Korszerű kombinált gyógyszeres és sugárkezelés eredményeként a Hodgkin-lymphoma (HL) az egyik legsikeresebben gyógyítható daganatos betegséggé vált. Hagyományos képalkotó eljárásokkal a reziduális masszában az aktív betegség, a nekrózis és a fibrózis elkülönítése nehéz. Célkitűzés: Retrospektív vizsgálatunk célja a restaging FDG-PET vizsgálat prediktív értékének vizsgálata. Módszer: Százhuszonnyolc olyan beteg adatait dolgoztuk fel, akiknél a kezelés utáni CT-vizsgálaton reziduális elváltozás ábrázolódott. Az FDG-PET vizsgálatokat 1995. január és 2005. február között végeztük, a vizsgálattól számított átlagos követési idő 75,5 hónap (20–180 hónap). Eredmények: Nyolcvankilenc beteg (70%) PET-vizsgálata negatív eredményű, 39 betegé (30%) pedig pozitív eredményű volt. A ténylegesen pozitív, ténylegesen negatív, álpozitív, álnegatív betegek száma sorrendben 29, 83, 10, 6. A kezelés utáni FDG-PET szenzitivitása 83%-nak, specificitása 93%-nak, pozitív prediktív értéke 74%-nak, negatív prediktív értéke 93%-nak, pontossága 88%-nak bizonyult. Az FDG-PET-negatív és -pozitív betegek eseménymentes túlélése – Mantel–Cox-analízissel – szignifikánsan (p = 0,0000) különbözött. Következtetések: Eredményeink az irodalmi adatokkal egyezően bizonyítják, hogy negatív FDG-PET vizsgálati eredmény esetén a betegség progressziója, relapszusa hosszú követés során sem valószínű. Az álpozitív eredmény azonban komoly diagnosztikus problémát jelent. Vizsgáltuk, hogy a betegek életkora, a betegség szövettani altípusa, klinikai stádiuma, a kezelés módja befolyásolja-e a vizsgálat pontosságát, de ilyen összefüggést nem tudtunk igazolni. Kimutattuk, hogy a 2000 előtt végzett vizsgálatok között több téves eredmény volt, mint 2000 után, ami a vizsgálók tapasztalatának jelentőségét igazolja.
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