Authors:
Antonia Kellnar Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

Search for other papers by Antonia Kellnar in
Current site
Google Scholar
PubMed
Close
https://orcid.org/0000-0001-9717-8208
,
Stefan Brunner Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

Search for other papers by Stefan Brunner in
Current site
Google Scholar
PubMed
Close
,
Anna Strüven Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

Search for other papers by Anna Strüven in
Current site
Google Scholar
PubMed
Close
,
Georges Weis Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

Search for other papers by Georges Weis in
Current site
Google Scholar
PubMed
Close
,
Korbinian Lackermair Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

Search for other papers by Korbinian Lackermair in
Current site
Google Scholar
PubMed
Close
, and
Magda Haum Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

Search for other papers by Magda Haum in
Current site
Google Scholar
PubMed
Close
Restricted access

Abstract

The global temperature rise will have extensive consequences on our organ systems, but hypohydration caused by reduced water intake or increased water loss through sweating plays the most relevant role. Many studies have already demonstrated the association between hypohydration and impaired exercise performance, but data related to the cardiac burden of hypohydration are scarce. This study is a sub-investigation of our large, prospective, self-controlled trial on the effects of hypohydration on cardiopulmonary exercise capacity with previously published results. In the current sub-study, we analyzed the impact of hypohydration on cardiac burden in this cohort of fifty healthy, recreational athletes during cardiopulmonary exercise test.

Therefore, each participant underwent cardiopulmonary exercise test with a standardized ramp protocol twice, once in hypohydrated state and once in euhydrated state as control, and the cardiac markers Troponin T, NT-pro-BNP and Chromogranin A were measured before and after the exercise test at each state. Mean age was 29.7 years and 34% of probands were female. Hypohydration led to a reduced body water, a significant decrease in oxygen uptake and lower levels of power output. Yet, Troponin T, NT-proBNP, Chromogranin A and lactate levels did not significantly differ between the two conditions.

In this study cohort, decreased exercise capacity during hypohydration was more likely due to impaired cardiac output with diminished plasma volume rather than measurable cardiac stress from fluid deprivation. However, whether these data are generalizable to a diseased cohort is left unanswered and should be addressed in future randomized controlled trials.

  • 1.

    Khatana SAM, Werner RM, Groeneveld PW. Association of extreme heat and cardiovascular mortality in the United States: a county-level longitudinal analysis from 2008 to 2017. Circulation 2022; 146(3): 24961. https://doi.org/10.1161/CIRCULATIONAHA.122.060746.

    • Search Google Scholar
    • Export Citation
  • 2.

    Liu J, Varghese BM, Hansen A, Zhang Y, Driscoll T, Morgan G, et al. Heat exposure and cardiovascular health outcomes: a systematic review and meta-analysis. Lancet Planet Health 2022; 6(6): e484e95. https://doi.org/10.1016/S2542-5196(22)00117-6.

    • Search Google Scholar
    • Export Citation
  • 3.

    Liu C, Yavar Z, Sun Q. Cardiovascular response to thermoregulatory challenges. Am J Physiol Heart Circ Physiol 2015; 309(11): H1793812. https://doi.org/10.1152/ajpheart.00199.2015.

    • Search Google Scholar
    • Export Citation
  • 4.

    Kang SH, Oh IY, Heo J, Lee H, Kim J, Lim WH, et al. Heat, heat waves, and out-of-hospital cardiac arrest. Int J Cardiol 2016; 221: 2327. https://doi.org/10.1016/j.ijcard.2016.07.071.

    • Search Google Scholar
    • Export Citation
  • 5.

    Struven A, Brunner S, Weis G, Stremmel C, Teupser D, Schlichtiger J, et al Impact of preparticipating hypohydration on cardiopulmonary exercise capacity in ambitious recreational athletes. Nutrients 2023; 15(15): 3333. https://doi.org/10.3390/nu15153333.

    • Search Google Scholar
    • Export Citation
  • 6.

    Cheuvront SN, Kenefick RW. Dehydration: physiology, assessment, and performance effects. Compr Physiol 2014; 4(1): 25785. https://doi.org/10.1002/cphy.c130017.

    • Search Google Scholar
    • Export Citation
  • 7.

