Search for other papers by Sanjeev K. Singh in
Current site
Google Scholar
PubMed
Search for other papers by M. B. Mandal in
Current site
Google Scholar
PubMed
Search for other papers by R. Ravindran in
Current site
Google Scholar
PubMed
Abstract
The physiology of baroreceptors and chemoreceptors present in large blood vessels of the heart is well known in the regulation of cardiorespiratory functions. Since large blood vessels and peripheral blood vessels are of the same mesodermal origin, therefore, involvement of the latter in the regulation of cardiorespiratory system is expected. The role of perivascular nerves in mediating cardiorespiratory alterations produced after intra-arterial injection of a nociceptive agent (bradykinin) was examined in urethane-anesthetized male rats. Respiratory frequency, blood pressure, and heart rate were recorded for 30 min after the retrograde injection of bradykinin/saline into the femoral artery. In addition, paw edema was determined and water content was expressed as percentage of wet weight. Injection of bradykinin produced immediate tachypneic, hypotensive and bradycardiac responses of shorter latency (5–8 s) favoring the neural mechanisms involved in it. Injection of equi-volume of saline did not produce any responses and served as time-matched control. Paw edema was observed in the ipsilateral hind limb. Pretreatment with diclofenac sodium significantly attenuated the bradykinin-induced responses and also blocked the paw edema. Ipsilateral femoral and sciatic nerve sectioning attenuated bradykinin-induced responses significantly, indicating the origin of responses from the local vascular bed. Administration of bradykinin in the segment of an artery produced reflex cardiorespiratory changes by stimulating the perivascular nociceptors involving prostaglandins. This is a novel study exhibiting the role of peripheral blood vessels in the regulation of the cardiorespiratory system.
-
[1]
Achyuthan KE, Agrawal OP, Ramachandran LK. Enzymes in the venoms of two species of Indian scorpion. Indian J Biochem Biophys. 1982; 19: 356–8.
-
[2]
Bagchi S, Deshpande SB. Indian red scorpion (Buthus tamulus) venom-induced augmentation of cardiac reflexes is mediated through involvement of peripheral 5-HT3 and central 5-HT1A receptor subtypes. Toxicon 1999; 37: 1697–709.
-
[3]
Bagchi S, Deshpande SB. Indian red scorpion venom-induced augmentation of cardiac reflexes is mediated through the mechanisms involving kinins in urethane anesthetized rats. Toxicon 1998; 36: 309–20.
-
[4]
Basu A, Gomes A, Dasgupta SC, Lahiri SC. Histamine, 5-HT and hyaluronidase in the venom of the scorpion Lychas laevifroms (Pock). Ind J Med Res. 1990; 92: 371–3.
-
[5]
Chhatwal GS, Habermann E. Neurotoxin, protease inhibitors and histamine releaser in the venom of Indian red scorpion (Buthus tamulus): Isolation and partial characterization. Toxicon 1981; 19: 807–23.
-
[6]
Davis AJ, Perkin MN. The involvement of bradykinin B1 and B2 receptor mechanisms in cytokine-induced mechanical hyperalgesia in rat. Br J Pharmacol. 1994; 113: 63–8.
-
[7]
Deshpande SB, Alex AB, Jagannadham MV, Rao GRK, Tiwari AK. Identification of a novel pulmonary edema producing toxin from Indian red scorpion (Mesobuthus tamulus) venom. Toxicon 2005; 45: 735–43.
-
[8]
Deshpande SB, Bagchi S, Rai OP, Aryya NC. Pulmonary oedema produced by scorpion venom augments phenylediguanide-induced reflex response in anesthetized rats. J Physiol. 1999; 521: 537–44.
-
[9]
Donnerer J, Lembeck F. Analysis of the effects of intravenously injected capsaicin in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1982; 320: 54–7.
-
[10]
Donnerer J, Lembeck F. Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurons via a reflex centre in the brainstem. Naunyn Schmiedebergs Arch Pharmacol. 1983; 324: 293–5.
-
[11]
Evans AR, Junger H, Michael DS, Nicol GD, Linda SS, Broome JT, et al.. Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons. J Pharmacol Exp Ther. 2000; 293: 912–20.
-
[12]
Ferreira SH, Nakamura M, de Abreu Castro MS. The hyperalgesic effects of prostacyclin and prostaglandin-E2. Prostaglandins 1978; 16: 31–7.
-
[13]
Galvez A, Gimnez-Gallego G, Reuben JP, Roy Contancin L, Fiegenbaun P, Kaczorowsky J, et al.. Purification and characterisation of a unique, potent peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem. 1990; 285: 11083–90.
