A vesék korfüggő morfológiai és funkcionális változásait nem lehet fiziológiásnak tekinteni. A korral csökken a glomerulusok száma, scleroticus glomerulusok és aglomerularis arteriolák jelennek meg. A tubulusok atrophiája mellett gyakori az interstitialis fibrosis, és az időskori érelváltozások is erősen érintik a veséket. Csökken a vesék keringése és a GFR, az utóbbit nem tükrözi a se-creatinin értéke. A tubularis transzportok zavara főként a só- és vízkiválasztást érinti, hyposthenuriát okoz. A korfüggő változások patogenezise komplex, és részleteiben még nem tisztázott. A változások mindenesetre rontják a kiválasztást, és befolyásolják a gyógyszerek farmakokinetikáját. Valódi krónikus veseelégtelenségben más funkciók (eritropoetin-képzés, D-vitamin, Ca- és P-anyagcsere) is károsodnak. Az időskorban gyakoribb szisztémás betegségek (diabétesz, hipertónia stb.) miatt a valódi krónikus veseelégtelenség is gyakoribb, de az akut veseelégtelenség különféle formái is könnyebben alakulnak ki.
Grimley, E. J., Bond, J.: The challenges of age research. Age Ageing, 1997, 26 (Suppl) , 43–46.
Bond J. , 'The challenges of age research ' (1997 ) 26 Age Ageing : 43 -46 .
Brown, W. W., Davis, B. B., Spry, L. A. és mtsai: Aging and the kidney. Arch. Int. Med., 1986, 146 , 790–1796.
Spry L. A. , 'Aging and the kidney ' (1986 ) 146 Arch. Int. Med. : 790 -1796 .
Anderson, S., Brenner, B. M.: Effects of aging on the renal glomerulus. Am. J. Med., 1986, 80 , 435–442.
Brenner B. M. , 'Effects of aging on the renal glomerulus ' (1986 ) 80 Am. J. Med. : 435 -442 .
Kaplan, C., Pasternack, B., Shah, H. és mtsa: Age-related incidence of sclerotic glomeruli in human kidneys. Am. J. Pathol., 1975, 80 , 227–234.
Shah H. , 'Age-related incidence of sclerotic glomeruli in human kidneys ' (1975 ) 80 Am. J. Pathol. : 227 -234 .
Takazakura, E., Sawabu, N., Handa, A. és mtsai: Intrarenal vascular changes with age and disease. Kidney Int., 1972, 2 , 224–230.
Handa A. , 'Intrarenal vascular changes with age and disease ' (1972 ) 2 Kidney Int. : 224 -230 .
Baylis, C., Schmidt, R.: The aging glomerulus. Semin. Nephrol., 1996, 16 , 265–276.
Schmidt R. , 'The aging glomerulus ' (1996 ) 16 Semin. Nephrol. : 265 -276 .
Nyengaard, J. R., Bendtsen, T. F.: Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat. Res., 1992, 232 , 194–201.
Bendtsen T. F. , 'Glomerular number and size in relation to age, kidney weight, and body surface in normal man ' (1992 ) 232 Anat. Res. : 194 -201 .
Hughson, M., Farris, A. B. 3rd, Douglas-Denton, R. és mtsai: Glomerular number and size in autopsy kidneys: The relationship to birth weight. Kidney Int., 2003, 63 , 2113–2122.
Douglas-Denton R. , 'Glomerular number and size in autopsy kidneys: The relationship to birth weight ' (2003 ) 63 Kidney Int. : 2113 -2122 .
Darmady, E. M., Offer, J., Woodhouse, M. A.: The parameters of the ageing kidney. J. Path., 1973, 109 , 195–207.
Woodhouse M. A. , 'The parameters of the ageing kidney ' (1973 ) 109 J. Path. : 195 -207 .
Hollenberg, N. K., Adams, D. F., Solomon, H. S. és mtsai: Senescence and the renal vasculature in normal man. Circ. Res., 1974, 34 , 309–316.
Solomon H. S. , 'Senescence and the renal vasculature in normal man ' (1974 ) 34 Circ. Res. : 309 -316 .
Takebayashi, S., Kiyoshi, Y., Hisano, S. és mtsai: Benign nephrosclerosis: incidence, morphology and prognosis. Clin. Nephrol., 2001, 55 , 349–356.
Hisano S. , 'Benign nephrosclerosis: incidence, morphology and prognosis ' (2001 ) 55 Clin. Nephrol. : 349 -356 .
Lindeman, R. D., Goldman, R.: Anatomic and physiologic age changes in the kidney. Exp. Gerontol., 1986, 21 , 379–406.
Goldman R. , 'Anatomic and physiologic age changes in the kidney ' (1986 ) 21 Exp. Gerontol. : 379 -406 .
