Orvosi Hetilap
Volume/Issue:
Volume 149: Issue 8
Mesenchymal stem cells and the immune system – Immunosuppression without drugs
Authors: Judit Kiss 1 , Veronika Urbán S., Valéria Dudics 3 , Virág Vas 1 , and Ferenc Uher 1
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  • 1 Országos Vérellátó Szolgálat Őssejt-biológia Budapest Diószegi út 64. 1113
  • 2 Semmelweis Egyetem, Egészségügyi Főiskolai Kar Morfológiai és Fiziológiai Intézet Budapest
  • 3 Budai Irgalmasrendi Kórház Reumatológiai Osztály Budapest
DOI:
https://doi.org/10.1556/oh.2008.28291
Page Count:
339–346
Publication Date:
01 Feb 2008
Online Publication Date:
16 Feb 2008
Article Category:
Research Article
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A mesenchymalis őssejteket (MSC-ket) már számos szövettípusból sikeresen izolálták. Ezek a sejtek terápiás felhasználás szempontjából különösen ígéretesnek tűnnek a felnőtt szöveti őssejtek közül, mivel könnyen izolálhatók, és viszonylag egyszerű a fenntartásuk és szaporításuk in vitro, valamint képesek számos sejttípussá, többek között csont-, porc-, ín-, izom- és zsírsejtekké alakulni. A szervezetben ezek a sejtek biztosítják azokat a növekedési faktorokat és cytokineket, amelyek a vérképző sejtek osztódását és differenciálódását szabályozzák. In vivo képesek lehetnek sérült szövetek regenerálására a vesében, szívben, májban, hasnyálmirigyben és az emésztőrendszerben. Emellett az MSC-k immunmoduláló és gyulladáscsökkentő hatással is rendelkeznek, és allogén szervezetben is csak minimális immunválaszt váltanak ki. Bár a folyamat háttere még nem teljesen ismert, az e sejtek immunszuppresszív hatásán alapuló módszerek már a klinikai kipróbálás fázisában vannak, és lehetséges, hogy a jövőben az MSC-k segítségével allograft-kilökődés, graft versus host betegség, rheumatoid arthritis, autoimmun eredetű ízületi gyulladás és más olyan betegségek lesznek kezelhetők, amelyek esetében immunszuppresszió és szöveti regeneráció is szükséges. A jelen összefoglaló célja a mesenchymalis őssejtekről szóló irodalom áttekintése, különös tekintettel azok immunmoduláló tulajdonságaira és jövőbeli lehetséges klinikai felhasználására.

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Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
autoimmunitás; immunszuppresszió; mesenchymalis őssejtek; őssejt-transzplantáció; autoimmunity; immunosuppression; mesenchymal stem cells; stem cell transplantation

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