View More View Less
  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar Családorvosi Tanszék Budapest Kútvölgyi út 4. 1125
  • | 2 Semmelweis Egyetem, Általános Orvostudományi Kar Magatartástudományi Intézet Budapest
  • | 3 Semmelweis Egyetem, Általános Orvostudományi Kar I. Belgyógyászati Klinika Budapest
Restricted access

Az obstruktív alvási apnoe az alvás alatti leggyakoribb légzészavar, kiemelt fontosságú kórkép az alvászavarok körében. Az össznépességben gyakorisága 2–4%, és legfontosabb jellemzője a felső légutak alvás alatti ismétlődő részleges vagy teljes elzáródása, amelyet oxigéndeszaturáció és hirtelen ébredés követ. A klinikai kép megjelenése komplex. A kórkép gyanúját veti fel a hangos horkolás légzésszünetekkel, amelyhez túlzott nappali aluszékonyság társul, de gondolnunk kell erre a betegségre terápiarezisztens hypertonia, szívelégtelenség, szívritmuszavarok, stroke vagy depresszió, memóriazavar esetén is. Az obstruktív alvási apnoe felismerésében fontos szerepe van a családorvosnak, aki a vezető tünetek alapján és a Berlin-kérdőív segítségével könnyen azonosíthatja a nagy kockázatú betegeket. A kiszűrt betegeket további kivizsgálás és terápiabeállítás céljából alváslaboratóriumba kell irányítani poliszomnográfiás vizsgálatra.

  • Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep, 1999, 22, 667–689.

  • Parati, G., Lombardi, C., Narkiewicz, K.: Sleep apnea: Epidemiology, pathophysiology and relation to cardiovascular risk. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2007, 293 , R1671–R1683.

    Narkiewicz K. , 'Sleep apnea: Epidemiology, pathophysiology and relation to cardiovascular risk ' (2007 ) 293 Am. J. Physiol. Regul. Integr. Comp. Physiol. : R1671 -R1683.

    • Search Google Scholar
  • Dunai, A., Mucsi, I., Juhász, J. és mtsa: Az obstruktív alvási apnoe epidemiológiája, diagnosztikája, kezelése és cardiovascularis következményei. Orv. Hetil., 2006, 147 , 1559–1564.

    Juhász J. , 'Az obstruktív alvási apnoe epidemiológiája, diagnosztikája, kezelése és cardiovascularis következményei ' (2006 ) 147 Orv. Hetil. : 1559 -1564.

    • Search Google Scholar
  • Hiestand, D. M., Britz, P., Goldman, M. és mtsa: Prevalence of symptoms and risk of sleep apnea in the US population: Results from the national sleep foundation sleep in America 2005 poll. Chest, 2006, 130 , 780–786.

    Goldman M. , 'Prevalence of symptoms and risk of sleep apnea in the US population: Results from the national sleep foundation sleep in America 2005 poll ' (2006 ) 130 Chest : 780 -786.

    • Search Google Scholar
  • Strohl, K. P., Redline, S.: Recognition of obstructive sleep apnea. Am. J. Respir. Crit. Care Med., 1996, 154 (2Pt1) , 279–289.

    Redline S. , 'Recognition of obstructive sleep apnea ' (1996 ) 154 Am. J. Respir. Crit. Care Med. : 279 -289.

    • Search Google Scholar
  • Strohl, K. P., Cherniack, N. S., Gothe, B.: Physiologic basis of therapy for sleep apnea. Am. Rev. Respir. Dis., 1986, 134 , 791–802.

    Gothe B. , 'Physiologic basis of therapy for sleep apnea ' (1986 ) 134 Am. Rev. Respir. Dis. : 791 -802.

    • Search Google Scholar
  • Bottini, P., Redolfi, S., Dottorini, M. L. és mtsa: Autonomic neuropathy increases the risk of obstructive sleep apnea in obese diabetics. Respiration, 2008, 75 , 265–271.

