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  • 1 Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ I. Belgyógyászati Klinika Pécs Ifjúság u. 13. 7624
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A hepatitis B-vírus az egyik legfontosabb etiológiai tényezője a hepatocellularis carcinomának. A dolgozat a vírus által indukált carcinogenesis molekuláris mechanizmusait, az infekció indirekt és direkt hatásait tárgyalja. Mind a májsejtkárosodás által kiváltott regeneráció és proliferáció, mind a vírusproteinek okozta kromoszomális, genetikai és epigenetikai változások kulcsszerepet játszanak a többlépéses folyamatban, amely végül malignus sejttranszformációhoz vezet. A HBV-DNS-szakaszok integrációja a celluláris DNS-be, az onkogének aktivációja és a tumorszuppresszorgén-funkciók kiesése alapvető jelentőségű tényezők. A hepatitis B-vírus okozta cirrhosis és májrák kialakulásának kockázata csökkenthető hatékony vakcináció révén vagy a kórokozó antivirális terápiával történő eradikációja által.

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