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  • 1 Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary
  • | 2 Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged, Hungary
  • | 3 Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged, Hungary
  • | 4 Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged, Hungary Please ask the editor of the journal.
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Alzheimer's disease (AD) related beta amyloid (Aβ) peptides possess high propensity towards aggregation. Their diffusion-controlled association follows a physico-chemically well-defined kinetics: the fibrillization starts from the monomeric/ dimeric state, and proceeds in the direction of oligomeric→protofibrillar→ fibrillar state producing neurotoxic aggregates. Nowadays one of the major directions of the drug design against AD is the synthesis of putative amyloid aggregation inhibitor molecules (AAI) which are able to hinder the formation of these toxic amyloid aggregates. Studies of both the Aβ aggregation and the effect of the AAIs on this process can be performed with several instrumental techniques. The size distribution of the aggregates up to the micron size range can be characterized with dynamic light scattering (DLS). On the other hand, species having a diameter above 5 nm can be visualized with transmission electron microscopy (TEM). In this work, we propose standardized sample preparation protocols in order to gain a reproducible aggregation profile of the Aβ peptides according to the experimental requirements. Besides, we investigate the effect of our formerly designed AAI, the RIIGLa pentapeptide on the aggregation of Aβ[1-42]. Based on our DLS and TEM results, we demonstrate the aggregation altering ability of this pentapeptide.

 

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Senior editors

Editor-in-Chief: Kukovecz Ákos (SZTE)

Editor-in-Chief: Kónya Zoltán (SZTE)

 

2019  
WoS
Cites
6
CrossRef
Documents
1

 

Nanopages
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Nanopages
Language English
Size B5
Year of
Foundation
2006
Publication
Programme
2019 Volume 14
Volumes
per Year
1
Issues
per Year
1
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1787-4033 (Print)
ISSN 1788-0718 (Online)

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