View More View Less
  • 1 Semmelweis Egyetem, Budapest, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088
  • 2 Magyar Tudományos Akadémia Molekuláris Medicina Kutatócsoport Budapest
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $1,070.00

Az elsődleges májrák az ötödik leggyakoribb daganat világszerte. A primer májrákok 85–90%-a hepatocellularis carcinoma. Földrajzi eloszlása jellegzetes, egyes népcsoportokban is eltérő. Férfiakban gyakoribb, mint nőkben. 70–90%-ban idült májbetegség vagy cirrhosis talaján alakul ki. A hepatitis B-, C-vírus-fertőzés és az aflatoxinszennyezettség a májrákok 80%-áért felelős. Kialakulása többlépcsős folyamat, molekuláris hátteréről egyre több ismerettel rendelkezünk. A genetikai és epigenetikai eltérések a sejtproliferációt serkentő mediátorokat aktiválják (onkogének), a szaporodást gátló mediátorokat hatástalanítják (tumorszuppresszor fehérjék), amely autonóm sejtproliferációt eredményez. A telomera kóros működés okozta kromoszómainstabilitás, a növekedésében gátolt környezet, a mikro- és makrokörnyezet megváltozása segíti a malignusan transzformált sejtek terjedését. A folyamatok pontos megismerése és megértése az idült májbetegek, májzsugorban szenvedők szűrését, a HCC megelőzését és a kezelést segítheti a jövőben.

  • Parikh, S., Hyman, D.: Hepatocellular cancer: A guide for the internist. Am. J. Med., 2007, 120 , 194–202.

    Hyman D. , 'Hepatocellular cancer: A guide for the internist ' (2007 ) 120 Am. J. Med. : 194 -202.

    • Search Google Scholar
  • El-Serag, H. B., Lenhard, R.: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 2007, 132 , 2557–2576.

    Lenhard R. , 'Hepatocellular carcinoma: epidemiology and molecular carcinogenesis ' (2007 ) 132 Gastroenterology : 2557 -2576.

    • Search Google Scholar
  • Farazi, P. A., DePinho, R. A.: Hepatocellular carcinoma pathogenesis from genes to environment. Nature Rev. Cancers, 2006, 6 , 674–687.

    DePinho R. A. , 'Hepatocellular carcinoma pathogenesis from genes to environment ' (2006 ) 6 Nature Rev. Cancers : 674 -687.

    • Search Google Scholar
  • Nagy P., László V., Schaff Zs.: A hepatokarcinogenezis folyamata human májban. Magyar Onkológia, 2006, 50 , 107–113.

    Schaff Zs. , 'A hepatokarcinogenezis folyamata human májban ' (2006 ) 50 Magyar Onkológia : 107 -113.

    • Search Google Scholar
  • Seeff, L. B., Hoofnagle, J. H.: Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity. Oncogene, 2006, 25 , 3771–3777.

    Hoofnagle J. H. , 'Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity ' (2006 ) 25 Oncogene : 3771 -3777.

    • Search Google Scholar
  • McGlynn, K. A., London, W. T.: Epidemiology and natural history of hepatocellular carcinoma. Best Practice Res. Clin. Gastroent., 2005, 19 , 3–23.

    London W. T. , 'Epidemiology and natural history of hepatocellular carcinoma ' (2005 ) 19 Best Practice Res. Clin. Gastroent. : 3 -23.

    • Search Google Scholar
  • Okuda, H.: Hepatocellular carcinoma development in cirrhosis. Best Practice Res. Clin. Gastroent., 2007, 21 , 161–173.

    Okuda H. , 'Hepatocellular carcinoma development in cirrhosis ' (2007 ) 21 Best Practice Res. Clin. Gastroent. : 161 -173.

    • Search Google Scholar
  • El-Serag, H. B.: Epidemiology of hepatocellular carcinoma in USA. Hepatol. Res., 2007, 37 (Suppl. 2) , S88–94.

    El-Serag H. B. , 'Epidemiology of hepatocellular carcinoma in USA ' (2007 ) 37 Hepatol. Res. : S88 -94.

    • Search Google Scholar
  • Kulik, L. M.: Advancements in hepatocellular carcinoma. Curr. Op. Gastroenterol., 2007, 23 , 268–274.

    Kulik L. M. , 'Advancements in hepatocellular carcinoma ' (2007 ) 23 Curr. Op. Gastroenterol. : 268 -274.

    • Search Google Scholar
  • Marrero, C. R., Marrero, J. A.: Viral hepatitis and hepatocellular carcinoma. Arch. Med. Sci., 2007, 38 , 612–620.

    Marrero J. A. , 'Viral hepatitis and hepatocellular carcinoma ' (2007 ) 38 Arch. Med. Sci. : 612 -620.

    • Search Google Scholar
  • Pang, R., Tse, E., Poon, R. T. P.: Molecular pathways in hepatocellular carcinoma. Cancer Letters, 2006, 240 , 157–169.