-
[14]
Julieus D, Basabaum AI. Molecular mechanism of nociception. Nature. 2001; 413: 203–10.
-
[15]
Kaufman MP, Iwamoto GA, Longhurst JC, Mitchell JH. Effects of capsaicin and bradykinin on afferent fibers with ending in skeletal muscle. Circ Res. 1982; 50: 133–9.
-
[16]
Kilo S, Berghoff M, Hilz M, Freeman R. Neural and endothelial control of the microcirculation in diabetic peripheral neuropathy. Neurology 2000; 54: 1246–52.
-
[17]
Marshall JN. Peripheral Chemoreceptors and Cardiovascular regulations. Physiol Rev. 1994; 74: 543–94.
-
[18]
McQueen DS, Bond SM, Moores C, Chessell L, Humphrey PPA, Dowd E. Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anesthetized rats. J Physiol. 1998; 507: 843–55.
-
[19]
Nassar AY, Abu-Sinna G, Soliman FM, Rahim SA, El-Saddan IM. Bradykinin potentiating fraction, isolated from venom of Buthus occitanus promotes spermatogenesis in premature mice. In: Gopalakrishnakone P, Tan CK, editors. Recent advances in toxicology research. Singapore: Venom and Toxin Research Group, National University; 1992, vol. 2, pp. 118–38.
-
[20]
Nicol GD, Cui M. Prostaglandin-E2 enhances bradykinin inactivation of embryonic rat sensory neurons. J Physiol (Lond). 1994; 480: 485–92.
-
[21]
Pedarzani PD, Hoedt D, Doorty KB, Wadswarth JDF, Joseph JS, Jeyaseelan K, et al.. Strong PN: Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca+ activated K+ channels and after hyperpolarization currents in central neurons. J Biol Chem. 2002; 277: 46101–9.
-
[22]
Sato A, Sato Y, Schmidt RF. Changes in heart rate and blood pressure upon injection of algesic agents in to skeletal muscle. Pflugers Arch. 1982; 393: 31–6.
-
[23]
Schaible HG, Schmidt RF. Excitation and sensitization of fine articular afferents from cats knee joint by prostaglandin-E2. J Physiol (Lond). 1988; 413: 91–104.
-
[24]
Singh SK, Deshpande SB. Injection of Mesobuthus tamulus venom in distal segment of femoral artery evokes hyperventilatory and hypertensive responses in anesthetised rats. Neurosci Lett. 2008a; 438: 64–6.
-
[25]
Singh SK, Deshpande SB. Intra-arterial injection of Mesobuthus tamulus venom elicits cardiorespiratory reflexes involving perivascular afferents. Toxicon 2005; 46: 820–6.
-
[26]
Singh SK, Deshpande SB. Vasosensory responses elicited by Indian red scorpion venom last longer than capsaicin-induced responses. Ind J Exp Biol. 2008b; 46: 755–9.
-
[27]
Smith PJW, McQueen DS. Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in anesthetized rat. Br J Pharmacol. 2001; 134: 655–63.
-
[28]
Smith PJW, McQueen DS. Perivascular nerves induce cardiorespiratory reflexes in response to algogens in anesthetized rats. Neurosci Res. 2004; 50: 271–81.
-
[29]
Stansberry KB, Peppard HR, Babyak LM, Popp G, McNitt PM, Vinik AI. Primary nociceptive afferents mediate the blood flow dysfunction in non-glabrous (hairy) skin of type 2 diabetes: a new model for the pathogenesis of microvascular dysfunction. Diabetes Care 1999; 22: 1549–54.
-
[30]
Wudayagiri R, Inceoglu B, Herrmann R, Derbel M, Choudary PV, Hemmock BD. Isolation and Characterization of a novel lepidopteran- selective toxin from the venom of South Indian red scorpion, Mesobuthus tamulus, BMC Biochemistry 2001; 2: 16–28.
