View More View Less
  • 1 Pécsi Tudományegyetem, Általános Orvostudományi Kar Neurológiai Klinika Pécs Rét u. 2. 7623
  • 2 Patológiai Intézet Pécs
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $1,070.00

Az intravascularis lymphomatosis ritka, high-grade malignitású non-Hodgkin lymphoma, melyben a sejtek immunhisztokémiailag B- vagy T-sejteknek bizonyulnak. A leginkább érintett szervek a bőr és a központi idegrendszer. A leggyakoribb tünetek közé sorolható az intermittáló láz, fokális neurológiai tünetek, progresszív demencia. A laborparaméterek emelkedett süllyedést, anémiát, magas LDH-szintet mutatnak, a cerebrális képalkotó eljárások általában aspecifikusnak bizonyulnak. A végleges diagnózis csak biopszia segítségével állítható fel. Egy, a fenti klinikai tüneteket mutató beteg esetét ismertetik a szerzők. Az előzőekben felsorolt jellegzetes laborleletek mellett a koponya MR vizsgálat aspecifikus volt. Paraneoplasiás encephalitis gyanúja miatt végzett tumorkutatás derített fényt mellékvese-malignitásra, melynek biopsziás szövettani vizsgálata vezetett a pontos diagnózishoz. Az eset kapcsán a szerzők felhívják a figyelmet a betegség célzott keresésének szükségességére, az érintett szervek biopsziájának elengedhetetlen voltára gyorsan progrediáló tisztázatlan tudatzavar, demenciának, stroke-nak vagy encephalitisnek imponáló klinikai kép esetén.

  • Amagasaki, K., Yamazaki, H., Ohmori, K. és mtsai: Malignant intravascular lymphomatosis associated with venous stenosis. Case report. J. Neurosurg., 1999, 90 , 355–358.

    Ohmori K. , 'Malignant intravascular lymphomatosis associated with venous stenosis. Case report ' (1999 ) 90 J. Neurosurg. : 355 -358.

    • Search Google Scholar
  • Aoki, A., Okamura, M., Ueda, A. és mtsai: An autopsy case of intravascular lymphomatosis with dermatomyositis. Intern. Med., 2002, 41 , 241–244.

    Ueda A. , 'An autopsy case of intravascular lymphomatosis with dermatomyositis ' (2002 ) 41 Intern. Med. : 241 -244.

    • Search Google Scholar
  • Baumann, T. P., Hurwitz, N., Karamitopolou-Diamantis, E. és mtsai: Diagnosis and treatment of intravascular lymphomatosis. Arch. Neurol., 2000, 57 , 374–377.

    Karamitopolou-Diamantis E. , 'Diagnosis and treatment of intravascular lymphomatosis ' (2000 ) 57 Arch. Neurol. : 374 -377.

    • Search Google Scholar
  • Beristain, X., Azzarelli, B.: The neurological masquerade of intravascular lymphomatosis. Arch. Neurol., 2002, 59 , 439–443.

    Azzarelli B. , 'The neurological masquerade of intravascular lymphomatosis ' (2002 ) 59 Arch. Neurol. : 439 -443.

    • Search Google Scholar
  • Chapin, J. E., Davis, L. E., Kornfeld, M. és mtsa: Neurologic manifestations of intravascular lymphomatosis. Acta Neurol. Scand., 1995, 91 , 494–499.

    Kornfeld M. , 'Neurologic manifestations of intravascular lymphomatosis ' (1995 ) 91 Acta Neurol. Scand. : 494 -499.

    • Search Google Scholar
  • D’Agati, V., Sablay, L. B., Knowles, D. M. és mtsai: Angiotropic large cell lymphoma (intravascular malignant lymphomatosis) of the kidney: Presentation as minimal change disease. Hum. Pathol., 1989, 20 , 263–268.

    Knowles D. M. , 'Angiotropic large cell lymphoma (intravascular malignant lymphomatosis) of the kidney: Presentation as minimal change disease ' (1989 ) 20 Hum. Pathol. : 263 -268.

    • Search Google Scholar
  • Daniel, S. E., Rudge, P., Scaravilli, F.: Malignant angioendotheliosis involving the nervous system: support for a lymphoid origin of the neoplastic cells. J. Neurol. Neurosurg. Psychiatr., 1987, 50 , 1173–1177.

    Scaravilli F. , 'Malignant angioendotheliosis involving the nervous system: support for a lymphoid origin of the neoplastic cells ' (1987 ) 50 J. Neurol. Neurosurg. Psychiatr. : 1173 -1177.

    • Search Google Scholar
  • Fozza, C., Bonfigli, S., Conti, M. és mtsai: Long-lasting fever of unknown origin preceding the diagnosis of intravascular lymphomatosis: a further case stimulates some remarks. Am. J. Hematol., 2003, 74 , 211–213.

