A dehidroepiandroszteron és szulfatált származéka androgén és ösztrogén hormonok előanyaga, a gonádok szexuálszteroid termeléséhez járul hozzá. A dehidroepiandroszteron-szulfát csak deszulfatálódása után képes részt venni a folyamatban. A harmadik dekádtól kezdve a szérumszintjük fokozatosan csökken, idősebb korban a maximális érték csupán 10–20%-a. Az alacsonyabb koncentráció különböző kórállapotokhoz vezethet, mint a csontritkulás, a lipidmetabolizmus romlása, szív-érrendszeri betegségek, 2-es típusú cukorbetegség. Autoimmun betegségben, szexuális diszfunkciók esetén szintén alacsonyabb szintet találtak. Az intrakrinológia az endokrinológia speciális ága, jelentése, hogy a hormonszintézis és hatás ugyanazon szövetben, szekréció nélkül jön létre. A magasabb helyi androgén- és/vagy ösztrogénkoncentráció a hirsutismus, acne, seborrhea, az emlő és prosztatadaganatok patomechanizmusában jelentős tényező lehet. A dehidroepiandroszteron-pótlás kedvező hatását látták posztmenopauzás csontritkulásban, lupus erythematosisban, pszichiátriai megbetegedésekben, a lipid- és szénhidrát-anyagcserében és szexuális diszfunkció esetén. Csökkentette a zsírszövet mennyiségét. A szerzők a dehidroepiandroszteron és szulfatált származékának metabolizmusát és klinikai szerepét mutatják be.
Barrett-Connor, E., Ferrara, A.: Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist-hip ratio, and noninsulin-dependent diabetes in postmenopausal women: the Rancho Bernardo Study. J. Clin. Endocrinol. Metab., 1996, 774 , 259–270.
Ferrara A. , 'Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist-hip ratio, and noninsulin-dependent diabetes in postmenopausal women: the Rancho Bernardo Study ' (1996 ) 774 J. Clin. Endocrinol. Metab. : 259 -270 .
Barrett-Connor, E., Khaw, K. T., Yen, S. S.: A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N. Engl. J. Med., 1986, 315 , 1519–1524.
Yen S. S. , 'A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease ' (1986 ) 315 N. Engl. J. Med. : 1519 -1524 .
Benz, D. J., Haussler, M. R., Thomas, M. A. és mtsai: High-affinity androgen binding and androgenic regulation of alpha 1(I)-procollagen and transforming growth factor-beta steady state messenger ribonucleic acid levels in human osteoblast-like osteosarcoma cells. Endocrinology, 1991, 128 , 2723–2730.
Thomas M. A. , 'High-affinity androgen binding and androgenic regulation of alpha 1(I)-procollagen and transforming growth factor-beta steady state messenger ribonucleic acid levels in human osteoblast-like osteosarcoma cells ' (1991 ) 128 Endocrinology : 2723 -2730 .
Bjornerem, A., Straume, B., Midtby, M. és mtsai: Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: The Tromso Study. J. Clin. Endocrinol. Metab., 2004, 89 , 6039–6047.
Midtby M. , 'Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: The Tromso Study ' (2004 ) 89 J. Clin. Endocrinol. Metab. : 6039 -6047 .
Casson, P. R., Andersen, R. N., Gerrod, H. G. és mtsai: Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. Am. J. Obstet. Gynecol., 1993, 169 , 1536–1539.
Gerrod H. G. , 'Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women ' (1993 ) 169 Am. J. Obstet. Gynecol. : 1536 -1539 .
Chang, D. M., Lan, J. L., Lin, H. Y. és mtsai: Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus – A multicenter randomized, double-blind, placebo-controlled trial. Arthritis Rheum., 2002, 46 , 2924–2927.
Lin H. Y. , 'Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus – A multicenter randomized, double-blind, placebo-controlled trial ' (2002 ) 46 Arthritis Rheum. : 2924 -2927 .
Cibula, D., Hill, M., Starka, L.: The best correlation of the new index of hyperandrogenism with the grade of increased body hair. Eur. J. Endocrinol., 2000, 143 , 405–408.
Starka L. , 'The best correlation of the new index of hyperandrogenism with the grade of increased body hair ' (2000 ) 143 Eur. J. Endocrinol. : 405 -408 .
Davis, S. R., Davison, S. L., Donath S. és mtsai: Circulating androgen levels and self-reported sexual function in women. JAMA, 2005, 294 , 91–96.
Donath S. , 'Circulating androgen levels and self-reported sexual function in women ' (2005 ) 294 JAMA : 91 -96 .
de la Torre, B., Fransson, J., Scheynius, A.: Blood dehydroepiandrosterone sulphate (DHEAS) levels in pemphigoid/pemphigus and psoriasis. Clin. Exp. Rheumatol., 1995, 13 , 345–348.
