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  • 1 Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Belgyógyászati Intézet, I. Belgyógyászati Klinika Debrecen
  • 2 Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Patológiai Intézet Debrecen
  • 3 Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Sebészeti Intézet Debrecen
  • 4 Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Klinikai Biokémiai és Molekuláris Patológiai Intézet Debrecen Nagyerdei krt. 98. 4032
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Huszonöt évvel ezelőtt izolálták először a Ki-67 fehérjét, ami napjainkra az osztódó sejtek első számú hisztológiai markere lett. Ez a kivételes szerkezetű molekula olyan alapvető biológiai funkciókkal bír, amelyek nélkülözhetetlenek a normális sejtciklushoz. Miután a Ki-67 fehérje minden osztódó sejtben (G1, S, G2/M fázis) jelen van, de a nyugvó sejtekből (G0 fázis) hiányzik, kiválóan alkalmazható az osztódó sejtfrakció kimutatására, ezáltal klinikai jelentőséggel is bír különböző tumoros folyamatok malignitásának megállapításában, a terápiára adott válasz megítélésében. A sejtproliferációban betöltött nélkülözhetetlen funkciói alapján felvetődik a tumorgenezisben is lehetséges szerepe. A szerzők munkájukban áttekintik a fehérje történetét, tulajdonságait, lehetséges szerepeit a sejtciklus szabályozásában és prognosztikai jelentőségét különböző tumoros betegségekben.

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Phone: (+36 1) 464 8235 ---- Fax: (+36 1) 464 8221
Email: orvosihetilap@akkrt.hu