    Conti M. , 'Long-lasting fever of unknown origin preceding the diagnosis of intravascular lymphomatosis: a further case stimulates some remarks ' (2003 ) 74 Am. J. Hematol. : 211 -213.

    • Search Google Scholar
  • Gaul, C., Hanisch, F., Neureiter, D. és mtsai: Intravascular lymphomatosis mimicking disseminated encephalomyelitis and encephalomyelopathy. Clin. Neurol. Neurosurg., 2006, 108 , 486–489.

    Neureiter D. , 'Intravascular lymphomatosis mimicking disseminated encephalomyelitis and encephalomyelopathy ' (2006 ) 108 Clin. Neurol. Neurosurg. : 486 -489.

    • Search Google Scholar
  • Hamada, K., Hamada, T., Satoh, M. és mtsai: Two cases of neoplastic angioendotheliomatosis presenting with myelopathy. Neurology, 1991, 41 , 1139–1140.

    Satoh M. , 'Two cases of neoplastic angioendotheliomatosis presenting with myelopathy ' (1991 ) 41 Neurology : 1139 -1140.

    • Search Google Scholar
  • Harris, C. P., Sigman, J. D., Jaeckle, K. A.: Intravascular malignant lymphomatosis: amelioration of neurological symptoms with plasmapheresis. Ann. Neurol., 1994, 35 , 357–359.

    Jaeckle K. A. , 'Intravascular malignant lymphomatosis: amelioration of neurological symptoms with plasmapheresis ' (1994 ) 35 Ann. Neurol. : 357 -359.

    • Search Google Scholar
  • Hashimoto, H., Naritomi, H., Kazui, S. és mtsai: Presymptomatic brain lesions on MRI in a patient with intravascular malignant lymphomatosis. J. Neuroimaging, 1998, 8 , 110–113.

    Kazui S. , 'Presymptomatic brain lesions on MRI in a patient with intravascular malignant lymphomatosis ' (1998 ) 8 J. Neuroimaging : 110 -113.

    • Search Google Scholar
  • Jain, S., Kotasek, D., Blumbergs, P. C. és mtsa: Aleukaemic leukostasis in a case of large cell non-Hodgkin’s lymphoma: report of a case with a distinctive central nervous system involvement. J. Neurol. Neurosurg. Psychiatr., 1986, 49 , 1079–1083.

    Blumbergs P. C. , 'Aleukaemic leukostasis in a case of large cell non-Hodgkin’s lymphoma: report of a case with a distinctive central nervous system involvement ' (1986 ) 49 J. Neurol. Neurosurg. Psychiatr. : 1079 -1083.

    • Search Google Scholar
  • Kenéz J., Barsi P., Majtényi K. és mtsai: Can intravascular lymphomatosis mimic sinus thrombosis? A case report with 8 months follow-up and fatal outcome. Neuroradiology, 2000, 42 , 436–440.

    Majtényi K. , 'Can intravascular lymphomatosis mimic sinus thrombosis? A case report with 8 months follow-up and fatal outcome ' (2000 ) 42 Neuroradiology : 436 -440.

    • Search Google Scholar
  • Kinoshita, T., Sugihara, S., Matusue, E. és mtsai: Intravascular malignant lymphomatosis: diffusion-weighted magnetic resonance imaging characteristics. Acta Radiol., 2005, 46 , 246–249.

    Matusue E. , 'Intravascular malignant lymphomatosis: diffusion-weighted magnetic resonance imaging characteristics ' (2005 ) 46 Acta Radiol. : 246 -249.

    • Search Google Scholar
  • Ko, J. H., Han, J. H., Go, J. H. és mtsai: Intravascular lymphomatosis: a clinicopathological study of two cases presenting as an interstitial lung disease. Histopathology, 1997, 31 , 555–562.

    Go J. H. , 'Intravascular lymphomatosis: a clinicopathological study of two cases presenting as an interstitial lung disease ' (1997 ) 31 Histopathology : 555 -562.

    • Search Google Scholar
  • Koizumi, M., Nishimura, M., Yokota, A. és mtsai: Successful treatment of intravascular malignant lymphomatosis with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Bone Marrow Transplant., 2001, 27 , 1101–1103.

    Yokota A. , 'Successful treatment of intravascular malignant lymphomatosis with high-dose chemotherapy and autologous peripheral blood stem cell transplantation ' (2001 ) 27 Bone Marrow Transplant. : 1101 -1103.

    • Search Google Scholar
  • LeWitt, P. A., Forno, L. S., Brant-Zawadzki, M.: Neoplastic angioendotheliosis: a case with spontaneous regression and radiographic appearance of cerebral arteritis. Neurology, 1983, 33 , 39–44.

    Brant-Zawadzki M. , 'Neoplastic angioendotheliosis: a case with spontaneous regression and radiographic appearance of cerebral arteritis ' (1983 ) 33 Neurology : 39 -44.