Scheynius A. , 'Blood dehydroepiandrosterone sulphate (DHEAS) levels in pemphigoid/pemphigus and psoriasis ' (1995 ) 13 Clin. Exp. Rheumatol. : 345 -348 .
DeFazio, J., Meldrum, D. R., Winer, J. H. és mtsai: Direct action of androgen on hot flushes in the human male. Maturitas, 1984, 6 , 3–8.
Winer J. H. , 'Direct action of androgen on hot flushes in the human male ' (1984 ) 6 Maturitas : 3 -8 .
Diamond, P., Cusan, L., Gomez, J. L. és mtsai: Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women. J. Endocrinol., 1996, 150 , 43–50.
Gomez J. L. , 'Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women ' (1996 ) 150 J. Endocrinol. : 43 -50 .
Eller, N. H., Netterstrom, B., Allerup, P.: Progression in intima media thickness–the significance of hormonal biomarkers of chronic stress. Psychoneuroendocrinology, 2005, 30 , 715–723.
Allerup P. , 'Progression in intima media thickness–the significance of hormonal biomarkers of chronic stress ' (2005 ) 30 Psychoneuroendocrinology : 715 -723 .
Ferrando, S. J., Rabkin, J. G., Poretsky, L.: Dehydroepiandrosterone sulfate (DHEAS) and testosterone: Relation to HIV illness stage and progression over one year. J. Acquir. Immune Defic. Syndr., 1999, 22 , 146–154.
Poretsky L. , 'Dehydroepiandrosterone sulfate (DHEAS) and testosterone: Relation to HIV illness stage and progression over one year ' (1999 ) 22 J. Acquir. Immune Defic. Syndr. : 146 -154 .
Haffner, S. M., Moss, S. E., Klein, B. E. és mtsai: Sex hormones and DHEA-SO4 in relation to ischemic heart disease mortality in diabetic subjects. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. Diabetes Care, 1996, 19 , 1045–1050.
Klein B. E. , 'Sex hormones and DHEA-SO4 in relation to ischemic heart disease mortality in diabetic subjects. The Wisconsin Epidemiologic Study of Diabetic Retinopathy ' (1996 ) 19 Diabetes Care : 1045 -1050 .
Hartkamp, A., Geenen, R., Godaert, G. L. és mtsai: The effect of dehydroepiandrosterone on lumbar spine bone mineral density in patients with quiescent systemic lupus erythematosus. Arthritis Rheum., 2004, 50 , 3591–3595.
Godaert G. L. , 'The effect of dehydroepiandrosterone on lumbar spine bone mineral density in patients with quiescent systemic lupus erythematosus ' (2004 ) 50 Arthritis Rheum. : 3591 -3595 .
Imrich, R., Rovensky, J., Malis, F. és mtsai: Low levels of dehydroepiandrosterone sulphate in plasma, and reduced sympathoadrenal response to hypoglycaemia in premenopausal women with rheumatoid arthritis. Ann. Rheum. Dis., 2005, 64 , 202–206.
Malis F. , 'Low levels of dehydroepiandrosterone sulphate in plasma, and reduced sympathoadrenal response to hypoglycaemia in premenopausal women with rheumatoid arthritis ' (2005 ) 64 Ann. Rheum. Dis. : 202 -206 .
Johannsson, G., Burman, P., Wiren, L. és mtsai: Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: A placebo-controlled trial. J. Clin. Endocrinol. Metab., 2002, 87 , 2046–2052.
Wiren L. , 'Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: A placebo-controlled trial ' (2002 ) 87 J. Clin. Endocrinol. Metab. : 2046 -2052 .
Kameda, W., Daimon, M., Oizumi, T. és mtsai: Association of decrease in serum dehydroepiandrosterone sulfate levels with the progression to type 2 diabetes in men of a Japanese population: The Funagata Study. Metab. Clin. Exp., 2005, 54 , 669–676.
Oizumi T. , 'Association of decrease in serum dehydroepiandrosterone sulfate levels with the progression to type 2 diabetes in men of a Japanese population: The Funagata Study ' (2005 ) 54 Metab. Clin. Exp. : 669 -676 .
Labrie, F., Belanger, A., Cusan, L. és mtsai: Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J. Clin. Endocrinol. Metab., 1997, 82 , 2396–2402.
Cusan L. , 'Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging ' (1997 ) 82 J. Clin. Endocrinol. Metab. : 2396 -2402 .
Labrie, F., Diamond, P., Cusan, L. és mtsai: Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. J. Clin. Endocrinol. Metab., 1997, 82 , 3498–3505.
Cusan L. , 'Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women ' (1997 ) 82 J. Clin. Endocrinol. Metab. : 3498 -3505 .