Meyer, B. R.: Renal function in aging. J. Am. Geriatr. Soc., 1989, 37 , 791–800.
Meyer B. R. , 'Renal function in aging ' (1989 ) 37 J. Am. Geriatr. Soc. : 791 -800 .
Corman, B., Chami-Khazraji, J., Schaeverbeke, J.: Effect of feeding on glomerular filtration rate and proteinuria in conscious aging rats. Am. J. Physiol. Renal Physiol., 1988, 255 , F250–F256.
Schaeverbeke J. , 'Effect of feeding on glomerular filtration rate and proteinuria in conscious aging rats ' (1988 ) 255 Am. J. Physiol. Renal Physiol. : F250 -F256 .
Lindeman, R. D., Tobin, J., Shock, N. W.: Longitudinal studies on the rate of decline in renal function with age. J. Am. Geriatr. Soc., 1985, 33 , 278–285.
Shock N. W. , 'Longitudinal studies on the rate of decline in renal function with age ' (1985 ) 33 J. Am. Geriatr. Soc. : 278 -285 .
Epstein, M.: Aging and the kidney. J. Am. Soc. Nephrol., 1996, 7 , 1106–1122.
Epstein M. , 'Aging and the kidney ' (1996 ) 7 J. Am. Soc. Nephrol. : 1106 -1122 .
Stevens, L. A., Levey, A. S.: Chronic kidney disease in the elderly – how to assess risk. N. Engl. J. Med., 2005, 352 , 2122–2124.
Levey A. S. , 'Chronic kidney disease in the elderly – how to assess risk ' (2005 ) 352 N. Engl. J. Med. : 2122 -2124 .
Verhave, J. C., Fesler, P., Ribstein, J. és mtsai: Estimation of renal function in elderly subjects with normal serum creatinine levels: Influence of age and body mass index. Am. J. Kidney Dis., 2005, 46 , 233–241.
Ribstein J. , 'Estimation of renal function in elderly subjects with normal serum creatinine levels: Influence of age and body mass index ' (2005 ) 46 Am. J. Kidney Dis. : 233 -241 .
Baylis, C.: Changes in renal hemodynamics and structure in the aging kidne. sexual dimorphism and the nitric oxide system.; Exp. Gerontol., 2005, 40 , 271–278.
Baylis C. , 'Changes in renal hemodynamics and structure in the aging kidne ' (2005 ) 40 sexual dimorphism and the nitric oxide system.; Exp. Gerontol. : 271 -278 .
Esposito, C., Plati, A. R., Mazzullo, T. és mtsai: A. Renal function and functional reserve in healthy elderly individuals. J. Nephrol., 2007, 20 , 617–625.
Mazzullo T. , 'A. Renal function and functional reserve in healthy elderly individuals ' (2007 ) 20 J. Nephrol. : 617 -625 .
Bosch, J. P., Saccaggi, A., Lauer, A. és mtsai: Renal functional reserve in humans. Am. J. Med., 1986, 75 , 953–5.
Lauer A. , 'Renal functional reserve in humans ' (1986 ) 75 Am. J. Med. : 953 -5 .
Luft, F. C., Grim, C. E., Gineberg, N. és mtsa: Effects of volume expansion and contraction in normotensive whites, blacks, and subjects of different ages. Circulation, 1979, 59 , 643–650.
Gineberg N. , 'Effects of volume expansion and contraction in normotensive whites, blacks, and subjects of different ages ' (1979 ) 59 Circulation : 643 -650 .
Epstein, M., Hollenberg, N. K.: Age as a determinant of renal sodium conservation in normal man. J. Lab. Clin. Med., 1976, 87 , 411–417.
Hollenberg N. K. , 'Age as a determinant of renal sodium conservation in normal man ' (1976 ) 87 J. Lab. Clin. Med. : 411 -417 .
Musso, C. G., Núnez, F. M., Oreopoulos, D. G.: Physiological similarities and differences between renal aging and chronic renal disease. J. Nephrol., 2007, 20 , 586–587.
Oreopoulos D. G. , 'Physiological similarities and differences between renal aging and chronic renal disease ' (2007 ) 20 J. Nephrol. : 586 -587 .
Claesson, S., Morrison, A., Wertheimer, A. I. és mtsa: Compliance with prescribed drugs: challenges for the elderly population. Pharm. W. Sci., 1999, 21 , 256–259.
Wertheimer A. I. , 'Compliance with prescribed drugs: challenges for the elderly population ' (1999 ) 21 Pharm. W. Sci. : 256 -259 .
Ferris, D., Menyah, D. K.: Reducing the use of inappropriate medications in the hospitalized elderly. Am. J. Health-Syst. Pharm., 2001, 58 , 1588–1592.
Menyah D. K. , 'Reducing the use of inappropriate medications in the hospitalized elderly ' (2001 ) 58 Am. J. Health-Syst. Pharm. : 1588 -1592 .
