View More View Less
  • 1 Szegedi Tudományegyetem, Általános Orvostudományi Kar Bőrgyógyászati és Allergológiai Klinika Szeged Korányi fasor 6. 6720
  • 2 Szegedi Tudományegyetem, Általános Orvostudományi Kar Aneszteziológiai és Intenzív Terápiás Intézet Szeged
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $1,070.00

Az elektrokemoterápia daganatok bőráttéteinek palliatív kezelésére alkalmas eljárás, amelynek során nagy energiájú elektromos impulzusok hatására a sejtek membránja áteresztővé válik olyan anyagok, így kemoterapeutikumok számára, amelyek egyébként nem vagy csak kismértékben kerülnének a sejt belsejébe, ezáltal megnövelve azok citotoxikus hatását. Módszer: Klinikánkon 7, előrehaladott melanomában szenvedő beteg 81 bőráttétének elektrokemoterápiás kezelését végeztük el. A beavatkozásokat altatásban, intravénás bleomycin adásával végeztük. Az átlagos követési idő 218 nap volt. Eredmények: A kezelés hatására 25%-ban észleltünk teljes, míg 43%-ban részleges remissziót. A kezelt metasztázisok 26%-ánál nem történt változás, míg 6%-ban a tumor növekedett. Következtetések: Eredményeink alátámasztják azokat az irodalmi adatokat, amelyek szerint az elektrokemoterápia egyszerűen kivitelezhető, hatásos módszer a melanoma többszörös bőráttéteinek palliatív kezelésére. Az új eljárás kevés mellékhatással jár, és javítja a betegek életminőségét.

  • Mir, L. M.: Therapeutic perspectives of in vivo cell electropermeabilization. Bioelectrochemistry, 2001, 53 , 1–10.

    Mir L. M. , 'Therapeutic perspectives of in vivo cell electropermeabilization ' (2001 ) 53 Bioelectrochemistry : 1 -10.

    • Search Google Scholar
  • Miklavcic, D., Corovic, S., Pucihar, G. és mtsai: Importance of tumour coverage by sufficiently high local electric field for effective electrochemotherapy. Eur. J. Cancer, 2006, 4 , 45–51.

    Pucihar G. , 'Importance of tumour coverage by sufficiently high local electric field for effective electrochemotherapy ' (2006 ) 4 Eur. J. Cancer : 45 -51.

    • Search Google Scholar
  • Miklavcic, D., Semrov, D., Mekid, H. és mtsai: A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochim. Biophys. Acta, 2000, 1523 , 73–83.

    Mekid H. , 'A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy ' (2000 ) 1523 Biochim. Biophys. Acta : 73 -83.

    • Search Google Scholar
  • Pucihar, G., Kotnik, T., Valic, B. és mtsai: Numerical determination of transmembrane voltage induced on irregularly shaped cells. Ann. Biomed. Eng., 2006, 34 , 642–652.

    Valic B. , 'Numerical determination of transmembrane voltage induced on irregularly shaped cells ' (2006 ) 34 Ann. Biomed. Eng. : 642 -652.

    • Search Google Scholar
  • Mir, L. M.: Bases and rationale of the electrochemotherapy. Eur. J. Cancer, 2006, 4 , 38–44.

    Mir L. M. , 'Bases and rationale of the electrochemotherapy ' (2006 ) 4 Eur. J. Cancer : 38 -44.

    • Search Google Scholar
  • Orlowski, S., Belehradek, J. Jr., Paoletti, C. és mtsai: Transient electropermeabilization of cells in culture. Increase of the cytotoxicity of anticancer drugs. Biochem. Pharmacol., 1988, 37 , 4727–4733.

    Paoletti C. , 'Transient electropermeabilization of cells in culture. Increase of the cytotoxicity of anticancer drugs ' (1988 ) 37 Biochem. Pharmacol. : 4727 -4733.

    • Search Google Scholar
  • Sersa, G., Cemazar, M., Miklavcic, D.: Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice. Cancer Res., 1995, 55 , 3450–3455.

    Miklavcic D. , 'Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice ' (1995 ) 55 Cancer Res. : 3450 -3455.

    • Search Google Scholar
  • Mir, L. M., Gehl, J., Sersa, G. és mtsai: Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the Cliniporator (TM) by means of invasive or non-invasive electrodes. Eur. J. Cancer, 2006, 4 , 14–25.

    Sersa G. , 'Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the Cliniporator (TM) by means of invasive or non-invasive electrodes ' (2006 ) 4 Eur. J. Cancer : 14 -25.

    • Search Google Scholar
  • Sersa, G.: The state-of-the-art of electrochemotherapy before the ESOPE study; advantages and clinical uses. Eur. J. Cancer, 2006, 4 , 52–59.

    Sersa G. , 'The state-of-the-art of electrochemotherapy before the ESOPE study; advantages and clinical uses ' (2006 ) 4 Eur. J. Cancer : 52 -59.

