Absztrakt:
A rendkívül komplex mechanizmusok révén megvalósuló intercelluláris kommunikációnak meghatározó szerepe van mind az egészséges, mind a különböző megbetegedések esetében tapasztalható, megváltozott szöveti homeosztázisban. A tumorsejtek és azok mikrokörnyezetében található egyéb sejtek között megfigyelhető sejt–sejt interakciók nemcsak a tumoros megbetegedések progressziójában, hanem a terápiával szemben fellépő rezisztenciában is kulcsszerepet játszanak. A membrán nanocsövek olyan újonnan felfedezett, nagy távolságot áthidalni képes intercelluláris összeköttetések, amelyek számos sejtalkotó cseréjét teszik lehetővé két vagy több sejt között, beleértve a különböző ionokat, makromolekulákat, de akár még az olyan nagyobb méretű organellumokat is, mint amilyenek a mitokondriumok. A membrán nanocsöveken keresztül átadott mitokondriumok egyértelműen megváltoztatják a recipiens sejtek metabolizmusát, funkcionális jellemzőit, a jelenség pedig mind az egészséges, mind a rákos sejtek esetében kimutatható. A metabolikus plaszticitást manapság a rák egyik legfontosabb jellemzőjének tekintik, mivel cáfolhatatlanul kulcsszerepet játszik a kezelés következtében kialakuló gyógyszer-rezisztenciában. Az elmúlt néhány évben vált teljesen világossá, hogy a gyógyszer-rezisztencia kialakulásában a membrán nanocsöveken keresztül zajló mitokondriumátadásnak meghatározó szerepe van, amely újfajta terápiás megközelítések kidolgozását teszi szükségessé.
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- Árpád ILLÉS (Debreceni Egyetem, főszerkesztő)
- Csaba BÖDÖR (Semmelweis Egyetem, főszerkesztő-helyettes)
- Judit DEMETER (Semmelweis Egyetem, főszerkesztő-helyettes)
- Lajos GERGELY (Debreceni Egyetem, főszerkesztő-helyettes)
- Imelda MARTON (Szegedi Tudományegyetem, főszerkesztő-helyettes)
- Gábor MIKALA (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, főszerkesztő-helyettes)
- Dezső LEHOCZKY (Semmelweis Egyetem, emeritus főszerkesztő)
- Sándor FEKETE (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, emeritus főszerkesztő)
- Hajnalka ANDRIKOVICS (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, szerkesztő)
- Zita BORBÉNYI (Szegedi Tudományegyetem, szerkesztő)
- Miklós EGYED (Somogy Megyei Kaposi Mór Oktató Kórház, szerkesztő)
- Alizadeh HUSSAIN (Pécsi Tudományegyetem, szerkesztő)
- Judit JAKAB (Országos Vérellátó Szolgálat, szerkesztő)
- Béla KAJTÁR (Pécsi Tudományegyetem, szerkesztő)
- Tamás MASSZI (Semmelweis Egyetem, szerkesztő)
- Zsolt György NAGY (Semmelweis Egyetem, szerkesztő)
- György PFLIEGLER (Debreceni Egyetem, szerkesztő)
- Péter REMÉNYI (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, szerkesztő)
- Marienn RÉTI (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, szerkesztő)
- Tamás SCHNEIDER (Országos Onkológiai Intézet, szerkesztő)
- László SZERAFIN (Szabolcs-Szatmár-Bereg Megyei Jósa András Oktatókórház, Nyíregyháza, szerkesztő)
- Attila TORDAI (Semmelweis Egyetem, szerkesztő)
Hematológia-Transzfuziológia Szerkesztőség
Dr. Illés Árpád
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