View More View Less
  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar I. Belgyógyászati Klinika Budapest Korányi S. u. 2/a 1083
  • 2 Gerincgyógyászati Központ Budai Egészségközpont Budapest
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $1,070.00

A csontpótlást igénylő műtéti beavatkozások során a beültetésre kerülő csontpótló graft tulajdonságai meghatározzák az eljárás kimenetelét, rövid és hosszú távú sikerét. Munkánk első részében áttekintést adunk a modern csontpótló eljárások előnyeiről-hátrányairól, illetve részletesen foglalkozunk a gipsz szintetikus csontpótló graftként történő alkalmazásának lehetőségével. A kísérletes klinikai leírások biztonsággal és jó hosszú távú eredménnyel alkalmazható csonthiánykitöltő anyagként írják le a kalcium-szulfát-dihidrátot, azonban a gipsz csontsejtekre kifejtett hatása, a csontpótlás mechanizmusa nem ismert. Molekuláris biológiai módszerekkel vizsgáltuk a gipsz csontsejtekre gyakorolt hatását. Az egér-praeosteoblastok szaporodására ideális tenyésztőfelületnek bizonyult a gipsz, míg a klinikumban gyakran csonthiánykitöltő anyagként alkalmazott polimetil-metakrilát-csontcement gátolta a sejtek osztódását. A gipsz megváltoztatta a sejtek génkifejeződési profilját, a csontképződés irányába mutató gének expresszálódtak nagyobb mértékben a gipszes tenyészetekben, és ezekben a sejtkultúrákban emelkedett alkalikusfoszfatáz-aktivitást mértünk. Eredményeink molekuláris biológiai szempontból támasztották alá a gipsz szintetikus csontpótló graftként történő alkalmazásának létjogosultságát, a kalcium-szulfát-dihidrát új – a csontgyógyulást támogató – tulajdonságát is kimutatva.

  • Peltier, L. F.: The use of plaster of Paris to fill defects in bone. Clin. Orthop., 1961, 21 , 1.

    Peltier L. F. , 'The use of plaster of Paris to fill defects in bone ' (1961 ) 21 Clin. Orthop. : 1 -.

    • Search Google Scholar
  • Kelly, C. M., Wilkins, R. M., Gitelis, S. és mtsai: The use of a surgical grade calcium sulfate as a bone graft substitute: results of a multicenter trial. Clin. Orthop. Relat. Res., 2001, 382 , 42.

    Gitelis S. , 'The use of a surgical grade calcium sulfate as a bone graft substitute: results of a multicenter trial ' (2001 ) 382 Clin. Orthop. Relat. Res. : 42 -.

    • Search Google Scholar
  • Borrelli, J., Jr., Prickett, W. D., Ricci, W. M.: Treatment of nonunions and osseous defects with bone graft and calcium sulfate. Clin. Orthop. Relat. Res., 2003, 411 , 245.

    Ricci W. M. , 'Treatment of nonunions and osseous defects with bone graft and calcium sulfate ' (2003 ) 411 Clin. Orthop. Relat. Res. : 245 -.

    • Search Google Scholar
  • Chen, W. J., Tsai, T. T., Chen, L. H. és mtsai: The fusion rate of calcium sulfate with local autograft bone compared with autologous iliac bone graft for instrumented short-segment spinal fusion. Spine, 2005, 30 , 2293.

    Chen L. H. , 'The fusion rate of calcium sulfate with local autograft bone compared with autologous iliac bone graft for instrumented short-segment spinal fusion ' (2005 ) 30 Spine : 2293 -.

    • Search Google Scholar
  • Silver, I. A., Murrills, R. J., Etherington, D. J.: Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp. Cell. Res., 1988, 175 , 266.

    Etherington D. J. , 'Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts ' (1988 ) 175 Exp. Cell. Res. : 266 -.

    • Search Google Scholar
  • Yamaguchi, T., Chattopadhyay, N., Kifor, O. és mtsai: Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca 2+ )-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells. J. Bone Miner. Res., 1998, 13 , 1530.

    Kifor O. , 'Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2+)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells ' (1998 ) 13 J. Bone Miner. Res. : 1530 -.

    • Search Google Scholar
  • Yamauchi, M., Yamaguchi, T., Kaji, H. és mtsai: Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells. Am. J. Physiol. Endocrinol. Metab., 2005, 288 , E608.

