Hematológia–Transzfuziológia
Volume/Issue:
Volume 54: Issue 1
Monoklonális ellenanyag-alapú terápia myeloma multiplexben
Authors:
Apor Hardi Dél-pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, Hematológiai és Őssejt-Transzplantációs Osztály, Budapest, Albert Flórián út 5–7.

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András Kozma Dél-pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, Molekuláris Genetikai Laboratórium, Budapest

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Andrea Ceglédi Dél-pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, Hematológiai és Őssejt-Transzplantációs Osztály, Budapest, Albert Flórián út 5–7.

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Ágnes Tomán Dél-pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, Molekuláris Genetikai Laboratórium, Budapest

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András Bors Dél-pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, Molekuláris Genetikai Laboratórium, Budapest

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Hajnalka Andrikovics Dél-pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, Molekuláris Genetikai Laboratórium, Budapest

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Gábor Mikala Dél-pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, Hematológiai és Őssejt-Transzplantációs Osztály, Budapest, Albert Flórián út 5–7.

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Pages:
27–36
Online Publication Date:
14 Apr 2021
Publication Date:
31 Mar 2021
Article Category:
Review Article
DOI:
https://doi.org/10.1556/2068.2021.54.1.5
Keywords:
myeloma; monoclonal antibody; anti-CD38; anti-SLAMF7; biscpecific antibody; BiTE;
Keywords (Hungarian):
myeloma; monoklonális antitest; anti-CD38; anti-SLAMF7; bispecifikus antitest; BiTE;
Restricted access

Összefoglaló. A monoklonális ellenanyagokat termelő plazmasejtburjánzás, a myeloma multiplex kezelésére a monoklonális ellenanyag-terápia viszonylag későn lépett a klinikumba. 2020 végén már három törzskönyvezett antitest, az elotuzumab, a daratumumab és az isatuximab áll rendelkezésre különböző gyógyszer-kombinációk részeként a myeloma betegség eltérő terápiás helyzeteinek megoldására. Emellett számos új antitest, nemcsak „csupasz” antitestek, hanem antitestdrug konjugátumok és bispecifikus antitestek állnak viszonylag előrehaladott klinikai fejlesztési stádiumban, közvetlenül a bevezetés előtt. Összefoglalónkban a rendelkezésünkre álló nagyszámú tanulmány eredményeit ismertetjük, fogódzót kínálva a terület eredményeit kritikus szemmel megismerni kívánó olvasóknak.

Summary. Although multiple myeloma is a plasma cell malignancy known to produce monoclonal antibodies, therapeutic monoclonal antibodies entered late into this clinical field. At the end of 2020, we already have three approved monoclonal antibodies: elotuzumab, daratumamab, and isatuximab – available in different drug combinations at different therapeutic settings of multiple myeloma. Additionally, there are a number of new antibodies, not just „bare” antibodies but antibody-dug conjugates and bispecific antibodies stand at advanced stages of clinical development, frequently just before approval. In this review, results of the large number of clinical studies are critically detailed in order to provide assistance for our interested readers.

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  • 64

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Hematológia–Transzfuziológia
Print ISSN:
1786-5913

 

  • Árpád ILLÉS (Debreceni Egyetem, főszerkesztő)
  • Csaba BÖDÖR (Semmelweis Egyetem, főszerkesztő-helyettes)
  • Judit DEMETER (Semmelweis Egyetem, főszerkesztő-helyettes)
  • Lajos GERGELY (Debreceni Egyetem, főszerkesztő-helyettes)
  • Imelda MARTON (Szegedi Tudományegyetem, főszerkesztő-helyettes)
  • Gábor MIKALA (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, főszerkesztő-helyettes)
  • Sándor FEKETE (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, emeritus főszerkesztő)
  • Hussain ALIZADEH (Pécsi Tudományegyetem, szerkesztő)
  • Hajnalka ANDRIKOVICS (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, szerkesztő)
  • Zita BORBÉNYI (Szegedi Tudományegyetem, szerkesztő)
  • Miklós EGYED (Somogy Megyei Kaposi Mór Oktató Kórház, szerkesztő)
  • Zsuzsanna FAUST (Pécsi Tudományegyetem, szerkesztő)
  • Béla KAJTÁR (Pécsi Tudományegyetem, szerkesztő)
  • Gergely KRIVÁN (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, szerkesztő)
  • András MASSZI (Országos Onkológiai Intézet, szerkesztő)
  • Tamás MASSZI (Semmelweis Egyetem, szerkesztő)
  • Zsolt György NAGY (Semmelweis Egyetem, szerkesztő)
  • Márk PLANDER (Vas Vármegyei Markusovszky Egyetemi Oktatókórház, szerkesztő)
  • György PFLIEGLER (Debreceni Egyetem, szerkesztő)
  • Péter REMÉNYI (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, szerkesztő)
  • Marienn RÉTI (Dél-Pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, szerkesztő)
  • János SINKÓ (Semmelweis Egyetem, szerkesztő)
  • László SZERAFIN (Szabolcs-Szatmár-Bereg Megyei Jósa András Oktatókórház, Nyíregyháza, szerkesztő)

Hematológia-Transzfuziológia Szerkesztőség
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E-mail: illesarpaddr@gmail.com

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Hematológia-Transzfuziológia
Language Hungarian
Size A4
Year of
Foundation		 2004
Volumes
per Year		 1
Issues
per Year		 4
Founder Magyar Hematológiai és Transzfuziológiai Társaság
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Address		 Szent László Kórház, Hematológiai Osztály H-1097 Budapest, Hungary Gyáli út 5-7.
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ISSN 1786-5913 (Print)

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