    • Search Google Scholar
  • Liow, K., Asmar, P., Liow, M. és mtsai: Intravascular lymphomatosis: contribution of cerebral MRI findings to diagnosis. J. Neuroimaging, 2000, 10 , 116–118.

    Liow M. , 'Intravascular lymphomatosis: contribution of cerebral MRI findings to diagnosis ' (2000 ) 10 J. Neuroimaging : 116 -118.

    • Search Google Scholar
  • Martin-Duverneuil, N., Mokhtari, K., Behin, A. és mtsai: Intravascular malignant lymphomatosis. Neuroradiology, 2002, 44 , 749–754.

    Behin A. , 'Intravascular malignant lymphomatosis ' (2002 ) 44 Neuroradiology : 749 -754.

  • Nagayama, M., Shinohara, Y., Sekiyama, S. és mtsai: Intravascular malignant lymphomatosis manifesting clinically as bilateral sudden hearing loss and cytomegalovirus encephalitis. Neurology, 1994, 44 , 1518–1520.

    Sekiyama S. , 'Intravascular malignant lymphomatosis manifesting clinically as bilateral sudden hearing loss and cytomegalovirus encephalitis ' (1994 ) 44 Neurology : 1518 -1520.

    • Search Google Scholar
  • Oei, M. E., Kraft, G. H., Sarnat, H. B.: Intravascular lymphomatosis. Muscle Nerve, 2002, 25 , 742–746.

    Sarnat H. B. , 'Intravascular lymphomatosis ' (2002 ) 25 Muscle Nerve : 742 -746.

  • Ossege, L. M., Postler, E., Pleger, B. és mtsai: Neoplastic cells in the cerebrospinal fluid in intravascular lymphomatosis. J. Neurol., 2000, 247 , 656–658.

    Pleger B. , 'Neoplastic cells in the cerebrospinal fluid in intravascular lymphomatosis ' (2000 ) 247 J. Neurol. : 656 -658.

    • Search Google Scholar
  • Pfleger, L., Tappeiner, J.: Zur Kenntnis der systemisierten Endotheliomatose der cutan Blutgefässe. Hautarzt, 1959, 10 , 359–363.

    Tappeiner J. , 'Zur Kenntnis der systemisierten Endotheliomatose der cutan Blutgefässe ' (1959 ) 10 Hautarzt : 359 -363.

    • Search Google Scholar
  • Sastre, J. M., Folgado, R., Burges, O. és mtsai: Intravascular lymphomatosis manifesting in the lung. An. Med. Interna, 2001, 18 , 319–322.

    Burges O. , 'Intravascular lymphomatosis manifesting in the lung ' (2001 ) 18 An. Med. Interna : 319 -322.

    • Search Google Scholar
  • Schwartz, S., Zoubaa, S., Knauth, M. és mtsai: Intravascular lymphomatosis presenting with a conus medullaris syndrome mimicking disseminated encephalomyelitis. Neuro-oncol., 2002, 4 , 187–191.

    Knauth M. , 'Intravascular lymphomatosis presenting with a conus medullaris syndrome mimicking disseminated encephalomyelitis ' (2002 ) 4 Neuro-oncol. : 187 -191.

    • Search Google Scholar
  • Sukpanichnant, S., Visuthisakchai, S.: Intravascular lymphomatosis: a study of 20 cases in Thailand and review of the literature. Clin. Lymphoma Myeloma, 2006, 6 , 319–328.

    Visuthisakchai S. , 'Intravascular lymphomatosis: a study of 20 cases in Thailand and review of the literature ' (2006 ) 6 Clin. Lymphoma Myeloma : 319 -328.

    • Search Google Scholar
  • Torenbeek, R., Scheltens, P., Strack van Schijdnel, R. J. M. és mtsai: Angiotropic intravascular large-cell lymphoma with massive cerebral extension. J. Neurol. Neurosurg. Psychiatr., 1993, 56 , 914–916.

    Strack van Schijdnel R. J. M. , 'Angiotropic intravascular large-cell lymphoma with massive cerebral extension ' (1993 ) 56 J. Neurol. Neurosurg. Psychiatr. : 914 -916.

    • Search Google Scholar
  • Viali, S., Hutchinson, D. O., Hawkins, T. E. és mtsai: Presentation of intravascular lymphomatosis as lumbosacral polyradiculopathy. Muscle Nerve, 2000, 23 , 1295–1300.

    Hawkins T. E. , 'Presentation of intravascular lymphomatosis as lumbosacral polyradiculopathy ' (2000 ) 23 Muscle Nerve : 1295 -1300.

    • Search Google Scholar
  • Vieren, M., Sciot, R., Robberecht, W.: Intravascular lymphomatosis of the brain: a diagnostic problem. Clin. Neurol. Neurosurg., 1999, 101 , 33–36.

    Robberecht W. , 'Intravascular lymphomatosis of the brain: a diagnostic problem ' (1999 ) 101 Clin. Neurol. Neurosurg. : 33 -36.

    • Search Google Scholar