    Kaji H. , 'Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells ' (2005 ) 288 Am. J. Physiol. Endocrinol. Metab. : E608 -.

    • Search Google Scholar
  • Nakade, O., Takahashi, K., Takuma, T. és mtsai: Effect of extracellular calcium on the gene expression of bone morphogenetic protein-2 and -4 of normal human bone cells. J. Bone Miner. Metab., 2001, 19 , 13.

    Takuma T. , 'Effect of extracellular calcium on the gene expression of bone morphogenetic protein-2 and -4 of normal human bone cells ' (2001 ) 19 J. Bone Miner. Metab. : 13 -.

    • Search Google Scholar
  • Giannoudis, P. V., Dinopoulos, H., Tsiridis, E.: Bone substitutes: an update. Injury, 2005, 36 Suppl 3 , S20–27.

    Tsiridis E. , 'Bone substitutes: an update ' (2005 ) 36 Injury : S20 -27.

  • Van Heest, A., Swiontkowski, M.: Bone-graft substitutes. Lancet, 1999, 353 Suppl 1 , S128–129.

    Swiontkowski M. , 'Bone-graft substitutes ' (1999 ) 353 Lancet : S128 -129.

  • Sandhu, H. S., Grewal, H. S., Parvataneni, H.: Bone grafting for spinal fusion. Orthop. Clin. North Am., 1999, 30 , 685–698.

    Parvataneni H. , 'Bone grafting for spinal fusion ' (1999 ) 30 Orthop. Clin. North Am. : 685 -698.

    • Search Google Scholar
  • Arrington, E. D., Smith, W. J., Chambers, H. G. és mtsai: Complications of iliac crest bone graft harvesting. Clin. Orthop. Relat. Res., 1996, 329 , 300–309.

    Chambers H. G. , 'Complications of iliac crest bone graft harvesting ' (1996 ) 329 Clin. Orthop. Relat. Res. : 300 -309.

    • Search Google Scholar
  • Boyce, T., Edwards, J., Scarborough, N.: Allograft bone. The influence of processing on safety and performance. Orthop. Clin. North Am., 1999, 30 , 571–581.

    Scarborough N. , 'Allograft bone. The influence of processing on safety and performance ' (1999 ) 30 Orthop. Clin. North Am. : 571 -581.

    • Search Google Scholar
  • Ehrler, D. M., Vaccaro, A. R.: The use of allograft bone in lumbar spine surgery. Clin. Orthop. Relat. Res., 2000, 371 , 38–45.

    Vaccaro A. R. , 'The use of allograft bone in lumbar spine surgery ' (2000 ) 371 Clin. Orthop. Relat. Res. : 38 -45.

    • Search Google Scholar
  • Tomford, W. W.: Transmission of disease through transplantation of musculoskeletal allografts. J. Bone Joint Surg., 1995, 77 , 1742–1754.

    Tomford W. W. , 'Transmission of disease through transplantation of musculoskeletal allografts ' (1995 ) 77 J. Bone Joint Surg. : 1742 -1754.

    • Search Google Scholar
  • Khan, S. N., Tomin, E., Lane, J. M.: Clinical applications of bone graft substitutes. Orthop. Clin. North Am., 2000, 31 , 389–398.

    Lane J. M. , 'Clinical applications of bone graft substitutes ' (2000 ) 31 Orthop. Clin. North Am. : 389 -398.

    • Search Google Scholar
  • Gazdag, A. R., Lane, J. M., Glaser, D. és mtsai: Alternatives to Autogenous Bone Graft: Efficacy and Indications. JAAOS, 1995, 3 , 1–8.

    Glaser D. , 'Alternatives to Autogenous Bone Graft: Efficacy and Indications ' (1995 ) 3 JAAOS : 1 -8.

    • Search Google Scholar
  • Kinnunen, I., Aitasalo, K., Pollonen, M. és mtsai: Reconstruction of orbital floor fractures using bioactive glass. J. Cranio-Max. Surg., 2000, 28 , 229–234.

    Pollonen M. , 'Reconstruction of orbital floor fractures using bioactive glass ' (2000 ) 28 J. Cranio-Max. Surg. : 229 -234.