    Poon R. T. P. , 'Molecular pathways in hepatocellular carcinoma ' (2006 ) 240 Cancer Letters : 157 -169.

    • Search Google Scholar
  • Lupberegr, J., Hildt, E.: Hepatitis B virus-induced oncogenesis. W. J. Gastroenterol., 2007, 13 , 74–81.

    Hildt E. , 'Hepatitis B virus-induced oncogenesis ' (2007 ) 13 W. J. Gastroenterol. : 74 -81.

  • Laurent-Puig, P., Zucmann-Rossi, J.: Genetics of hepatocellular tumors. Oncogene, 2006, 25 , 3778–3786.

    Zucmann-Rossi J. , 'Genetics of hepatocellular tumors ' (2006 ) 25 Oncogene : 3778 -3786.

  • Anzola, M.: Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis. J. Viral Hepatitis, 2004, 11 , 383–393.

    Anzola M. , 'Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis ' (2004 ) 11 J. Viral Hepatitis : 383 -393.

    • Search Google Scholar
  • Suriawinata, A., Xu, R.: An update on molecular genetics of hepatocellular carcinoma. Seminars Liv. Dis., 2004, 24 , 77–88.

    Xu R. , 'An update on molecular genetics of hepatocellular carcinoma ' (2004 ) 24 Seminars Liv. Dis. : 77 -88.

    • Search Google Scholar
  • Okanoue, T., Minami, M.: Update of reserach and management of hepatitis B. J. Gastroenterol., 2006, 41 , 107–118.

    Minami M. , 'Update of reserach and management of hepatitis B ' (2006 ) 41 J. Gastroenterol. : 107 -118.

    • Search Google Scholar
  • Cougot, D., Neuveut, C., Buendia, M. A.: HBV induced carcinogenesis. J. Clin. Virol., 2005, 34 (Suppl. 1) , 875–878.

    Buendia M. A. , 'HBV induced carcinogenesis ' (2005 ) 34 J. Clin. Virol. : 875 -878.

  • Jin, D. Y.: Molecular pathogenesis of hepatitis C virus-associated hepatocellular carcinoma. Front. Biosci., 2007, 12 , 222–233.

    Jin D. Y. , 'Molecular pathogenesis of hepatitis C virus-associated hepatocellular carcinoma ' (2007 ) 12 Front. Biosci. : 222 -233.

    • Search Google Scholar
  • Koike, K.: Hepatitis C virus contributes to hepatocarcinogenesis by modulating metabolic and intracellular signalling pathways. J. Gastroenterol. Hepatol., 2007, 22 (Suppl. 1) , 108–111.

    Koike K. , 'Hepatitis C virus contributes to hepatocarcinogenesis by modulating metabolic and intracellular signalling pathways ' (2007 ) 22 J. Gastroenterol. Hepatol. : 108 -111.

    • Search Google Scholar
  • Perlemuter, G., Bigorgne, A., Cassard-Doulcier, A. M. és mtsa: Nonalcoholic fatty liver disease: from pathogenesis to patient care. Nat. Clin. Pract. Endocrinol. Metab., 2007, 3 , 458–469.

    Cassard-Doulcier A. M. , 'Nonalcoholic fatty liver disease: from pathogenesis to patient care ' (2007 ) 3 Nat. Clin. Pract. Endocrinol. Metab. : 458 -469.

    • Search Google Scholar
  • Yeh, M. M., Brunt, E. M.: Pathology of nonalcoholic fatty liver disease. Am. J. Clin. Pathol., 2007, 128 , 837–847.

    Brunt E. M. , 'Pathology of nonalcoholic fatty liver disease ' (2007 ) 128 Am. J. Clin. Pathol. : 837 -847.

    • Search Google Scholar
  • El-Serag, H. B., Hampel, H., Javadi, F.: The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin. Gastroenterol. Hepatol., 2006, 4 , 369–380.

    Javadi F. , 'The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence ' (2006 ) 4 Clin. Gastroenterol. Hepatol. : 369 -380.

    • Search Google Scholar
  • Maheshwari, S., Sarraj, A., Kramer, J. és mtsa: Oral contraception and the risk of hepatocellular carcinoma. J. Hepatol., 2007, 47 , 506–513.

    Kramer J. , 'Oral contraception and the risk of hepatocellular carcinoma ' (2007 ) 47 J. Hepatol. : 506 -513.

    • Search Google Scholar
  • Cauza, E., Peck-Radosavljevic, M., Ulrich-Pur, H. és mtsai: Mutations of the HFE gene in patients with hepatocellular carcinoma. Am. J. Gastroenterol., 2003, 98 , 442–447.

    Ulrich-Pur H. , 'Mutations of the HFE gene in patients with hepatocellular carcinoma ' (2003 ) 98 Am. J. Gastroenterol. : 442 -447.

    • Search Google Scholar
  • Talamini, R., Polesel, J., Montella, M. és mtsai: Food groups and risk of hepatocellular carcinoma: A multicenter case-control study in Italy. Int. J. Cancer, 2006, 119 , 2916–2921.

