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  • 1 Department of Ophthalmology, Affiliated Zhongshan Hospital of Dalian University, 116001, Dalian, Liaoning, China
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The present report evaluates the protective effects of luteolin against diabetic retinopathy (DR).

Materials and methods

Diabetes was induced in rats by i.p. administration of 60 mg/kg of streptozotocin (STZ), followed by treatment with luteolin for 4 weeks. The effects of luteolin were determined based on the blood glucose and cytokine levels, and parameters of oxidative stress in retinal tissue of DR rats. The diameter of retinal vessels was estimated by fundus photography. A Western blot assay was used to determine the expression of apoptotic proteins and Nod-like receptor 3 (NLRP3) pathway proteins in the retina of DR rats. A molecular docking study was performed to evaluate the interaction between luteolin and NLRP3.


The level of blood glucose was reduced in the luteolin-treated group compared with the DR group. Reductions in cytokines and oxidative stress were observed in the retinal tissues of the luteolin-treated group relative to the DR group. Moreover, treatment with luteolin reduced the expression of NLRP1, NOX4, TXNIP, and NLRP3 proteins, and ameliorated the altered expression of apoptotic proteins in the retina of DR rats.


In conclusion, luteolin prevents retinal apoptosis in DR rats by regulating the NLRP/NOX4 signalling pathway.

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Total Cites 245
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Citation Indicator  
Rank by Journal  Physiology 67/84 (Q4)
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Citable 42
Total 42
Total 0
Scimago 29
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Scite Score  
Scopus Physiology (medical) 71/98 (Q3)
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Days from  172
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Total Cites
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Journal Self Cites
5 Year
Impact Factor
Article Influence
% Articles
Citable Items
Journal Rank
Scite Score
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Physiology (medical) 73/99 (Q3)


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Physiology International
Language English
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2021 Volume 108
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Founder Magyar Tudományos Akadémia
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