Authors:
T. Laskow Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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J. Langdon Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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P. Abadir Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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Q.-L. Xue Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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J. Walston Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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https://orcid.org/0000-0002-6965-2723
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Abstract

Background

Chronic inflammation (CI) is a common trait of aging associated with adverse outcomes including mortality. We hypothesized that recombinant human Lactoferrin (rhLf) would reduce chronic inflammation of aging.

Methods

Thirty-six community dwelling older adults were randomly assigned to rhLf or placebo treatment in 1:1 ratio for 3 months. IL-6, sTNFR1, Comprehensive Metabolic Panel (CMP), and Complete Blood Count (CBC) were measured at baseline, 1 month, 3 months, and 6 months. Physical and cognitive measures were completed at same timepoints, including 4-m walking speed (m/s), grip strength (kg), 6-min walking distance (m), home activity measured by accelerometer, trail making test – Part A (s) and – Part B (s), and Digit symbol substitution test (number correctly coded). Primary outcomes were differences in IL-6 and sTNFR1 concentrations evaluated by generalized linear model with log-link and gamma family distribution, controlling for baseline cytokine concentrations.

Results

rhLF was well-tolerated. There were a significant number of abdominal complaints and increased drop-out rate in placebo group. Participants in rhLf arm had non-significant lower mean percent increase in IL6 at 3 months (rhLf mean IL-6 6% lower than control, P = 0.843), and sTNFaR1 (rhLf mean 2% lower than control, P = 0.36). No significant changes were observed for the cognitive or physical measures.

Conclusion

Treatment with rhLf did not significantly alter serum IL6 or sTNFR1 concentrations of older adults. This study may have been underpowered to detect difference, but provided evidence that a larger sample-size could more definitively determine the effect of rhLF on age-associated CI.

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Editor-in-Chief

László ROSIVALL (Semmelweis University, Budapest, Hungary)

Managing Editor

Anna BERHIDI (Semmelweis University, Budapest, Hungary)

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  • Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
  • László LÉNÁRD (University of Pécs, Hungary)
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  • Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
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  • László CSERNOCH (University of Debrecen, Hungary)
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  • László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
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  • Gyula PAPP (University of Szeged, Hungary)
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  • Zoltán SZELÉNYI (University of Pécs, Hungary)
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2022  
Web of Science  
Total Cites
WoS
335
Journal Impact Factor 1.4
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Physiology (Q4)

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Physiology 68/102 (33rd PCTL)
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2021  
Web of Science  
Total Cites
WoS
330
Journal Impact Factor 1,697
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Physiology 73/81

Impact Factor
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1,697
5 Year
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1,806
Journal Citation Indicator 0,47
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Physiology 69/86

Scimago  
Scimago
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31
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0,32
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Physiology (medical) (Q3)
Scopus  
Scopus
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2,7
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Physiology (medical) 69/101 (Q3)
Scopus
SNIP
0,591

 

2020  
Total Cites 245
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Journal
Impact Factor
2,090
Rank by Physiology 62/81 (Q4)
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Impact Factor 1,866
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5 Year 1,703
Impact Factor
Journal  0,51
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Rank by Journal  Physiology 67/84 (Q4)
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Citable 42
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Total 0
Reviews
Scimago 29
H-index
Scimago 0,417
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Scimago Physiology (medical) Q3
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Scopus 270/1140=1,9
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Scopus Physiology (medical) 71/98 (Q3)
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Scopus 0,528
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2019  
Total Cites
WoS
137
Impact Factor 1,410
Impact Factor
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1,361
5 Year
Impact Factor
1,221
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Index
0,294
Citable
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34
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Articles
33
Total
Reviews
1
Cited
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2,1
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9,3
Eigenfactor
Score
0,00028
Article Influence
Score
0,215
% Articles
in
Citable Items
97,06
Normalized
Eigenfactor
0,03445
Average
IF
Percentile
12,963
Scimago
H-index
27
Scimago
Journal Rank
0,267
Scopus
Scite Score
235/157=1,5
Scopus
Scite Score Rank
Physiology (medical) 73/99 (Q3)
Scopus
SNIP
0,38

 

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Physiology International
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