    • Search Google Scholar
  • Peltola, M., Suonpaa, J., Aitasalo, K. és mtsai: Experimental follow-up model for clinical frontal sinus obliteration with bioactive glass (S53P4). Acta Oto-laryngol., 2000, 543 , 167–169.

    Aitasalo K. , 'Experimental follow-up model for clinical frontal sinus obliteration with bioactive glass (S53P4) ' (2000 ) 543 Acta Oto-laryngol. : 167 -169.

    • Search Google Scholar
  • Chiu, R., Ma, T., Smith, R. L. és mtsai: Polymethylmethacrylate particles inhibit osteoblastic differentiation of bone marrow osteoprogenitor cells. J. Biomed. Mater. Res. A., 2006, 77 , 850.

    Smith R. L. , 'Polymethylmethacrylate particles inhibit osteoblastic differentiation of bone marrow osteoprogenitor cells ' (2006 ) 77 J. Biomed. Mater. Res. A. : 850 -.

    • Search Google Scholar
  • Obrant, K. J., Ivaska, K. K., Gerdhem, P. és mtsai: Biochemical markers of bone turnover are influenced by recently sustained fracture. Bone, 2005, 36 , 786.

    Gerdhem P. , 'Biochemical markers of bone turnover are influenced by recently sustained fracture ' (2005 ) 36 Bone : 786 -.

    • Search Google Scholar
  • Veitch, S. W., Findlay, S. C., Hamer, A. J. és mtsai: Changes in bone mass and bone turnover following tibial shaft fracture. Osteoporos. Int., 2006, 17 , 364.

    Hamer A. J. , 'Changes in bone mass and bone turnover following tibial shaft fracture ' (2006 ) 17 Osteoporos. Int. : 364 -.

    • Search Google Scholar
  • Sidqui, M., Collin, P., Vitte, C. és mtsai: Osteoblast adherence and resorption activity of isolated osteoclasts on calcium sulphate hemihydrate. Biomaterials, 1995, 16 , 1327.

    Vitte C. , 'Osteoblast adherence and resorption activity of isolated osteoclasts on calcium sulphate hemihydrate ' (1995 ) 16 Biomaterials : 1327 -.

    • Search Google Scholar
  • Winn, S. R., Hollinger, J. O.: An osteogenic cell culture system to evaluate the cytocompatibility of Osteoset, a calcium sulfate bone void filler. Biomaterials, 2000, 21 , 2413.

    Hollinger J. O. , 'An osteogenic cell culture system to evaluate the cytocompatibility of Osteoset, a calcium sulfate bone void filler ' (2000 ) 21 Biomaterials : 2413 -.

    • Search Google Scholar
  • Sowa, H., Kaji, H., Yamaguchi, T. és mtsai: Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells. J. Bone Miner. Res., 2002, 17 , 1190.

    Yamaguchi T. , 'Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells ' (2002 ) 17 J. Bone Miner. Res. : 1190 -.

    • Search Google Scholar
  • Balooch, G., Balooch, M., Nalla, R. K. és mtsai: TGF-beta regulates the mechanical properties and composition of bone matrix. Proc. Natl. Acad. Sci. USA, 2005, 102 , 18813.

    Nalla R. K. , 'TGF-beta regulates the mechanical properties and composition of bone matrix ' (2005 ) 102 Proc. Natl. Acad. Sci. USA : 18813 -.

    • Search Google Scholar
  • Sugama, R., Koike, T., Imai, Y. és mtsai: Bone morphogenetic protein activities are enhanced by 3’,5’-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells. Bone, 2006, 38 , 206.

    Imai Y. , 'Bone morphogenetic protein activities are enhanced by 3’,5’-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells ' (2006 ) 38 Bone : 206 -.

    • Search Google Scholar
  • Rundle, C. H., Wang, H., Yu, H. és mtsai: Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair. Bone, 2006, 38 , 521.

    Yu H. , 'Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair ' (2006 ) 38 Bone : 521 -.

    • Search Google Scholar
  • Heiner, D. E., Meyer, M. H., Frick, S. L. és mtsai: Gene expression during fracture healing in rats comparing intramedullary fixation to plate fixation by DNA microarray. J. Orthop. Trauma, 2006, 20 , 27.