    • Search Google Scholar
  • Byrne, C. M., Thompson, J. F.: Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors. Expert. Rev. Anticancer Ther., 2006, 6 , 671–678.

    Thompson J. F. , 'Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors ' (2006 ) 6 Expert. Rev. Anticancer Ther. : 671 -678.

    • Search Google Scholar
  • Mir, L. M., Glass, L. F., Sersa, G. és mtsai: Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br. J. Cancer, 1998, 77 , 2336–2342.

    Sersa G. , 'Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy ' (1998 ) 77 Br. J. Cancer : 2336 -2342.

    • Search Google Scholar
  • Heller, R., Jaroszeski, M., Perrott, R. és mtsai: Effective treatment of B16 melanoma by direct delivery of bleomycin using electrochemotherapy. Melanoma Res., 1997, 7 , 10–18.

    Perrott R. , 'Effective treatment of B16 melanoma by direct delivery of bleomycin using electrochemotherapy ' (1997 ) 7 Melanoma Res. : 10 -18.

    • Search Google Scholar
  • Sersa, G., Stabuc, B., Cemazar, M. és mtsai: Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patients. Clin. Cancer Res., 2000, 6 , 863–867.

    Cemazar M. , 'Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patients ' (2000 ) 6 Clin. Cancer Res. : 863 -867.

    • Search Google Scholar
  • Bloom, D. C., Goldfarb, P. M.: The role of intratumour therapy with electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck. Eur. J. Surg. Oncol., 2005, 31 , 1029–1035.

    Goldfarb P. M. , 'The role of intratumour therapy with electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck ' (2005 ) 31 Eur. J. Surg. Oncol. : 1029 -1035.

    • Search Google Scholar
  • Byrne, C. M., Thompson, J. F., Johnston, H. és mtsai: Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy). Melanoma Res., 2005, 15 , 45–51.

    Johnston H. , 'Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy) ' (2005 ) 15 Melanoma Res. : 45 -51.

    • Search Google Scholar
  • Marty, M., Sersa, G., Garbay, J. R. és mtsai: Electrochemotherapy – An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur. J. Cancer, 2006, 4 , 3–13.

    Garbay J. R. , 'Electrochemotherapy – An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study ' (2006 ) 4 Eur. J. Cancer : 3 -13.

    • Search Google Scholar
  • Domenge, C., Orlowski, S., Luboinski, B. és mtsai: Antitumor electrochemotherapy: new advances in the clinical protocol. Cancer, 1996, 77 , 956–963.

    Luboinski B. , 'Antitumor electrochemotherapy: new advances in the clinical protocol ' (1996 ) 77 Cancer : 956 -963.

    • Search Google Scholar
  • WHO: Handbook for reporting results of cancer treatment. 1997, 22–27.

  • Campana, L. G., Mocellin, S., Basso, M. és mtsai: Bleomycin-based electrochemotherapy: clinical outcome from a single institution’s experience with 52 patients. Ann. Surg. Oncol., 2009, 16 , 191–199.

    Basso M. , 'Bleomycin-based electrochemotherapy: clinical outcome from a single institution’s experience with 52 patients ' (2009 ) 16 Ann. Surg. Oncol. : 191 -199.

    • Search Google Scholar
  • Snoj, M., Rudolf, Z., Paulin-Kosir, S. M. és mtsai: Long lasting complete response in melanoma treated by electrochemotherapy. Eur. J. Cancer, 2006, 4 , 26–28.

    Paulin-Kosir S. M. , 'Long lasting complete response in melanoma treated by electrochemotherapy ' (2006 ) 4 Eur. J. Cancer : 26 -28.

    • Search Google Scholar
  • Quaglino, P., Mortera, C., Osella-Abate, S. és mtsai: Electrochemotherapy with intravenous bleomycin in the local treatment of skin melanoma metastases. Ann. Surg. Oncol., 2008, 15 , 2215–2222.

    Osella-Abate S. , 'Electrochemotherapy with intravenous bleomycin in the local treatment of skin melanoma metastases ' (2008 ) 15 Ann. Surg. Oncol. : 2215 -2222.

    • Search Google Scholar
  • Cemazar, M., Milacic, R., Miklavcic, D. és mtsai: Intratumoral cisplatin administration in electrochemotherapy: antitumor effectiveness, sequence dependence and platinum content. Anticancer Drugs, 1998, 9 , 525–530.

    Miklavcic D. , 'Intratumoral cisplatin administration in electrochemotherapy: antitumor effectiveness, sequence dependence and platinum content ' (1998 ) 9 Anticancer Drugs : 525 -530.

    • Search Google Scholar
  • Puc, M., Corovic, S., Flisar, K. és mtsai: Techniques of signal generation required for electropermeabilization. Survey of electropermeabilization devices. Bioelectrochemistry, 2004, 64 , 113–124.

