Scoliosis may create muscle imbalance and disturb muscle metabolism. However, no studies have examined muscle cell metabolism in scoliosis. This study evaluates lactate concentration in female college students with scoliosis.
One hundred fifty female college students followed this cross-sectional analytic study. Inclusion and exclusion criteria were applied. Scoliosis was measured using a scoliometer. A scoliometer reading of 5° was considered scoliosis. Lactate concentration was measured using a lactate analyzer, and a lactate value above 2 mg dL−1 was denoted as ‘elevated.’ Anova and post hoc tests were used to analyze differences in the variables between scoliosis and normal subgroups. The results were significant if P < 0.05.
One hundred participants (66.7%) had a spinal curve angle of more than 5°. Only weight in thoracic scoliosis was lower than normal (P = 0.022). Lactate was significantly higher than normal in all scoliosis subtypes (P < 0.001). Lactate in both types was considerably higher than thoracic and lumbar scoliosis (P = 0.04 and 0.03, respectively).
Lactate concentration increased in female students with scoliosis.
Negrini S, Donzelli S, Aulisa AG, Czaprowski D, Schreiber S, de Mauroy JC, et al. 2016 SOSORT guidelines: orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth. Scoliosis Spinal Disord 2018; 13: 3. https://doi.org/10.1186/s13013-017-0145-8.
Konieczny MR, Senyurt H, Krauspe R. Epidemiology of adolescent idiopathic scoliosis. J Child Orthop 2013; 7(1): 3–9. https://doi.org/10.1007/s11832-012-0457-4.
Reamy BV, Slakey JB. Adolescent idiopathic scoliosis: review and current concepts. Am Fam Physician 2001; 64(1): 111–6.
Tan KJ, Moe MM, Vaithinathan R, Wong HK. Curve progression in idiopathic scoliosis: follow-up study to skeletal maturity. Spine (Phila Pa 1976) 2009; 34(7): 697–700. https://doi.org/10.1097/BRS.0b013e31819c9431.
Ilharreborde B, Simon AL, Shadi M, Kotwicki T. Is scoliosis a source of pain? J Child Orthop 2023; 17(6): 527–34. https://doi.org/10.1177/18632521231215861.
Ramirez N, Johnston CE, Browne RH. The prevalence of back pain in children who have idiopathic scoliosis. J Bone Joint Surg Am 1997; 79(3): 364–8. https://doi.org/10.2106/00004623-199703000-00007.
Trief PM, Elliott DJ, Stein N, Frederickson BE. Functional vs. organic pain: a meaningful distinction? J Clin Psychol 1987; 43(2): 219–26. https://doi.org/10.1002/1097-4679(198703)43:2<219::aid-jclp2270430209>3.0.co;2-s.
Cirrincione PM, Thakur A, Zucker CP, Wisch JL, Groisser BN, Nguyen J, et al. Exploring correlations between pain and deformity in idiopathic scoliosis with validated self-reported pain scores, radiographic measurements, and trunk surface topographic measurements. J Pediatr Orthop 2023; 43(10): 608–14. https://doi.org/10.1097/BPO.0000000000002493.
An JK, Berman D, Schulz J. Back pain in adolescent idiopathic scoliosis: a comprehensive review. J Child Orthop 2023; 17(2): 126–40. https://doi.org/10.1177/18632521221149058.
Makino T, Kaito T, Sakai Y, Takenaka S, Yoshikawa H. Health-related quality of life and postural changes of spinal alignment in female adolescents associated with back pain in adolescent idiopathic scoliosis: a prospective cross-sectional study. Spine (Phila Pa 1976) 2019; 44(14): E833–E40. https://doi.org/10.1097/BRS.0000000000002996.
Matamalas A, Figueras C, Pizones J, Moreno-Manzanaro L, Betegón J, Esteban M, et al. How back pain intensity relates to clinical and psychosocial factors in patients with idiopathic scoliosis. Eur Spine J 2022; 31(4): 1006–12. https://doi.org/10.1007/s00586-022-07117-x.
Wong C. Mechanism of right thoracic adolescent idiopathic scoliosis at risk for progression; a unifying pathway of development by normal growth and imbalance. Scoliosis 2015; 10: 2. https://doi.org/10.1186/s13013-015-0030-2.
Park Y, Ko JY, Jang JY, Lee S, Beom J, Ryu JS. Asymmetrical activation and asymmetrical weakness as two different mechanisms of adolescent idiopathic scoliosis. Sci Rep 2021; 11(1): 17582. https://doi.org/10.1038/s41598-021-96882-8.
Ng PTT, Claus A, Izatt MT, Pivonka P, Tucker K. Is spinal neuromuscular function asymmetrical in adolescents with idiopathic scoliosis compared to those without scoliosis?: a narrative review of surface EMG studies. J Electromyogr Kinesiol 2022; 63: 102640. https://doi.org/10.1016/j.jelekin.2022.102640.
Wong C, Shayestehpour H, Koutras C, Dahl B, Otaduy MA, Rasmussen J, et al. Using electric stimulation of the spinal muscles and electromyography during motor tasks for evaluation of the role in development and progression of Adolescent Idiopathic Scoliosis. J Clin Med 2024; 13(6): 1758. https://doi.org/10.3390/jcm13061758.
Ohkuwa T, Tsukamoto K, Yamai K, Itoh H, Yamazaki Y, Tsuda T. The relationship between exercise intensity and lactate concentration on the skin surface. Int J Biomed Sci 2009; 5(1): 23–7. https://doi.org/10.59566/ijbs.2009.5023.
Hargreaves M, Spriet LL. Skeletal muscle energy metabolism during exercise. Nat Metab 2020; 2(9): 817–28. https://doi.org/10.1038/s42255-020-0251-4.
Szurmik T, Ogrodzka-Ciechanowicz K, Kurzeja P, Gasienica-Walczak B, Prusak J, Bibrowicz K. Assessment of the functional state of the back muscles in girls with C-shaped low-grade scoliosis in a tensiomyographic image: an observational cross-sectional study. PLoS One 2023; 18(10): e0292555. https://doi.org/10.1371/journal.pone.0292555.
Gerdle B, Larsson B, Forsberg F, Ghafouri N, Karlsson L, Stensson N, et al. Chronic widespread pain: increased glutamate and lactate concentrations in the trapezius muscle and plasma. Clin J Pain 2014; 30(5): 409–20. https://doi.org/10.1097/AJP.0b013e31829e9d2a.
Keshari KR, Lotz JC, Link TM, Hu S, Majumdar S, Kurhanewicz J. Lactic acid and proteoglycans as metabolic markers for discogenic back pain. Spine (Phila Pa 1976) 2008; 33(3): 312–7. https://doi.org/10.1097/BRS.0b013e31816201c3.
Ma HH, Tai CL, Chen LH, Niu CC, Chen WJ, Lai PL. Application of two-parameter scoliometer values for predicting scoliotic Cobb angle. Biomed Eng Online 2017; 16(1): 136. https://doi.org/10.1186/s12938-017-0427-7.