    Dottorini M. L. , 'Autonomic neuropathy increases the risk of obstructive sleep apnea in obese diabetics ' (2008 ) 75 Respiration : 265 -271.

    • Search Google Scholar
  • Novak, M., Mendelssohn, D., Shapiro, C. M. és mtsa: Diagnosis and management of sleep apnea syndrome and restless legs syndrome in dialysis patients. Semin. Dial., 2006, 19 , 210–216.

    Shapiro C. M. , 'Diagnosis and management of sleep apnea syndrome and restless legs syndrome in dialysis patients ' (2006 ) 19 Semin. Dial. : 210 -216.

    • Search Google Scholar
  • Young, T., Palta, M., Dempsey, J. és mtsai: The occurrence of sleep-disordered breathing among middle-aged adults. N. Engl. J. Med., 1993, 328 , 1230–1235.

    Dempsey J. , 'The occurrence of sleep-disordered breathing among middle-aged adults ' (1993 ) 328 N. Engl. J. Med. : 1230 -1235.

    • Search Google Scholar
  • Duran, J., Esnaola, S., Rubio, R. és mtsa: Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. Am. J. Respir. Crit. Care Med., 2001, 163 (3Pt1) , 685–689.

    Rubio R. , 'Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr ' (2001 ) 163 Am. J. Respir. Crit. Care Med. : 685 -689.

    • Search Google Scholar
  • Young, T., Shahar, E., Nieto, F. J. és mtsai: Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch. Intern. Med., 2002, 162 , 893–900.

    Nieto F. J. , 'Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study ' (2002 ) 162 Arch. Intern. Med. : 893 -900.

    • Search Google Scholar
  • Banno, K., Walld, R., Kryger, M. H.: Increasing obesity trends in patients with sleep-disordered breathing referred to a sleep disorders center. J. Clin. Sleep Med., 2005, 1 , 364–366.

    Kryger M. H. , 'Increasing obesity trends in patients with sleep-disordered breathing referred to a sleep disorders center ' (2005 ) 1 J. Clin. Sleep Med. : 364 -366.

    • Search Google Scholar
  • Ohayon, M. M., Guilleminault, C., Priest, R. G. és mtsai: Is sleep-disordered breathing an independent risk factor for hypertension in the general population (13,057 subjects)? J. Psychosom. Res., 2000, 48 , 593–601.

    Priest R. G. , 'Is sleep-disordered breathing an independent risk factor for hypertension in the general population (13,057 subjects)? ' (2000 ) 48 J. Psychosom. Res. : 593 -601.

    • Search Google Scholar
  • Zoller, R., Novák, M., Dunai, A. és mtsai: Correlates of snoring in a large representative population sample. J. Sleep Res., 2004, 26 , 826.

    Dunai A. , 'Correlates of snoring in a large representative population sample ' (2004 ) 26 J. Sleep Res. : 826 -.

    • Search Google Scholar
  • Young, T., Peppard, P. E., Gottlieb, D. J.: Epidemiology of obstructive sleep apnea: a population health perspective. Am. J. Respir. Crit. Care Med., 2002, 165 , 1217–1239.

    Gottlieb D. J. , 'Epidemiology of obstructive sleep apnea: a population health perspective ' (2002 ) 165 Am. J. Respir. Crit. Care Med. : 1217 -1239.

    • Search Google Scholar
  • Peppard, P. E., Young, T., Palta, M. és mtsai: Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA, 2000, 284 , 3015–3021.

    Palta M. , 'Longitudinal study of moderate weight change and sleep-disordered breathing ' (2000 ) 284 JAMA : 3015 -3021.

    • Search Google Scholar
  • Tishler, P. V., Larkin, E. K., Schluchter, M. D. és mtsa: Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep-disordered breathing. JAMA, 2003, 289 , 2230–2237.

    Schluchter M. D. , 'Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep-disordered breathing ' (2003 ) 289 JAMA : 2230 -2237.

