Ákos Nagy I. sz. Patológiai és Kísérleti Rákkutató Intézet, MTA-SE Lendület Molekuláris Onkohematológiai Kutatócsoport, Semmelweis Egyetem, 1085 Budapest, Üllői út 26.

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Bence Bátai I. sz. Patológiai és Kísérleti Rákkutató Intézet, MTA-SE Lendület Molekuláris Onkohematológiai Kutatócsoport, Semmelweis Egyetem, 1085 Budapest, Üllői út 26.

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Laura Kiss I. sz. Patológiai és Kísérleti Rákkutató Intézet, MTA-SE Lendület Molekuláris Onkohematológiai Kutatócsoport, Semmelweis Egyetem, 1085 Budapest, Üllői út 26.

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Anita Marx Természettudományi Kar, Immunológiai Tanszék, Eötvös Lóránd Tudományegyetem, Budapest

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László Imre Pinczés Általános Orvostudományi Kar, Belgyógyászati Intézet, Hematológiai Tanszék, Debreceni Egyetem, Debrecen

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Gergő Papp I. sz. Patológiai és Kísérleti Rákkutató Intézet, MTA-SE Lendület Molekuláris Onkohematológiai Kutatócsoport, Semmelweis Egyetem, 1085 Budapest, Üllői út 26.

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Imre Kacskovics Természettudományi Kar, Immunológiai Tanszék, Eötvös Lóránd Tudományegyetem, Budapest

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Donát Alpár I. sz. Patológiai és Kísérleti Rákkutató Intézet, MTA-SE Lendület Molekuláris Onkohematológiai Kutatócsoport, Semmelweis Egyetem, 1085 Budapest, Üllői út 26.

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Csaba Bödör I. sz. Patológiai és Kísérleti Rákkutató Intézet, MTA-SE Lendület Molekuláris Onkohematológiai Kutatócsoport, Semmelweis Egyetem, 1085 Budapest, Üllői út 26.

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Advances in molecular biology techniques during the past decades allowed for the scrutiny of tumor derived biomolecules, including circulating tumor DNA fragments at an unprecedented level. In case of metastatic tumors, the minimally invasive liquid biopsy sampling provides great opportunity to simultaneously detect and monitor genetic aberrations emerging at distinct anatomical sites, and to identify alterations associated with clonal evolution. Consequently, several studies have recently interrogated the utility of liquid biopsy in the analysis of solid tumors, with this approach already being incorporated into the diagnostic workflow of some diseases. In oncohematology, diffuse large B-cell lymphoma, Hodgkin lymphoma and multiple myeloma are the most intensively studied entities in this regard. Based on data previously published by our group and others, the investigation of circulating tumor DNA in hematology has a potential to convey invaluable prognostic information prior to treatment, to detect actionable genetic alterations, to monitor treatment efficacy and minimal residual disease as well as to identify therapy resistant clones. In this review, we provide an overview of the potential applications of liquid biopsy analysis in oncohematology.

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  • Árpád ILLÉS (Debreceni Egyetem, főszerkesztő)
  • Csaba BÖDÖR (Semmelweis Egyetem, főszerkesztő-helyettes)
  • Judit DEMETER (Semmelweis Egyetem, főszerkesztő-helyettes)
  • Lajos GERGELY (Debreceni Egyetem, főszerkesztő-helyettes)
  • Imelda MARTON (Szegedi Tudományegyetem, főszerkesztő-helyettes)
  • Gábor MIKALA (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, főszerkesztő-helyettes)
  • Dezső LEHOCZKY (Semmelweis Egyetem, emeritus főszerkesztő)
  • Sándor FEKETE (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, emeritus főszerkesztő)
  • Hajnalka ANDRIKOVICS (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, szerkesztő)
  • Zita BORBÉNYI (Szegedi Tudományegyetem, szerkesztő)
  • Miklós EGYED (Somogy Megyei Kaposi Mór Oktató Kórház, szerkesztő)
  • Alizadeh HUSSAIN (Pécsi Tudományegyetem, szerkesztő)
  • Judit JAKAB (Országos Vérellátó Szolgálat, szerkesztő)
  • Béla KAJTÁR (Pécsi Tudományegyetem, szerkesztő)
  • Tamás MASSZI (Semmelweis Egyetem, szerkesztő)
  • Zsolt György NAGY (Semmelweis Egyetem, szerkesztő)
  • György PFLIEGLER (Debreceni Egyetem, szerkesztő)
  • Péter REMÉNYI (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, szerkesztő)
  • Marienn RÉTI (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, szerkesztő)
  • Tamás SCHNEIDER (Országos Onkológiai Intézet, szerkesztő)
  • László SZERAFIN (Szabolcs-Szatmár-Bereg Megyei Jósa András Oktatókórház, Nyíregyháza, szerkesztő)
  • Attila TORDAI (Semmelweis Egyetem, szerkesztő)

Hematológia-Transzfuziológia Szerkesztőség
Dr. Illés Árpád
Debreceni Egyetem Klinikai Központ
Belgyógyászati Intézet B épület
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