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Antonia Kellnar Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

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Stefan Brunner Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

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Anna Strüven Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

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Georges Weis Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

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Korbinian Lackermair Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

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Magda Haum Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany

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Abstract

The global temperature rise will have extensive consequences on our organ systems, but hypohydration caused by reduced water intake or increased water loss through sweating plays the most relevant role. Many studies have already demonstrated the association between hypohydration and impaired exercise performance, but data related to the cardiac burden of hypohydration are scarce. This study is a sub-investigation of our large, prospective, self-controlled trial on the effects of hypohydration on cardiopulmonary exercise capacity with previously published results. In the current sub-study, we analyzed the impact of hypohydration on cardiac burden in this cohort of fifty healthy, recreational athletes during cardiopulmonary exercise test.

Therefore, each participant underwent cardiopulmonary exercise test with a standardized ramp protocol twice, once in hypohydrated state and once in euhydrated state as control, and the cardiac markers Troponin T, NT-pro-BNP and Chromogranin A were measured before and after the exercise test at each state. Mean age was 29.7 years and 34% of probands were female. Hypohydration led to a reduced body water, a significant decrease in oxygen uptake and lower levels of power output. Yet, Troponin T, NT-proBNP, Chromogranin A and lactate levels did not significantly differ between the two conditions.

In this study cohort, decreased exercise capacity during hypohydration was more likely due to impaired cardiac output with diminished plasma volume rather than measurable cardiac stress from fluid deprivation. However, whether these data are generalizable to a diseased cohort is left unanswered and should be addressed in future randomized controlled trials.

  • 1.

    Khatana SAM, Werner RM, Groeneveld PW. Association of extreme heat and cardiovascular mortality in the United States: a county-level longitudinal analysis from 2008 to 2017. Circulation 2022; 146(3): 24961. https://doi.org/10.1161/CIRCULATIONAHA.122.060746.

    • Search Google Scholar
    • Export Citation
  • 2.

    Liu J, Varghese BM, Hansen A, Zhang Y, Driscoll T, Morgan G, et al. Heat exposure and cardiovascular health outcomes: a systematic review and meta-analysis. Lancet Planet Health 2022; 6(6): e484e95. https://doi.org/10.1016/S2542-5196(22)00117-6.

    • Search Google Scholar
    • Export Citation
  • 3.

    Liu C, Yavar Z, Sun Q. Cardiovascular response to thermoregulatory challenges. Am J Physiol Heart Circ Physiol 2015; 309(11): H1793812. https://doi.org/10.1152/ajpheart.00199.2015.

    • Search Google Scholar
    • Export Citation
  • 4.

    Kang SH, Oh IY, Heo J, Lee H, Kim J, Lim WH, et al. Heat, heat waves, and out-of-hospital cardiac arrest. Int J Cardiol 2016; 221: 2327. https://doi.org/10.1016/j.ijcard.2016.07.071.

    • Search Google Scholar
    • Export Citation
  • 5.

    Struven A, Brunner S, Weis G, Stremmel C, Teupser D, Schlichtiger J, et al Impact of preparticipating hypohydration on cardiopulmonary exercise capacity in ambitious recreational athletes. Nutrients 2023; 15(15): 3333. https://doi.org/10.3390/nu15153333.

    • Search Google Scholar
    • Export Citation
  • 6.

    Cheuvront SN, Kenefick RW. Dehydration: physiology, assessment, and performance effects. Compr Physiol 2014; 4(1): 25785. https://doi.org/10.1002/cphy.c130017.

    • Search Google Scholar
    • Export Citation
  • 7.

    Foster J, Hodder SG, Lloyd AB, Havenith G. Individual responses to heat stress: implications for hyperthermia and physical work capacity. Front Physiol 2020; 11: 541483. https://doi.org/10.3389/fphys.2020.541483.

    • Search Google Scholar
    • Export Citation
  • 8.

    Watanabe K, Stohr EJ, Akiyama K, Watanabe S, Gonzalez-Alonso J. Dehydration reduces stroke volume and cardiac output during exercise because of impaired cardiac filling and venous return, not left ventricular function. Physiol Rep 2020; 8(11): e14433. https://doi.org/10.14814/phy2.14433.

    • Search Google Scholar
    • Export Citation
  • 9.

    Trangmar SJ, Gonzalez-Alonso J. New insights into the impact of dehydration on blood flow and metabolism during exercise. Exerc Sport Sci Rev 2017; 45(3): 14653. https://doi.org/10.1249/JES.0000000000000109.

    • Search Google Scholar
    • Export Citation
  • 10.

    Hall C. Essential biochemistry and physiology of (NT-pro)BNP. Eur J Heart Fail 2004; 6(3): 25760. https://doi.org/10.1016/j.ejheart.2003.12.015.