    Frick S. L. , 'Gene expression during fracture healing in rats comparing intramedullary fixation to plate fixation by DNA microarray ' (2006 ) 20 J. Orthop. Trauma : 27 -.

    • Search Google Scholar
  • Chiba, S., Okada, K., Lee, K. és mtsai: Molecular analysis of defect healing in rat diaphyseal bone. J. Vet. Med. Sci., 2001, 63 , 603.

    Lee K. , 'Molecular analysis of defect healing in rat diaphyseal bone ' (2001 ) 63 J. Vet. Med. Sci. : 603 -.

    • Search Google Scholar
  • Corsi, A., Xu, T., Chen, X. D. és mtsai: Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues. J. Bone Miner. Res., 2002, 17 , 1180.

    Chen X. D. , 'Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues ' (2002 ) 17 J. Bone Miner. Res. : 1180 -.

    • Search Google Scholar
  • Coetzee, A. S.: Regeneration of bone in the presence of calcium sulfate. Arch. Otolaryngol., 1980, 106 , 405.

    Coetzee A. S. , 'Regeneration of bone in the presence of calcium sulfate ' (1980 ) 106 Arch. Otolaryngol. : 405 -.

    • Search Google Scholar
  • Bucholz, R. W.: Nonallograft osteoconductive bone graft substitutes. Clin. Orthop. Relat. Res., 2002, 395 , 44.

    Bucholz R. W. , 'Nonallograft osteoconductive bone graft substitutes ' (2002 ) 395 Clin. Orthop. Relat. Res. : 44 -.

    • Search Google Scholar
  • Tay, B. K., Patel, V. V., Bradford, D. S.: Calcium sulfate- and calcium phosphate-based bone substitutes. Mimicry of the mineral phase of bone. Orthop. Clin. North Am., 1999, 30 , 615.

    Bradford D. S. , 'Calcium sulfate- and calcium phosphate-based bone substitutes. Mimicry of the mineral phase of bone ' (1999 ) 30 Orthop. Clin. North Am. : 615 -.

    • Search Google Scholar
  • Hadjipavlou, A. G., Simmons, J. W., Yang, J. és mtsai: Plaster of Paris as an osteoconductive material for interbody vertebral fusion in mature sheep. Spine, 2000, 25 , 10.

    Yang J. , 'Plaster of Paris as an osteoconductive material for interbody vertebral fusion in mature sheep ' (2000 ) 25 Spine : 10 -.

    • Search Google Scholar
  • Walsh, W. R., Morberg, P., Yu, Y. és mtsai: Response of a calcium sulfate bone graft substitute in a confined cancellous defect. Clin. Orthop. Relat. Res., 2003, 406 , 228.

    Yu Y. , 'Response of a calcium sulfate bone graft substitute in a confined cancellous defect ' (2003 ) 406 Clin. Orthop. Relat. Res. : 228 -.

    • Search Google Scholar

 

The author instructions are available in PDF.
Instructions for Authors in Hungarian HERE.

 

Mendeley citation style is available HERE.

Senior editors

Editor(s)-in-Chief: Papp Zoltán

Read the professional career of Papp Zoltán HERE.

 

Editorial Board

Click for the Editorial Board

Akadémiai Kiadó
Address: Prielle Kornélia u. 21-35. H-1117 Budapest, Hungary
Phone: (+36 1) 464 8235 ---- Fax: (+36 1) 464 8221
Email: orvosihetilap@akkrt.hu

2019  
Total Cites
WoS
1 085
Impact Factor 0,497
Impact Factor
without
Journal Self Cites
0,212
5 Year
Impact Factor
0,396
Immediacy
Index
0,126
Citable
Items
247
Total
Articles
176
Total
Reviews
71
Cited
Half-Life
6,1
Citing
Half-Life
7,3
Eigenfactor
Score
0,00071
Article Influence
Score
0,045
% Articles
in
Citable Items
71,26
Normalized
Eigenfactor
0,08759
Average
IF
Percentile
10,606
Scimago
H-index
20
Scimago
Journal Rank
0,176
Scopus
Scite Score
864/1178=0,4
Scopus
Scite Score Rank
General Medicine 267/529 (Q3)
Scopus
SNIP
0,254
Acceptance
Rate
73%

 

Language: Hungarian

Founded in 1857
Publication: Weekly, one volume of 52 issues annually