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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088
  • 2 Magyar Tudományos Akadémia Molekuláris Medicina Kutatócsoport Budapest
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A nyelőcsőrák a kilencedik leggyakoribb rosszindulatú daganat. Több mint 90%-ban előrehaladott állapotban kerül felismerésre. A sebészi beavatkozás, a kemo-, illetve radioterápia lehetőségei korlátozottak. Napjainkban a génterápia került az érdeklődés előterébe. A szerzők a nyelőcsőlaphámrák genetikai és molekuláris hátterét és a génterápiával elért kezdeti tapasztalatokat tekintik át. Ismertetik a komplementer nukleinsavak (antisense terápia), a génpótlás, a kis interferáló RNS-k alkalmazásának lehetőségeit.

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