    • Search Google Scholar
    • Export Citation
  • 11.

    Katrukha IA. Human cardiac troponin complex. Structure and functions. Biochemistry (Mosc). 2013; 78(13): 144765. https://doi.org/10.1134/s0006297913130063.

    • Search Google Scholar
    • Export Citation
  • 12.

    Nickel T, Vogeser M, Emslander I, David R, Heilmeier B, Op den Winkel M, et al. Extreme exercise enhances chromogranin A levels correlating with stress levels but not with cardiac burden. Atherosclerosis 2012; 220(1): 21922. https://doi.org/10.1016/j.atherosclerosis.2011.09.036.

    • Search Google Scholar
    • Export Citation
  • 13.

    Goetze JP, Alehagen U, Flyvbjerg A, Rehfeld JF. Chromogranin A as a biomarker in cardiovascular disease. Biomark Med 2014; 8(1): 13340. https://doi.org/10.2217/bmm.13.102.

    • Search Google Scholar
    • Export Citation
  • 14.

    Clauss S, Scherr J, Hanley A, Schneider J, Klier I, Lackermair K, et al. Impact of polyphenols on physiological stress and cardiac burden in marathon runners - results from a substudy of the BeMaGIC study. Appl Physiol Nutr Metab 2017; 42(5): 5238. https://doi.org/10.1139/apnm-2016-0457.

    • Search Google Scholar
    • Export Citation
  • 15.

    Palka T, Koteja PM, Tota L, Rydzik L, Kopanska M, Kaczorowska I, et al. The influence of various hydration strategies (isotonic, water, and No hydration) on hematological indices, plasma volume, and lactate concentration in young men during prolonged cycling in elevated ambient temperatures. Biology (Basel) 2023; 12(5): 687. https://doi.org/10.3390/biology12050687.

    • Search Google Scholar
    • Export Citation
  • 16.

    Rosjo H, Masson S, Latini R, Flyvbjerg A, Milani V, La Rovere MT, et al. Prognostic value of chromogranin A in chronic heart failure: data from the GISSI-Heart Failure trial. Eur J Heart Fail 2010; 12(6): 54956. https://doi.org/10.1093/eurjhf/hfq055.

    • Search Google Scholar
    • Export Citation
  • 17.

    Brunner S, Rizas K, Hamm W, Mehr M, Lackermair K. Effect of physical exercise on platelet reactivity in patients with dual antiplatelet therapy. Int J Sports Med 2018; 39(8): 64652. https://doi.org/10.1055/a-0631-3302.

    • Search Google Scholar
    • Export Citation
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Editor-in-Chief

László ROSIVALL (Semmelweis University, Budapest, Hungary)

Managing Editor

Anna BERHIDI (Semmelweis University, Budapest, Hungary)

Co-Editors

  • Gábor SZÉNÁSI (Semmelweis University, Budapest, Hungary)
  • Ákos KOLLER (Semmelweis University, Budapest, Hungary)
  • Zsolt RADÁK (University of Physical Education, Budapest, Hungary)
  • László LÉNÁRD (University of Pécs, Hungary)
  • Zoltán UNGVÁRI (Semmelweis University, Budapest, Hungary)

Assistant Editors

  • Gabriella DÖRNYEI (Semmelweis University, Budapest, Hungary)
  • Zsuzsanna MIKLÓS (Semmelweis University, Budapest, Hungary)
  • György NÁDASY (Semmelweis University, Budapest, Hungary)