Editor-in-Chief
László ROSIVALL (Semmelweis University, Budapest, Hungary)
Managing Editor
Anna BERHIDI (Semmelweis University, Budapest, Hungary)
Co-Editors
- Gábor SZÉNÁSI (Semmelweis University, Budapest, Hungary)
- Ákos KOLLER (Semmelweis University, Budapest, Hungary)
- Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
- László LÉNÁRD (University of Pécs, Hungary)
- Zoltán UNGVÁRI (Semmelweis University, Budapest, Hungary)
Assistant Editors
- Gabriella DÖRNYEI (Semmelweis University, Budapest, Hungary)
- Zsuzsanna MIKLÓS (Semmelweis University, Budapest, Hungary)
- György NÁDASY (Semmelweis University, Budapest, Hungary)
Hungarian Editorial Board
- György BENEDEK (University of Szeged, Hungary)
- Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
- Mihály BOROS (University of Szeged, Hungary)
- László CSERNOCH (University of Debrecen, Hungary)
- Magdolna DANK (Semmelweis University, Budapest, Hungary)
- László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
- Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
- Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
- Zoltán HEROLD (Semmelweis University, Budapest, Hungary)
- László HUNYADI (Semmelweis University, Budapest, Hungary)
- Gábor JANCSÓ (University of Pécs, Hungary)
- Zoltán KARÁDI (University of Pecs, Hungary)
- Miklós PALKOVITS (Semmelweis University, Budapest, Hungary)
- Gyula PAPP (University of Szeged, Hungary)
- Gábor PAVLIK (University of Physical Education, Budapest, Hungary)
- András SPÄT (Semmelweis University, Budapest, Hungary)
- Gyula SZABÓ (University of Szeged, Hungary)
- Zoltán SZELÉNYI (University of Pécs, Hungary)
- Lajos SZOLLÁR (Semmelweis University, Budapest, Hungary)
- József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
- Árpád TÓSAKI (University of Debrecen, Hungary)
International Editorial Board
- Dragan DJURIC (University of Belgrade, Serbia)
- Christopher H. FRY (University of Bristol, UK)
- Stephen E. GREENWALD (Blizard Institute, Barts and Queen Mary University of London, UK)
- Tibor HORTOBÁGYI (University of Groningen, Netherlands)
- George KUNOS (National Institutes of Health, Bethesda, USA)
- Massoud MAHMOUDIAN (Iran University of Medical Sciences, Tehran, Iran)
- Tadaaki MANO (Gifu University of Medical Science, Japan)
- Luis Gabriel NAVAR (Tulane University School of Medicine, New Orleans, USA)
- Hitoo NISHINO (Nagoya City University, Japan)
- Ole H. PETERSEN (Cardiff University, UK)
- Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
- Andrej A. ROMANOVSKY (University of Arizona, USA)
- Anwar Ali SIDDIQUI (Aga Khan University, Karachi, Pakistan)
- Csaba SZABÓ (University of Fribourg, Switzerland)
- Eric VICAUT (Université de Paris, UMRS 942 INSERM, France)
Editorial Correspondence:
Physiology International
Semmelweis University
Faculty of Medicine, Institute of Translational Medicine
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: pi@semmelweis.hu
Indexing and Abstracting Services:
- Biological Abstracts
- BIOSIS Previews
- CAB Abstracts
- CABELLS Journalytics
- EMBASE/Excerpta Medica
- Global Health
- Index Copernicus
- Index Medicus
- Medline
- Referativnyi Zhurnal
- SCOPUS
- WoS - Science Citation Index Expanded
| 2023 | |
|---|---|
| Web of Science | |
| Journal Impact Factor | 2.2 |
| Rank by Impact Factor | Q3 (Physiology) |
| Journal Citation Indicator | 0.58 |
| Scopus | |
| CiteScore | 3.4 |
| CiteScore rank | Q2 (Physical Therapy, Sports Therapy and Rehabilitation) |
| SNIP | 0.508 |
| Scimago | |
| SJR index | 0.407 |
| SJR Q rank | Q2 |
| Physiology International | |
|---|---|
| Publication Model | Hybrid |
| Submission Fee | none |
| Article Processing Charge | 1100 EUR/article |
| Printed Color Illustrations | 40 EUR (or 10 000 HUF) + VAT / piece |
| Regional discounts on country of the funding agency | World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100% |
| Further Discounts | Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100% |
| Subscription fee 2025 | Online subsscription: 752 EUR / 828 USD Print + online subscription: 880 EUR / 968 USD |
| Subscription Information | Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content. |
| Purchase per Title | Individual articles are sold on the displayed price. |
| Physiology International | |
|---|---|
| Language | English |
| Size | B5 |
| Year of Foundation |
2006 (1950) |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Magyar Tudományos Akadémia |
| Founder's Address |
H-1051 Budapest, Hungary, Széchenyi István tér 9. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 2498-602X (Print) |
| ISSN | 2677-0164 (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Oct 2024 | 105 | 0 | 0 |
| Nov 2024 | 54 | 1 | 0 |
| Dec 2024 | 44 | 0 | 0 |
| Jan 2025 | 49 | 0 | 0 |
| Feb 2025 | 53 | 2 | 2 |
| Mar 2025 | 53 | 0 | 0 |
| Apr 2025 | 0 | 0 | 0 |
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.