. 87, 10031008 (1998)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Burke EJ : Validity of selected laboratory and field tests of physical working capacity. Res. Q. 47, 95104 (1976)

  • 6.

    Cadegiani FA , Kater CE : Basal hormones and biochemical markers as predictors of overtraining syndrome in male athletes: the EROS-BASAL study. J Athl. Train. 54, 906914 (2019)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Cangemi R , Friedmann AJ , Holloszy JO , Fontana L : Long-term effects of calorie restriction on serum sex hormone concentrations in men. Aging Cell 9, 236242 (2010)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8.

    Cooper KH : A means of assessing maximal oxygen intake. JAMA 203, 201204 (1968)

  • 9.

    Cumming DC , Quigley ME , Yen SS : Acute suppression of circulating testosterone levels by cortisol in men. J. Clin. Endocrinol. Metab. 57, 671673 (1983)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10.

    Daly W , Seegers CA , Rubin DA , Dobridge JD , Hackney AC : Relationship between stress hormones and testosterone with prolonged endurance exercise. Eur. J. Appl. Physiol. 93, 375380 (2005)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Goodman HM : Endocrinology concepts for medical students. Adv. Physiol. Educ. 25, 213224 (2001)

  • 12.

    Hackney AC : Hormonal changes at rest in overtrained endurance athletes. Bio. Sport. 2, 4956 (1991)

  • 13.

    Hackney AC (1999): Neuroendocrine system: exercise overload and regeneration. In: Overload, Performance Incompetence, and Regeneration in Sport, eds Lehmann M, Foster C, Gastmann U, Keizer H, Steinacker JM, Plenum Press, New York, pp. 173186

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14.

    Hackney AC : Stress and the neuroendocrine system: the role of exercise as a stressor and modifier of stress. Expert Rev. Endocrinol. Metab. 1, 783792 (2006)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 15.

    Hackney AC , Viru A : Research methodology: endocrinologic measurements in exercise science and sports medicine. J. Athl. Train. 43(6), 631639 (2008)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16.

    Hooper DR , Kraemer WJ , Focht BC , Volek JS , DuPont WH , Caldwell LK , Maresh CM : Endocrinological roles for testosterone in resistance exercise responses and adaptations. Sports Med. 47, 17091720 (2017)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17.

    Hooper DR , Kraemer WJ , Saenz C , Schill KE , Focht BC , Volek JS , Maresh CM : The presence of symptoms of testosterone deficiency in the exercise-hypogonadal male condition and the role of nutrition. Eur. J. Appl. Physiol. 117, 13491357 (2017)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 18.

    Hooper SL , Mackinnon LT , Howard A , Gordon RD , Bachmann AW : Markers for monitoring overtraining and recovery. Med. Sci. Sports Exerc. 27, 106112 (1995)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 19.

    Jürimäe J , Mäestu J , Purge P , Jürimäe T : Changes in stress and recovery after heavy training in rowers. J. Sci. Med. Sport. 7, 335339 (2004)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 20.

    Lee EC , Fragala MS , Kavouras SA , Queen RM , Pryor JL , Casa DJ : Biomarkers in sports and exercise: tracking health, performance, and recovery in athletes. J. Strength Cond. Res. 31, 29202937 (2017)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21.

    Lehmann M , Foster C , Keul J : Overtraining in endurance athletes: a brief review. Med. Sci. Sports Exerc. 25, 854862 (1993)

  • 22.

    Levitt DG , Levitt MD : Human serum albumin homeostasis: a new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements. Int. J. Gen. Med. 9, 229255 (2016)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 23.

    Meeusen R , Duclos M , Foster C , Fry A , Gleeson M , Nieman D , Raglin J , Rietjens G , Steinacker J , Urhausen A : Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sports Science and the American College of Sports Medicine. Med. Sci. Sports Exerc. 45, 186205 (2013)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 24.

    Mountjoy M , Sundgot-Borgen J , Burke L , Carter S , Constantini N , Lebrun C , Meyer N , Sherman R , Steffen K , Budgett R , Ljungqvist A : The IOC consensus statement: beyond the Female Athlete Triad – Relative Energy Deficiency in Sport (RED-S). Br. J. Sports Med. 48, 491497 (2014)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 25.

    Röjdmark S : Influence of short-term fasting on the pituitary-testicular axis in normal men. Horm. Res. 25(3), 140146 (1987)

  • 26.

    Rooyackers OE , Nair KS : Hormonal regulation of human muscle protein metabolism. Annu. Rev. Nutr. 17, 457485 (1997)

  • 27.

    Sgro P , Di Luigi L : Sport and male sexuality. J. Endocrinol. Invest. 40, 911923 (2017)

  • 28.

    Simpson ER : Role of aromatase in sex steroid action. J. Mol. Endocrinol. 25, 149156 (2000)

  • 29.

    Tietz NW (1987): Fundamentals of Clinical Chemistry (3rd ed.), W.B. Saunders, Philadelphia, PA, pp. 76123

  • 30.

    Trembly MS , Chu SY , Mureika R : Methodological and statistical considerations for exercise-related hormone evaluations. Sports Med. 20, 90108 (1990)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 31.

    Urhausen A , Gabriel H , Kindermann W : Blood hormones as markers of training stress and overtraining. Sports Med. 20, 251276 (1995)

  • 32.

    Urhausen A , Gabriel HHW , Kindermann W : Impaired pituitary hormonal response to exhaustive exercise in overtrained endurance athletes. Med. Sci. Sports Exerc. 30, 407414 (1998)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 33.

    Uusitalo ALT , Huttunen P , Hanin Y , Uusitalo AJ , Rusko HK : Hormonal responses to endurance training and overtraining in female athletes. Clin. J. Sport Med. 8, 178186 (1998)

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 34.

    Vermeulen A , Verdonck L , Kaufman JM : A critical evaluation of simple methods for the estimation of free testosterone in serum. J. Clin. Endocrinol. Metab. 84, 36663672 (1999)

    • Crossref
    • Search Google Scholar
    • Export Citation

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