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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088
  • 2 MTA-SE Gastroenterológiai és Endokrinológiai Kutatócsoport Budapest
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A iatrogén Cushing-szindróma a hypercortisolismus leggyakoribb formája. Számos betegség kezelésében alkalmaznak sokszor nagy adagban glükokortikoidokat, ami nem ritkán súlyos klinikai képpel jellemzett hypercortisolismus kialakulásához vezet. A iatrogén Cushing-szindróma különlegességét az exogén glükokortikoidok okozta hypercortisolismus tüneteinek és az endogén hypothalamo-hypophysis-mellékvese rendszer gátlásának kettőssége adja. A kórkép kezelésének központi kérdése a glükokortikoid terápia leépítésének nehézsége. A hypothalamus-hypophysis-mellékvese rendszer gátlásában és regenerálódásában igen nagy fokú az egyének közötti variabilitás, emiatt a leépítés megtervezése csak fokozatosan, a klinikai kép és az endogén hormonaktivitás hatékonyságát jelző laboratóriumi paraméterek figyelembe vételével lehetséges. A leépítés során három fő szövődmény jelentkezhet: az alapbetegség reaktiválódása, másodlagos mellékvesekéreg-elégtelenség kialakulása, ill. az ún. szteroid megvonási tünetegyüttes. A szerzők saját klinikai tapasztalataik és a nemzetközi irodalom javaslatai alapján foglalják össze a témakör legfontosabb kérdéseit.

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