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  • 1 Debreceni Egyetem, Orvos- és Egészségtudományi Centrum III. Belgyógyászati Klinika Debrecen Móricz Zs. u. 22. 4032
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Az autoimmun betegségek diagnózisát megelőzően a betegeknek sokszor hónapokkal vagy évekkel korábban vannak olyan panaszai, amelyek a kóros immunreakció megnyilvánulásai. Nem differenciált collagenosis, vagy ahogy a nemzetközi irodalomban nevezik: nem differenciált kötőszöveti betegség esetén a poliszisztémás autoimmun betegségnek csak a gyanúja merül fel, de nincsen meg az adott kórkép diagnosztizálásához szükséges tünetcsoport és autoantitest, mert a meglevő eltérések nem merítik ki a szisztémás lupus erythematosus (SLE), Sjögren-szindróma, kevert kötőszöveti betegség, szisztémás sclerosis, polymyositis/dermatomyositis (PM/DM), rheumatoid arthritis (RA) diagnosztikus kritériumait. Az NDC-s betegek 30–40%-a általában a követés első öt évében differenciálódik a már ismert szisztémás autoimmun kórképekbe, míg 60–70% az NDC stádiumban marad. Az NDC egy dinamikus állapot, ami a kórlefolyás során bármikor progrediálhat definitív szisztémás kórképbe. Az NDC stádiumban már kimutatható az immunreguláció zavara, a vasculatura károsodása, az endotheldiszfunkció. A nem differenciált collagenosis állapotban alapvető feladat, hogy minél korábban felismerjük egy poliszisztémás kórkép alakulásának lehetőségét.

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