    • Search Google Scholar
  • Davies, R. J., Ali, N. J., Stradling, J. R.: Neck circumference and other clinical features in the diagnosis of the obstructive sleep apnoea syndrome. Thorax, 1992, 47 , 101–105.

    Stradling J. R. , 'Neck circumference and other clinical features in the diagnosis of the obstructive sleep apnoea syndrome ' (1992 ) 47 Thorax : 101 -105.

    • Search Google Scholar
  • Resta, O., Bonfitto, P., Sabato, R. és mtsai: Prevalence of obstructive sleep apnoea in a sample of obese women: effect of menopause. Diabet. Nutr. Metab., 2004, 17 , 296–303.

    Sabato R. , 'Prevalence of obstructive sleep apnoea in a sample of obese women: effect of menopause ' (2004 ) 17 Diabet. Nutr. Metab. : 296 -303.

    • Search Google Scholar
  • Kadotani, H. K. T., Young, T., Peppard, P. E. és mtsai: Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults. JAMA, 2001, 285 , 2888–2890.

    Peppard P. E. , 'Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults ' (2001 ) 285 JAMA : 2888 -2890.

    • Search Google Scholar
  • Pack, A. I.: Sleep apnea: pathogenesis, diagnosis, and treatment. Marcel Dekker, New York, 2002.

    Pack A. I. , '', in Sleep apnea: pathogenesis, diagnosis, and treatment , (2002 ) -.

  • Mathur, R., Douglas, N. J.: Family studies in patients with the sleep apnea-hypopnea syndrome. Ann. Intern. Med., 1995, 122 , 174–178.

    Douglas N. J. , 'Family studies in patients with the sleep apnea-hypopnea syndrome ' (1995 ) 122 Ann. Intern. Med. : 174 -178.

    • Search Google Scholar
  • Malhortra, A. Cs., Pillar, G., Kikinis, R. és mtsa: Aging-related changes in the pharyngeal structure and function in normal subjects. Sleep, 2000, 23 , A42.

    Kikinis R. , 'Aging-related changes in the pharyngeal structure and function in normal subjects ' (2000 ) 23 Sleep : A42 -.

    • Search Google Scholar
  • Ancoli-Israel, S., Gehrman, P., Kripke, D. F. és mtsa: Long-term follow-up of sleep disordered breathing in older adults. Sleep Med., 2001, 2 , 511–516.

    Kripke D. F. , 'Long-term follow-up of sleep disordered breathing in older adults ' (2001 ) 2 Sleep Med. : 511 -516.

    • Search Google Scholar
  • Young, T.: Sleep-disordered breathing in older adults: is it a condition distinct from that in middle-aged adults? Sleep, 1996, 19 , 529–530.

    Young T. , 'Sleep-disordered breathing in older adults: is it a condition distinct from that in middle-aged adults? ' (1996 ) 19 Sleep : 529 -530.

    • Search Google Scholar
  • Bielicki, P., Byskiniewicz, K., Kumor, M. és mtsai: Obstructive sleep apnoea syndrome in younger and older age groups – differences and similarities. Pneumonol. Alergol. Pol., 2006, 74 , 56–58.

    Kumor M. , 'Obstructive sleep apnoea syndrome in younger and older age groups – differences and similarities ' (2006 ) 74 Pneumonol. Alergol. Pol. : 56 -58.

    • Search Google Scholar
  • Lavie, P., Lavie, L., Herer, P.: All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age. Eur. Respir. J., 2005, 25 , 514–520.

    Herer P. , 'All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age ' (2005 ) 25 Eur. Respir. J. : 514 -520.

    • Search Google Scholar
  • Banno, K., Kryger, M. H.: Sleep apnea: clinical investigations in humans. Sleep Med., 2007, 8 , 400–426.

    Kryger M. H. , 'Sleep apnea: clinical investigations in humans ' (2007 ) 8 Sleep Med. : 400 -426.

