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  • 1 Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ Neurológiai Klinika Pécs Rét u. 2. 7623
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Az összefoglaló közleményben a szerzők áttekintést nyújtanak a neuromyelitis optica (NMO) epidemiológiájáról, klinikai jellegzetességeiről. A közelmúltban leírt anti-aquaporin-4 (AQP-4) antitest a betegséget az ellenanyag-mediált csatornabetegségek közé sorolja, és kimutatása a diagnosztika fontos elemét képezi. A szerzők hangsúlyozzák a betegség multidiszciplináris jellegét: az NMO spektrumbetegségként definiált relapszáló látóideg-gyulladás (RION) az NMO-hoz hasonló terápiát igényelhet és szemészeti diagnózisa alapvető, míg a szisztémás autoimmun kórképekhez társuló myelitisek és az NMO-val gyakran asszociálódó szisztémás autoimmun betegségek a klinikai immunológusok és reumatológusok figyelmét igénylik. Alapvető a sclerosis multiplextől való elkülönítés az eltérő terápiás protokollok miatt. A kritériumrendszer változása, az NMO-spektrum-betegségek definiálása, az NMO-specifikus IgG (anti-AQP-4) azonosítása, valamint megbízható diagnosztikus tesztek a betegség korai diagnózisát és így adekvát terápiát eredményezhetnek, amely létfontosságú a tartós remisszió és az életminőség fenntartásában. A szerzők esetek ismertetésével szemléltetik a diagnosztikai gondolkozást.

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