Hungarian Editorial Board

  • György BENEDEK (University of Szeged, Hungary)
  • Zoltán BENYÓ (Semmelweis University, Budapest, Hungary)
  • Mihály BOROS (University of Szeged, Hungary)
  • László CSERNOCH (University of Debrecen, Hungary)
  • Magdolna DANK (Semmelweis University, Budapest, Hungary)
  • László DÉTÁRI (Eötvös Loránd University, Budapest, Hungary)
  • Zoltán GIRICZ (Semmelweis University, Budapest, Hungary and Pharmahungary Group, Szeged, Hungary)
  • Zoltán HANTOS (Semmelweis University, Budapest and University of Szeged, Hungary)
  • Zoltán HEROLD (Semmelweis University, Budapest, Hungary) 
  • László HUNYADI (Semmelweis University, Budapest, Hungary)
  • Gábor JANCSÓ (University of Pécs, Hungary)
  • Zoltán KARÁDI (University of Pecs, Hungary)
  • Miklós PALKOVITS (Semmelweis University, Budapest, Hungary)
  • Gyula PAPP (University of Szeged, Hungary)
  • Gábor PAVLIK (University of Physical Education, Budapest, Hungary)
  • András SPÄT (Semmelweis University, Budapest, Hungary)
  • Gyula SZABÓ (University of Szeged, Hungary)
  • Zoltán SZELÉNYI (University of Pécs, Hungary)
  • Lajos SZOLLÁR (Semmelweis University, Budapest, Hungary)
  • Gyula TELEGDY (MTA-SZTE, Neuroscience Research Group and University of Szeged, Hungary)
  • József TOLDI (MTA-SZTE Neuroscience Research Group and University of Szeged, Hungary)
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  • Stephen E. GREENWALD (Blizard Institute, Barts and Queen Mary University of London, UK)
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  • Tibor HORTOBÁGYI (University of Groningen, Netherlands)
  • George KUNOS (National Institutes of Health, Bethesda, USA)
  • Massoud MAHMOUDIAN (Iran University of Medical Sciences, Tehran, Iran)
  • Tadaaki MANO (Gifu University of Medical Science, Japan)
  • Luis Gabriel NAVAR (Tulane University School of Medicine, New Orleans, USA)
  • Hitoo NISHINO (Nagoya City University, Japan)
  • Ole H. PETERSEN (Cardiff University, UK)
  • Ulrich POHL (German Centre for Cardiovascular Research and Ludwig-Maximilians-University, Planegg, Germany)
  • Andrej A. ROMANOVSKY (University of Arizona, USA)
  • Anwar Ali SIDDIQUI (Aga Khan University, Karachi, Pakistan)
  • Csaba SZABÓ (University of Fribourg, Switzerland)
  • Eric VICAUT (Université de Paris, UMRS 942 INSERM, France)
  • Nico WESTERHOF (Vrije Universiteit Amsterdam, The Netherlands)

 

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2022  
Web of Science  
Total Cites
WoS
335
Journal Impact Factor 1.4
Rank by Impact Factor

Physiology (Q4)

Impact Factor
without
Journal Self Cites
1.4
5 Year
Impact Factor
1.6
Journal Citation Indicator 0.42
Rank by Journal Citation Indicator

Physiology (Q4)

Scimago  
Scimago
H-index
33
Scimago
Journal Rank
0.362
Scimago Quartile Score

Physiology (medical) (Q3)
Medicine (miscellaneous) (Q3)

Scopus  
Scopus
Cite Score
2.8
Scopus
CIte Score Rank
Physiology 68/102 (33rd PCTL)
Scopus
SNIP
0.508

2021  
Web of Science  
Total Cites
WoS
330
Journal Impact Factor 1,697
Rank by Impact Factor

Physiology 73/81

Impact Factor
without
Journal Self Cites
1,697
5 Year
Impact Factor
1,806
Journal Citation Indicator 0,47
Rank by Journal Citation Indicator

Physiology 69/86

Scimago  
Scimago
H-index
31
Scimago
Journal Rank
0,32
Scimago Quartile Score Medicine (miscellaneous) (Q3)
Physiology (medical) (Q3)
Scopus  
Scopus
Cite Score
2,7
Scopus
CIte Score Rank
Physiology (medical) 69/101 (Q3)
Scopus
SNIP
0,591

 

2020  
Total Cites 245
WoS
Journal
Impact Factor
2,090
Rank by Physiology 62/81 (Q4)
Impact Factor  
Impact Factor 1,866
without
Journal Self Cites
5 Year 1,703
Impact Factor
Journal  0,51
Citation Indicator  
Rank by Journal  Physiology 67/84 (Q4)
Citation Indicator   
Citable 42
Items
Total 42
Articles
Total 0
Reviews
Scimago 29
H-index
Scimago 0,417
Journal Rank
Scimago Physiology (medical) Q3
Quartile Score  
Scopus 270/1140=1,9
Scite Score  
Scopus Physiology (medical) 71/98 (Q3)
Scite Score Rank  
Scopus 0,528
SNIP  
Days from  172
submission  
to acceptance  
Days from  106
acceptance  
to publication  

2019  
Total Cites
WoS
137
Impact Factor 1,410
Impact Factor
without
Journal Self Cites
1,361
5 Year
Impact Factor
1,221
Immediacy
Index
0,294
Citable
Items
34
Total
Articles
33
Total
Reviews
1
Cited
Half-Life
2,1
Citing
Half-Life
9,3
Eigenfactor
Score
0,00028
Article Influence
Score
0,215
% Articles
in
Citable Items
97,06
Normalized
Eigenfactor
0,03445
Average
IF
Percentile
12,963
Scimago
H-index
27
Scimago
Journal Rank
0,267
Scopus
Scite Score
235/157=1,5
Scopus
Scite Score Rank
Physiology (medical) 73/99 (Q3)
Scopus
SNIP
0,38

 

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Physiology International
Language English
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Founder Magyar Tudományos Akadémia
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