    • Search Google Scholar
  • Young, T., Evans, L., Finn, L. és mtsa: Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep, 1997, 20 , 705–706.

    Finn L. , 'Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women ' (1997 ) 20 Sleep : 705 -706.

    • Search Google Scholar
  • Smith, R., Ronald, J., Delaive, K. és mtsai: What are obstructive sleep apnea patients being treated for prior to this diagnosis? Chest, 2002, 121 , 164–172.

    Delaive K. , 'What are obstructive sleep apnea patients being treated for prior to this diagnosis? ' (2002 ) 121 Chest : 164 -172.

    • Search Google Scholar
  • Leech, J. A., Onal, E., Dulberg, C. és mtsa: A comparison of men and women with occlusive sleep apnea syndrome. Chest, 1988, 94 , 983–988.

    Dulberg C. , 'A comparison of men and women with occlusive sleep apnea syndrome ' (1988 ) 94 Chest : 983 -988.

    • Search Google Scholar
  • Resta, O., Carpanano, G. E., Lacedonia, D. és mtsai: Gender difference in sleep profile of severely obese patients with obstructive sleep apnea (OSA). Respir. Med., 2005, 99 , 91–96.

    Lacedonia D. , 'Gender difference in sleep profile of severely obese patients with obstructive sleep apnea (OSA) ' (2005 ) 99 Respir. Med. : 91 -96.

    • Search Google Scholar
  • Shepertycky, B. K., Kryger, M. H.: Gender differences in clinical presentation of patients diagnosed with obstructive sleep apnea syndrome. Sleep, 2005, 28 , 309–324.

    Kryger M. H. , 'Gender differences in clinical presentation of patients diagnosed with obstructive sleep apnea syndrome ' (2005 ) 28 Sleep : 309 -324.

    • Search Google Scholar
  • Cistulli, P. A., Grunstein, R. R., Sullivan, C. E.: Effect of testosterone administration on upper airway collapsibility during sleep. Am. J. Respir. Crit. Care Med., 1994, 149 (2Pt1) , 530–532.

    Sullivan C. E. , 'Effect of testosterone administration on upper airway collapsibility during sleep ' (1994 ) 149 Am. J. Respir. Crit. Care Med. : 530 -532.

    • Search Google Scholar
  • Fogel, R. B., Malhotra, A., Pillar, G. és mtsai: Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 2001, 86 , 1175–1180.

    Pillar G. , 'Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome ' (2001 ) 86 J. Clin. Endocrinol. Metab. : 1175 -1180.

    • Search Google Scholar
  • Bixler, E. O., Vgontzas, A. N., Lin, H. M. és mtsai: Prevalence of sleep-disordered breathing in women: effects of gender. Am. J. Respir. Crit. Care Med., 2001, 163 (3Pt1) , 608–613.

    Lin H. M. , 'Prevalence of sleep-disordered breathing in women: effects of gender ' (2001 ) 163 Am. J. Respir. Crit. Care Med. : 608 -613.

    • Search Google Scholar
  • Arbus, L., Tiberge, M., Serres, A. és mtsa: Drowsiness and traffic accidents. Importance of diagnosis. Neurophysiol. Clin., 1991, 21 , 39–43.

    Serres A. , 'Drowsiness and traffic accidents. Importance of diagnosis ' (1991 ) 21 Neurophysiol. Clin. : 39 -43.

    • Search Google Scholar
  • Gottlieb, D. J., Whitney, C. W., Bonekat, W. H. és mtsai: Relation of sleepiness to respiratory disturbance index: the Sleep Heart Health Study. Am. J. Respir. Crit. Care Med., 1999, 159 , 502–507.

    Bonekat W. H. , 'Relation of sleepiness to respiratory disturbance index: the Sleep Heart Health Study ' (1999 ) 159 Am. J. Respir. Crit. Care Med. : 502 -507.

    • Search Google Scholar
  • Engleman, H. M., Hirst, W. S., Douglas, N. J.: Under reporting of sleepiness and driving impairment in patients with sleep apnoea/hypopnoea syndrome. J. Sleep Res., 1997, 6 , 272–275.