Leowattana, W.: DHEAS as a new diagnostic tool. Clin. Chim. Acta, 2004, 341 , 1–15.
Leowattana W. , 'DHEAS as a new diagnostic tool ' (2004 ) 341 Clin. Chim. Acta : 1 -15 .
Maccario, M., Mazza, E., Ramunni, J. és mtsai: Relationships between dehydroepiandrosterone-sulphate and anthropometric, metabolic and hormonal variables in a large cohort of obese women. Clin. Endocrinol., 1999, 50 , 595–600.
Ramunni J. , 'Relationships between dehydroepiandrosterone-sulphate and anthropometric, metabolic and hormonal variables in a large cohort of obese women ' (1999 ) 50 Clin. Endocrinol. : 595 -600 .
Majewska, M. D.: Neuronal actions of dehydroepiandrosterone. possible roles in brain development, aging, memory, and affect. Ann. N. Y. Acad. Sci., 1995, 774 , 111–120.
Majewska M. D. , 'Neuronal actions of dehydroepiandrosterone. possible roles in brain development, aging, memory, and affect ' (1995 ) 774 Ann. N. Y. Acad. Sci. : 111 -120 .
Mazat, L., Lafont, S., Berr, C. és mtsai: Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc. Natl. Acad. Sci., 2001, 98 , 8145–8150.
Berr C. , 'Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality ' (2001 ) 98 Proc. Natl. Acad. Sci. : 8145 -8150 .
Moriyama, Y., Yasue, H., Yoshimura, M. és mtsai: The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J. Clin. Endocrinol. Metab., 2000, 85 , 1834–1840.
Yoshimura M. , 'The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity ' (2000 ) 85 J. Clin. Endocrinol. Metab. : 1834 -1840 .
Okamoto, K.: Relationship between dehydroepiandrosterone sulfate and serum lipid levels in Japanese men. J. Epidemiol., 1996, 6 , 63–67.
Okamoto K. , 'Relationship between dehydroepiandrosterone sulfate and serum lipid levels in Japanese men ' (1996 ) 6 J. Epidemiol. : 63 -67 .
Pitts, R. L.: Serum elevation of dehydroepiandrosterone sulfate associated with male pattern baldness in young men. J. Am. Acad. Dermatol., 1987, 16 , 571–573.
Pitts R. L. , 'Serum elevation of dehydroepiandrosterone sulfate associated with male pattern baldness in young men ' (1987 ) 16 J. Am. Acad. Dermatol. : 571 -573 .
Ponjee, G. A., De Rooy, H. A., Vader, H. L.: Androgen turnover during marathon running. Med. Sci. Sports. Exerc., 1994, 26 , 1274–1277.
Vader H. L. , 'Androgen turnover during marathon running ' (1994 ) 26 Med. Sci. Sports. Exerc. : 1274 -1277 .
Rainey, W. E., Carr, B. R., Sasano, H. és mtsai: Dissecting human adrenal androgen production. Trends Endocrinol. Metab., 2002, 13 , 234–239.
Sasano H. , 'Dissecting human adrenal androgen production ' (2002 ) 13 Trends Endocrinol. Metab. : 234 -239 .
Ramsaransing, G. S., Heersema, D. J., De Keyser, J.: Serum uric acid, dehydroepiandrosterone sulphate, and apolipoprotein E genotype in benign vs. progressive multiple sclerosis. Eur. J. Neurol., 2005, 12 , 514–518.
Keyser J. , 'Serum uric acid, dehydroepiandrosterone sulphate, and apolipoprotein E genotype in benign vs. progressive multiple sclerosis ' (2005 ) 12 Eur. J. Neurol. : 514 -518 .
Reiter, W. J., Pycha, A., Schatzl G. és mtsai: Serum dehydroepiandrosterone sulfate concentrations in men with erectile dysfunction. Urology, 2000, 55 , 755–758.
Schatzl G. , 'Serum dehydroepiandrosterone sulfate concentrations in men with erectile dysfunction ' (2000 ) 55 Urology : 755 -758 .
Reiter, W. J., Pycha, A., Schatzl, G. és mtsai: Dehydroepiandrosterone in the treatment of erectile dysfunction: A prospective, double-blind, randomized, placebo-controlled study. Urology, 1999, 53 , 590–594.
Schatzl G. , 'Dehydroepiandrosterone in the treatment of erectile dysfunction: A prospective, double-blind, randomized, placebo-controlled study ' (1999 ) 53 Urology : 590 -594 .
Slayden, S. M., Moran, C., Sams, W. M. és mtsai: Hyperandrogenemia in patients presenting with acne. Fertil. Steril., 2001, 75 , 889–892.
