Poly (vinyl alcohol) (PVA) is a biocompatible and non-toxic polymer able to form a hydrogel network suitable for drug encapsulation and delivery. A directional controlled release device for porphyrins used in cancer therapy has been devised and implemented based on the swelling and collapse capability of the PVA-based hydrogel. An improved version of this device, having a multi-laminar design with a retarder membrane, is accomplished. The devices can function as model systems for the advanced engineering of transdermal drug-delivery devices for various therapeutic applications (photodynamic therapy, viral inactivation and treatment of psoriasis).
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Peppas N. A. Assemblage of novel release modules for the development of adaptable drug delivery systemsJ. Control. Release2006111212218)| false
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Papancea A. A permittivity study for PVA membranes, obtained by freeze-thaw techniquePollack Periodica20061105114)| false