    Foster J, Hodder SG, Lloyd AB, Havenith G. Individual responses to heat stress: implications for hyperthermia and physical work capacity. Front Physiol 2020; 11: 541483. https://doi.org/10.3389/fphys.2020.541483.

    • Search Google Scholar
    • Export Citation
  • 8.

    Watanabe K, Stohr EJ, Akiyama K, Watanabe S, Gonzalez-Alonso J. Dehydration reduces stroke volume and cardiac output during exercise because of impaired cardiac filling and venous return, not left ventricular function. Physiol Rep 2020; 8(11): e14433. https://doi.org/10.14814/phy2.14433.

    • Search Google Scholar
    • Export Citation
  • 9.

    Trangmar SJ, Gonzalez-Alonso J. New insights into the impact of dehydration on blood flow and metabolism during exercise. Exerc Sport Sci Rev 2017; 45(3): 14653. https://doi.org/10.1249/JES.0000000000000109.

    • Search Google Scholar
    • Export Citation
  • 10.

    Hall C. Essential biochemistry and physiology of (NT-pro)BNP. Eur J Heart Fail 2004; 6(3): 25760. https://doi.org/10.1016/j.ejheart.2003.12.015.

    • Search Google Scholar
    • Export Citation
  • 11.

    Katrukha IA. Human cardiac troponin complex. Structure and functions. Biochemistry (Mosc). 2013; 78(13): 144765. https://doi.org/10.1134/s0006297913130063.

    • Search Google Scholar
    • Export Citation
  • 12.

    Nickel T, Vogeser M, Emslander I, David R, Heilmeier B, Op den Winkel M, et al. Extreme exercise enhances chromogranin A levels correlating with stress levels but not with cardiac burden. Atherosclerosis 2012; 220(1): 21922. https://doi.org/10.1016/j.atherosclerosis.2011.09.036.

    • Search Google Scholar
    • Export Citation
  • 13.

    Goetze JP, Alehagen U, Flyvbjerg A, Rehfeld JF. Chromogranin A as a biomarker in cardiovascular disease. Biomark Med 2014; 8(1): 13340. https://doi.org/10.2217/bmm.13.102.

    • Search Google Scholar
    • Export Citation
  • 14.

    Clauss S, Scherr J, Hanley A, Schneider J, Klier I, Lackermair K, et al. Impact of polyphenols on physiological stress and cardiac burden in marathon runners - results from a substudy of the BeMaGIC study. Appl Physiol Nutr Metab 2017; 42(5): 5238. https://doi.org/10.1139/apnm-2016-0457.

    • Search Google Scholar
    • Export Citation
  • 15.

    Palka T, Koteja PM, Tota L, Rydzik L, Kopanska M, Kaczorowska I, et al. The influence of various hydration strategies (isotonic, water, and No hydration) on hematological indices, plasma volume, and lactate concentration in young men during prolonged cycling in elevated ambient temperatures. Biology (Basel) 2023; 12(5): 687. https://doi.org/10.3390/biology12050687.

    • Search Google Scholar
    • Export Citation
  • 16.

    Rosjo H, Masson S, Latini R, Flyvbjerg A, Milani V, La Rovere MT, et al. Prognostic value of chromogranin A in chronic heart failure: data from the GISSI-Heart Failure trial. Eur J Heart Fail 2010; 12(6): 54956. https://doi.org/10.1093/eurjhf/hfq055.

    • Search Google Scholar
    • Export Citation
  • 17.

    Brunner S, Rizas K, Hamm W, Mehr M, Lackermair K. Effect of physical exercise on platelet reactivity in patients with dual antiplatelet therapy. Int J Sports Med 2018; 39(8): 64652. https://doi.org/10.1055/a-0631-3302.