Sams W. M. , 'Hyperandrogenemia in patients presenting with acne ' (2001 ) 75 Fertil. Steril. : 889 -892 .
Smit, P., van Schaik, R. H., van Werf, M. és mtsai: A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. J. Clin. Endocrinol. Metab., 2005, 90 , 5313–5316.
Werf M. , 'A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels ' (2005 ) 90 J. Clin. Endocrinol. Metab. : 5313 -5316 .
Spark, R. F.: Dehydroepiandrosterone: A springboard hormone for female sexuality. Fertil. Steril., 2002, 77 , 19–25.
Spark R. F. , 'Dehydroepiandrosterone: A springboard hormone for female sexuality ' (2002 ) 77 Fertil. Steril. : 19 -25 .
Spivak, B., Maayan R., Kotler M. és mtsai: Elevated circulatory level of GABA(A)-antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder. Psychol. Med., 2000, 30 , 1227–1231.
Kotler M. , 'Elevated circulatory level of GABA(A)-antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder ' (2000 ) 30 Psychol. Med. : 1227 -1231 .
Stomati, M., Monteleone, P., Casarosa, E. és mtsai: Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause. Gynecol. Endocrinol., 2000, 14 , 342–363.
Casarosa E. , 'Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause ' (2000 ) 14 Gynecol. Endocrinol. : 342 -363 .
Straub, R. H., Vogl, D., Gross, V. és mtsai: Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease. Am. J. Gastroenterol., 1998, 93 , 2197–2202.
Gross V. , 'Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease ' (1998 ) 93 Am. J. Gastroenterol. : 2197 -2202 .
Straub, R. H., Weidler, C., Demmel, B. és mtsai: Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. Ann. Rheum. Dis., 2004, 63 , 961–968.
Demmel B. , 'Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus ' (2004 ) 63 Ann. Rheum. Dis. : 961 -968 .
Thiboutot, D., Gilliland, K., Light, J. és mtsai: Androgen metabolism in sebaceous glands from subjects with and without acne. Arch. Dermatol., 1999, 135 , 1041–1045.
Light J. , 'Androgen metabolism in sebaceous glands from subjects with and without acne ' (1999 ) 135 Arch. Dermatol. : 1041 -1045 .
Thijs, L., Fagard, R., Forette, F. és mtsai: Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies. Acta Cardiol., 2003, 58 , 403–410.
Forette F. , 'Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies ' (2003 ) 58 Acta Cardiol. : 403 -410 .
Tok, E. C., Ertunc, D., Oz, U. és mtsai: The effect of circulating androgens on bone mineral density in postmenopausal women. Maturitas, 2004, 48 , 235–242.
Oz U. , 'The effect of circulating androgens on bone mineral density in postmenopausal women ' (2004 ) 48 Maturitas : 235 -242 .
Toth M., Racz K., Varga I. és mtsai: Plasma dehydroepiandrosterone sulfate levels in patients with hyperfunctioning and non-hyperfunctioning adrenal tumors before and after adrenal surgery. Eur. J. Endocrinol., 1997, 136 , 290–295.
Varga I. , 'Plasma dehydroepiandrosterone sulfate levels in patients with hyperfunctioning and non-hyperfunctioning adrenal tumors before and after adrenal surgery ' (1997 ) 136 Eur. J. Endocrinol. : 290 -295 .
Vermeulen, A., Suy, E., Rubens, R.: Effect of prolactin on plasma DHEA (s) levels. J. Clin. Endocrinol. Metab., 1977, 44 , 1222–1225.
Rubens R. , 'Effect of prolactin on plasma DHEA (s) levels ' (1977 ) 44 J. Clin. Endocrinol. Metab. : 1222 -1225 .
Villareal, D. T., Holloszy, J. O.: Effect of DHEA on abdominal fat and insulin action in elderly women and men – A randomized controlled trial. J. Am. Med. Assoc., 2004, 292 , 2243–2248.
Holloszy J. O. , 'Effect of DHEA on abdominal fat and insulin action in elderly women and men – A randomized controlled trial ' (2004 ) 292 J. Am. Med. Assoc. : 2243 -2248 .
Villareal, D. T., Holloszy, J. O., Kohrt, W. M.: Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin. Endocrinol., 2000, 53 , 561–568.
Kohrt W. M. , 'Effects of DHEA replacement on bone mineral density and body composition in elderly women and men ' (2000 ) 53 Clin. Endocrinol. : 561 -568 .
Wierman, E. M., Basson, R., Davis, S. R. és mtsai: Androgen therapy in women: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab., 2006, 91 , 3697–3710.
Davis S. R. , 'Androgen therapy in women: an endocrine society clinical practice guideline ' (2006 ) 91 J. Clin. Endocrinol. Metab. : 3697 -3710 .