    Douglas N. J. , 'Under reporting of sleepiness and driving impairment in patients with sleep apnoea/hypopnoea syndrome ' (1997 ) 6 J. Sleep Res. : 272 -275.

    • Search Google Scholar
  • Johns, M. W.: A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep, 1991, 14 , 540–545.

    Johns M. W. , 'A new method for measuring daytime sleepiness: the Epworth sleepiness scale ' (1991 ) 14 Sleep : 540 -545.

    • Search Google Scholar
  • Fong, S. Y., Ho, C. K., Wing, Y. K.: Comparing MSLT and ESS in the measurement of excessive daytime sleepiness in obstructive sleep apnoea syndrome. J. Psychosom. Res., 2005, 58 , 55–60.

    Wing Y. K. , 'Comparing MSLT and ESS in the measurement of excessive daytime sleepiness in obstructive sleep apnoea syndrome ' (2005 ) 58 J. Psychosom. Res. : 55 -60.

    • Search Google Scholar
  • Beninati, W., Harris, C. D., Herold, D. L. és mtsa: The effect of snoring and obstructive sleep apnea on the sleep quality of bed partners. Mayo Clin. Proc., 1999, 74 , 955–958.

    Herold D. L. , 'The effect of snoring and obstructive sleep apnea on the sleep quality of bed partners ' (1999 ) 74 Mayo Clin. Proc. : 955 -958.

    • Search Google Scholar
  • Netzer, N. C., Stoohs, R. A., Netzer, C. M. és mtsai: Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann. Intern. Med., 1999, 131 , 485–491.

    Netzer C. M. , 'Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome ' (1999 ) 131 Ann. Intern. Med. : 485 -491.

    • Search Google Scholar
  • Hoffstein, V., Szalai, J. P.: Predictive value of clinical features in diagnosing obstructive sleep apnea. Sleep, 1993, 16 , 118–122.

    Szalai J. P. , 'Predictive value of clinical features in diagnosing obstructive sleep apnea ' (1993 ) 16 Sleep : 118 -122.

    • Search Google Scholar
  • Szakács Z.: Alvási apnoe szindróma, mint stroke és CV-rizikófaktor. Háziorv. Továbbk. Szle, 2007, 12 , 250–256.

    Szakács Z. , 'Alvási apnoe szindróma, mint stroke és CV-rizikófaktor ' (2007 ) 12 Háziorv. Továbbk. Szle : 250 -256.

    • Search Google Scholar
  • Coughlin, S. R., Mawdsley, L., Mugarza, J. A. és mtsai: Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur. Heart J., 2004, 25 , 735–741.

    Mugarza J. A. , 'Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome ' (2004 ) 25 Eur. Heart J. : 735 -741.

    • Search Google Scholar
  • Elmasry, A., Lindberg, E., Berne, C. és mtsai: Sleep-disordered breathing and glucose metabolism in hypertensive men: a population-based study. J. Intern. Med., 2001, 249 , 153–161.

    Berne C. , 'Sleep-disordered breathing and glucose metabolism in hypertensive men: a population-based study ' (2001 ) 249 J. Intern. Med. : 153 -161.

    • Search Google Scholar
  • Plywaczewski, R., Bednarek, M., Jonczak, L. és mtsai: Hyperuricaemia in males with obstructive sleep apnoea (osa). Pneumonol. Alergol. Pol., 2005, 73 , 254–259.

    Jonczak L. , 'Hyperuricaemia in males with obstructive sleep apnoea (osa) ' (2005 ) 73 Pneumonol. Alergol. Pol. : 254 -259.

    • Search Google Scholar

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Dec 2020 6 0 0
Jan 2021 13 0 0
Feb 2021 19 0 0
Mar 2021 10 0 0
Apr 2021 14 1 1
May 2021 19 1 1
Jun 2021 3 0 0