    Montella M. , 'Food groups and risk of hepatocellular carcinoma: A multicenter case-control study in Italy ' (2006 ) 119 Int. J. Cancer : 2916 -2921.

    • Search Google Scholar
  • Wiemann, S. U., Satyanarayana, A., Buer, J. és mtsai: Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage. Oncogene, 2005, 24 , 1501–1509.

    Buer J. , 'Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage ' (2005 ) 24 Oncogene : 1501 -1509.

    • Search Google Scholar
  • Farazi, P. A., Glickman, J., Jiang, S. és mtsai: Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma. Cancer Res., 2003, 63 , 5021–5027.

    Jiang S. , 'Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma ' (2003 ) 63 Cancer Res. : 5021 -5027.

    • Search Google Scholar
  • Zhu, J.: DNA methylation and hepatocellular carcinoma. J. Hepato-Biliary-Pancreatic Surgery, 2006, 13 , 265–273.

    Zhu J. , 'DNA methylation and hepatocellular carcinoma ' (2006 ) 13 J. Hepato-Biliary-Pancreatic Surgery : 265 -273.

    • Search Google Scholar
  • Peyrin-Biroulet, L., Barraud, H., Darfeuil, F. és mtsai: Epigenetic changes and liver carcinogenesis. Gastroenterol. Clin. Biolog., 2006, 30 , 1354–1359.

    Darfeuil F. , 'Epigenetic changes and liver carcinogenesis ' (2006 ) 30 Gastroenterol. Clin. Biolog. : 1354 -1359.

    • Search Google Scholar
  • Herath, N. I., Leggett, B. A., MacDonald, G. A.: Review of genetic and epigenetic alterations in hepatocarcinogenesis. J. Gastroent. Hepatol., 2006, 21 , 15–21.

    MacDonald G. A. , 'Review of genetic and epigenetic alterations in hepatocarcinogenesis ' (2006 ) 21 J. Gastroent. Hepatol. : 15 -21.

    • Search Google Scholar
  • Fabregat, I., Roncero, C., Fernández, M.: Survival and apoptosis: a dysregulated balance in liver cancer. Liver Int., 2007, 27 , 155–162.

    Fernández M. , 'Survival and apoptosis: a dysregulated balance in liver cancer ' (2007 ) 27 Liver Int. : 155 -162.

    • Search Google Scholar
  • Mann, C. D., Neal, C. P., Garcea, G. és mtsai: Prognostic molecular markers in hepatocellular carcinoma. A systematic review. Eur. J. Cancer, 2007, 43 , 979–992.

    Garcea G. , 'Prognostic molecular markers in hepatocellular carcinoma. A systematic review ' (2007 ) 43 Eur. J. Cancer : 979 -992.

    • Search Google Scholar
  • Hussain, S. P., Schwank, J., Staib, F. és mtsai: TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene, 2007, 26 , 2166–2176.

    Staib F. , 'TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer ' (2007 ) 26 Oncogene : 2166 -2176.

    • Search Google Scholar
  • Matsuda, Y., Ichida, T.: p16 and p27 are functionally correlated during the progress of hepatocarcinogenesis. Med. Mol. Morphology, 2006, 39 , 169–175.

    Ichida T. , 'p16 and p27 are functionally correlated during the progress of hepatocarcinogenesis ' (2006 ) 39 Med. Mol. Morphology : 169 -175.

    • Search Google Scholar
  • Breuhahn, K., Longerich, T., Schimacher, P.: Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene, 2006, 25 , 3787–3800.

    Schimacher P. , 'Dysregulation of growth factor signaling in human hepatocellular carcinoma ' (2006 ) 25 Oncogene : 3787 -3800.

    • Search Google Scholar
  • Shupe, T., Petersen, B. E.: Evidence regarding a stem cell origin of hepatocellular carcinoma. Stem Cells Rev., 2005, 1 , 261–264.

    Petersen B. E. , 'Evidence regarding a stem cell origin of hepatocellular carcinoma ' (2005 ) 1 Stem Cells Rev. : 261 -264.

    • Search Google Scholar
  • Lechel, A., Holstege, H., Begus, Y. és mtsai: Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. Gastroenterology, 2007, 132 , 1465–1475.

    Begus Y. , 'Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease ' (2007 ) 132 Gastroenterology : 1465 -1475.

    • Search Google Scholar
  • Djojosubroto, M. W., Chin, A. C., Go, N. és mtsai: Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology, 2005, 42 , 1127–1136.

    Go N. , 'Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma ' (2005 ) 42 Hepatology : 1127 -1136.

    • Search Google Scholar
  • Gua, Y. S., La, Z., Yang, L. és mtsai: p53 gene in the treatment of hepatic carcinoma: status quo. W. J. Gastroenterol., 2007, 13 , 985–992.

    Yang L. , 'p53 gene in the treatment of hepatic carcinoma: status quo ' (2007 ) 13 W. J. Gastroenterol. : 985 -992.

    • Search Google Scholar