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  • 1 Szegedi Tudományegyetem Bőrgyógyászati és Allergológiai Klinika Szeged Korányi fasor 6. 6720
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A hám eredetű tumorok a leggyakrabban előforduló bőrdaganatok. Az arcon és a kézen való gyakori elhelyezkedésük miatt ellátásuk során az onkológiai szempontok mellett esztétikai szempontokat is figyelembe kell venni. Kezelésük során általában elsőként választandó a sebészi kimetszés, de számos más alternatíva is létezik, különösen a felületes, nem mélyre terjedő tumorok esetében. A fotodinámiás terápia bizonyos nem melanoma típusú rosszindulatú bőrdaganatok kezelésében napjainkra széles körben elfogadott eljárássá vált. A fotodinámiás terápia során fényérzékenyítő anyag alkalmazását követően a kezelt bőrfelületet az adott fényérzékenyítő abszorpciós maximumának megfelelő hullámhosszúságú fénnyel sugarazzuk be. A fényérzékenyítő anyagok akkumulációja a gyorsan osztódó sejtekben és újonnan képződött erekben sokkal nagyobb mértékű, mint a környező, egészséges szövetekben – ez biztosítja a kezelés daganatszelektivitását. A terápia során a fény hatására gerjesztett állapotba kerülő fényérzékenyítő anyagból reaktív oxigéngyökök szabadulnak fel, melyek végső soron megváltozott sejtfolyamatokhoz, illetve a sejtek apoptózisához vezetnek. A fotodinámiás terápia hatékonysága solaris keratosis, superficialis basalioma és morbus Bowen esetén bizonyított, kozmetikai eredményessége pedig felülmúlja a többi elfogadott kezelését. A mellékhatások – fájdalom, erythema, pörkképződés, nedvedzés, ödéma – általában enyhék, és gyorsan megszűnnek. A szerzők a Szegedi Tudományegyetem Bőrgyógyászati és Allergológiai Klinikán 2003. december és 2006. január között 212 betegnél végzett fotodinámiás kezelések során szerzett tapasztalataikat ismertetik, és áttekintik a fotodinámiás kezelés dermatoonkológiai irodalmát.

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