    • Search Google Scholar
    • Export Citation
  • Collapse
  • Expand
The author instructions are available in PDF.
Please, download the file from HERE

 

Editor-in-Chief

László ROSIVALL (Semmelweis University, Budapest, Hungary)

Managing Editor

Anna BERHIDI (Semmelweis University, Budapest, Hungary)

Co-Editors

  • Gábor SZÉNÁSI (Semmelweis University, Budapest, Hungary)
  • Ákos KOLLER (Semmelweis University, Budapest, Hungary)
  • Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
  • László LÉNÁRD (University of Pécs, Hungary)
  • Zoltán UNGVÁRI (Semmelweis University, Budapest, Hungary)

Assistant Editors

  • Gabriella DÖRNYEI (Semmelweis University, Budapest, Hungary)
  • Zsuzsanna MIKLÓS (Semmelweis University, Budapest, Hungary)
  • György NÁDASY (Semmelweis University, Budapest, Hungary)

Hungarian Editorial Board

  • György BENEDEK (University of Szeged, Hungary)
  • Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
  • Mihály BOROS (University of Szeged, Hungary)
  • László CSERNOCH (University of Debrecen, Hungary)
  • Magdolna DANK (Semmelweis University, Budapest, Hungary)
  • László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
  • Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
  • Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
  • Zoltán HEROLD (Semmelweis University, Budapest, Hungary) 
  • László HUNYADI (Semmelweis University, Budapest, Hungary)
  • Gábor JANCSÓ (University of Pécs, Hungary)
  • Zoltán KARÁDI (University of Pecs, Hungary)
  • Miklós PALKOVITS (Semmelweis University, Budapest, Hungary)
  • Gyula PAPP (University of Szeged, Hungary)
  • Gábor PAVLIK (University of Physical Education, Budapest, Hungary)
  • András SPÄT (Semmelweis University, Budapest, Hungary)
  • Gyula SZABÓ (University of Szeged, Hungary)
  • Zoltán SZELÉNYI (University of Pécs, Hungary)
  • Lajos SZOLLÁR (Semmelweis University, Budapest, Hungary)
  • József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
  • Árpád TÓSAKI (University of Debrecen, Hungary)

International Editorial Board

  • Dragan DJURIC (University of Belgrade, Serbia)
  • Christopher H.  FRY (University of Bristol, UK)
  • Stephen E. GREENWALD (Blizard Institute, Barts and Queen Mary University of London, UK)
  • Tibor HORTOBÁGYI (University of Groningen, Netherlands)
  • George KUNOS (National Institutes of Health, Bethesda, USA)
  • Massoud MAHMOUDIAN (Iran University of Medical Sciences, Tehran, Iran)
  • Tadaaki MANO (Gifu University of Medical Science, Japan)
  • Luis Gabriel NAVAR (Tulane University School of Medicine, New Orleans, USA)
  • Hitoo NISHINO (Nagoya City University, Japan)
  • Ole H. PETERSEN (Cardiff University, UK)
  • Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
  • Andrej A. ROMANOVSKY (University of Arizona, USA)
  • Anwar Ali SIDDIQUI (Aga Khan University, Karachi, Pakistan)
  • Csaba SZABÓ (University of Fribourg, Switzerland)
  • Eric VICAUT (Université de Paris, UMRS 942 INSERM, France)

 

Editorial Correspondence:
Physiology International
Semmelweis University
Faculty of Medicine, Institute of Translational Medicine
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: pi@semmelweis-univ.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • CABELLS Journalytics
  • EMBASE/Excerpta Medica
  • Global Health
  • Index Copernicus
  • Index Medicus
  • Medline
  • Referativnyi Zhurnal
  • SCOPUS
  • WoS - Science Citation Index Expanded

 

2023  
Web of Science  
Journal Impact Factor 2.2
Rank by Impact Factor Q3 (Physiology)
Journal Citation Indicator 0.58
Scopus  
CiteScore 3.4
CiteScore rank Q2 (Physical Therapy, Sports Therapy and Rehabilitation)
SNIP 0.508
Scimago  
SJR index 0.407
SJR Q rank Q2

Physiology International
Publication Model Hybrid
Submission Fee none
Article Processing Charge 1100 EUR/article
Printed Color Illustrations 40 EUR (or 10 000 HUF) + VAT / piece
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription fee 2025 Online subsscription: 752 EUR / 828 USD
Print + online subscription: 880 EUR / 968 USD
Subscription Information Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content.
Purchase per Title Individual articles are sold on the displayed price.

Physiology International
Language English
Size B5
Year of
Foundation
2006 (1950)
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2498-602X (Print)
ISSN 2677-0164 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jan 2024 0 0 0
Feb 2024 0 0 0
Mar 2024 0 0 0
Apr 2024 0 0 0
May 2024 393 7 7
Jun 2024 164 7 7
Jul 2024 34 1 2