    Flisar K. , 'Techniques of signal generation required for electropermeabilization. Survey of electropermeabilization devices ' (2004 ) 64 Bioelectrochemistry : 113 -124.

    • Search Google Scholar
  • Mir, L. M., Orlowski, S., Belehradek, J. Jr. és mtsai: Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur. J. Cancer, 1991, 27 , 68–72.

    Belehradek J. , 'Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses ' (1991 ) 27 Eur. J. Cancer : 68 -72.

    • Search Google Scholar
  • Belehradek, J. Jr., Orlowski, S., Poddevin, B. és mtsai: Electrochemotherapy of spontaneous mammary tumours in mice. Eur. J. Cancer, 1991, 27 , 73–76.

    Poddevin B. , 'Electrochemotherapy of spontaneous mammary tumours in mice ' (1991 ) 27 Eur. J. Cancer : 73 -76.

    • Search Google Scholar
  • Snoj, M., Rudolf, Z., Cemazar, M. és mtsai: Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy. Anticancer Drugs, 2005, 16 , 345–348.

    Cemazar M. , 'Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy ' (2005 ) 16 Anticancer Drugs : 345 -348.

    • Search Google Scholar
  • Shimizu, T., Nikaido, T., Gomyo, H. és mtsai: Electrochemotherapy for digital chondrosarcoma. J. Orthop. Sci., 2003, 8 , 248–251.

    Gomyo H. , 'Electrochemotherapy for digital chondrosarcoma ' (2003 ) 8 J. Orthop. Sci. : 248 -251.

    • Search Google Scholar
  • Glass, L. F., Pepine, M. L., Fenske, N. A. és mtsai: Bleomycin-mediated electrochemotherapy of metastatic melanoma. Arch. Dermatol., 1996, 132 , 1353–1357.

    Fenske N. A. , 'Bleomycin-mediated electrochemotherapy of metastatic melanoma ' (1996 ) 132 Arch. Dermatol. : 1353 -1357.

    • Search Google Scholar
  • Gaudy, C., Richard, M. A., Folchetti, G. és mtsai: Randomized controlled study of electrochemotherapy in the local treatment of skin metastases of melanoma. J. Cutan. Med. Surg., 2006, 10 , 115–121.

    Folchetti G. , 'Randomized controlled study of electrochemotherapy in the local treatment of skin metastases of melanoma ' (2006 ) 10 J. Cutan. Med. Surg. : 115 -121.

    • Search Google Scholar
  • Pavselj, N., Bregar, Z., Cukjati, D. és mtsai: The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals. IEEE Trans. Biomed. Eng., 2005, 52 , 1373–1381.

    Cukjati D. , 'The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals ' (2005 ) 52 IEEE Trans. Biomed. Eng. : 1373 -1381.

    • Search Google Scholar
  • Colombo, G. L., Matteo, S. D., Mir, L. M.: Cost-effectiveness analysis of electrochemotherapy with the Cliniporatortrade mark vs other methods for the control and treatment of cutaneous and subcutaneous tumors. Ther. Clin. Risk Manag., 2008, 4 , 541–548.

    Mir L. M. , 'Cost-effectiveness analysis of electrochemotherapy with the Cliniporatortrade mark vs other methods for the control and treatment of cutaneous and subcutaneous tumors ' (2008 ) 4 Ther. Clin. Risk Manag. : 541 -548.

    • Search Google Scholar
  • Snoj, M., Cemazar, M., Slekovec, K. B. és mtsai: Effective treatment of multiple unresectable skin melanoma metastases by electrochemotherapy. Croat. Med. J., 2007, 48 , 391–395.

    Slekovec K. B. , 'Effective treatment of multiple unresectable skin melanoma metastases by electrochemotherapy ' (2007 ) 48 Croat. Med. J. : 391 -395.

    • Search Google Scholar
  • Glass, L. F., Fenske, N. A., Jaroszeski, M. és mtsai: Bleomycin-mediated electrochemotherapy of basal cell carcinoma. J. Am. Acad. Dermatol., 1996, 34 , 82–86.

    Jaroszeski M. , 'Bleomycin-mediated electrochemotherapy of basal cell carcinoma ' (1996 ) 34 J. Am. Acad. Dermatol. : 82 -86.

    • Search Google Scholar
  • Rols, M. P., Bachaud, J. M., Giraud, P. és mtsai: Electrochemotherapy of cutaneous metastases in malignant melanoma. Melanoma Res., 2000, 10 , 468–474.

    Giraud P. , 'Electrochemotherapy of cutaneous metastases in malignant melanoma ' (2000 ) 10 Melanoma Res. : 468 -474.

    • Search Google Scholar
  • Heller, R., Jaroszeski, M. J., Reintgen, D. S. és mtsai: Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin. Cancer, 1998, 83 , 148–157.

    Reintgen D. S. , 'Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin ' (1998 ) 83 Cancer : 148 -157.

    • Search Google Scholar