Chutka, D. S., Evans, J. M., Fleming, K. C. és mtsa: Drug prescribing for elderly patients. Mayo Clinic. Proc., 1995, 70 , 685–693.
Fleming K. C. , 'Drug prescribing for elderly patients ' (1995 ) 70 Mayo Clinic. Proc. : 685 -693 .
Hemmelgarn, B. R., Zhang, J., Manns, B. J. és mtsai: Progression of kidney dysfunction in the community-dwelling elderly. Kidney Int., 2006, 69 , 2155–2161.
Manns B. J. , 'Progression of kidney dysfunction in the community-dwelling elderly ' (2006 ) 69 Kidney Int. : 2155 -2161 .
Beckman, K. B., Ames, B. N.: The free radical theory of aging matures. Physiol. Rev., 1998, 78 , 547–581.
Ames B. N. , 'The free radical theory of aging matures ' (1998 ) 78 Physiol. Rev. : 547 -581 .
Melk, A., Ramassar, V., Helms, L. M. és mtsai: Telomere shortening in kidneys with age. J. Am. Soc. Nephrol., 2000, 11 , 444–453.
Helms L. M. , 'Telomere shortening in kidneys with age ' (2000 ) 11 J. Am. Soc. Nephrol. : 444 -453 .
Johnson, F. B., Sinclair, D. A., Guarente, L.: Molecular biology of aging. Cell., 1999, 96 , 291–302.
Guarente L. , 'Molecular biology of aging ' (1999 ) 96 Cell. : 291 -302 .
Silva, F. G.: The aging kidney. A review – Part II. Int. Urol. Nephrol., 2005, 37 , 419–432.
Silva F. G. , 'The aging kidney. A review – Part II ' (2005 ) 37 Int. Urol. Nephrol. : 419 -432 .
Long, D. A., Mu, W., Price, K. L. és mtsa: Blood vessels and the aging kidney. Nephron Exp. Nephrol., 2005, 101 , 95–99.
Price K. L. , 'Blood vessels and the aging kidney ' (2005 ) 101 Nephron Exp. Nephrol. : 95 -99 .
Anderson, S., Rennke, H. G., Zatz, R.: Glomerular adaptations with normal aging and with long-term converting enzyme inhibition in rats. Am. J. Physiol. Renal Physiol., 1994, 36 , F35–43.
Zatz R. , 'Glomerular adaptations with normal aging and with long-term converting enzyme inhibition in rats ' (1994 ) 36 Am. J. Physiol. Renal Physiol. : F35 -43 .
Basso, N., Paglia, N., Stella, I. és mtsai: Protective effect of the inhibition of the renin-angiotensin system on aging. Regul. Pept., 2005, 128 , 247–252.
Stella I. , 'Protective effect of the inhibition of the renin-angiotensin system on aging ' (2005 ) 128 Regul. Pept. : 247 -252 .
Locatelli, F., Pozzoni, P.: Chronic kidney disease in the elderly: is it really a premise for overwhelming renal failure? Kidney Int., 2006, 69 , 2118–2120.
Pozzoni P. , 'Chronic kidney disease in the elderly: is it really a premise for overwhelming renal failure? ' (2006 ) 69 Kidney Int. : 2118 -2120 .
Coresh, J., Astor, B. C., Greene, T. és mtsai: Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Thirt National Health and Nutrition Examination Survey. Am. J. Kidney Dis., 2003, 41 , 1–12.
Greene T. , 'Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Thirt National Health and Nutrition Examination Survey ' (2003 ) 41 Am. J. Kidney Dis. : 1 -12 .
Vendemia, F., Gesualdo, L., Schena, F. P. és mtsa: Epidemiology of primary glomerulonephritis in the elderly. Report from the Italian Registry of Renal Biopsy. J. Nephrol., 2001, 14 , 340–352.
Schena F. P. , 'Epidemiology of primary glomerulonephritis in the elderly. Report from the Italian Registry of Renal Biopsy ' (2001 ) 14 J. Nephrol. : 340 -352 .
Scolari, F., Tardanico, R., Zani, R. és mtsai: Cholesterol crystal embolism: a recognizable cause of renal disease. Am. J. Kidney Dis., 2000, 36 , 1089–1109.
Zani R. , 'Cholesterol crystal embolism: a recognizable cause of renal disease ' (2000 ) 36 Am. J. Kidney Dis. : 1089 -1109 .
Akposso, K., Hertig, A., Couprie, R. és mtsai: Acute renal failure in patients over 80 years old: 25-years’ experience. Int. Care Med., 2000, 26 , 400–406.
Couprie R. , 'Acute renal failure in patients over 80 years old: 25-years’ experience ' (2000 ) 26 Int. Care Med. : 400 -406 .